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The map label for this gene is cobD [H]

Identifier: 94311514

GI number: 94311514

Start: 2802185

End: 2803165

Strand: Reverse

Name: cobD [H]

Synonym: Rmet_2578

Alternate gene names: 94311514

Gene position: 2803165-2802185 (Counterclockwise)

Preceding gene: 94311515

Following gene: 94311510

Centisome position: 71.36

GC content: 63.51

Gene sequence:

>981_bases
ATGACTTTCGTTTCCATTCTTCTGGCGCTGATTGCCGAACAGTTCCGCGCCTTGGGTCGGAACAATCCGATTTTCGATAT
CGTGCGCGTGCTGGGCGACCGGGCCGAGCACGCATTCGATACCGGACGCCCGCGCGACGCCGCGCTGGCCTGGCTGACCG
TGGTGTTGCCGCTGACGCTGGCGGTAGTGATCGTCCACTATCTGCTGTCTTCGATCAGCATCGCGCTGACGCTGGTCTGG
AATGTGCTGCTGCTGTACCTGACCCTCGGATTCCGGCAGTTCAGCCACTACTTCACCGACATCCACGAGGCGCTCAACCG
CGACGACCTACATACCGCGAGGACGATCCTGCACGAGTGGACCGGGCTCGATACCGTCGAAATGCCGGTCAGCGAGATCG
TGCGCCATACGCTTGAAGCGGCGATCGTCGCCGTGCATCGCCATGTCTTCGGCGTGTTCTTCTGGTTCCTGGTGCCGATC
GGCCCGGGTGGCGTGATCCTCTATCGCACCGCCGAGTATCTGAGCCGGCAGTGGAACAGCCCGTCCAACGAACGCAGTCC
GGCCTTGGGTTGTTTCGCCGCGCAGGCGTTCTACGTGCTCGATTGGGTCCCGTCGCGCCTGACCTCGATCGGGTTTGCGA
TCGTCGGCAACTTCGAGGATGCGGTCTACGCGTGGCGCAACCACGCGCGCAAATGGAACGACGCGGTCAACGGCATCCTG
CTTGCCAGTGGTGGTGGGGCCCTCGGCGTCCGGCTCGGCGCGCCGCTGGCCGAGGACGATTCGAGTGTGATACTGCGCAT
GAGCGTGGCGGGCGTCGACTATGCTCCCGGCATGGACGATGGTTCGGACCCCGTGCCGCCCGAATTCGGCAGCGATCCAG
GTGTTCGCACGCTGCAATCGGCAGTTGGTCTGGTCTGGCGTGCCGTGGTCCTCTGGATGATTCTGCTGGCGATGATCTCG
CTGGCGTTGTGGGTGGGTTGA

Upstream 100 bases:

>100_bases
CACGAGTATTGCAAAGCCACCGGGGCGCTATGCTATCGTCTGGCTATACCGCCAAGGGACCGCCGCGGCACTTCGCCGCA
CACCGATTAATCGTCACCCG

Downstream 100 bases:

>100_bases
GCCCGCAACGATTCTCGCAACTATCGCAATGCCCGCAAAGAAAAAAGCGCCACATCGTTGGCGCTTTTTTCTTTCTCCCG
GCGGCCAATGGCTGGTCTAT

Product: CobD/CbiB family protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTFVSILLALIAEQFRALGRNNPIFDIVRVLGDRAEHAFDTGRPRDAALAWLTVVLPLTLAVVIVHYLLSSISIALTLVW
NVLLLYLTLGFRQFSHYFTDIHEALNRDDLHTARTILHEWTGLDTVEMPVSEIVRHTLEAAIVAVHRHVFGVFFWFLVPI
GPGGVILYRTAEYLSRQWNSPSNERSPALGCFAAQAFYVLDWVPSRLTSIGFAIVGNFEDAVYAWRNHARKWNDAVNGIL
LASGGGALGVRLGAPLAEDDSSVILRMSVAGVDYAPGMDDGSDPVPPEFGSDPGVRTLQSAVGLVWRAVVLWMILLAMIS
LALWVG

Sequences:

>Translated_326_residues
MTFVSILLALIAEQFRALGRNNPIFDIVRVLGDRAEHAFDTGRPRDAALAWLTVVLPLTLAVVIVHYLLSSISIALTLVW
NVLLLYLTLGFRQFSHYFTDIHEALNRDDLHTARTILHEWTGLDTVEMPVSEIVRHTLEAAIVAVHRHVFGVFFWFLVPI
GPGGVILYRTAEYLSRQWNSPSNERSPALGCFAAQAFYVLDWVPSRLTSIGFAIVGNFEDAVYAWRNHARKWNDAVNGIL
LASGGGALGVRLGAPLAEDDSSVILRMSVAGVDYAPGMDDGSDPVPPEFGSDPGVRTLQSAVGLVWRAVVLWMILLAMIS
LALWVG
>Mature_325_residues
TFVSILLALIAEQFRALGRNNPIFDIVRVLGDRAEHAFDTGRPRDAALAWLTVVLPLTLAVVIVHYLLSSISIALTLVWN
VLLLYLTLGFRQFSHYFTDIHEALNRDDLHTARTILHEWTGLDTVEMPVSEIVRHTLEAAIVAVHRHVFGVFFWFLVPIG
PGGVILYRTAEYLSRQWNSPSNERSPALGCFAAQAFYVLDWVPSRLTSIGFAIVGNFEDAVYAWRNHARKWNDAVNGILL
ASGGGALGVRLGAPLAEDDSSVILRMSVAGVDYAPGMDDGSDPVPPEFGSDPGVRTLQSAVGLVWRAVVLWMILLAMISL
ALWVG

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 35914; Mature: 35783

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFVSILLALIAEQFRALGRNNPIFDIVRVLGDRAEHAFDTGRPRDAALAWLTVVLPLTL
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AVVIVHYLLSSISIALTLVWNVLLLYLTLGFRQFSHYFTDIHEALNRDDLHTARTILHEW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
TGLDTVEMPVSEIVRHTLEAAIVAVHRHVFGVFFWFLVPIGPGGVILYRTAEYLSRQWNS
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCC
PSNERSPALGCFAAQAFYVLDWVPSRLTSIGFAIVGNFEDAVYAWRNHARKWNDAVNGIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCEEE
LASGGGALGVRLGAPLAEDDSSVILRMSVAGVDYAPGMDDGSDPVPPEFGSDPGVRTLQS
EECCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
AVGLVWRAVVLWMILLAMISLALWVG
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TFVSILLALIAEQFRALGRNNPIFDIVRVLGDRAEHAFDTGRPRDAALAWLTVVLPLTL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AVVIVHYLLSSISIALTLVWNVLLLYLTLGFRQFSHYFTDIHEALNRDDLHTARTILHEW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
TGLDTVEMPVSEIVRHTLEAAIVAVHRHVFGVFFWFLVPIGPGGVILYRTAEYLSRQWNS
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCC
PSNERSPALGCFAAQAFYVLDWVPSRLTSIGFAIVGNFEDAVYAWRNHARKWNDAVNGIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCEEE
LASGGGALGVRLGAPLAEDDSSVILRMSVAGVDYAPGMDDGSDPVPPEFGSDPGVRTLQS
EECCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
AVGLVWRAVVLWMILLAMISLALWVG
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA