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The map label for this gene is pdxH

Identifier: 94311578

GI number: 94311578

Start: 2879666

End: 2880304

Strand: Direct

Name: pdxH

Synonym: Rmet_2642

Alternate gene names: 94311578

Gene position: 2879666-2880304 (Clockwise)

Preceding gene: 94311577

Following gene: 94311579

Centisome position: 73.31

GC content: 64.63

Gene sequence:

>639_bases
ATGACCCAACTCGCAGACCTGCGCCGCAACTACATGCTGAGCGCGCTTTCCGAAACCGACGTCGCTCCCGACCCGATTCG
CCAGTTCCAGTCGTGGTTCGACGAAGCCATGCAAGCCAAGCTGCCTGAGCCGAACGCCATGACGCTGGCCACCGTGGGCG
CCGACGGCCAGCCGTCCGCGCGCATCGTGCTGCTCAAGGGCATGGATGCCGACGGCTTCACATTCTTCACCAATTACGAA
AGCCGCAAGGGCGTTGACCTGCTGGCCAACCCGCGCGCGGCTCTGTTGTTCCATTGGGTGCAGCTCGAGCGGCAGATCCG
CGTCGAAGGCATCGTCGAGAAGGTCGAGGATGCGGAGAGCGACGCCTACTACGCGTCGCGGCCGCTCGGTTCACGCCTGG
GTGCCTGGGCATCCGAACAGAGCCGCGAGGTTGCTGGCCGCGACGTGATCGAAGCGCGCGAAGCGGATTTCCGCAACAAG
TTCGGCGAGAACCCGCCGCGCCCGCCGCACTGGGGCGGCTACAGGCTCAAACCGACTTGGATCGAGTTCTGGCAAGGCCG
CCCTTCGCGCCTGCACGATCGAATCGCCTATCGCCAGAACGCTGATGGAAACTGGCAAATCGTGAGGCTCTCGCCCTGA

Upstream 100 bases:

>100_bases
TTGCGGCAACGCAAATGCAGCGTGCAGCGCATTCGCTATACTCGAAGTACGCATATCCGCGCGATTCGTGCGCGGAACGC
AAACCTTCCTGATACGCGAC

Downstream 100 bases:

>100_bases
CGCCATCAGCGTCTGCGAGGTCTGATAGACATTTGTCCAATGAAGGACCTGCACTGCACAATTTCAAAAATTGGCGTAAA
GTTTGACGGTTGCTGCACCG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MTQLADLRRNYMLSALSETDVAPDPIRQFQSWFDEAMQAKLPEPNAMTLATVGADGQPSARIVLLKGMDADGFTFFTNYE
SRKGVDLLANPRAALLFHWVQLERQIRVEGIVEKVEDAESDAYYASRPLGSRLGAWASEQSREVAGRDVIEAREADFRNK
FGENPPRPPHWGGYRLKPTWIEFWQGRPSRLHDRIAYRQNADGNWQIVRLSP

Sequences:

>Translated_212_residues
MTQLADLRRNYMLSALSETDVAPDPIRQFQSWFDEAMQAKLPEPNAMTLATVGADGQPSARIVLLKGMDADGFTFFTNYE
SRKGVDLLANPRAALLFHWVQLERQIRVEGIVEKVEDAESDAYYASRPLGSRLGAWASEQSREVAGRDVIEAREADFRNK
FGENPPRPPHWGGYRLKPTWIEFWQGRPSRLHDRIAYRQNADGNWQIVRLSP
>Mature_211_residues
TQLADLRRNYMLSALSETDVAPDPIRQFQSWFDEAMQAKLPEPNAMTLATVGADGQPSARIVLLKGMDADGFTFFTNYES
RKGVDLLANPRAALLFHWVQLERQIRVEGIVEKVEDAESDAYYASRPLGSRLGAWASEQSREVAGRDVIEAREADFRNKF
GENPPRPPHWGGYRLKPTWIEFWQGRPSRLHDRIAYRQNADGNWQIVRLSP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=202, Percent_Identity=45.5445544554455, Blast_Score=181, Evalue=5e-46,
Organism=Escherichia coli, GI1787926, Length=213, Percent_Identity=43.6619718309859, Blast_Score=184, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17553712, Length=195, Percent_Identity=45.6410256410256, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6319509, Length=209, Percent_Identity=43.5406698564593, Blast_Score=169, Evalue=3e-43,
Organism=Drosophila melanogaster, GI45551845, Length=180, Percent_Identity=44.4444444444444, Blast_Score=160, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24644901, Length=203, Percent_Identity=42.3645320197044, Blast_Score=160, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24644903, Length=175, Percent_Identity=30.2857142857143, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_RALME (Q1LK07)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_584788.1
- ProteinModelPortal:   Q1LK07
- SMR:   Q1LK07
- STRING:   Q1LK07
- GeneID:   4039468
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_2642
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- PhylomeDB:   Q1LK07
- ProtClustDB:   PRK05679
- BioCyc:   RMET266264:RMET_2642-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24190; Mature: 24059

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 61-61 BINDING 64-64 BINDING 66-66 BINDING 83-83 BINDING 123-123 BINDING 127-127 BINDING 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLADLRRNYMLSALSETDVAPDPIRQFQSWFDEAMQAKLPEPNAMTLATVGADGQPSA
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCE
RIVLLKGMDADGFTFFTNYESRKGVDLLANPRAALLFHWVQLERQIRVEGIVEKVEDAES
EEEEEECCCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DAYYASRPLGSRLGAWASEQSREVAGRDVIEAREADFRNKFGENPPRPPHWGGYRLKPTW
CCEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCHHH
IEFWQGRPSRLHDRIAYRQNADGNWQIVRLSP
HHHHCCCHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
TQLADLRRNYMLSALSETDVAPDPIRQFQSWFDEAMQAKLPEPNAMTLATVGADGQPSA
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCE
RIVLLKGMDADGFTFFTNYESRKGVDLLANPRAALLFHWVQLERQIRVEGIVEKVEDAES
EEEEEECCCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DAYYASRPLGSRLGAWASEQSREVAGRDVIEAREADFRNKFGENPPRPPHWGGYRLKPTW
CCEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCHHH
IEFWQGRPSRLHDRIAYRQNADGNWQIVRLSP
HHHHCCCHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA