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The map label for this gene is tdo

Identifier: 94311585

GI number: 94311585

Start: 2886815

End: 2887714

Strand: Direct

Name: tdo

Synonym: Rmet_2651

Alternate gene names: 94311585

Gene position: 2886815-2887714 (Clockwise)

Preceding gene: 94311584

Following gene: 94311587

Centisome position: 73.49

GC content: 63.0

Gene sequence:

>900_bases
ATGAGCGAATTCAAGGGATGCCCGATGGGGCACGGAGCCGCCCCGCAAAACGGTGATGGCGGTGATAGCGGTGATACCGG
CAATGGCTGGCACGGCGCGCAAATGGATTTCGCGCGCGACATGAGCTATGGGGACTACCTGGGCCTGGACCAGATCCTGA
GCGCCCAGCATCCGCTGTCTCCGGATCACAACGAGATGCTGTTCATCGTCCAGCACCAGACCACCGAACTCTGGATGAAG
CTGATGCTGCACGAGCTGCGCGCGGCGCGTGATGGCGTCAAGTCGGATCAGCTTCAGCCGGCATTCAAAATGCTGGCGCG
CGTCTCGCGCATCATGGATCAGCTCGTGCAGGCGTGGAACGTGCTGGCGACGATGACGCCGCCCGAGTACTCGGCGATGC
GCCCATACCTGGGGGCATCGTCCGGCTTCCAGTCATACCAGTATCGCGAGATCGAGTTCATCCTCGGCAACAAGAACGCA
GCCATGCTGCGTCCGCACGCGCATCGGCCCGAACATCTCGAACTGGTGGAGACCGCGCTGCATACGCCGTCGATGTACGA
CGAGGCCATCCGGCTGATGGCCCGCCGCGGCTTCCAGATCGACCCCGAGGTGGTGGAACGCGACTGGACTCAGCCGACGC
AGTACAACGCATCGGTGGAAGCGGCCTGGCTCGAGGTCTACCGCAACCCGTCGGCCCACTGGGAGCTCTACGAACTCGGC
GAGAAGTTCGTCGATCTGGAAGACGCGTTCCGGCAATGGCGCTTCCGCCACGTGACCACAGTCGAGCGCGTAATCGGATT
CAAGCGCGGCACCGGCGGCACCGAAGGCGTCAGCTATCTGCGCAGGATGCTGGACGTGGTGCTGTTTCCGGAACTGTGGA
AACTGCGGACAGACCTGTAG

Upstream 100 bases:

>100_bases
TGGGACGCCGTCGAGATCATCCGCGACGTGCTCGACAGCGGCGTCTATCGTGACGCGCGCTTTGCCGTGCGGACGGCGGT
GACCTGAGCGGGAGTCGATC

Downstream 100 bases:

>100_bases
TACCTGCTGGTTTGCTCCCCTCCCCCCAATTCATGGGCGAGGGGAGCGCATAGCTGCGGCACTCAGACTTGTCGCCCGGC
CGGGTCCGACAGCCGCGTGG

Product: Tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSEFKGCPMGHGAAPQNGDGGDSGDTGNGWHGAQMDFARDMSYGDYLGLDQILSAQHPLSPDHNEMLFIVQHQTTELWMK
LMLHELRAARDGVKSDQLQPAFKMLARVSRIMDQLVQAWNVLATMTPPEYSAMRPYLGASSGFQSYQYREIEFILGNKNA
AMLRPHAHRPEHLELVETALHTPSMYDEAIRLMARRGFQIDPEVVERDWTQPTQYNASVEAAWLEVYRNPSAHWELYELG
EKFVDLEDAFRQWRFRHVTTVERVIGFKRGTGGTEGVSYLRRMLDVVLFPELWKLRTDL

Sequences:

>Translated_299_residues
MSEFKGCPMGHGAAPQNGDGGDSGDTGNGWHGAQMDFARDMSYGDYLGLDQILSAQHPLSPDHNEMLFIVQHQTTELWMK
LMLHELRAARDGVKSDQLQPAFKMLARVSRIMDQLVQAWNVLATMTPPEYSAMRPYLGASSGFQSYQYREIEFILGNKNA
AMLRPHAHRPEHLELVETALHTPSMYDEAIRLMARRGFQIDPEVVERDWTQPTQYNASVEAAWLEVYRNPSAHWELYELG
EKFVDLEDAFRQWRFRHVTTVERVIGFKRGTGGTEGVSYLRRMLDVVLFPELWKLRTDL
>Mature_298_residues
SEFKGCPMGHGAAPQNGDGGDSGDTGNGWHGAQMDFARDMSYGDYLGLDQILSAQHPLSPDHNEMLFIVQHQTTELWMKL
MLHELRAARDGVKSDQLQPAFKMLARVSRIMDQLVQAWNVLATMTPPEYSAMRPYLGASSGFQSYQYREIEFILGNKNAA
MLRPHAHRPEHLELVETALHTPSMYDEAIRLMARRGFQIDPEVVERDWTQPTQYNASVEAAWLEVYRNPSAHWELYELGE
KFVDLEDAFRQWRFRHVTTVERVIGFKRGTGGTEGVSYLRRMLDVVLFPELWKLRTDL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family

Homologues:

Organism=Homo sapiens, GI5032165, Length=376, Percent_Identity=27.3936170212766, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI32564651, Length=201, Percent_Identity=28.8557213930348, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17552370, Length=201, Percent_Identity=28.8557213930348, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17530891, Length=361, Percent_Identity=28.2548476454294, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): T23O_RALME (Q1LK00)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_584795.1
- PDB:   2NOX
- PDBsum:   2NOX
- ProteinModelPortal:   Q1LK00
- SMR:   Q1LK00
- STRING:   Q1LK00
- GeneID:   4039476
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_2651
- eggNOG:   COG3483
- HOGENOM:   HBG647485
- OMA:   HWELYEL
- ProtClustDB:   CLSK896672
- BioCyc:   RMET266264:RMET_2651-MONOMER
- InterPro:   IPR017485
- InterPro:   IPR004981
- PANTHER:   PTHR10138
- TIGRFAMs:   TIGR03036

Pfam domain/function: PF03301 Trp_dioxygenase

EC number: =1.13.11.11

Molecular weight: Translated: 34304; Mature: 34173

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: BINDING 130-130 BINDING 134-134 BINDING 141-141 BINDING 271-271

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFKGCPMGHGAAPQNGDGGDSGDTGNGWHGAQMDFARDMSYGDYLGLDQILSAQHPLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHCCCCCC
PDHNEMLFIVQHQTTELWMKLMLHELRAARDGVKSDQLQPAFKMLARVSRIMDQLVQAWN
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VLATMTPPEYSAMRPYLGASSGFQSYQYREIEFILGNKNAAMLRPHAHRPEHLELVETAL
HHHCCCCCCHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHH
HTPSMYDEAIRLMARRGFQIDPEVVERDWTQPTQYNASVEAAWLEVYRNPSAHWELYELG
CCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
EKFVDLEDAFRQWRFRHVTTVERVIGFKRGTGGTEGVSYLRRMLDVVLFPELWKLRTDL
HHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEFKGCPMGHGAAPQNGDGGDSGDTGNGWHGAQMDFARDMSYGDYLGLDQILSAQHPLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHCCCCCC
PDHNEMLFIVQHQTTELWMKLMLHELRAARDGVKSDQLQPAFKMLARVSRIMDQLVQAWN
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VLATMTPPEYSAMRPYLGASSGFQSYQYREIEFILGNKNAAMLRPHAHRPEHLELVETAL
HHHCCCCCCHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHH
HTPSMYDEAIRLMARRGFQIDPEVVERDWTQPTQYNASVEAAWLEVYRNPSAHWELYELG
CCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
EKFVDLEDAFRQWRFRHVTTVERVIGFKRGTGGTEGVSYLRRMLDVVLFPELWKLRTDL
HHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA