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The map label for this gene is trpF [H]

Identifier: 94311404

GI number: 94311404

Start: 2679434

End: 2680129

Strand: Reverse

Name: trpF [H]

Synonym: Rmet_2468

Alternate gene names: 94311404

Gene position: 2680129-2679434 (Counterclockwise)

Preceding gene: 94311405

Following gene: 94311403

Centisome position: 68.23

GC content: 64.94

Gene sequence:

>696_bases
ATGGCGCTTGAGCCCCGCACGCGCATCAAGATCTGCGGCCTGACGCGCGAAGAGGACGTGCGCGCCGCCGTGGACGCCGG
TGCCGATGCGATCGGTCTGGTCTTCTACGCCAGGAGCCCACGCCACGTGGATGTGGCCCACGCCGCGGCCCTGGCCGAAC
TGGTGCCGCCGTTCGTGTCCGTGGTTGGCCTGTTCGTCAATGCAGATGCCGAAGAGGTGGCCCATGTGGCCGAGCGTGTG
CCGTTGACGTTGCTTCAGTTCCACGGCGACGAGACGCCCCAGCAGTGCACCGAGATCGCCCGGCGCTGCCGGCTGCCATT
CATGCGTGCCGCACGTGTCCGCCCGGGGCTCGATTTGGTAGAATTCGCAAATCAATATCGTGACGCTTCCGGCCTGCTGC
TCGATGCCTTCGTGGAAGGCTATGGCGGTGGCGGCCACGTTTTCGACTGGACCCTGATTCCTGCCCAATGGCTTCCGCCC
AATCCTGCCAATCCCCGCGCAAACGACGCTCCTCGCATCGTTTTGAGTGGTGGATTGAACGCGCAAAACGTCGCTGGAGC
GATTGAGCGCGTGCGGCCCTACGCTGTGGATGTCAGCAGCGGCGTGGAGGCCAGCAAGGGTGTGAAAGACCACGCCCGTA
TTGCCGCATTCGTGCGCGCCGTTCGACAGGCCGACGCAGGGCGATCCGCAGGATAA

Upstream 100 bases:

>100_bases
CTCTATCTGGTCGACGTGAAGTATCCTGAGCCATACCAGTTGCCCAAGGCGGACCCGGCCGCCAGCTTCTTCCACGGAGT
ATTTGTCGATGACAGCCACG

Downstream 100 bases:

>100_bases
TTCCCTCCGCCTTCCGTGGCTCACGGCCGCGCCGACCCCGATACCCCGCGCGTCATCCCATGGCTGACGCGCTTCCTGAG
AGCCTGGACATGTACGACCT

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MALEPRTRIKICGLTREEDVRAAVDAGADAIGLVFYARSPRHVDVAHAAALAELVPPFVSVVGLFVNADAEEVAHVAERV
PLTLLQFHGDETPQQCTEIARRCRLPFMRAARVRPGLDLVEFANQYRDASGLLLDAFVEGYGGGGHVFDWTLIPAQWLPP
NPANPRANDAPRIVLSGGLNAQNVAGAIERVRPYAVDVSSGVEASKGVKDHARIAAFVRAVRQADAGRSAG

Sequences:

>Translated_231_residues
MALEPRTRIKICGLTREEDVRAAVDAGADAIGLVFYARSPRHVDVAHAAALAELVPPFVSVVGLFVNADAEEVAHVAERV
PLTLLQFHGDETPQQCTEIARRCRLPFMRAARVRPGLDLVEFANQYRDASGLLLDAFVEGYGGGGHVFDWTLIPAQWLPP
NPANPRANDAPRIVLSGGLNAQNVAGAIERVRPYAVDVSSGVEASKGVKDHARIAAFVRAVRQADAGRSAG
>Mature_230_residues
ALEPRTRIKICGLTREEDVRAAVDAGADAIGLVFYARSPRHVDVAHAAALAELVPPFVSVVGLFVNADAEEVAHVAERVP
LTLLQFHGDETPQQCTEIARRCRLPFMRAARVRPGLDLVEFANQYRDASGLLLDAFVEGYGGGGHVFDWTLIPAQWLPPN
PANPRANDAPRIVLSGGLNAQNVAGAIERVRPYAVDVSSGVEASKGVKDHARIAAFVRAVRQADAGRSAG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=215, Percent_Identity=33.4883720930233, Blast_Score=89, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320210, Length=222, Percent_Identity=28.3783783783784, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 24746; Mature: 24615

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALEPRTRIKICGLTREEDVRAAVDAGADAIGLVFYARSPRHVDVAHAAALAELVPPFVS
CCCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
VVGLFVNADAEEVAHVAERVPLTLLQFHGDETPQQCTEIARRCRLPFMRAARVRPGLDLV
HHHHHHCCCHHHHHHHHHHCCHHEEECCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCHHH
EFANQYRDASGLLLDAFVEGYGGGGHVFDWTLIPAQWLPPNPANPRANDAPRIVLSGGLN
HHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCC
AQNVAGAIERVRPYAVDVSSGVEASKGVKDHARIAAFVRAVRQADAGRSAG
HHHHHHHHHHHCCEEEECCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ALEPRTRIKICGLTREEDVRAAVDAGADAIGLVFYARSPRHVDVAHAAALAELVPPFVS
CCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
VVGLFVNADAEEVAHVAERVPLTLLQFHGDETPQQCTEIARRCRLPFMRAARVRPGLDLV
HHHHHHCCCHHHHHHHHHHCCHHEEECCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCHHH
EFANQYRDASGLLLDAFVEGYGGGGHVFDWTLIPAQWLPPNPANPRANDAPRIVLSGGLN
HHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCC
AQNVAGAIERVRPYAVDVSSGVEASKGVKDHARIAAFVRAVRQADAGRSAG
HHHHHHHHHHHCCEEEECCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA