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The map label for this gene is thrC [H]

Identifier: 94310903

GI number: 94310903

Start: 2140320

End: 2141765

Strand: Reverse

Name: thrC [H]

Synonym: Rmet_1965

Alternate gene names: 94310903

Gene position: 2141765-2140320 (Counterclockwise)

Preceding gene: 94310904

Following gene: 94310902

Centisome position: 54.52

GC content: 64.18

Gene sequence:

>1446_bases
ATGAATTACCAGTCGACGCGCGGCCATGACGTGCCGCAATCGTTCTCCGAGATCCTGCTCGGTGGCCTGGCGCCCGATGG
CGGCTTGTATCTGCCCAAGCAGTACCCGCAGATCACGGCCGAGGAACTCGAAGCCTGGCGCAAGCTCCCGTACGCCGACC
TGGCGTTCGAGGTGCTGTCGCGCTTCTGTGACGACATCCCCGCCGAGGACCTGCGCGCGCTGACGCGCAAGACCTACACG
GCTGACGTGTACTGCAACGCGCGAGCCGGCGACAACACTGCCGACATTACGCCGTTGCGTACACTGGGCGAAGAGGGCGG
CACGAAGCTGCAACTGCTGGGCCTGTCCAACGGCCCGACGCTGGCCTTCAAGGACATGGCGATGCAGTTGCTGGGCAACC
TGTTCGAGTACGCGCTCAAGCGCGCGGGTCTGAAGCTGAACATCCTTGGCGCGACTTCCGGCGATACCGGTAGCGCGGCC
GAGTACGCGATGCGCGGCAAGGAAGGCATTCGCGTGTTCATGCTGAGCCCGCACCGCAAGATGAGCGCGTTCCAGACCGC
CCAGATGTTCAGCCTGCAGGACCCGAACATCTTCAATATCGCGATCGAAGGTGTGTTCGACGACGCTCAGGACATCGTCA
AGGCCGTCTCGAACGATCATGCGTTCAAGGCGCGCCAGCGCATTGGCACGGTCAACTCGATCAACTGGGCCCGCGTGGTC
GCCCAGGTGGTCTACTACTTCAAGGGCTGGCTGCTGGCGACCAGCGGTCCGGGACAGAAGGTGTCGTTCTGCGTGCCGTC
GGGCAACTTCGGCAACGTCTGCGCCGGCCACATCGCGCGCATGATGGGCCTGCCGATCGACAAGCTCGTGGTGGCCACCA
ACGAGAACGACGTGCTGGACGAGTTCTTCCGCACCGGCACGTATCGCGTGCGGACCTCGGCCCAGACGTACCACACGTCG
AGCCCGAGCATGGACATCTCGAAGGCATCGAACTTCGAGCGTTTCGTGTTCGATCTGCTGGGCCAGGACGCCGACAAGCT
GGTGGCGCTGTTCAGCGACGTCGACACCAAGGGTGGCTTCGATCTGGCGGGCACGCCGGAATTCGCGCGCATCGGCCAGT
TTGGCTTTGTTTCCGGCCGCAGCTCGCACCAGGACCGTCTGGCGACGATCCGCGACGTGAACCAGCGCTATGGCGTGACG
ATCGACACCCATACCGCCGATGGCGTGAAGGTGGCGCGCGAGTACCTGCAGCCGGGCGTGCCGATGGTGGTGCTGGAAAC
CGCGCTGCCGGCCAAGTTCGCCGACACAATCCACGAGGCTTTGGGCCATGAGCCGGAACGTCCGGCTGCGTTCGACGGTA
TCGAGAAGCTGCCGCAACGCTTCGAGGTGATGCCGGCCGACGCGGACAGCGTGAAGGCGTATATCGCCCAGCACACCGGT
TTGTGA

Upstream 100 bases:

>100_bases
ATTCGCAGCATCGAAGCGCTCCAGACCGTGCTGTCGCCGGTCACGCGCCTGCGCATGGAAGAACTGAACTGATAGCTGAC
AGACGGACCTGACTCGCCTC

Downstream 100 bases:

>100_bases
TCGAAGGGCGAATAGCCCTTATCACAGCAGGATCGGCCGGTCCGGCGCCAACTCGCTACAATCGGGTTTGCCGGGCTCCG
CTGCCACGGCCCCCAGGCTT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MNYQSTRGHDVPQSFSEILLGGLAPDGGLYLPKQYPQITAEELEAWRKLPYADLAFEVLSRFCDDIPAEDLRALTRKTYT
ADVYCNARAGDNTADITPLRTLGEEGGTKLQLLGLSNGPTLAFKDMAMQLLGNLFEYALKRAGLKLNILGATSGDTGSAA
EYAMRGKEGIRVFMLSPHRKMSAFQTAQMFSLQDPNIFNIAIEGVFDDAQDIVKAVSNDHAFKARQRIGTVNSINWARVV
AQVVYYFKGWLLATSGPGQKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLDEFFRTGTYRVRTSAQTYHTS
SPSMDISKASNFERFVFDLLGQDADKLVALFSDVDTKGGFDLAGTPEFARIGQFGFVSGRSSHQDRLATIRDVNQRYGVT
IDTHTADGVKVAREYLQPGVPMVVLETALPAKFADTIHEALGHEPERPAAFDGIEKLPQRFEVMPADADSVKAYIAQHTG
L

Sequences:

>Translated_481_residues
MNYQSTRGHDVPQSFSEILLGGLAPDGGLYLPKQYPQITAEELEAWRKLPYADLAFEVLSRFCDDIPAEDLRALTRKTYT
ADVYCNARAGDNTADITPLRTLGEEGGTKLQLLGLSNGPTLAFKDMAMQLLGNLFEYALKRAGLKLNILGATSGDTGSAA
EYAMRGKEGIRVFMLSPHRKMSAFQTAQMFSLQDPNIFNIAIEGVFDDAQDIVKAVSNDHAFKARQRIGTVNSINWARVV
AQVVYYFKGWLLATSGPGQKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLDEFFRTGTYRVRTSAQTYHTS
SPSMDISKASNFERFVFDLLGQDADKLVALFSDVDTKGGFDLAGTPEFARIGQFGFVSGRSSHQDRLATIRDVNQRYGVT
IDTHTADGVKVAREYLQPGVPMVVLETALPAKFADTIHEALGHEPERPAAFDGIEKLPQRFEVMPADADSVKAYIAQHTG
L
>Mature_481_residues
MNYQSTRGHDVPQSFSEILLGGLAPDGGLYLPKQYPQITAEELEAWRKLPYADLAFEVLSRFCDDIPAEDLRALTRKTYT
ADVYCNARAGDNTADITPLRTLGEEGGTKLQLLGLSNGPTLAFKDMAMQLLGNLFEYALKRAGLKLNILGATSGDTGSAA
EYAMRGKEGIRVFMLSPHRKMSAFQTAQMFSLQDPNIFNIAIEGVFDDAQDIVKAVSNDHAFKARQRIGTVNSINWARVV
AQVVYYFKGWLLATSGPGQKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLDEFFRTGTYRVRTSAQTYHTS
SPSMDISKASNFERFVFDLLGQDADKLVALFSDVDTKGGFDLAGTPEFARIGQFGFVSGRSSHQDRLATIRDVNQRYGVT
IDTHTADGVKVAREYLQPGVPMVVLETALPAKFADTIHEALGHEPERPAAFDGIEKLPQRFEVMPADADSVKAYIAQHTG
L

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=447, Percent_Identity=34.4519015659955, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI149193323, Length=473, Percent_Identity=28.5412262156448, Blast_Score=179, Evalue=4e-45,
Organism=Escherichia coli, GI1786185, Length=480, Percent_Identity=28.5416666666667, Blast_Score=180, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319901, Length=473, Percent_Identity=39.7463002114165, Blast_Score=308, Evalue=1e-84,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52704; Mature: 52704

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYQSTRGHDVPQSFSEILLGGLAPDGGLYLPKQYPQITAEELEAWRKLPYADLAFEVLS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
RFCDDIPAEDLRALTRKTYTADVYCNARAGDNTADITPLRTLGEEGGTKLQLLGLSNGPT
HHHCCCCHHHHHHHHHHCEEEEEEEECCCCCCCCCCCHHHHHCCCCCCEEEEEECCCCCC
LAFKDMAMQLLGNLFEYALKRAGLKLNILGATSGDTGSAAEYAMRGKEGIRVFMLSPHRK
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCHH
MSAFQTAQMFSLQDPNIFNIAIEGVFDDAQDIVKAVSNDHAFKARQRIGTVNSINWARVV
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHH
AQVVYYFKGWLLATSGPGQKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLD
HHHHHHHCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHH
EFFRTGTYRVRTSAQTYHTSSPSMDISKASNFERFVFDLLGQDADKLVALFSDVDTKGGF
HHHHCCCEEEEECCCEEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
DLAGTPEFARIGQFGFVSGRSSHQDRLATIRDVNQRYGVTIDTHTADGVKVAREYLQPGV
CCCCCCCHHHHCCCEECCCCCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCC
PMVVLETALPAKFADTIHEALGHEPERPAAFDGIEKLPQRFEVMPADADSVKAYIAQHTG
CEEEEEHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEECCCCHHHHHHHHHHHCC
L
C
>Mature Secondary Structure
MNYQSTRGHDVPQSFSEILLGGLAPDGGLYLPKQYPQITAEELEAWRKLPYADLAFEVLS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
RFCDDIPAEDLRALTRKTYTADVYCNARAGDNTADITPLRTLGEEGGTKLQLLGLSNGPT
HHHCCCCHHHHHHHHHHCEEEEEEEECCCCCCCCCCCHHHHHCCCCCCEEEEEECCCCCC
LAFKDMAMQLLGNLFEYALKRAGLKLNILGATSGDTGSAAEYAMRGKEGIRVFMLSPHRK
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCHH
MSAFQTAQMFSLQDPNIFNIAIEGVFDDAQDIVKAVSNDHAFKARQRIGTVNSINWARVV
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHH
AQVVYYFKGWLLATSGPGQKVSFCVPSGNFGNVCAGHIARMMGLPIDKLVVATNENDVLD
HHHHHHHCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHH
EFFRTGTYRVRTSAQTYHTSSPSMDISKASNFERFVFDLLGQDADKLVALFSDVDTKGGF
HHHHCCCEEEEECCCEEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
DLAGTPEFARIGQFGFVSGRSSHQDRLATIRDVNQRYGVTIDTHTADGVKVAREYLQPGV
CCCCCCCHHHHCCCEECCCCCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCC
PMVVLETALPAKFADTIHEALGHEPERPAAFDGIEKLPQRFEVMPADADSVKAYIAQHTG
CEEEEEHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEECCCCHHHHHHHHHHHCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]