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The map label for this gene is uvrC

Identifier: 94311346

GI number: 94311346

Start: 2619361

End: 2621382

Strand: Reverse

Name: uvrC

Synonym: Rmet_2410

Alternate gene names: 94311346

Gene position: 2621382-2619361 (Counterclockwise)

Preceding gene: 94311349

Following gene: 94311345

Centisome position: 66.73

GC content: 65.68

Gene sequence:

>2022_bases
ATGCCCGAGCAGGAACCCGTCCCTCCCACCGAGACAACGTCGCCCGAATCCGATACCCCGGAATCGTCCGACGCGCCGGC
GTTCGACCCGCGCCCGATCCTGGCGCGTATGCCGGGGTTGCCTGGCGTCTATCGCTACTTCGATGCCGACGGCAACATCC
TCTATGTCGGCAAAGCGCGCGACCTGAAGAAGCGGGTCTCGAGCTATTTCAACAAGACGCAGTTGTCGCCGCGCATTGCG
ATGATGGTGGCCAAGATCGCGCGCATCGACACCACGGTGGTGCGGACCGAGGCGGAAGCGCTGCTGCTTGAGAACAACCT
CATCAAGGCCCTGGCGCCGCGTTACAACATTCTGTTTCGCGACGACAAGTCCTATCCATTCCTCAGGCTGACTGGGCACA
AGTTCCCGCGCATGGCGTACTACCGTGGCGCCACCGATCGCAAGCACCAGTATTTCGGGCCGTTCCCAAGCGCTCACGCC
GTGCGCGAGAGCATGCAGATCTTGCAGAAGGTCTTTCAGTTGCGAACCTGCGAGGATACGGTTTTCAACAATCGCACGCG
GCCGTGCCTGCTGCATCAGATCCACCGCTGCACCGGGCCGTGCGTCGGCGCGATCAGCGAGGACGACTACGCGCGCGACG
TGTCGAACGCGGCGCGCTTCCTGCAGGGCCGCGAGACCGAGGTGCTTGAGGGTTTGCAATCCAAGATGGAAGCCCATGCG
GTGCAGCTGGAGTTCGAGCAGGCTGCGGCGGTTCGGGACCAGATCGCCGCGCTGTCGACCGTGCTCAAGCGGCAGGCCGT
GGAGGAAGTCGGCCAGGCGCGCGACATCGACATCCTGGCCGTGGCGGTGCAGGGTGGGCGTGCCTGCGTGAACCTGGCAA
TGGTGCGCGGTGGTCGTCATCTCGGCGACAAGGCGTACTTCCCGGCCCACGTCGACGAGGCGGCGATGATCGTGGAGGAG
GGAGACGAGGCAGACGGTAGCGCGCATGAAGGAGCGGCTGCCGATACGGATCAGTTGCCCATCGACCGCATCGCCGCTCG
CGTGCTGTCCGCTTTCATGGTGCAGCACTATCTGGATCAGGCACCGCCGCCCATCGTGGTGGTGAGTCATCGGCCGGCCG
ATTCCGCCTTGGTCGAGGCGCTGTCGATGCAGGCGGGCCGGAAGATCACGCTGGTGCGCCAGCCTCAGGGTCAGCGCAAG
ACCTGGCTGGAGATGGCAGCGCAGGGTGCGGGCTTGGCGCTGGCTCGTCGGCTGGCAGAGCAGGGCAGCCAGGAGGCGCG
CACGCGCGCGCTGGCCGAAACCATTGGCCTCGACCTGGAGGATCTGGCGACATTGCGCATCGAGTGTTTCGATATCAGTC
ACACCGCTGGCGAGGCCACGCAGGCATCGTGCGTAGTGTTCCATCATCACGAGATGCAGAACAGCGAGTACCGACGCTAC
AACATCGCCGATATCACGCCGGGCGATGATTACGCGGCGATGCGCCAGGTGTTGACGCGCCGGTACCAGAAGCTCGTCGA
GCAACTGCAGGAGGCGGGTGGCGATCCGGCTGGCGATGGCGGCGACGGTGTGCCCCGCATGCCCCGCGTGGTGCTGATCG
ACGGTGGCAAGGGGCAGGTCGAGGTCGCGCGGCAGGTGTTCGAAGAACTCGGTCTCGATATCGGCCTGCTGGTTGGCGTG
GCCAAGGGCGAGGGACGCAAGGTGGGTCTCGAGACGCTGGTGTTTGCCGACGGCCGGCCGTCGCTGGAACTGGGGCAGGG
CAGCGCGGCGCTGATGCTGGTTGCGCAGATCCGCGACGAGGCGCACCGGTTCGCGATCACGGGTATGCGCGCGCGCCGGG
CCAAGGCACGCACCACTTCGCGGCTCGAGGAAATCGAAGGCGTGGGGGCGCGCCGCCGGCAGAAGCTTTTGACGCGCTTC
GGTGGTTTGCGGGGTGTGATGGCGGCCAGCATCGACGAGCTGGCCAGCGTTGAAGGCATTTCGCGCACCCTGGCCGAGGA
GATCTACCGACAGTTGCACTGA

Upstream 100 bases:

>100_bases
GCCCGCCTGCGGAAAGTCCGGCGGGAGAATTGCTCTAAACTTGCGATTCTAGAGCGAGCGCCCCACGTTGGCGCGTTACG
TCACACACTTTCCGTCCCCG

Downstream 100 bases:

>100_bases
GCCTCGCGTGCCCACGAATTGGGCGGTTTTCGGCCCGAAACTACGTGTCGGGTCCGAAATCGGCGACAATCGCGGCAATC
GACATCGCAATCCGGCGTTG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MPEQEPVPPTETTSPESDTPESSDAPAFDPRPILARMPGLPGVYRYFDADGNILYVGKARDLKKRVSSYFNKTQLSPRIA
MMVAKIARIDTTVVRTEAEALLLENNLIKALAPRYNILFRDDKSYPFLRLTGHKFPRMAYYRGATDRKHQYFGPFPSAHA
VRESMQILQKVFQLRTCEDTVFNNRTRPCLLHQIHRCTGPCVGAISEDDYARDVSNAARFLQGRETEVLEGLQSKMEAHA
VQLEFEQAAAVRDQIAALSTVLKRQAVEEVGQARDIDILAVAVQGGRACVNLAMVRGGRHLGDKAYFPAHVDEAAMIVEE
GDEADGSAHEGAAADTDQLPIDRIAARVLSAFMVQHYLDQAPPPIVVVSHRPADSALVEALSMQAGRKITLVRQPQGQRK
TWLEMAAQGAGLALARRLAEQGSQEARTRALAETIGLDLEDLATLRIECFDISHTAGEATQASCVVFHHHEMQNSEYRRY
NIADITPGDDYAAMRQVLTRRYQKLVEQLQEAGGDPAGDGGDGVPRMPRVVLIDGGKGQVEVARQVFEELGLDIGLLVGV
AKGEGRKVGLETLVFADGRPSLELGQGSAALMLVAQIRDEAHRFAITGMRARRAKARTTSRLEEIEGVGARRRQKLLTRF
GGLRGVMAASIDELASVEGISRTLAEEIYRQLH

Sequences:

>Translated_673_residues
MPEQEPVPPTETTSPESDTPESSDAPAFDPRPILARMPGLPGVYRYFDADGNILYVGKARDLKKRVSSYFNKTQLSPRIA
MMVAKIARIDTTVVRTEAEALLLENNLIKALAPRYNILFRDDKSYPFLRLTGHKFPRMAYYRGATDRKHQYFGPFPSAHA
VRESMQILQKVFQLRTCEDTVFNNRTRPCLLHQIHRCTGPCVGAISEDDYARDVSNAARFLQGRETEVLEGLQSKMEAHA
VQLEFEQAAAVRDQIAALSTVLKRQAVEEVGQARDIDILAVAVQGGRACVNLAMVRGGRHLGDKAYFPAHVDEAAMIVEE
GDEADGSAHEGAAADTDQLPIDRIAARVLSAFMVQHYLDQAPPPIVVVSHRPADSALVEALSMQAGRKITLVRQPQGQRK
TWLEMAAQGAGLALARRLAEQGSQEARTRALAETIGLDLEDLATLRIECFDISHTAGEATQASCVVFHHHEMQNSEYRRY
NIADITPGDDYAAMRQVLTRRYQKLVEQLQEAGGDPAGDGGDGVPRMPRVVLIDGGKGQVEVARQVFEELGLDIGLLVGV
AKGEGRKVGLETLVFADGRPSLELGQGSAALMLVAQIRDEAHRFAITGMRARRAKARTTSRLEEIEGVGARRRQKLLTRF
GGLRGVMAASIDELASVEGISRTLAEEIYRQLH
>Mature_672_residues
PEQEPVPPTETTSPESDTPESSDAPAFDPRPILARMPGLPGVYRYFDADGNILYVGKARDLKKRVSSYFNKTQLSPRIAM
MVAKIARIDTTVVRTEAEALLLENNLIKALAPRYNILFRDDKSYPFLRLTGHKFPRMAYYRGATDRKHQYFGPFPSAHAV
RESMQILQKVFQLRTCEDTVFNNRTRPCLLHQIHRCTGPCVGAISEDDYARDVSNAARFLQGRETEVLEGLQSKMEAHAV
QLEFEQAAAVRDQIAALSTVLKRQAVEEVGQARDIDILAVAVQGGRACVNLAMVRGGRHLGDKAYFPAHVDEAAMIVEEG
DEADGSAHEGAAADTDQLPIDRIAARVLSAFMVQHYLDQAPPPIVVVSHRPADSALVEALSMQAGRKITLVRQPQGQRKT
WLEMAAQGAGLALARRLAEQGSQEARTRALAETIGLDLEDLATLRIECFDISHTAGEATQASCVVFHHHEMQNSEYRRYN
IADITPGDDYAAMRQVLTRRYQKLVEQLQEAGGDPAGDGGDGVPRMPRVVLIDGGKGQVEVARQVFEELGLDIGLLVGVA
KGEGRKVGLETLVFADGRPSLELGQGSAALMLVAQIRDEAHRFAITGMRARRAKARTTSRLEEIEGVGARRRQKLLTRFG
GLRGVMAASIDELASVEGISRTLAEEIYRQLH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=655, Percent_Identity=44.7328244274809, Blast_Score=531, Evalue=1e-152,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_RALME (Q1LKN9)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_584556.1
- ProteinModelPortal:   Q1LKN9
- STRING:   Q1LKN9
- GeneID:   4039232
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_2410
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q1LKN9
- ProtClustDB:   PRK00558
- BioCyc:   RMET266264:RMET_2410-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 74071; Mature: 73940

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEQEPVPPTETTSPESDTPESSDAPAFDPRPILARMPGLPGVYRYFDADGNILYVGKAR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHEEECCCCCEEEEECCH
DLKKRVSSYFNKTQLSPRIAMMVAKIARIDTTVVRTEAEALLLENNLIKALAPRYNILFR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
DDKSYPFLRLTGHKFPRMAYYRGATDRKHQYFGPFPSAHAVRESMQILQKVFQLRTCEDT
CCCCCCEEEECCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VFNNRTRPCLLHQIHRCTGPCVGAISEDDYARDVSNAARFLQGRETEVLEGLQSKMEAHA
HHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VQLEFEQAAAVRDQIAALSTVLKRQAVEEVGQARDIDILAVAVQGGRACVNLAMVRGGRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCC
LGDKAYFPAHVDEAAMIVEEGDEADGSAHEGAAADTDQLPIDRIAARVLSAFMVQHYLDQ
CCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
APPPIVVVSHRPADSALVEALSMQAGRKITLVRQPQGQRKTWLEMAAQGAGLALARRLAE
CCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHH
QGSQEARTRALAETIGLDLEDLATLRIECFDISHTAGEATQASCVVFHHHEMQNSEYRRY
CCHHHHHHHHHHHHHCCCHHHHHEEEEEEEECCCCCCCCCCCEEEEEECHHCCCCCCCEE
NIADITPGDDYAAMRQVLTRRYQKLVEQLQEAGGDPAGDGGDGVPRMPRVVLIDGGKGQV
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCHH
EVARQVFEELGLDIGLLVGVAKGEGRKVGLETLVFADGRPSLELGQGSAALMLVAQIRDE
HHHHHHHHHHCCCEEEEEEEECCCCCEECCEEEEEECCCCCCEECCCCHHHHHHHHHHHH
AHRFAITGMRARRAKARTTSRLEEIEGVGARRRQKLLTRFGGLRGVMAASIDELASVEGI
HHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SRTLAEEIYRQLH
HHHHHHHHHHHCC
>Mature Secondary Structure 
PEQEPVPPTETTSPESDTPESSDAPAFDPRPILARMPGLPGVYRYFDADGNILYVGKAR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHEEECCCCCEEEEECCH
DLKKRVSSYFNKTQLSPRIAMMVAKIARIDTTVVRTEAEALLLENNLIKALAPRYNILFR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
DDKSYPFLRLTGHKFPRMAYYRGATDRKHQYFGPFPSAHAVRESMQILQKVFQLRTCEDT
CCCCCCEEEECCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VFNNRTRPCLLHQIHRCTGPCVGAISEDDYARDVSNAARFLQGRETEVLEGLQSKMEAHA
HHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VQLEFEQAAAVRDQIAALSTVLKRQAVEEVGQARDIDILAVAVQGGRACVNLAMVRGGRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCC
LGDKAYFPAHVDEAAMIVEEGDEADGSAHEGAAADTDQLPIDRIAARVLSAFMVQHYLDQ
CCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
APPPIVVVSHRPADSALVEALSMQAGRKITLVRQPQGQRKTWLEMAAQGAGLALARRLAE
CCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHH
QGSQEARTRALAETIGLDLEDLATLRIECFDISHTAGEATQASCVVFHHHEMQNSEYRRY
CCHHHHHHHHHHHHHCCCHHHHHEEEEEEEECCCCCCCCCCCEEEEEECHHCCCCCCCEE
NIADITPGDDYAAMRQVLTRRYQKLVEQLQEAGGDPAGDGGDGVPRMPRVVLIDGGKGQV
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCHH
EVARQVFEELGLDIGLLVGVAKGEGRKVGLETLVFADGRPSLELGQGSAALMLVAQIRDE
HHHHHHHHHHCCCEEEEEEEECCCCCEECCEEEEEECCCCCCEECCCCHHHHHHHHHHHH
AHRFAITGMRARRAKARTTSRLEEIEGVGARRRQKLLTRFGGLRGVMAASIDELASVEGI
HHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SRTLAEEIYRQLH
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA