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The map label for this gene is rfbD [H]

Identifier: 94311666

GI number: 94311666

Start: 2969501

End: 2970421

Strand: Reverse

Name: rfbD [H]

Synonym: Rmet_2734

Alternate gene names: 94311666

Gene position: 2970421-2969501 (Counterclockwise)

Preceding gene: 94311667

Following gene: 94311665

Centisome position: 75.62

GC content: 61.02

Gene sequence:

>921_bases
ATGCTGCGTGAAGCACAGAGAGCCCCCACGCTTCTTGTAACAGGAAGCAATGGCCAGGTCGGCTTCGAACTGCGTCGCAG
TCTGGCGCCGCTGGGCCGGGTCGTGGCGCTGGACCGAAGCCAATTTGACCTGACTCGACCGGATGCATTGCGCGAACTGG
TTCGCTCGATTCGGCCAGACGTCATCGTCAATCCAGCGGCATACACTGCCGTAGACAAGGCCGAAACCGAAGCAGAGGCG
GCGTTCGCGGTAAATGGCGTGGCGCCTGGGGTCCTTGCGGAGGAGGCACGCCGCCTGGGCAGTCTGTTCGTCCATTACTC
GACCGACTACGTTTTCGATGGCACCAAGGATGGCGCCTATCTGGAAGGTGATGCAGTTAATCCGCAATCGGTGTATGGCA
AGAGCAAACTGGCCGGCGAGCAAGTAGTTGCAGCTACTGGTGCGGCATCGCTTGTGCTGCGCACCTGTTGGGTGGCTGGT
GCGCACGGCGGGAACTTTGCGAAGACCATGCTCAGGCTGGCACGCGAGCGAGACAGCCTGAGGGTAATTGCGGATCAGTT
CGGCGCCCCGACAACCGCTTCCCTGATTGCGGATGTGACTGCGCAAATCGTCGCGCGCCACTGGCTCCATGCCCCAGGCC
GCGAAGCATTTCCCACTGGTGTGTATCACCTGGCAGCCGGGGGGGAAACTACCTGGCACGGATATGCCACTCACGTGCTG
TCAAGAGCCGCAGCCAAGGGCGTGGAGATGAAGGTCGATCCCACCCGCATCGAACCAATTCCAGCTTCGCAGTATCCGCT
GCCCGCGCCGCGCCCAGCCAACTCACGGCTGGATACCGGCAAGCTGCGGGACACATTCAATATTCACCTTCCTGACTGGG
CGGAGGGCATTGACCTTCTTCTCGATCAGATCCTTTCCTGA

Upstream 100 bases:

>100_bases
GAAAGCGGACTGCGCAAGACTGTCCAGTGGTACCTGGACAATCAGCCCTGGGTTCAGGACGTGATCTCCGGTGAGTACCG
CAACTGGGTAGCGAAGCAAT

Downstream 100 bases:

>100_bases
CCACTTGTACCATGCGCAAAGGCATTATTCTGGCCGGCGGTTCCGGCACTCGGCTCTATCCCATCACGCGGTCGGTGTCC
AAACAACTGCTGCCCGTGTA

Product: dTDP-4-dehydrorhamnose reductase subunit, NAD(P)-binding, of dTDP-L-rhamnose synthase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MLREAQRAPTLLVTGSNGQVGFELRRSLAPLGRVVALDRSQFDLTRPDALRELVRSIRPDVIVNPAAYTAVDKAETEAEA
AFAVNGVAPGVLAEEARRLGSLFVHYSTDYVFDGTKDGAYLEGDAVNPQSVYGKSKLAGEQVVAATGAASLVLRTCWVAG
AHGGNFAKTMLRLARERDSLRVIADQFGAPTTASLIADVTAQIVARHWLHAPGREAFPTGVYHLAAGGETTWHGYATHVL
SRAAAKGVEMKVDPTRIEPIPASQYPLPAPRPANSRLDTGKLRDTFNIHLPDWAEGIDLLLDQILS

Sequences:

>Translated_306_residues
MLREAQRAPTLLVTGSNGQVGFELRRSLAPLGRVVALDRSQFDLTRPDALRELVRSIRPDVIVNPAAYTAVDKAETEAEA
AFAVNGVAPGVLAEEARRLGSLFVHYSTDYVFDGTKDGAYLEGDAVNPQSVYGKSKLAGEQVVAATGAASLVLRTCWVAG
AHGGNFAKTMLRLARERDSLRVIADQFGAPTTASLIADVTAQIVARHWLHAPGREAFPTGVYHLAAGGETTWHGYATHVL
SRAAAKGVEMKVDPTRIEPIPASQYPLPAPRPANSRLDTGKLRDTFNIHLPDWAEGIDLLLDQILS
>Mature_306_residues
MLREAQRAPTLLVTGSNGQVGFELRRSLAPLGRVVALDRSQFDLTRPDALRELVRSIRPDVIVNPAAYTAVDKAETEAEA
AFAVNGVAPGVLAEEARRLGSLFVHYSTDYVFDGTKDGAYLEGDAVNPQSVYGKSKLAGEQVVAATGAASLVLRTCWVAG
AHGGNFAKTMLRLARERDSLRVIADQFGAPTTASLIADVTAQIVARHWLHAPGREAFPTGVYHLAAGGETTWHGYATHVL
SRAAAKGVEMKVDPTRIEPIPASQYPLPAPRPANSRLDTGKLRDTFNIHLPDWAEGIDLLLDQILS

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=284, Percent_Identity=27.8169014084507, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI11034825, Length=284, Percent_Identity=27.8169014084507, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1788352, Length=301, Percent_Identity=46.5116279069767, Blast_Score=269, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32882; Mature: 32882

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLREAQRAPTLLVTGSNGQVGFELRRSLAPLGRVVALDRSQFDLTRPDALRELVRSIRPD
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHCCCC
VIVNPAAYTAVDKAETEAEAAFAVNGVAPGVLAEEARRLGSLFVHYSTDYVFDGTKDGAY
EEECCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHEEEEECCCEEECCCCCCCE
LEGDAVNPQSVYGKSKLAGEQVVAATGAASLVLRTCWVAGAHGGNFAKTMLRLARERDSL
EECCCCCHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHH
RVIADQFGAPTTASLIADVTAQIVARHWLHAPGREAFPTGVYHLAAGGETTWHGYATHVL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHH
SRAAAKGVEMKVDPTRIEPIPASQYPLPAPRPANSRLDTGKLRDTFNIHLPDWAEGIDLL
HHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHH
LDQILS
HHHHCC
>Mature Secondary Structure
MLREAQRAPTLLVTGSNGQVGFELRRSLAPLGRVVALDRSQFDLTRPDALRELVRSIRPD
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHCCCC
VIVNPAAYTAVDKAETEAEAAFAVNGVAPGVLAEEARRLGSLFVHYSTDYVFDGTKDGAY
EEECCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHEEEEECCCEEECCCCCCCE
LEGDAVNPQSVYGKSKLAGEQVVAATGAASLVLRTCWVAGAHGGNFAKTMLRLARERDSL
EECCCCCHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHH
RVIADQFGAPTTASLIADVTAQIVARHWLHAPGREAFPTGVYHLAAGGETTWHGYATHVL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHH
SRAAAKGVEMKVDPTRIEPIPASQYPLPAPRPANSRLDTGKLRDTFNIHLPDWAEGIDLL
HHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHH
LDQILS
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]