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The map label for this gene is ispA [H]

Identifier: 94311552

GI number: 94311552

Start: 2847259

End: 2848143

Strand: Reverse

Name: ispA [H]

Synonym: Rmet_2616

Alternate gene names: 94311552

Gene position: 2848143-2847259 (Counterclockwise)

Preceding gene: 94311553

Following gene: 94311551

Centisome position: 72.51

GC content: 66.33

Gene sequence:

>885_bases
ATGAGCGATTTCGCCACTTGGATGCGGGCGCAGGGCGCCCGCACCGAAGCCGCTTTGGAAGCGGCCCTACCTTCCACGGA
CACAATTCCATACACCCTCCATGAGGCGATGCGCTATGCTGTGCTCGGCGGTGGCAAGCGTGTGCGCCCCCTGTTAGTGC
ACGCTGCGGGCGAGGTGGTCGGTGCGACACCCGAGGCCTGCGACGCCGCAGCATGCGCCGTCGAGATGATTCACGCCTAT
TCGCTGGTCCACGACGACATGCCCTGCATGGACGACGACGATCTGCGCCGCGGACGCCCCACGGTCCACAAGGCCTATGA
CGAGGCCACGGCCCTGCTGGTCGGTGACGCGCTGCAGAGCCAGGCGTTTATCGTGCTGGCCCAGACCCCGGCTCTGGCTG
CGGAAGCGCGCCTGAAAGTGGTGGCGGAACTGGCCGTGGCATCGGGCTCGATAGGCATGTGCGGTGGACAAGCCATCGAC
CTCCAGAACGTTGGCAAGGCCATGACCCGCGAGGCGCTCGAAGGCATGCACCGCATGAAGACCGGCGCCCTGTTGCGCGC
CAGCGTGCGCATGGGTGCGTTGTGCGGAAACATCGACCAGGCCGGCCTTGTGGCGCTTGATCGATATGCCGCGGCCGTGG
GATTGGCGTTCCAGGTCGTGGACGATATTCTCGACGTCACTGCCGACACGGCAACGCTTGGCAAGACGGCGGGCAAGGAT
GCCGCGAACGACAAGCCGACCTACGTATCGCTGCTTGGCCTGGATGCCGCACGCGAGCTGGCTGCCCAGCTTCGCACCGA
CGCCCACGAGGCGCTGGAGGGATTCGGCACACGCGCTGGCCGGCTCGCCGAACTGGCCGACCTGATCGTGCTGCGCTCAA
ACTGA

Upstream 100 bases:

>100_bases
TGGCGCAGCAGGTCAAGGTACTCGAAGGTGACGCACTGAAGCCGCTAGCCGGCGAGTCGCGCACCCAGAACAACGCAGAC
AGCAACAGCGCAGATTTCGA

Downstream 100 bases:

>100_bases
ACTGAAAAGCCGGACGCACAGAATCCGGCGGCCGAACGGACACCATGACCTACACGCTGCTCAATAAAATCGACGACCCC
GCGGACCTGCGCAAGCTGGA

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSDFATWMRAQGARTEAALEAALPSTDTIPYTLHEAMRYAVLGGGKRVRPLLVHAAGEVVGATPEACDAAACAVEMIHAY
SLVHDDMPCMDDDDLRRGRPTVHKAYDEATALLVGDALQSQAFIVLAQTPALAAEARLKVVAELAVASGSIGMCGGQAID
LQNVGKAMTREALEGMHRMKTGALLRASVRMGALCGNIDQAGLVALDRYAAAVGLAFQVVDDILDVTADTATLGKTAGKD
AANDKPTYVSLLGLDAARELAAQLRTDAHEALEGFGTRAGRLAELADLIVLRSN

Sequences:

>Translated_294_residues
MSDFATWMRAQGARTEAALEAALPSTDTIPYTLHEAMRYAVLGGGKRVRPLLVHAAGEVVGATPEACDAAACAVEMIHAY
SLVHDDMPCMDDDDLRRGRPTVHKAYDEATALLVGDALQSQAFIVLAQTPALAAEARLKVVAELAVASGSIGMCGGQAID
LQNVGKAMTREALEGMHRMKTGALLRASVRMGALCGNIDQAGLVALDRYAAAVGLAFQVVDDILDVTADTATLGKTAGKD
AANDKPTYVSLLGLDAARELAAQLRTDAHEALEGFGTRAGRLAELADLIVLRSN
>Mature_293_residues
SDFATWMRAQGARTEAALEAALPSTDTIPYTLHEAMRYAVLGGGKRVRPLLVHAAGEVVGATPEACDAAACAVEMIHAYS
LVHDDMPCMDDDDLRRGRPTVHKAYDEATALLVGDALQSQAFIVLAQTPALAAEARLKVVAELAVASGSIGMCGGQAIDL
QNVGKAMTREALEGMHRMKTGALLRASVRMGALCGNIDQAGLVALDRYAAAVGLAFQVVDDILDVTADTATLGKTAGKDA
ANDKPTYVSLLGLDAARELAAQLRTDAHEALEGFGTRAGRLAELADLIVLRSN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=220, Percent_Identity=32.2727272727273, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1786623, Length=301, Percent_Identity=49.1694352159468, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1789578, Length=213, Percent_Identity=34.2723004694836, Blast_Score=105, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24651612, Length=228, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 30783; Mature: 30651

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFATWMRAQGARTEAALEAALPSTDTIPYTLHEAMRYAVLGGGKRVRPLLVHAAGEVV
CCHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHEECCCHHH
GATPEACDAAACAVEMIHAYSLVHDDMPCMDDDDLRRGRPTVHKAYDEATALLVGDALQS
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCC
QAFIVLAQTPALAAEARLKVVAELAVASGSIGMCGGQAIDLQNVGKAMTREALEGMHRMK
CEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHH
TGALLRASVRMGALCGNIDQAGLVALDRYAAAVGLAFQVVDDILDVTADTATLGKTAGKD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
AANDKPTYVSLLGLDAARELAAQLRTDAHEALEGFGTRAGRLAELADLIVLRSN
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECC
>Mature Secondary Structure 
SDFATWMRAQGARTEAALEAALPSTDTIPYTLHEAMRYAVLGGGKRVRPLLVHAAGEVV
CHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHEECCCHHH
GATPEACDAAACAVEMIHAYSLVHDDMPCMDDDDLRRGRPTVHKAYDEATALLVGDALQS
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCC
QAFIVLAQTPALAAEARLKVVAELAVASGSIGMCGGQAIDLQNVGKAMTREALEGMHRMK
CEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHH
TGALLRASVRMGALCGNIDQAGLVALDRYAAAVGLAFQVVDDILDVTADTATLGKTAGKD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
AANDKPTYVSLLGLDAARELAAQLRTDAHEALEGFGTRAGRLAELADLIVLRSN
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9655913; 12597275 [H]