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The map label for this gene is emrE [H]

Identifier: 94311479

GI number: 94311479

Start: 2769029

End: 2769358

Strand: Direct

Name: emrE [H]

Synonym: Rmet_2543

Alternate gene names: 94311479

Gene position: 2769029-2769358 (Clockwise)

Preceding gene: 94311477

Following gene: 94311481

Centisome position: 70.49

GC content: 61.21

Gene sequence:

>330_bases
ATGAACGGATATCTGCTCCTCGCCCTGGCCATCGTTGCCGAAGTCATCGCCACCAGCAGTCTCAAGGCCGCCGAGAACTT
CACGCGCCTGGTCCCCAGCGTCCTGGTGGTGACCGGATACGTAGCGGCGTTCTGGTTACTGATGCAGGTGATGAAAACAG
TGCCAGTCGGTGTGGCCTATGCGATCTGGTGCGGCGCCGGAATCGTGCTGGTGACGCTCATCGCATCGGTGCTCTACCGT
CAGGTCCCAGACCTGGCGGCCTGGCTCGGCATCGGGCTGATCATTGCCGGCGTGGCGGTGATCCAGCTTTTCTCGAAGAT
GTCGCATTGA

Upstream 100 bases:

>100_bases
CAATTCGTCCCATGGTTTGCAGCCCCGTTTGGGGGTGATCGGGGGCGCGGATTGCATAATATCGAATCCGCGTGCCGCAA
CAGTCTCTTTTGATCAATTC

Downstream 100 bases:

>100_bases
TTCCGGCAGCACCCTGCCCGGCTGCGCTCACCCCTTCGGTGGCAGCGTACGCAGCAGCCGGTTGACCTGTGCCAGCGTCT
CGCATTCGTCAGCCTTGCGC

Product: multidrug resistance protein; DLP12 prophage

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant F [H]

Number of amino acids: Translated: 109; Mature: 109

Protein sequence:

>109_residues
MNGYLLLALAIVAEVIATSSLKAAENFTRLVPSVLVVTGYVAAFWLLMQVMKTVPVGVAYAIWCGAGIVLVTLIASVLYR
QVPDLAAWLGIGLIIAGVAVIQLFSKMSH

Sequences:

>Translated_109_residues
MNGYLLLALAIVAEVIATSSLKAAENFTRLVPSVLVVTGYVAAFWLLMQVMKTVPVGVAYAIWCGAGIVLVTLIASVLYR
QVPDLAAWLGIGLIIAGVAVIQLFSKMSH
>Mature_109_residues
MNGYLLLALAIVAEVIATSSLKAAENFTRLVPSVLVVTGYVAAFWLLMQVMKTVPVGVAYAIWCGAGIVLVTLIASVLYR
QVPDLAAWLGIGLIIAGVAVIQLFSKMSH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=106, Percent_Identity=50, Blast_Score=99, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11546; Mature: 11546

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGYLLLALAIVAEVIATSSLKAAENFTRLVPSVLVVTGYVAAFWLLMQVMKTVPVGVAY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AIWCGAGIVLVTLIASVLYRQVPDLAAWLGIGLIIAGVAVIQLFSKMSH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGYLLLALAIVAEVIATSSLKAAENFTRLVPSVLVVTGYVAAFWLLMQVMKTVPVGVAY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AIWCGAGIVLVTLIASVLYRQVPDLAAWLGIGLIIAGVAVIQLFSKMSH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9756755 [H]