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The map label for this gene is trpB [H]

Identifier: 94311403

GI number: 94311403

Start: 2678151

End: 2679374

Strand: Reverse

Name: trpB [H]

Synonym: Rmet_2467

Alternate gene names: 94311403

Gene position: 2679374-2678151 (Counterclockwise)

Preceding gene: 94311404

Following gene: 94311402

Centisome position: 68.21

GC content: 64.87

Gene sequence:

>1224_bases
ATGGCTGACGCGCTTCCTGAGAGCCTGGACATGTACGACCTGCCCGATTCCCGTGGCCACTTTGGCCCCTATGGCGGTAC
CTTCGTTTCCGAAACCCTGGTTCACGCGCTGGACGAGTTGCGCGACGCCTACGCGCGATACCAGAAGGACCCTGATTTCG
ACGCCGAGTATCGCCGCGAACTGAAGCACTTCGTTGGCCGCCCGTCGCCGATCTATCACGCGCAACGCTGGAGCGAGACG
CTCGGTGGCGCGCAGATCTACCTCAAGCGCGAAGACCTGAACCACACTGGCGCGCACAAGATCAACAACGTGATCGGCCA
GGCGCTGCTTGCCAAGCGCATGGGCAAGAAGCGTGTGATTGCCGAAACCGGCGCGGGCCAGCATGGCGTGGCCACGGCCA
CGATCGCGGCGCGCTTTGGCATGGAGTGCGTGGTCTACATGGGCTCCGAGGACGTGCGCCGCCAGGCGGCCAATGTCTAT
CGCATGAAGCTGCTGGGCGCCACCGTGGTGCCTGTGGAAAGCGGCTCGCGCACGCTCAAGGACGCGCTCAATGAAGCGAT
GCGCGACTGGGTGACCAACGTCGAGACCACGTTCTACATCATCGGCACCGTGGCCGGCCCGCACCCCTACCCGATGATGG
TGCGCGATTTCCAGTGCGTGATCGGCGAGGAAGCCAAGGTGCAGATGCCCGAACTCGCGGGTCGCCAGCCCGACGCCGTG
ATCGCGTGCGTCGGCGGCGGTTCGAACGCGATGGGCATCTTCTATCCGTATATCGAACACAAGGATGTGCAGTTGATCGG
CGTGGAAGCGGCCGGTGATGGCCTGGATTCGGGTCGCCACGCTGCTGCGCTGATCGGCGGTTCCCCGGGCGTGCTGCACG
GCAACCGTACCTATCTGCTGCAGGACGCCAACGGCCAGATCATCGAGACGCACTCGGTGTCGGCAGGCCTGGACTACCCC
GGCGTCGGCCCCGAGCACGCGTGGCTGAAGGACATGGGCCGCGCGCAGTACGTGCCGATCACCGACGAAGAGGCCCTCAA
GGCGTTTCACGACTGCTGCCGCATCGAAGGCATCATCCCAGCGCTCGAATCGAGCCATGCGATCGCCTATGCGTGCAAGC
TGGCGCCGACGCTGGGCCGCGACAAGCTGCTGCTCGTGAACCTGTCCGGGCGTGGCGACAAGGACATGCATACCGTGGCC
GAACGCGCGGGGTTGAAGCTCTGA

Upstream 100 bases:

>100_bases
GCGCCGTTCGACAGGCCGACGCAGGGCGATCCGCAGGATAATTCCCTCCGCCTTCCGTGGCTCACGGCCGCGCCGACCCC
GATACCCCGCGCGTCATCCC

Downstream 100 bases:

>100_bases
TGCGTACGCTGCCTCCCAATACGACGCTGCCCCAGTCCGAGGCGGGCGGGGCGGGCTCGGAACCGTTCGATATTCTCGAT
ACGGCAACCATGCGCCTCTA

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MADALPESLDMYDLPDSRGHFGPYGGTFVSETLVHALDELRDAYARYQKDPDFDAEYRRELKHFVGRPSPIYHAQRWSET
LGGAQIYLKREDLNHTGAHKINNVIGQALLAKRMGKKRVIAETGAGQHGVATATIAARFGMECVVYMGSEDVRRQAANVY
RMKLLGATVVPVESGSRTLKDALNEAMRDWVTNVETTFYIIGTVAGPHPYPMMVRDFQCVIGEEAKVQMPELAGRQPDAV
IACVGGGSNAMGIFYPYIEHKDVQLIGVEAAGDGLDSGRHAAALIGGSPGVLHGNRTYLLQDANGQIIETHSVSAGLDYP
GVGPEHAWLKDMGRAQYVPITDEEALKAFHDCCRIEGIIPALESSHAIAYACKLAPTLGRDKLLLVNLSGRGDKDMHTVA
ERAGLKL

Sequences:

>Translated_407_residues
MADALPESLDMYDLPDSRGHFGPYGGTFVSETLVHALDELRDAYARYQKDPDFDAEYRRELKHFVGRPSPIYHAQRWSET
LGGAQIYLKREDLNHTGAHKINNVIGQALLAKRMGKKRVIAETGAGQHGVATATIAARFGMECVVYMGSEDVRRQAANVY
RMKLLGATVVPVESGSRTLKDALNEAMRDWVTNVETTFYIIGTVAGPHPYPMMVRDFQCVIGEEAKVQMPELAGRQPDAV
IACVGGGSNAMGIFYPYIEHKDVQLIGVEAAGDGLDSGRHAAALIGGSPGVLHGNRTYLLQDANGQIIETHSVSAGLDYP
GVGPEHAWLKDMGRAQYVPITDEEALKAFHDCCRIEGIIPALESSHAIAYACKLAPTLGRDKLLLVNLSGRGDKDMHTVA
ERAGLKL
>Mature_406_residues
ADALPESLDMYDLPDSRGHFGPYGGTFVSETLVHALDELRDAYARYQKDPDFDAEYRRELKHFVGRPSPIYHAQRWSETL
GGAQIYLKREDLNHTGAHKINNVIGQALLAKRMGKKRVIAETGAGQHGVATATIAARFGMECVVYMGSEDVRRQAANVYR
MKLLGATVVPVESGSRTLKDALNEAMRDWVTNVETTFYIIGTVAGPHPYPMMVRDFQCVIGEEAKVQMPELAGRQPDAVI
ACVGGGSNAMGIFYPYIEHKDVQLIGVEAAGDGLDSGRHAAALIGGSPGVLHGNRTYLLQDANGQIIETHSVSAGLDYPG
VGPEHAWLKDMGRAQYVPITDEEALKAFHDCCRIEGIIPALESSHAIAYACKLAPTLGRDKLLLVNLSGRGDKDMHTVAE
RAGLKL

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine [H]

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family [H]

Homologues:

Organism=Escherichia coli, GI1787515, Length=381, Percent_Identity=55.6430446194226, Blast_Score=433, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6321412, Length=404, Percent_Identity=55.6930693069307, Blast_Score=463, Evalue=1e-131,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 44298; Mature: 44167

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADALPESLDMYDLPDSRGHFGPYGGTFVSETLVHALDELRDAYARYQKDPDFDAEYRRE
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LKHFVGRPSPIYHAQRWSETLGGAQIYLKREDLNHTGAHKINNVIGQALLAKRMGKKRVI
HHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEE
AETGAGQHGVATATIAARFGMECVVYMGSEDVRRQAANVYRMKLLGATVVPVESGSRTLK
EECCCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCCHHHH
DALNEAMRDWVTNVETTFYIIGTVAGPHPYPMMVRDFQCVIGEEAKVQMPELAGRQPDAV
HHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEECHHHCCCCCCEE
IACVGGGSNAMGIFYPYIEHKDVQLIGVEAAGDGLDSGRHAAALIGGSPGVLHGNRTYLL
EEEECCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCCEEECCEEEEE
QDANGQIIETHSVSAGLDYPGVGPEHAWLKDMGRAQYVPITDEEALKAFHDCCRIEGIIP
ECCCCCEEEECCCCCCCCCCCCCCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCH
ALESSHAIAYACKLAPTLGRDKLLLVNLSGRGDKDMHTVAERAGLKL
HHCCCCEEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
ADALPESLDMYDLPDSRGHFGPYGGTFVSETLVHALDELRDAYARYQKDPDFDAEYRRE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LKHFVGRPSPIYHAQRWSETLGGAQIYLKREDLNHTGAHKINNVIGQALLAKRMGKKRVI
HHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEE
AETGAGQHGVATATIAARFGMECVVYMGSEDVRRQAANVYRMKLLGATVVPVESGSRTLK
EECCCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCCHHHH
DALNEAMRDWVTNVETTFYIIGTVAGPHPYPMMVRDFQCVIGEEAKVQMPELAGRQPDAV
HHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEECHHHCCCCCCEE
IACVGGGSNAMGIFYPYIEHKDVQLIGVEAAGDGLDSGRHAAALIGGSPGVLHGNRTYLL
EEEECCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCCEEECCEEEEE
QDANGQIIETHSVSAGLDYPGVGPEHAWLKDMGRAQYVPITDEEALKAFHDCCRIEGIIP
ECCCCCEEEECCCCCCCCCCCCCCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCH
ALESSHAIAYACKLAPTLGRDKLLLVNLSGRGDKDMHTVAERAGLKL
HHCCCCEEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]