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The map label for this gene is ftsI1 [H]

Identifier: 94311089

GI number: 94311089

Start: 2346608

End: 2348353

Strand: Direct

Name: ftsI1 [H]

Synonym: Rmet_2151

Alternate gene names: 94311089

Gene position: 2346608-2348353 (Clockwise)

Preceding gene: 94311088

Following gene: 94311090

Centisome position: 59.74

GC content: 63.75

Gene sequence:

>1746_bases
ATGCGCCCGATTGCTTGCAACCGCCGCAACTTTGCCAACAGGCTGACGATGCCCAGCAAGCGCTACATTGCCCATTCCCA
GAGCTTCGCGAACACCATCGGGAGTTTTCACCCCGGTCGCTCCCGGTTTCTTGTGTTCCTGATCACGCTCTGCTTCCTGG
GGCTCGCTATCCGCGCCATCTGGATCGCCGGACCTGGCAACGCGTTCTACCAGCAGCAAGGCGATTTACGCGTCAGGCGA
CAGCTCGATGTTCCGCCGACGCGCGGGCGAATTCTTGATCGCAACGGCCATACGCTCGCACAGAGCCTCCCGGCCGGCGC
CATCTACTTAAGCCCCCGTCAGATGGTCTCCAGTGACAAATACACGGGGCTTGCGGAGGCACTCGGTATGCCCCTGACAG
AGATCGAGGCGGCATCGGCATCGGACCGGGGCTTTGTGTACCTCAGGCGCCAGACCGACGCGGCAACGCTGGAACTGGTC
AAGACGCTTGCGTTGCCAGGCGTGGGAACGGTACGCGAGTTCAAGCGTGTCTATCCATCCGGCCCGCCCTTCGACGCCCT
TCTCGGGCTGGTCAATCTTGACGGCATCGGTATCGAGGGACTGGAACTCGCACTCAATGACCGGCTGAAAGGCGCGCGCG
GGCGGAGCGTCGTCGAGAAGGACCGCCTTGGCAACATCCTCTCCCAGCTGGTGATTGCCGAGGCCGAGGACGGCGGCGAT
ATCCATCTGTCGATCGATGAGCGGCTGCAAACCGCCACATACCAGGCACTGCAGCAGGCATCGGAAACGGTGAAGGCTCG
ATCCAGCCTTGCCGTGGTCACTGACGTCAAGACCGGCGAGATCCTCGCCGCCGCAAGCTGGCACGCCGATAGCAGCAAAC
GTCGCGCTGCGGCGCTGATCGACGCCTTCGAGCCAGGCAGCATCATCAAGCCGCTGATCGTCGCGGGTGCGCTGGAACTG
AAGCGCGTTGCACCAGACACGTTGATCGAGACGAACGGCAGATTCGATTTTGCCGGCGCGAAGATCACAGACGTCCGGAA
CTTCGGCCAGCTATCGGTCGCGGGCGTTATCGAGAAATCGAGCAACATCGGCATGGTGAAAATCGTCTCCCGCCTCTCGC
CGGACGAACTGTGGACGCACATGCACGCGCTCGGCTTTGGGCGAAAGGCTGACTCCTTCCCATTTCCCGGCCTGGGTAGT
GGTCGCATGCATAGCGCGCGGGGGATGACGCCGATTACCCAGGCGACCATGGCATATGGATACGGGCTGACCGCCTCCGC
GCTACAGATCGCGCAGGCATATGCGGCGATCGGCAATCGCGGCCAGCTTATCCCCCTTACCCTCGAACGGCGGCCAGCAG
GAAGCGAGACGCGCGGCACGCAGGTCCTGACGCCAGCAACCGCGGAGGCCGTGCTGGCCATGCTCGAACGCGTGACCGGT
GCCGGAGGGTCAGGCCGACAAGCCCGCGTGAACGAGTACCGCGTCGGCGGCAAAACGGGCACGGCCTACCTGCACGTCCC
GGGACGTGGATACGACAAGAAGCGCTACCGCGCGTCGTTTGCCGGCGTGGCACCCCTGTCCGCGCCCGAGATCGCCGTCG
TGGTCAGCGTCGAGGATCCCAGCGAAGGCAGCCACTTCGGCGGCAAAGTCGCAGCGCCAATCTTCGCGCAAATCGTCTCG
CGTGCCATGCAATTGCGGCATGTGGTTCCAGATGCCCCACCGGCCGAGGCCAACATCGCACGTTGA

Upstream 100 bases:

>100_bases
ATCAATTCCAGACTAGTCCGGCCCGCCGGTCGGCCGCGCATCAGTACCCTGTTCGATCCTGATTTGTGGGCGCGAGCCGC
ACGTATGTGTCCGGCGTTCA

Downstream 100 bases:

>100_bases
GTCTCAGTTCGGGCCAATTCCAGACCAGTCTTGTATGCAGTCCGGAAACCGTCCGACAGACTGATGGTCACAGCCACCCT
CAGGATATACCGGCGCGCGG

Product: peptidoglycan glycosyltransferase (penicillin-binding domain)

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MRPIACNRRNFANRLTMPSKRYIAHSQSFANTIGSFHPGRSRFLVFLITLCFLGLAIRAIWIAGPGNAFYQQQGDLRVRR
QLDVPPTRGRILDRNGHTLAQSLPAGAIYLSPRQMVSSDKYTGLAEALGMPLTEIEAASASDRGFVYLRRQTDAATLELV
KTLALPGVGTVREFKRVYPSGPPFDALLGLVNLDGIGIEGLELALNDRLKGARGRSVVEKDRLGNILSQLVIAEAEDGGD
IHLSIDERLQTATYQALQQASETVKARSSLAVVTDVKTGEILAAASWHADSSKRRAAALIDAFEPGSIIKPLIVAGALEL
KRVAPDTLIETNGRFDFAGAKITDVRNFGQLSVAGVIEKSSNIGMVKIVSRLSPDELWTHMHALGFGRKADSFPFPGLGS
GRMHSARGMTPITQATMAYGYGLTASALQIAQAYAAIGNRGQLIPLTLERRPAGSETRGTQVLTPATAEAVLAMLERVTG
AGGSGRQARVNEYRVGGKTGTAYLHVPGRGYDKKRYRASFAGVAPLSAPEIAVVVSVEDPSEGSHFGGKVAAPIFAQIVS
RAMQLRHVVPDAPPAEANIAR

Sequences:

>Translated_581_residues
MRPIACNRRNFANRLTMPSKRYIAHSQSFANTIGSFHPGRSRFLVFLITLCFLGLAIRAIWIAGPGNAFYQQQGDLRVRR
QLDVPPTRGRILDRNGHTLAQSLPAGAIYLSPRQMVSSDKYTGLAEALGMPLTEIEAASASDRGFVYLRRQTDAATLELV
KTLALPGVGTVREFKRVYPSGPPFDALLGLVNLDGIGIEGLELALNDRLKGARGRSVVEKDRLGNILSQLVIAEAEDGGD
IHLSIDERLQTATYQALQQASETVKARSSLAVVTDVKTGEILAAASWHADSSKRRAAALIDAFEPGSIIKPLIVAGALEL
KRVAPDTLIETNGRFDFAGAKITDVRNFGQLSVAGVIEKSSNIGMVKIVSRLSPDELWTHMHALGFGRKADSFPFPGLGS
GRMHSARGMTPITQATMAYGYGLTASALQIAQAYAAIGNRGQLIPLTLERRPAGSETRGTQVLTPATAEAVLAMLERVTG
AGGSGRQARVNEYRVGGKTGTAYLHVPGRGYDKKRYRASFAGVAPLSAPEIAVVVSVEDPSEGSHFGGKVAAPIFAQIVS
RAMQLRHVVPDAPPAEANIAR
>Mature_581_residues
MRPIACNRRNFANRLTMPSKRYIAHSQSFANTIGSFHPGRSRFLVFLITLCFLGLAIRAIWIAGPGNAFYQQQGDLRVRR
QLDVPPTRGRILDRNGHTLAQSLPAGAIYLSPRQMVSSDKYTGLAEALGMPLTEIEAASASDRGFVYLRRQTDAATLELV
KTLALPGVGTVREFKRVYPSGPPFDALLGLVNLDGIGIEGLELALNDRLKGARGRSVVEKDRLGNILSQLVIAEAEDGGD
IHLSIDERLQTATYQALQQASETVKARSSLAVVTDVKTGEILAAASWHADSSKRRAAALIDAFEPGSIIKPLIVAGALEL
KRVAPDTLIETNGRFDFAGAKITDVRNFGQLSVAGVIEKSSNIGMVKIVSRLSPDELWTHMHALGFGRKADSFPFPGLGS
GRMHSARGMTPITQATMAYGYGLTASALQIAQAYAAIGNRGQLIPLTLERRPAGSETRGTQVLTPATAEAVLAMLERVTG
AGGSGRQARVNEYRVGGKTGTAYLHVPGRGYDKKRYRASFAGVAPLSAPEIAVVVSVEDPSEGSHFGGKVAAPIFAQIVS
RAMQLRHVVPDAPPAEANIAR

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=555, Percent_Identity=34.4144144144144, Blast_Score=291, Evalue=1e-79,
Organism=Escherichia coli, GI1786854, Length=570, Percent_Identity=24.0350877192982, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 62219; Mature: 62219

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPIACNRRNFANRLTMPSKRYIAHSQSFANTIGSFHPGRSRFLVFLITLCFLGLAIRAI
CCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEE
WIAGPGNAFYQQQGDLRVRRQLDVPPTRGRILDRNGHTLAQSLPAGAIYLSPRQMVSSDK
EEECCCCHHHHCCCCEEEEEECCCCCCCCEEECCCCCHHHHHCCCCEEEECHHHHHCCCC
YTGLAEALGMPLTEIEAASASDRGFVYLRRQTDAATLELVKTLALPGVGTVREFKRVYPS
CCCHHHHHCCCHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCCC
GPPFDALLGLVNLDGIGIEGLELALNDRLKGARGRSVVEKDRLGNILSQLVIAEAEDGGD
CCCHHHHHHHHCCCCCCCCCCEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCE
IHLSIDERLQTATYQALQQASETVKARSSLAVVTDVKTGEILAAASWHADSSKRRAAALI
EEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHH
DAFEPGSIIKPLIVAGALELKRVAPDTLIETNGRFDFAGAKITDVRNFGQLSVAGVIEKS
HCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCEEECCCEEECHHCCCCEEEEEEEECC
SNIGMVKIVSRLSPDELWTHMHALGFGRKADSFPFPGLGSGRMHSARGMTPITQATMAYG
CCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHC
YGLTASALQIAQAYAAIGNRGQLIPLTLERRPAGSETRGTQVLTPATAEAVLAMLERVTG
CCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHC
AGGSGRQARVNEYRVGGKTGTAYLHVPGRGYDKKRYRASFAGVAPLSAPEIAVVVSVEDP
CCCCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCC
SEGSHFGGKVAAPIFAQIVSRAMQLRHVVPDAPPAEANIAR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRPIACNRRNFANRLTMPSKRYIAHSQSFANTIGSFHPGRSRFLVFLITLCFLGLAIRAI
CCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEE
WIAGPGNAFYQQQGDLRVRRQLDVPPTRGRILDRNGHTLAQSLPAGAIYLSPRQMVSSDK
EEECCCCHHHHCCCCEEEEEECCCCCCCCEEECCCCCHHHHHCCCCEEEECHHHHHCCCC
YTGLAEALGMPLTEIEAASASDRGFVYLRRQTDAATLELVKTLALPGVGTVREFKRVYPS
CCCHHHHHCCCHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCCC
GPPFDALLGLVNLDGIGIEGLELALNDRLKGARGRSVVEKDRLGNILSQLVIAEAEDGGD
CCCHHHHHHHHCCCCCCCCCCEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCE
IHLSIDERLQTATYQALQQASETVKARSSLAVVTDVKTGEILAAASWHADSSKRRAAALI
EEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHH
DAFEPGSIIKPLIVAGALELKRVAPDTLIETNGRFDFAGAKITDVRNFGQLSVAGVIEKS
HCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCEEECCCEEECHHCCCCEEEEEEEECC
SNIGMVKIVSRLSPDELWTHMHALGFGRKADSFPFPGLGSGRMHSARGMTPITQATMAYG
CCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHC
YGLTASALQIAQAYAAIGNRGQLIPLTLERRPAGSETRGTQVLTPATAEAVLAMLERVTG
CCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHC
AGGSGRQARVNEYRVGGKTGTAYLHVPGRGYDKKRYRASFAGVAPLSAPEIAVVVSVEDP
CCCCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCC
SEGSHFGGKVAAPIFAQIVSRAMQLRHVVPDAPPAEANIAR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]