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The map label for this gene is folE2-2

Identifier: 94311550

GI number: 94311550

Start: 2844166

End: 2844969

Strand: Reverse

Name: folE2-2

Synonym: Rmet_2614

Alternate gene names: 94311550

Gene position: 2844969-2844166 (Counterclockwise)

Preceding gene: 94311551

Following gene: 94311546

Centisome position: 72.43

GC content: 62.56

Gene sequence:

>804_bases
ATGAATGACATCAATCCCGCCTTCGTCATGCCCGACGTACAGTCGAGCGTCGATACCCGCCAGATCGTGATCCAGCGCGT
CGGCGTGAAGGGTGTGCGATATCCGCTGACGCTGAAGACGCCTGCCGGCGCAGTGGGCACGGTCGGTACGTTCAATATGG
ACGTGCGCCTGCCGGCCGACCAGAAGGGCACGCACATGTCGCGCTTCGTGGCGCTGCTCGAGGAAAACCGCGCGCCACTG
GACCTGGCCGCTTTCCGCGCGCTGGTCGACGACATGCTGGTTCGCCTGGAAGCCGATGCGGGCCGTATCGAAGTGTCGTT
CCCGTACTTCATCACGAAGACCGCGCCGGTGTCGGGCGTGCAGTCGTTGCTGGACTACGAAGTCACGCTCGTGGCCGAGG
CGCGTGACGGCCAGACACGCATGTTCATGACCGCTCTGGTGCCGGTGACGAGCCTGTGCCCGTGCTCGAAGAAGATCTCG
CAGTACGGCGCGCACAACCAGCGCTCGCATATCACGATGCGCGTGGAGCTTGCCGGTGACCTCGATGTCGAGGCGCTGGT
GCGCATGGCCGAGGAAGAGGCATCGTGCGAACTGTGGGGCCTGCTCAAGCGCCCCGACGAGAAGTTCGTGACCGAGCGTG
CCTACGAGAATCCGAAGTTCGTGGAAGACCTGGTGCGCGATATCGCGATGCGGCTGAACGCCGACGATCGTATCGTCGCA
TACACGCTGGAAGCCGAGAATTTCGAATCGATCCACAATCACAGCGCCTATGCTGTGATCGAGCACGACAAGCGGCATCA
GTAA

Upstream 100 bases:

>100_bases
CGTTTCACACTCGTTGCGCGGCGTAGAGATGTTCTGCGAAATCGCCGCGACCGTAAGGACGGCCGCGCCCCCTTTGTCGG
CCTCCTGGAGGAAACCGTAG

Downstream 100 bases:

>100_bases
CAGTCGCTAGTTTTTCGCCCCTCGCCCACGTGTGGGAGAGGGGCGCATTGCCGCATCAAACTGGTATCAGGCCAGCGTCA
CCGCAGGCGTTCCCGCCGCA

Product: putative GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MNDINPAFVMPDVQSSVDTRQIVIQRVGVKGVRYPLTLKTPAGAVGTVGTFNMDVRLPADQKGTHMSRFVALLEENRAPL
DLAAFRALVDDMLVRLEADAGRIEVSFPYFITKTAPVSGVQSLLDYEVTLVAEARDGQTRMFMTALVPVTSLCPCSKKIS
QYGAHNQRSHITMRVELAGDLDVEALVRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNADDRIVA
YTLEAENFESIHNHSAYAVIEHDKRHQ

Sequences:

>Translated_267_residues
MNDINPAFVMPDVQSSVDTRQIVIQRVGVKGVRYPLTLKTPAGAVGTVGTFNMDVRLPADQKGTHMSRFVALLEENRAPL
DLAAFRALVDDMLVRLEADAGRIEVSFPYFITKTAPVSGVQSLLDYEVTLVAEARDGQTRMFMTALVPVTSLCPCSKKIS
QYGAHNQRSHITMRVELAGDLDVEALVRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNADDRIVA
YTLEAENFESIHNHSAYAVIEHDKRHQ
>Mature_267_residues
MNDINPAFVMPDVQSSVDTRQIVIQRVGVKGVRYPLTLKTPAGAVGTVGTFNMDVRLPADQKGTHMSRFVALLEENRAPL
DLAAFRALVDDMLVRLEADAGRIEVSFPYFITKTAPVSGVQSLLDYEVTLVAEARDGQTRMFMTALVPVTSLCPCSKKIS
QYGAHNQRSHITMRVELAGDLDVEALVRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNADDRIVA
YTLEAENFESIHNHSAYAVIEHDKRHQ

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH42_RALME (Q1LK35)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_584760.1
- ProteinModelPortal:   Q1LK35
- SMR:   Q1LK35
- STRING:   Q1LK35
- GeneID:   4039440
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_2614
- eggNOG:   COG1469
- HOGENOM:   HBG626871
- OMA:   EASCEVF
- ProtClustDB:   PRK13674
- BioCyc:   RMET266264:RMET_2614-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 29909; Mature: 29909

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDINPAFVMPDVQSSVDTRQIVIQRVGVKGVRYPLTLKTPAGAVGTVGTFNMDVRLPAD
CCCCCCEEECCCHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCC
QKGTHMSRFVALLEENRAPLDLAAFRALVDDMLVRLEADAGRIEVSFPYFITKTAPVSGV
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEECCEEEECCCCHHHH
QSLLDYEVTLVAEARDGQTRMFMTALVPVTSLCPCSKKISQYGAHNQRSHITMRVELAGD
HHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEEEECCC
LDVEALVRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNADDRIVA
CCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEE
YTLEAENFESIHNHSAYAVIEHDKRHQ
EEECCCCHHHHHCCCEEEEEECCCCCC
>Mature Secondary Structure
MNDINPAFVMPDVQSSVDTRQIVIQRVGVKGVRYPLTLKTPAGAVGTVGTFNMDVRLPAD
CCCCCCEEECCCHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCC
QKGTHMSRFVALLEENRAPLDLAAFRALVDDMLVRLEADAGRIEVSFPYFITKTAPVSGV
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEECCEEEECCCCHHHH
QSLLDYEVTLVAEARDGQTRMFMTALVPVTSLCPCSKKISQYGAHNQRSHITMRVELAGD
HHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEEEECCC
LDVEALVRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNADDRIVA
CCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEE
YTLEAENFESIHNHSAYAVIEHDKRHQ
EEECCCCHHHHHCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA