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The map label for this gene is dxs

Identifier: 94311551

GI number: 94311551

Start: 2845301

End: 2847214

Strand: Reverse

Name: dxs

Synonym: Rmet_2615

Alternate gene names: 94311551

Gene position: 2847214-2845301 (Counterclockwise)

Preceding gene: 94311552

Following gene: 94311550

Centisome position: 72.48

GC content: 65.99

Gene sequence:

>1914_bases
ATGACCTACACGCTGCTCAATAAAATCGACGACCCCGCGGACCTGCGCAAGCTGGACCGTCGCCAGCTCGACACGCTGGC
CGAGGAACTCCGCGCCTACGTGCTCGAATCGGTCTCGCAAACCGGCGGGCACCTGTCGTCCAACCTCGGCACGGTGGAGC
TGACGATCGCGCTGCACTATGTCTTCGACACACCGAACGATCGCGTGGTCTGGGACGTGGGTCACCAGAGCTATCCCCAC
AAGATCCTGACTGGCCGCCGCGACCGCATGTCGACGCTGCGCCAGTACGGTGGCATCTCCGGCTTCCCGCGCCGTGCCGA
GAGCGAGTACGACACTTTCGGTACTGCGCATTCGTCGACGTCGATTTCCGCGGCGCTGGGCATGGCGCTCGGTGCCCGTA
CCCGGGGCGAGAAGCGCGTGGGTATTGCCGTGATCGGCGATGGCGCGATGACCGCCGGCATGGCTTTCGAAGCCATGAAC
AATGCGGGCGTCTACAAGGACCTGCCGATGCTGGTGGTGCTGAACGACAACGACATGTCGATCTCCCCGCCGGTGGGCAT
GTTGAACAAGCACCTGGCGCGCCTGATGTCGGGCCAGTTCTACGCGGCCACCAAGAAGGGCATCGAGAAGGTGCTGTCGG
TGGCGCCGCCGGTGCTCGAATTCGCCAAGCGCCTGGAAGAACATGCCAAGGGCATGGTCGTGCCGGCCACGCTGTTCGAA
GAATTCGGTTTCGACTACGTCGGCCCGATCGACGGCCACGACCTCGAGTCGCTGGTCCCGACGCTGCAGAACATCCGCCA
GCGCGCGCTGGAAGGCCACGGCCCGCAGTTCCTGCACGTGGTGACCAAGAAGGGCCAGGGCTACAAGCTGGCCGAGGCCG
ATCCGATCCTCTACCACGGCCCGGGCAAGTTCAATCCGGCCGAGGGTATCCGTCCGTCGGCCAAGCCGTCGCGCAAGACC
TACACGCAGGTGTTTGGCGAGTGGCTGTGCGACATGGCCGCCGCCGACAAGCGTCTGATCGGCGTGACGCCGGCCATGCG
CGAAGGCTCGGGCATGGTCGAGTTCGAAAAGCGCTTCCCGGACCGCTACTACGACGTCGGTATCGCAGAGCAGCACGCGG
TGACCTTCGCCGGCGGCCTGGCCTGTGAGGGCCTGAAGCCGGTTGTGGCGATCTACTCGACGTTCCTGCAACGTGGTTAC
GACCAGCTTATTCACGACGTGGCGCTGCAGAACCTGCCAGTGGTGTTCGCGCTGGACCGCGCTGGTCTGGTGGGCGCCGA
TGGTGCCACGCACGCCGGTGTGTACGACATCCCGTTCCTGCGCTGCATCCCGAACATGATGGTGATGGTGCCGGCAGACG
AGAACGAGTGCCGTCAGTTGCTGACGACCGCGTTCCAGCAGGACTGCCCGACCGCCGTGCGCTATCCGCGCGGCGCCGGC
GTCGGCGTGGCCACGCAGCCCGAACTGACCGCGCTGCCGGTGGGCAAGGGCGAGATCCGCCGCGAAGGCCATGCCCGCGC
AGGTCAGCGTGTGGCGATCATGGCGTTCGGTTCGATGGTGCATCCGGCCCTGACCGCGGCTGAGCAACTCGATGCCACGG
TGGCCAACATGCGTTTCGTGAAGCCGCTCGATGTGGAGCTGGTCAAACAACTGGCCGCCAATCACGACTTCCTGGTCACG
GTGGAAGAGGGCGCCACGATGGGCGGTGCCGGTAGCGCCGTGCTCGAGGCGCTGGCCGAGGCGGGTATCGAACTGCCGAC
GTTGGTGCTGGGCCTGCCCGACAAGTTCATCGACCATGGCGATCCGGCGCATCTGCTGTCGCTGTGCGGCCTCGATGCGG
CCGGCATCGAGCGTTCGGTGCGCGAGCGCTTCAGCCTGACGGCGCAACCGGTCAAGGTGGCGAGCGTGGCCTGA

Upstream 100 bases:

>100_bases
CACGCGCTGGCCGGCTCGCCGAACTGGCCGACCTGATCGTGCTGCGCTCAAACTGAACTGAAAAGCCGGACGCACAGAAT
CCGGCGGCCGAACGGACACC

Downstream 100 bases:

>100_bases
CGCCATTCGACACAGGTCATACGCGGTACTGAAAACCGGCGCGGCAACCCCGCGCCGGTTTGTTTTTGGGCGCGCGGGAA
TGGCATTTTTCTGCAGCGCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MTYTLLNKIDDPADLRKLDRRQLDTLAEELRAYVLESVSQTGGHLSSNLGTVELTIALHYVFDTPNDRVVWDVGHQSYPH
KILTGRRDRMSTLRQYGGISGFPRRAESEYDTFGTAHSSTSISAALGMALGARTRGEKRVGIAVIGDGAMTAGMAFEAMN
NAGVYKDLPMLVVLNDNDMSISPPVGMLNKHLARLMSGQFYAATKKGIEKVLSVAPPVLEFAKRLEEHAKGMVVPATLFE
EFGFDYVGPIDGHDLESLVPTLQNIRQRALEGHGPQFLHVVTKKGQGYKLAEADPILYHGPGKFNPAEGIRPSAKPSRKT
YTQVFGEWLCDMAAADKRLIGVTPAMREGSGMVEFEKRFPDRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGY
DQLIHDVALQNLPVVFALDRAGLVGADGATHAGVYDIPFLRCIPNMMVMVPADENECRQLLTTAFQQDCPTAVRYPRGAG
VGVATQPELTALPVGKGEIRREGHARAGQRVAIMAFGSMVHPALTAAEQLDATVANMRFVKPLDVELVKQLAANHDFLVT
VEEGATMGGAGSAVLEALAEAGIELPTLVLGLPDKFIDHGDPAHLLSLCGLDAAGIERSVRERFSLTAQPVKVASVA

Sequences:

>Translated_637_residues
MTYTLLNKIDDPADLRKLDRRQLDTLAEELRAYVLESVSQTGGHLSSNLGTVELTIALHYVFDTPNDRVVWDVGHQSYPH
KILTGRRDRMSTLRQYGGISGFPRRAESEYDTFGTAHSSTSISAALGMALGARTRGEKRVGIAVIGDGAMTAGMAFEAMN
NAGVYKDLPMLVVLNDNDMSISPPVGMLNKHLARLMSGQFYAATKKGIEKVLSVAPPVLEFAKRLEEHAKGMVVPATLFE
EFGFDYVGPIDGHDLESLVPTLQNIRQRALEGHGPQFLHVVTKKGQGYKLAEADPILYHGPGKFNPAEGIRPSAKPSRKT
YTQVFGEWLCDMAAADKRLIGVTPAMREGSGMVEFEKRFPDRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGY
DQLIHDVALQNLPVVFALDRAGLVGADGATHAGVYDIPFLRCIPNMMVMVPADENECRQLLTTAFQQDCPTAVRYPRGAG
VGVATQPELTALPVGKGEIRREGHARAGQRVAIMAFGSMVHPALTAAEQLDATVANMRFVKPLDVELVKQLAANHDFLVT
VEEGATMGGAGSAVLEALAEAGIELPTLVLGLPDKFIDHGDPAHLLSLCGLDAAGIERSVRERFSLTAQPVKVASVA
>Mature_636_residues
TYTLLNKIDDPADLRKLDRRQLDTLAEELRAYVLESVSQTGGHLSSNLGTVELTIALHYVFDTPNDRVVWDVGHQSYPHK
ILTGRRDRMSTLRQYGGISGFPRRAESEYDTFGTAHSSTSISAALGMALGARTRGEKRVGIAVIGDGAMTAGMAFEAMNN
AGVYKDLPMLVVLNDNDMSISPPVGMLNKHLARLMSGQFYAATKKGIEKVLSVAPPVLEFAKRLEEHAKGMVVPATLFEE
FGFDYVGPIDGHDLESLVPTLQNIRQRALEGHGPQFLHVVTKKGQGYKLAEADPILYHGPGKFNPAEGIRPSAKPSRKTY
TQVFGEWLCDMAAADKRLIGVTPAMREGSGMVEFEKRFPDRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGYD
QLIHDVALQNLPVVFALDRAGLVGADGATHAGVYDIPFLRCIPNMMVMVPADENECRQLLTTAFQQDCPTAVRYPRGAGV
GVATQPELTALPVGKGEIRREGHARAGQRVAIMAFGSMVHPALTAAEQLDATVANMRFVKPLDVELVKQLAANHDFLVTV
EEGATMGGAGSAVLEALAEAGIELPTLVLGLPDKFIDHGDPAHLLSLCGLDAAGIERSVRERFSLTAQPVKVASVA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=647, Percent_Identity=23.8021638330757, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI4507521, Length=647, Percent_Identity=23.8021638330757, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI225637461, Length=430, Percent_Identity=24.6511627906977, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI225637459, Length=430, Percent_Identity=24.6511627906977, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI225637463, Length=430, Percent_Identity=24.6511627906977, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI133778974, Length=424, Percent_Identity=24.0566037735849, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI156564403, Length=244, Percent_Identity=26.2295081967213, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=56.6129032258065, Blast_Score=729, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=638, Percent_Identity=23.6677115987461, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17538422, Length=248, Percent_Identity=26.6129032258064, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319698, Length=310, Percent_Identity=26.4516129032258, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24666278, Length=621, Percent_Identity=24.6376811594203, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551847, Length=676, Percent_Identity=23.0769230769231, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45550715, Length=676, Percent_Identity=23.0769230769231, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24645119, Length=561, Percent_Identity=23.5294117647059, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_RALME (Q1LK34)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_584761.1
- ProteinModelPortal:   Q1LK34
- SMR:   Q1LK34
- STRING:   Q1LK34
- GeneID:   4039441
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_2615
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q1LK34
- ProtClustDB:   PRK05444
- BioCyc:   RMET266264:RMET_2615-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68871; Mature: 68740

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYTLLNKIDDPADLRKLDRRQLDTLAEELRAYVLESVSQTGGHLSSNLGTVELTIALHY
CCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEEEEEEE
VFDTPNDRVVWDVGHQSYPHKILTGRRDRMSTLRQYGGISGFPRRAESEYDTFGTAHSST
EEECCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCC
SISAALGMALGARTRGEKRVGIAVIGDGAMTAGMAFEAMNNAGVYKDLPMLVVLNDNDMS
HHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCC
ISPPVGMLNKHLARLMSGQFYAATKKGIEKVLSVAPPVLEFAKRLEEHAKGMVVPATLFE
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEHHHHHH
EFGFDYVGPIDGHDLESLVPTLQNIRQRALEGHGPQFLHVVTKKGQGYKLAEADPILYHG
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCCEEEEC
PGKFNPAEGIRPSAKPSRKTYTQVFGEWLCDMAAADKRLIGVTPAMREGSGMVEFEKRFP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCCCCHHHHHCC
DRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLPVVFALDR
CHHHCCCCCCHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGLVGADGATHAGVYDIPFLRCIPNMMVMVPADENECRQLLTTAFQQDCPTAVRYPRGAG
CCEECCCCCCCCCCCCCHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCHHHCCCCCCC
VGVATQPELTALPVGKGEIRREGHARAGQRVAIMAFGSMVHPALTAAEQLDATVANMRFV
CCCCCCCCCEEECCCCHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCEEC
KPLDVELVKQLAANHDFLVTVEEGATMGGAGSAVLEALAEAGIELPTLVLGLPDKFIDHG
CCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHCCC
DPAHLLSLCGLDAAGIERSVRERFSLTAQPVKVASVA
CHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEECCCC
>Mature Secondary Structure 
TYTLLNKIDDPADLRKLDRRQLDTLAEELRAYVLESVSQTGGHLSSNLGTVELTIALHY
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEEEEEEE
VFDTPNDRVVWDVGHQSYPHKILTGRRDRMSTLRQYGGISGFPRRAESEYDTFGTAHSST
EEECCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCC
SISAALGMALGARTRGEKRVGIAVIGDGAMTAGMAFEAMNNAGVYKDLPMLVVLNDNDMS
HHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCC
ISPPVGMLNKHLARLMSGQFYAATKKGIEKVLSVAPPVLEFAKRLEEHAKGMVVPATLFE
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEHHHHHH
EFGFDYVGPIDGHDLESLVPTLQNIRQRALEGHGPQFLHVVTKKGQGYKLAEADPILYHG
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCCEEEEC
PGKFNPAEGIRPSAKPSRKTYTQVFGEWLCDMAAADKRLIGVTPAMREGSGMVEFEKRFP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCCCCHHHHHCC
DRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLPVVFALDR
CHHHCCCCCCHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGLVGADGATHAGVYDIPFLRCIPNMMVMVPADENECRQLLTTAFQQDCPTAVRYPRGAG
CCEECCCCCCCCCCCCCHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCHHHCCCCCCC
VGVATQPELTALPVGKGEIRREGHARAGQRVAIMAFGSMVHPALTAAEQLDATVANMRFV
CCCCCCCCCEEECCCCHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCEEC
KPLDVELVKQLAANHDFLVTVEEGATMGGAGSAVLEALAEAGIELPTLVLGLPDKFIDHG
CCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHCCC
DPAHLLSLCGLDAAGIERSVRERFSLTAQPVKVASVA
CHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA