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The map label for this gene is gcdH [H]

Identifier: 94311587

GI number: 94311587

Start: 2888824

End: 2890017

Strand: Direct

Name: gcdH [H]

Synonym: Rmet_2653

Alternate gene names: 94311587

Gene position: 2888824-2890017 (Clockwise)

Preceding gene: 94311585

Following gene: 94311589

Centisome position: 73.54

GC content: 64.32

Gene sequence:

>1194_bases
ATGGCTGCCAACGCCGAATTCAACTGGGCTGACCCGCTGTTGCTCGACCAGCAACTGACCGCCGACGAACGCATGGTGCG
TGACGCCGCCGCGGCTTACTGCCAGGACAAGCTGATGCCGCGCGTGCTGCAGTCCTTCCGTAACGAGAAGACCGATGTGG
AGATCTTCCGCGAGATGGGCGAACTGGGCCTGCTCGGCCCGACCATCCCCGAGCAGTACGGCGGCCCCGGCCTGAACTAC
GTCAGCTACGGCCTGATCGCGCGTGAAGTGGAGCGCGTGGATTCGGGCTACCGCTCGATGATGAGCGTGCAGTCGTCGCT
GGTCATGGTCCCGATCTACGAGTTCGGCACCGAAGCCCAGAAGCAGAAGTACCTGCCCAAGCTGGCCACCGGCGAGTGGA
TTGGCTGCTTCGGCCTGACCGAACCGAACCATGGCTCGGACCCGGGCTCGATGGTCACGCGCGCCAAGAAGGTGGCTGGC
GGCTACGAGCTGACCGGCGCCAAGATGTGGATCACCAACTCGCCGATCGCCGACGTGTTCGTGGTGTGGGCCAAGCTGAT
GGGCGACGATGGCAAGGAAGCCATCCGCGGTTTCATCCTGGAAAAGGGCTGGAAGGGTCTGTCGGCCCCGGCCATCCACG
GCAAGGTTGGCCTGCGCACGTCGATCACCGGTGAAATCGTGCTGGACCAGGTATTCGTGCCGGAAGAGAACATCATGCCG
GGCGTCAGCGGCCTGAAGGGTCCGTTCACCTGCCTGAACTCGGCCCGATATGGCATTGCCTGGGGTGCGCTCGGTGCTGC
CGAATTCTGCTGGCATACCGCACGCCAGTACACGCTGGACCGCAAGCAGTTCGGCCGCCCGCTGGCCGCCACCCAGCTGG
TGCAGAAGAAGCTGGCCGACATGCAGACCGAGATCACGCTGGGCCTGCAAGGCTGCCTGCGCCTGGGCCGCATGAAGGAC
GAAGGCACGGCCGCGGTGGAAATCACCTCGATCATGAAGCGCAACTCGTGCGGCAAGTCGCTCGACATCGCCCGCGTGGC
GCGTGACATGCTCGGCGGCAACGGTATTTCCGACGAGTTCGGCGTGATCCGCCACGTGGTCAACCTCGAGGTGGTCAACA
CCTACGAAGGCACGCACGACATCCACGCGCTGATCCTGGGTCGCGCGCAAACTGGCCTCCAGGCATTCTTCTGA

Upstream 100 bases:

>100_bases
GGAACTTAAGAAATTCCACCCGATTTCCATTTCGTGTCGTTTTTCCCGGATTGTGTGAAGGCTACAGGCCTTCCTCGCCA
CACCAAAGAAGGAGACCTCC

Downstream 100 bases:

>100_bases
AGCTGGAAGCATGAAAAAAGCCCGGTCTTGAGTCATCAAGCCGGGCGGAAGCACACTACCAAGGAGACGACGGGCAAGCC
CGCCGTTTTACGACATCATT

Product: glutaryl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MAANAEFNWADPLLLDQQLTADERMVRDAAAAYCQDKLMPRVLQSFRNEKTDVEIFREMGELGLLGPTIPEQYGGPGLNY
VSYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGTEAQKQKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRAKKVAG
GYELTGAKMWITNSPIADVFVVWAKLMGDDGKEAIRGFILEKGWKGLSAPAIHGKVGLRTSITGEIVLDQVFVPEENIMP
GVSGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAATQLVQKKLADMQTEITLGLQGCLRLGRMKD
EGTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEFGVIRHVVNLEVVNTYEGTHDIHALILGRAQTGLQAFF

Sequences:

>Translated_397_residues
MAANAEFNWADPLLLDQQLTADERMVRDAAAAYCQDKLMPRVLQSFRNEKTDVEIFREMGELGLLGPTIPEQYGGPGLNY
VSYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGTEAQKQKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRAKKVAG
GYELTGAKMWITNSPIADVFVVWAKLMGDDGKEAIRGFILEKGWKGLSAPAIHGKVGLRTSITGEIVLDQVFVPEENIMP
GVSGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAATQLVQKKLADMQTEITLGLQGCLRLGRMKD
EGTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEFGVIRHVVNLEVVNTYEGTHDIHALILGRAQTGLQAFF
>Mature_396_residues
AANAEFNWADPLLLDQQLTADERMVRDAAAAYCQDKLMPRVLQSFRNEKTDVEIFREMGELGLLGPTIPEQYGGPGLNYV
SYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGTEAQKQKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRAKKVAGG
YELTGAKMWITNSPIADVFVVWAKLMGDDGKEAIRGFILEKGWKGLSAPAIHGKVGLRTSITGEIVLDQVFVPEENIMPG
VSGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAATQLVQKKLADMQTEITLGLQGCLRLGRMKDE
GTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEFGVIRHVVNLEVVNTYEGTHDIHALILGRAQTGLQAFF

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=397, Percent_Identity=67.2544080604534, Blast_Score=549, Evalue=1e-156,
Organism=Homo sapiens, GI7669494, Length=377, Percent_Identity=66.0477453580902, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=32.9787234042553, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=30.9139784946237, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=33.6231884057971, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=29.4277929155313, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI76496475, Length=337, Percent_Identity=33.8278931750742, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI4557235, Length=337, Percent_Identity=33.8278931750742, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI21361497, Length=350, Percent_Identity=32.5714285714286, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=29.8666666666667, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=29.8666666666667, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=28.4182305630027, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4501857, Length=383, Percent_Identity=27.9373368146214, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1786223, Length=337, Percent_Identity=25.2225519287834, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081958, Length=339, Percent_Identity=25.9587020648968, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17534353, Length=391, Percent_Identity=63.1713554987212, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17538396, Length=336, Percent_Identity=33.6309523809524, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17508101, Length=367, Percent_Identity=31.8801089918256, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17569725, Length=375, Percent_Identity=30.9333333333333, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=29.8630136986301, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71990804, Length=274, Percent_Identity=36.1313868613139, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71985184, Length=370, Percent_Identity=31.6216216216216, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=30.4232804232804, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=280, Percent_Identity=34.2857142857143, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=28.7598944591029, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=30.7692307692308, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=32.9004329004329, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17533517, Length=373, Percent_Identity=25.201072386059, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=382, Percent_Identity=23.8219895287958, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17505929, Length=354, Percent_Identity=24.2937853107345, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI19920834, Length=399, Percent_Identity=62.65664160401, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=31.266846361186, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=32.3287671232877, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=31.4516129032258, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=31.2, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=31.2169312169312, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI281363737, Length=356, Percent_Identity=31.1797752808989, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43462; Mature: 43330

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANAEFNWADPLLLDQQLTADERMVRDAAAAYCQDKLMPRVLQSFRNEKTDVEIFREMG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ELGLLGPTIPEQYGGPGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGTEAQ
HCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHCCHHH
KQKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRAKKVAGGYELTGAKMWITNSPIADVF
HHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEECCCEEEEECCCHHHHH
VVWAKLMGDDGKEAIRGFILEKGWKGLSAPAIHGKVGLRTSITGEIVLDQVFVPEENIMP
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCHHEEEHEEECCCCCCCC
GVSGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAATQLVQKKLAD
CCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHH
MQTEITLGLQGCLRLGRMKDEGTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEF
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHH
GVIRHVVNLEVVNTYEGTHDIHALILGRAQTGLQAFF
HHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AANAEFNWADPLLLDQQLTADERMVRDAAAAYCQDKLMPRVLQSFRNEKTDVEIFREMG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ELGLLGPTIPEQYGGPGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGTEAQ
HCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHCCHHH
KQKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRAKKVAGGYELTGAKMWITNSPIADVF
HHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEECCCEEEEECCCHHHHH
VVWAKLMGDDGKEAIRGFILEKGWKGLSAPAIHGKVGLRTSITGEIVLDQVFVPEENIMP
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCHHEEEHEEECCCCCCCC
GVSGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAATQLVQKKLAD
CCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHH
MQTEITLGLQGCLRLGRMKDEGTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEF
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHH
GVIRHVVNLEVVNTYEGTHDIHALILGRAQTGLQAFF
HHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]