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The map label for this gene is evgS [H]

Identifier: 94311092

GI number: 94311092

Start: 2351526

End: 2353973

Strand: Direct

Name: evgS [H]

Synonym: Rmet_2154

Alternate gene names: 94311092

Gene position: 2351526-2353973 (Clockwise)

Preceding gene: 94311091

Following gene: 335055581

Centisome position: 59.86

GC content: 61.4

Gene sequence:

>2448_bases
TTGCCCGCAACCCAGGACGAAGATATCGATGTCGGCACCGAATCCCCACGCATCATGAAACGGGCACTGCTTCTGATCCT
GGCTGTCCTGGCCGGCTTCATTCCGTACGCCCGCGCCATGGCGCAAGGTTCCTGGGGAGCGACGGAGGAAGCATGGCTGA
AGGAGCACCACGTCCTGCGTATCGCGGTGGACCCCTACTGGCAACCGCTCGAATATGTCGAGAAAGGAACCGCTCACGGG
CTCAGCATCGCCTATATCCATGCCATTGCCGATCGGCTTGGCCTGACGGTGCAACTGGTGCCCACGAAGTCATGGTCGGA
ATCCGTGCGCAAGCTTCTGGACGGCGAGGTGGACGTGCTGCCCGCCGTGCCCGACTTCCAGTTGCCCAAGTCCGCCGGAA
CACGGATTGCACTGACACGTCCCTACTACGTCGGCACGACACTGGTTGTCGCAAAGGCGCGGGACAACAACTACTTCGAT
CTATCGAGCTTGGGCTGCATTACCGTAGCGGTCAAGGAAGGCGGCGCCTATCACCAATGGTTCGAAGGGCACCCGTTGCC
TTGCACGCGGCTACTCCCGGAGCCGAGCGACAGCATGGCATTGGCGGCAGTTCGTGACGGCAAGGCTGCCGCCGCTGTCG
GGCCGAGCGCGGTACTTCATCCGCTCATCCGGCTGCAGTACGACAAGACGCTTCATATCGCGGGGACCATCGCCGAGCTG
CCGCTGGTGCTGCGCATGGCTGTCCGCCAGGATTCCGCGCCGCTGCTCTCCCTGATGAATCAGGCGCTGGCATCGCTCAG
CGCCGGGGAAACCGACCAGCTCTATCAGAACTGGCTGGAGGGCGCGGATTACCTTCAGCCATCGCTCAAGGCACTCTGGC
ACTACTACGGCGCCACGATTGTGCTTTTCCTGATCGTCCTGATATCACTGGGCGTTTCCGTCTACCAGGCGATGCGTGCC
CGCGCCAATGCCTTGAAGAGCGAGAAGGTGAAATCCGAGTTCCTGGCCATCATGAGCCATGAGATACGGACGCCCATTAG
TGCGGTCGTGGGCGCGCTGGAGTTACTCGATCGGGAAGACAACAACACGCCAAGACGAGAACTTCTTCATCGGGCTCGAG
AAAGCGCCGACTCGTTGCTCGCGGTACTCAATAACGTCCTGGACTATTCAAGCATCAGTACCGGGAAGATCCTCGTGAAG
CCCTCGGCGCTGCGTGTGAACGACCTCGTCCGCTCGGTGCTCGATGGCTTCGAAGCCATCGCCGATCGCAAGGGCATTGC
GCTCCAGCTGAACGACCAGTCTGGCGGTCACACCATCAACCTGGACGGTAATCGCATACGCCAGGTGCTGGGCAATCTCG
TGGCAAATGCGATCAAGTTCACCGAGCAGGGTACCGTCACGGTCGACGTCCGGTTGTCCCGGTCAGAGCGATCGTCGGAA
CGCGTCACGCTGGCGATCCGCGTAAGCGACACGGGCATCGGCATCGCGCCAGAGGATCAACCAAGGCTGTTTCAGCCCTT
CAGCCAGGTGGGGAACGCCCGTCAACGCCAAACGGGTAGCAGTGGCCTTGGCCTCTCCATCTGCAAGAAGCTCGTGGAAG
CCATGGGGGGAAGCATCTCGATCTGGAGCACCCTCGGGCAGGGTACGACGGTCGAGTTCTCGCTGGAATCGACGATTGCC
GACACACACGAAACCGCCTTGCCCCCCTCGCCACAGGTGGCAGCAAGCGTCTCCGGGGAGATTCTGGTCGTTGAAGACAC
GCCGGCCAACCAGTTGGTGCTCATGGAGCAGTTGCGCGCGCTTGGGTATGACCCGGTGCTTGCGGAAGCCGGCGCCCAGG
CCATCGACCTGTTCTCGACTCGATCGTTTGCCGCCATTCTGCTGGACCTTCACTTGCCGGACGTCGACGGCTTCACAGTC
GCAAAGCAAATGCGCGCCCGGGAGGACTCGACGCATTCGCAACCCACACCAATCATCGCCGTGACGGCCGAAGCCGGGCC
GGAACAGGCATTGCGTTCGCTGGATGCGGGCATCGATTGCGTTCTAGCCAAACCGATCAATCTGCAGGGATTGCAGGAAA
CATTGCACCTGTGGATTCCGGATTGCCACGCGACTGGCGCGATCGGGGCGACTGCTACCGACGCACTCAACGCACTCGAC
GCCAGCCATTCCAGCCATTTGGAACGTACCAAGTCCATGGCGGAATACGCGCTGCTCGAACTTGCGGCCCTCGATGTCGC
CGCGCGGGCGCGAGACCCTGTCATGGCCGGACATCATCTCCATCGCCTAAAGGGGACACTGCTCCAGTCCTCGCAGCTCA
CAAACCTGGCTGAGAGCATCCCGTCCATCGAGGCCAGCCTCGACAAGGACGTCGACTGGGATGGCATTGTCCTGAGCCTT
CAATACCTTCGACCCGAGATTCTCAGGCGGTCAGCAGATGACGCTTGA

Upstream 100 bases:

>100_bases
GGTGAGCGGCCACAAGCAGTCGGCGCTCCGCAAGCTGGGGATCCGCTCCGACAACGAACTGTTCAAGGTGCGCCACCTTA
TCTGACCTACGCCCAGCGAC

Downstream 100 bases:

>100_bases
TGCTGGCGAGCGCGGCAGATCGCCCTCTTCCGGACTCCACCTCGACACCCGGCAAGCGCGACGCGCTTGCGCACACCGAA
CTATCCAGATCGCACAGACA

Product: hybrid sensory histidine kinase in two-component regulatory system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 815; Mature: 814

Protein sequence:

>815_residues
MPATQDEDIDVGTESPRIMKRALLLILAVLAGFIPYARAMAQGSWGATEEAWLKEHHVLRIAVDPYWQPLEYVEKGTAHG
LSIAYIHAIADRLGLTVQLVPTKSWSESVRKLLDGEVDVLPAVPDFQLPKSAGTRIALTRPYYVGTTLVVAKARDNNYFD
LSSLGCITVAVKEGGAYHQWFEGHPLPCTRLLPEPSDSMALAAVRDGKAAAAVGPSAVLHPLIRLQYDKTLHIAGTIAEL
PLVLRMAVRQDSAPLLSLMNQALASLSAGETDQLYQNWLEGADYLQPSLKALWHYYGATIVLFLIVLISLGVSVYQAMRA
RANALKSEKVKSEFLAIMSHEIRTPISAVVGALELLDREDNNTPRRELLHRARESADSLLAVLNNVLDYSSISTGKILVK
PSALRVNDLVRSVLDGFEAIADRKGIALQLNDQSGGHTINLDGNRIRQVLGNLVANAIKFTEQGTVTVDVRLSRSERSSE
RVTLAIRVSDTGIGIAPEDQPRLFQPFSQVGNARQRQTGSSGLGLSICKKLVEAMGGSISIWSTLGQGTTVEFSLESTIA
DTHETALPPSPQVAASVSGEILVVEDTPANQLVLMEQLRALGYDPVLAEAGAQAIDLFSTRSFAAILLDLHLPDVDGFTV
AKQMRAREDSTHSQPTPIIAVTAEAGPEQALRSLDAGIDCVLAKPINLQGLQETLHLWIPDCHATGAIGATATDALNALD
ASHSSHLERTKSMAEYALLELAALDVAARARDPVMAGHHLHRLKGTLLQSSQLTNLAESIPSIEASLDKDVDWDGIVLSL
QYLRPEILRRSADDA

Sequences:

>Translated_815_residues
MPATQDEDIDVGTESPRIMKRALLLILAVLAGFIPYARAMAQGSWGATEEAWLKEHHVLRIAVDPYWQPLEYVEKGTAHG
LSIAYIHAIADRLGLTVQLVPTKSWSESVRKLLDGEVDVLPAVPDFQLPKSAGTRIALTRPYYVGTTLVVAKARDNNYFD
LSSLGCITVAVKEGGAYHQWFEGHPLPCTRLLPEPSDSMALAAVRDGKAAAAVGPSAVLHPLIRLQYDKTLHIAGTIAEL
PLVLRMAVRQDSAPLLSLMNQALASLSAGETDQLYQNWLEGADYLQPSLKALWHYYGATIVLFLIVLISLGVSVYQAMRA
RANALKSEKVKSEFLAIMSHEIRTPISAVVGALELLDREDNNTPRRELLHRARESADSLLAVLNNVLDYSSISTGKILVK
PSALRVNDLVRSVLDGFEAIADRKGIALQLNDQSGGHTINLDGNRIRQVLGNLVANAIKFTEQGTVTVDVRLSRSERSSE
RVTLAIRVSDTGIGIAPEDQPRLFQPFSQVGNARQRQTGSSGLGLSICKKLVEAMGGSISIWSTLGQGTTVEFSLESTIA
DTHETALPPSPQVAASVSGEILVVEDTPANQLVLMEQLRALGYDPVLAEAGAQAIDLFSTRSFAAILLDLHLPDVDGFTV
AKQMRAREDSTHSQPTPIIAVTAEAGPEQALRSLDAGIDCVLAKPINLQGLQETLHLWIPDCHATGAIGATATDALNALD
ASHSSHLERTKSMAEYALLELAALDVAARARDPVMAGHHLHRLKGTLLQSSQLTNLAESIPSIEASLDKDVDWDGIVLSL
QYLRPEILRRSADDA
>Mature_814_residues
PATQDEDIDVGTESPRIMKRALLLILAVLAGFIPYARAMAQGSWGATEEAWLKEHHVLRIAVDPYWQPLEYVEKGTAHGL
SIAYIHAIADRLGLTVQLVPTKSWSESVRKLLDGEVDVLPAVPDFQLPKSAGTRIALTRPYYVGTTLVVAKARDNNYFDL
SSLGCITVAVKEGGAYHQWFEGHPLPCTRLLPEPSDSMALAAVRDGKAAAAVGPSAVLHPLIRLQYDKTLHIAGTIAELP
LVLRMAVRQDSAPLLSLMNQALASLSAGETDQLYQNWLEGADYLQPSLKALWHYYGATIVLFLIVLISLGVSVYQAMRAR
ANALKSEKVKSEFLAIMSHEIRTPISAVVGALELLDREDNNTPRRELLHRARESADSLLAVLNNVLDYSSISTGKILVKP
SALRVNDLVRSVLDGFEAIADRKGIALQLNDQSGGHTINLDGNRIRQVLGNLVANAIKFTEQGTVTVDVRLSRSERSSER
VTLAIRVSDTGIGIAPEDQPRLFQPFSQVGNARQRQTGSSGLGLSICKKLVEAMGGSISIWSTLGQGTTVEFSLESTIAD
THETALPPSPQVAASVSGEILVVEDTPANQLVLMEQLRALGYDPVLAEAGAQAIDLFSTRSFAAILLDLHLPDVDGFTVA
KQMRAREDSTHSQPTPIIAVTAEAGPEQALRSLDAGIDCVLAKPINLQGLQETLHLWIPDCHATGAIGATATDALNALDA
SHSSHLERTKSMAEYALLELAALDVAARARDPVMAGHHLHRLKGTLLQSSQLTNLAESIPSIEASLDKDVDWDGIVLSLQ
YLRPEILRRSADDA

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=378, Percent_Identity=34.6560846560847, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI87081816, Length=347, Percent_Identity=34.8703170028818, Blast_Score=165, Evalue=1e-41,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=37.5527426160338, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI48994928, Length=389, Percent_Identity=27.2493573264781, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI145693157, Length=258, Percent_Identity=32.1705426356589, Blast_Score=139, Evalue=7e-34,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=31.5789473684211, Blast_Score=107, Evalue=4e-24,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=29.3859649122807, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=26.4957264957265, Blast_Score=84, Evalue=5e-17,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=26.8595041322314, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=26.9230769230769, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1787894, Length=245, Percent_Identity=29.3877551020408, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1790436, Length=278, Percent_Identity=26.978417266187, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=26.3374485596708, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=226, Percent_Identity=26.9911504424779, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 88124; Mature: 87992

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPATQDEDIDVGTESPRIMKRALLLILAVLAGFIPYARAMAQGSWGATEEAWLKEHHVLR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEE
IAVDPYWQPLEYVEKGTAHGLSIAYIHAIADRLGLTVQLVPTKSWSESVRKLLDGEVDVL
EEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCEEE
PAVPDFQLPKSAGTRIALTRPYYVGTTLVVAKARDNNYFDLSSLGCITVAVKEGGAYHQW
CCCCCCCCCCCCCCEEEEECCEEECEEEEEEEECCCCEEEECCCCEEEEEEECCCCCHHC
FEGHPLPCTRLLPEPSDSMALAAVRDGKAAAAVGPSAVLHPLIRLQYDKTLHIAGTIAEL
CCCCCCCHHHCCCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHHHCCCCEEEEEHHHHHH
PLVLRMAVRQDSAPLLSLMNQALASLSAGETDQLYQNWLEGADYLQPSLKALWHYYGATI
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCHHHHHHHHHHHHHH
VLFLIVLISLGVSVYQAMRARANALKSEKVKSEFLAIMSHEIRTPISAVVGALELLDRED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
NNTPRRELLHRARESADSLLAVLNNVLDYSSISTGKILVKPSALRVNDLVRSVLDGFEAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHH
ADRKGIALQLNDQSGGHTINLDGNRIRQVLGNLVANAIKFTEQGTVTVDVRLSRSERSSE
HCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCC
RVTLAIRVSDTGIGIAPEDQPRLFQPFSQVGNARQRQTGSSGLGLSICKKLVEAMGGSIS
EEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCCEE
IWSTLGQGTTVEFSLESTIADTHETALPPSPQVAASVSGEILVVEDTPANQLVLMEQLRA
EEECCCCCCEEEEEEHHHHHCCHHCCCCCCCCCHHCCCCCEEEEECCCCCHHHHHHHHHH
LGYDPVLAEAGAQAIDLFSTRSFAAILLDLHLPDVDGFTVAKQMRAREDSTHSQPTPIIA
CCCCCHHHHCCCHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCEEE
VTAEAGPEQALRSLDAGIDCVLAKPINLQGLQETLHLWIPDCHATGAIGATATDALNALD
EECCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
ASHSSHLERTKSMAEYALLELAALDVAARARDPVMAGHHLHRLKGTLLQSSQLTNLAESI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PSIEASLDKDVDWDGIVLSLQYLRPEILRRSADDA
CCHHHHCCCCCCCCHHEEEHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PATQDEDIDVGTESPRIMKRALLLILAVLAGFIPYARAMAQGSWGATEEAWLKEHHVLR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEE
IAVDPYWQPLEYVEKGTAHGLSIAYIHAIADRLGLTVQLVPTKSWSESVRKLLDGEVDVL
EEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCEEE
PAVPDFQLPKSAGTRIALTRPYYVGTTLVVAKARDNNYFDLSSLGCITVAVKEGGAYHQW
CCCCCCCCCCCCCCEEEEECCEEECEEEEEEEECCCCEEEECCCCEEEEEEECCCCCHHC
FEGHPLPCTRLLPEPSDSMALAAVRDGKAAAAVGPSAVLHPLIRLQYDKTLHIAGTIAEL
CCCCCCCHHHCCCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHHHCCCCEEEEEHHHHHH
PLVLRMAVRQDSAPLLSLMNQALASLSAGETDQLYQNWLEGADYLQPSLKALWHYYGATI
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCHHHHHHHHHHHHHH
VLFLIVLISLGVSVYQAMRARANALKSEKVKSEFLAIMSHEIRTPISAVVGALELLDRED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
NNTPRRELLHRARESADSLLAVLNNVLDYSSISTGKILVKPSALRVNDLVRSVLDGFEAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHH
ADRKGIALQLNDQSGGHTINLDGNRIRQVLGNLVANAIKFTEQGTVTVDVRLSRSERSSE
HCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCC
RVTLAIRVSDTGIGIAPEDQPRLFQPFSQVGNARQRQTGSSGLGLSICKKLVEAMGGSIS
EEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCCEE
IWSTLGQGTTVEFSLESTIADTHETALPPSPQVAASVSGEILVVEDTPANQLVLMEQLRA
EEECCCCCCEEEEEEHHHHHCCHHCCCCCCCCCHHCCCCCEEEEECCCCCHHHHHHHHHH
LGYDPVLAEAGAQAIDLFSTRSFAAILLDLHLPDVDGFTVAKQMRAREDSTHSQPTPIIA
CCCCCHHHHCCCHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCEEE
VTAEAGPEQALRSLDAGIDCVLAKPINLQGLQETLHLWIPDCHATGAIGATATDALNALD
EECCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
ASHSSHLERTKSMAEYALLELAALDVAARARDPVMAGHHLHRLKGTLLQSSQLTNLAESI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PSIEASLDKDVDWDGIVLSLQYLRPEILRRSADDA
CCHHHHCCCCCCCCHHEEEHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA