Click here to switch to the map view.

The map label for this gene is pgsA [H]

Identifier: 94311345

GI number: 94311345

Start: 2618628

End: 2619227

Strand: Reverse

Name: pgsA [H]

Synonym: Rmet_2409

Alternate gene names: 94311345

Gene position: 2619227-2618628 (Counterclockwise)

Preceding gene: 94311346

Following gene: 94311337

Centisome position: 66.68

GC content: 60.17

Gene sequence:

>600_bases
ATGCCACTTAACATTCCCATTCTGCTGACCTGGCTTCGCGTGGCCATGATCCCGCTGGTCGTCGGGGTTTATTACCTGCC
CGAGGCCTGGCTGCCGATGCACACCAAGAACGTCACCGCGGCATCGTTCTTCGTCATCGCGGCAGTGACGGATTGGCTCG
ATGGCTTTCTGGCGCGGCGCTGGAATCAGACCTCGGCCTTCGGTGCCTTCCTCGATCCGGTGGCCGACAAGCTTATGGTG
ACAGCCGCATTGCTGTCGTTGCTGGCGCTGGGGCGGGTGGCCGACCTGATCGCGCTGATCATCATCGGGCGTGAGATCAC
GATTTCGGCACTGCGCGAATGGATGGCCCAGATCGGCGCTTCGAAGAGCGTAGCGGTAAATTTCCTTGGTAAGCTGAAGA
CCACCGTGCAGATGATCGCGATCCCGTTGCTGCTGTTCAACGACGCGCTGTTCGGTGTGGACGCATCGCTGCTTGGTGGC
TGGATGATCTACCTGGCGGCCGTGCTCACGTTGTGGTCGATGTTCTATTACATGAAGCTCGCCTGGCCGCAGATTCGCGA
GCGCAGCGAGGTCATCAGCGGGGCTCGGACACAAAAGTGA

Upstream 100 bases:

>100_bases
CCCGAAACTACGTGTCGGGTCCGAAATCGGCGACAATCGCGGCAATCGACATCGCAATCCGGCGTTGTCTGCCCGGGAAC
ACACTGCCCTAGCACCGCCC

Downstream 100 bases:

>100_bases
GATTTGCTGCAAAAAGTTGTTGACGAGCCGGATCGTCCTTTGCAATAATCTCGTTCTCGCTGCTGACGACGCAAACGAAA
GCAGCAAGATAAGCGGTACA

Product: phosphatidylglycerophosphate synthetase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MPLNIPILLTWLRVAMIPLVVGVYYLPEAWLPMHTKNVTAASFFVIAAVTDWLDGFLARRWNQTSAFGAFLDPVADKLMV
TAALLSLLALGRVADLIALIIIGREITISALREWMAQIGASKSVAVNFLGKLKTTVQMIAIPLLLFNDALFGVDASLLGG
WMIYLAAVLTLWSMFYYMKLAWPQIRERSEVISGARTQK

Sequences:

>Translated_199_residues
MPLNIPILLTWLRVAMIPLVVGVYYLPEAWLPMHTKNVTAASFFVIAAVTDWLDGFLARRWNQTSAFGAFLDPVADKLMV
TAALLSLLALGRVADLIALIIIGREITISALREWMAQIGASKSVAVNFLGKLKTTVQMIAIPLLLFNDALFGVDASLLGG
WMIYLAAVLTLWSMFYYMKLAWPQIRERSEVISGARTQK
>Mature_198_residues
PLNIPILLTWLRVAMIPLVVGVYYLPEAWLPMHTKNVTAASFFVIAAVTDWLDGFLARRWNQTSAFGAFLDPVADKLMVT
AALLSLLALGRVADLIALIIIGREITISALREWMAQIGASKSVAVNFLGKLKTTVQMIAIPLLLFNDALFGVDASLLGGW
MIYLAAVLTLWSMFYYMKLAWPQIRERSEVISGARTQK

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=172, Percent_Identity=29.0697674418605, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI10092647, Length=172, Percent_Identity=29.0697674418605, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1788220, Length=183, Percent_Identity=50.2732240437158, Blast_Score=158, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 22072; Mature: 21941

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNIPILLTWLRVAMIPLVVGVYYLPEAWLPMHTKNVTAASFFVIAAVTDWLDGFLARR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
WNQTSAFGAFLDPVADKLMVTAALLSLLALGRVADLIALIIIGREITISALREWMAQIGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
SKSVAVNFLGKLKTTVQMIAIPLLLFNDALFGVDASLLGGWMIYLAAVLTLWSMFYYMKL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AWPQIRERSEVISGARTQK
HHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PLNIPILLTWLRVAMIPLVVGVYYLPEAWLPMHTKNVTAASFFVIAAVTDWLDGFLARR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
WNQTSAFGAFLDPVADKLMVTAALLSLLALGRVADLIALIIIGREITISALREWMAQIGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
SKSVAVNFLGKLKTTVQMIAIPLLLFNDALFGVDASLLGGWMIYLAAVLTLWSMFYYMKL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AWPQIRERSEVISGARTQK
HHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]