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The map label for this gene is purM [H]

Identifier: 94311843

GI number: 94311843

Start: 3165378

End: 3166430

Strand: Reverse

Name: purM [H]

Synonym: Rmet_2911

Alternate gene names: 94311843

Gene position: 3166430-3165378 (Counterclockwise)

Preceding gene: 94311852

Following gene: 94311839

Centisome position: 80.61

GC content: 65.62

Gene sequence:

>1053_bases
ATGAGCGCATCCCCGACCGCCGGCCAGGCAGGCCTTTCCTACCGCGATGCCGGTGTTGACATCGAAGCCGGCGACGCGCT
GGTTGATCGAATCAAGCCGTTTGCCAAGCGCACCATGCGCGAAGGCGTGATGGCCGGCATCGGCGGTTTCGGCGCGCTGT
TCGAGCTGTCGAAGAAGTACCAAGAACCGGTCCTGGTTTCTGGCACCGACGGCGTGGGCACCAAGCTCAAGCTGGCGTTC
CAGCTCAACCGCCATGACACGGTGGGCCAGGATCTGGTGGCAATGAGCGTCAACGACATCCTCGTGCAGGGTGCCGAGCC
GCTGTTCTTCCTCGACTACTTTGCCTGCGGCAAGCTGGATGTGGAAACCGCGGCCACCGTGATCAAGGGCATCGCCCACG
GCTGCGAACTGGCTGGCTGCGCGCTGATCGGCGGCGAAACCGCTGAAATGCCGAGCATGTACCCGGACGGCGAATACGAC
CTGGCCGGTTTCGCGGTCGGCGCCGTGGAAAAGAAGAAGATCATCGACGGCAGCACGATCACCCCGGGTGACGTGGTGCT
GGGCCTGGCTTCGTCGGGCGCGCATTCGAACGGCTACTCGCTGGTGCGCAAGATCATTGACGTGGCCCGCCCGAACCTGG
ACGCGGACTTCCACGGCCAGCGCCTGCAGGACGCCATCATGGCGCCGACGCGCATCTACGTGAAGCCGCTGCTGTCGCTG
ATCGAAACGCTGCCGGTCAAGGGCATGGCCCACATCACTGGTGGCGGCCTGACCGAGAACGTGCCGCGCGTGCTGGCCGA
CAACGTCACCGCCGTGATCCAGCGCGACGCCTGGACGCTGCCGCCGCTGTTCCAGTGGCTGCAGGCAGAAGGCCGCGTGG
CCGACGCCGAAATGCACCGCGTGTTCAACTGCGGTATCGGCATGGTCGTGATTGTGGCGAAGGAAGACGCTGAACGCGCC
ATCCGCCACCTGCAGGCGGCCGGTGAGGCCGTGTGGCAGATCGGTGAGATCCGCGAGCGTGCCGAAGGCCAGGCGCAGAC
CGTGGTGGTCTGA

Upstream 100 bases:

>100_bases
TACTGGACTCGAGCCCGCCTTCTACGCCAGATTTGGCGAAAAGCGCGTCAGCCGAGCGCCGGAATCCACACTTCACCTCC
TCAAAGACAAGCAGGTTCTC

Downstream 100 bases:

>100_bases
TCAGCCTTGCTGACGTACCAACAAAAAGCCCGGCCGAGAGGCCGGGTTTTTTGTTTTCTGGGCGTCAGGGATCACGCACC
CAGCTTCGTCAGCGCATCGC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSASPTAGQAGLSYRDAGVDIEAGDALVDRIKPFAKRTMREGVMAGIGGFGALFELSKKYQEPVLVSGTDGVGTKLKLAF
QLNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAATVIKGIAHGCELAGCALIGGETAEMPSMYPDGEYD
LAGFAVGAVEKKKIIDGSTITPGDVVLGLASSGAHSNGYSLVRKIIDVARPNLDADFHGQRLQDAIMAPTRIYVKPLLSL
IETLPVKGMAHITGGGLTENVPRVLADNVTAVIQRDAWTLPPLFQWLQAEGRVADAEMHRVFNCGIGMVVIVAKEDAERA
IRHLQAAGEAVWQIGEIRERAEGQAQTVVV

Sequences:

>Translated_350_residues
MSASPTAGQAGLSYRDAGVDIEAGDALVDRIKPFAKRTMREGVMAGIGGFGALFELSKKYQEPVLVSGTDGVGTKLKLAF
QLNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAATVIKGIAHGCELAGCALIGGETAEMPSMYPDGEYD
LAGFAVGAVEKKKIIDGSTITPGDVVLGLASSGAHSNGYSLVRKIIDVARPNLDADFHGQRLQDAIMAPTRIYVKPLLSL
IETLPVKGMAHITGGGLTENVPRVLADNVTAVIQRDAWTLPPLFQWLQAEGRVADAEMHRVFNCGIGMVVIVAKEDAERA
IRHLQAAGEAVWQIGEIRERAEGQAQTVVV
>Mature_349_residues
SASPTAGQAGLSYRDAGVDIEAGDALVDRIKPFAKRTMREGVMAGIGGFGALFELSKKYQEPVLVSGTDGVGTKLKLAFQ
LNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAATVIKGIAHGCELAGCALIGGETAEMPSMYPDGEYDL
AGFAVGAVEKKKIIDGSTITPGDVVLGLASSGAHSNGYSLVRKIIDVARPNLDADFHGQRLQDAIMAPTRIYVKPLLSLI
ETLPVKGMAHITGGGLTENVPRVLADNVTAVIQRDAWTLPPLFQWLQAEGRVADAEMHRVFNCGIGMVVIVAKEDAERAI
RHLQAAGEAVWQIGEIRERAEGQAQTVVV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=346, Percent_Identity=54.6242774566474, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI209869995, Length=346, Percent_Identity=54.6242774566474, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI209869993, Length=346, Percent_Identity=54.6242774566474, Blast_Score=372, Evalue=1e-103,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=58.3090379008746, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17567511, Length=347, Percent_Identity=43.8040345821326, Blast_Score=266, Evalue=9e-72,
Organism=Saccharomyces cerevisiae, GI6321203, Length=344, Percent_Identity=46.8023255813954, Blast_Score=318, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24582400, Length=303, Percent_Identity=42.5742574257426, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37197; Mature: 37066

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASPTAGQAGLSYRDAGVDIEAGDALVDRIKPFAKRTMREGVMAGIGGFGALFELSKKY
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QEPVLVSGTDGVGTKLKLAFQLNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLD
CCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCC
VETAATVIKGIAHGCELAGCALIGGETAEMPSMYPDGEYDLAGFAVGAVEKKKIIDGSTI
HHHHHHHHHHHHHCCCHHCEEEECCCCCCCCCCCCCCCCCCHHEEECCHHHHHCCCCCCC
TPGDVVLGLASSGAHSNGYSLVRKIIDVARPNLDADFHGQRLQDAIMAPTRIYVKPLLSL
CCCHHEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
IETLPVKGMAHITGGGLTENVPRVLADNVTAVIQRDAWTLPPLFQWLQAEGRVADAEMHR
HHHCCCCCEEEECCCCCCHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHH
VFNCGIGMVVIVAKEDAERAIRHLQAAGEAVWQIGEIRERAEGQAQTVVV
HHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
>Mature Secondary Structure 
SASPTAGQAGLSYRDAGVDIEAGDALVDRIKPFAKRTMREGVMAGIGGFGALFELSKKY
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QEPVLVSGTDGVGTKLKLAFQLNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLD
CCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCC
VETAATVIKGIAHGCELAGCALIGGETAEMPSMYPDGEYDLAGFAVGAVEKKKIIDGSTI
HHHHHHHHHHHHHCCCHHCEEEECCCCCCCCCCCCCCCCCCHHEEECCHHHHHCCCCCCC
TPGDVVLGLASSGAHSNGYSLVRKIIDVARPNLDADFHGQRLQDAIMAPTRIYVKPLLSL
CCCHHEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
IETLPVKGMAHITGGGLTENVPRVLADNVTAVIQRDAWTLPPLFQWLQAEGRVADAEMHR
HHHCCCCCEEEECCCCCCHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHH
VFNCGIGMVVIVAKEDAERAIRHLQAAGEAVWQIGEIRERAEGQAQTVVV
HHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA