| Definition | Cupriavidus metallidurans CH34 chromosome, complete genome. |
|---|---|
| Accession | NC_007973 |
| Length | 3,928,089 |
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The map label for this gene is lon [H]
Identifier: 94310821
GI number: 94310821
Start: 2046844
End: 2049255
Strand: Reverse
Name: lon [H]
Synonym: Rmet_1883
Alternate gene names: 94310821
Gene position: 2049255-2046844 (Counterclockwise)
Preceding gene: 94310822
Following gene: 94310820
Centisome position: 52.17
GC content: 61.61
Gene sequence:
>2412_bases ATGTCCGGAACACAACTCCTCCCGGCTGAGCCGATTCGCCTCCCACTGTTGCCGCTGCGCGACGTGGTGGTGTTTCCGCA CATGGTGATCCCGCTGTTCGTGGGACGCCCGAAGTCCATCAAGGCGCTTGAGACTGCGATGGAGTCGGGCAAGAGCATCA TGCTCGTGGCCCAGAAGACTGCGGCCAAAGATGAGCCCACCGCGGATGACCTGTATGAGGTCGGCTGCATCGCCAATATC CTGCAAATGCTGAAGCTGCCCGACGGCACCGTGAAGGTGCTGGTGGAGGGTACGCAACGTGCAAATATCACCGAGGTGAG CGAGGACGATTCGCACTTCATGTGCGAAGCCGTGCCTGTGCCGCCCGCACCGGTTGAATCGGCCGAGACCGAGGCCCTGC GCCGCGCGATCGTGTCCCAGTTCGACCAGTACGTGAAGCTGAACAAGAAGATCCCTCCTGAGATCCTGACGTCGCTGTCC GGTATCGATGAGGCCGGTCGTTTGGCCGATACGATCGCCGCGCATCTGCCGATCAAGCTCGAGCAGAAGCAGAAGATCCT TGAGATGGTCAAGGTGACCGAGCGTCTCGAGAGCCTGCTGTCGCAGCTCGAGGGCGAGATCGACATCCTGCAGGTGGAAA AGCGCATTCGTGGCCGCGTCAAGCGCCAGATGGAAAAGAGCCAGCGCGAGTACTACCTGAACGAGCAGGTCAAGGCGATC CAGAAGGAACTGGGCGAGGGCGAGGAAGGCGCTGATCTGGAAGAACTGGACAAGCGCATCAAGGCCGCCCGCATGCCCAA GGAGGCCAAGAAGAAGGCCGACGCCGAGTTCAAGAAGCTCAAGCTGATGTCGCCGATGTCGGCCGAGGCCACCGTCGTGC GCAACTATATCGACACGCTGGTCAGCCTGCCGTGGCGCAAGAAGAGCAAGGTCAACAACGACCTGGCTAACGCCGAGCGC GTGCTCGATGAAGACCACTATGGCCTCGAGAAGGTCAAGGAACGGATTCTCGAGTACCTTGCCGTGCAACAGCGCGTGGA CAAGGTGAAGGCGCCGATCCTGTGCCTGGTTGGCCCTCCGGGCGTCGGCAAGACCTCGCTCGGTCAGTCGGTTGCGCGTG CCACGAACCGCAAGTTCGTGCGTATGGCGCTGGGTGGTGTGCGTGACGAGGCCGAGATCCGCGGTCACCGTCGTACGTAC ATTGGATCGATGCCGGGCAAGATCCTGCAGAGCCTGTCGAAGGTTGGCGTGCGCAATCCGCTGTTCCTGCTCGACGAGAT CGACAAGATGGGCATGGATTTCCGTGGCGATCCTTCGTCGGCGCTGCTCGAGGTGCTGGACCCGGAACAGAACCACACGT TCCAGGACCACTACATCGAGGTGGACTTTGACCTGTCGGATGTGATGTTCGTGGCGACGTCGAACTCGCTGAACATTCCG CCGCCGCTGCTGGACCGGATGGAAGTGATCCGCCTGTCAGGCTACACGGAGGACGAAAAGGTCAACATCGCTACGCGCTA CCTGTTACCGAAGCAGATCCGTAACAACGGCCTGAAGCAAGGCGAGATCGAGGTGACCGAAGCGGCAATCCGCGACATCA TCCGCTACTACACGCGAGAAGCCGGTGTGCGTTCGCTGGAACGCGAAGTGTCGAAGATCGCTCGCAAGGTTGTGAAGATG CTGCTCCTGAAGAAGGAGTCCACGGCGGTGAAGGTGGATTCCGAGAACCTGGACAAATTCCTTGGCGTGCGCAAGTACGA CTTCGGTTTAGCCGGCAAGGAAAACCAGGTGGGTCAGGTGACGGGTCTGGCGTGGACGGAAGTCGGCGGCGACCTGCTGA CGATTGAAGCCGCGATCATGCCAGGCAAGGGCAACATCACGCGCACCGGTTCGCTCGGCGATGTGATGAAGGAGTCGGTC GAAGCCGCGCGCTCGGTGGTGCGTTCGCGGGCGCGTCGTCTGGGTATCGCGGATGAGATGTTCGAGAAGCGCGACATCCA CATCCACGTGCCCGAGGGCGCCACGCCGAAGGATGGTCCGTCGGCCGGTATCGCGATGACGACCGCGCTAGTGTCGGTGC TGACTGGCATCCCGGTGCGTGCCGATGTGGCGATGACGGGTGAAATCACGCTGCGCGGAGAGGTGCTGCCGATCGGCGGT CTCAAGGAGAAGCTGCTGGCTGCCCATCGCGGCGGTATCAAGCTGGTGCTGATCCCCGAAGAGAACGTCAAGGATCTGGC TGACATTCCGGACAACGTGAAGAACGCCATCGAGATCATGCCGGTGCGCTGGATCGACCGGGTGCTGGAGCTGGCGCTCG AGCGAAAGCCCGAGCCGCTGCCTGAGGAAGATGCCAAGCCCGCCGAGGTGGCGGACAAGGCCGCGTCCCAGGTGGAGCGT ATCCATCACTGA
Upstream 100 bases:
>100_bases GTTTGCAGCATGTTTTTCTGCGTACAGATTCGATGATGGGCATCTTGCAATCGAATTCCGCGACCCTATTTACGCCTTAA ATGACTGACTGGGGAAAATG
Downstream 100 bases:
>100_bases TCGACGCACACGTCAGTCTGAGATGTAGTTAGGAACGCCGCAGGGTCAAACCTGCGGCGTTTTTGTTTGCGCAATGCCCG CGGCACCGTGTGCCTTGCGG
Product: DNA-binding ATP-dependent protease La
Products: NA
Alternate protein names: ATP-dependent protease La [H]
Number of amino acids: Translated: 803; Mature: 802
Protein sequence:
>803_residues MSGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKTAAKDEPTADDLYEVGCIANI LQMLKLPDGTVKVLVEGTQRANITEVSEDDSHFMCEAVPVPPAPVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS GIDEAGRLADTIAAHLPIKLEQKQKILEMVKVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI QKELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTLVSLPWRKKSKVNNDLANAER VLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTY IGSMPGKILQSLSKVGVRNPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP PPLLDRMEVIRLSGYTEDEKVNIATRYLLPKQIRNNGLKQGEIEVTEAAIRDIIRYYTREAGVRSLEREVSKIARKVVKM LLLKKESTAVKVDSENLDKFLGVRKYDFGLAGKENQVGQVTGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESV EAARSVVRSRARRLGIADEMFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIMPVRWIDRVLELALERKPEPLPEEDAKPAEVADKAASQVER IHH
Sequences:
>Translated_803_residues MSGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKTAAKDEPTADDLYEVGCIANI LQMLKLPDGTVKVLVEGTQRANITEVSEDDSHFMCEAVPVPPAPVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS GIDEAGRLADTIAAHLPIKLEQKQKILEMVKVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI QKELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTLVSLPWRKKSKVNNDLANAER VLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTY IGSMPGKILQSLSKVGVRNPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP PPLLDRMEVIRLSGYTEDEKVNIATRYLLPKQIRNNGLKQGEIEVTEAAIRDIIRYYTREAGVRSLEREVSKIARKVVKM LLLKKESTAVKVDSENLDKFLGVRKYDFGLAGKENQVGQVTGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESV EAARSVVRSRARRLGIADEMFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIMPVRWIDRVLELALERKPEPLPEEDAKPAEVADKAASQVER IHH >Mature_802_residues SGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKTAAKDEPTADDLYEVGCIANIL QMLKLPDGTVKVLVEGTQRANITEVSEDDSHFMCEAVPVPPAPVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSG IDEAGRLADTIAAHLPIKLEQKQKILEMVKVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ KELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTLVSLPWRKKSKVNNDLANAERV LDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYI GSMPGKILQSLSKVGVRNPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIPP PLLDRMEVIRLSGYTEDEKVNIATRYLLPKQIRNNGLKQGEIEVTEAAIRDIIRYYTREAGVRSLEREVSKIARKVVKML LLKKESTAVKVDSENLDKFLGVRKYDFGLAGKENQVGQVTGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESVE AARSVVRSRARRLGIADEMFEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGGL KEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIMPVRWIDRVLELALERKPEPLPEEDAKPAEVADKAASQVERI HH
Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced
COG id: COG0466
COG function: function code O; ATP-dependent Lon protease, bacterial type
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Lon domain [H]
Homologues:
Organism=Homo sapiens, GI31377667, Length=838, Percent_Identity=38.5441527446301, Blast_Score=529, Evalue=1e-150, Organism=Homo sapiens, GI21396489, Length=827, Percent_Identity=37.1221281741233, Blast_Score=513, Evalue=1e-145, Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=70.1298701298701, Blast_Score=1090, Evalue=0.0, Organism=Caenorhabditis elegans, GI17505831, Length=705, Percent_Identity=40, Blast_Score=491, Evalue=1e-139, Organism=Caenorhabditis elegans, GI17556486, Length=801, Percent_Identity=32.9588014981273, Blast_Score=423, Evalue=1e-118, Organism=Saccharomyces cerevisiae, GI6319449, Length=709, Percent_Identity=40.9026798307475, Blast_Score=518, Evalue=1e-147, Organism=Drosophila melanogaster, GI221513036, Length=620, Percent_Identity=44.0322580645161, Blast_Score=515, Evalue=1e-146, Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=44.0322580645161, Blast_Score=514, Evalue=1e-146,
Paralogues:
None
Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR003959 - InterPro: IPR008269 - InterPro: IPR004815 - InterPro: IPR003111 - InterPro: IPR001984 - InterPro: IPR015947 - InterPro: IPR020568 [H]
Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]
EC number: =3.4.21.53 [H]
Molecular weight: Translated: 89106; Mature: 88974
Theoretical pI: Translated: 6.68; Mature: 6.68
Prosite motif: PS01046 LON_SER
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKT CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECC AAKDEPTADDLYEVGCIANILQMLKLPDGTVKVLVEGTQRANITEVSEDDSHFMCEAVPV CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCC PPAPVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPIKL CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCH EQKQKILEMVKVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH QKELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTL HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH VSLPWRKKSKVNNDLANAERVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP HCCCCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC GVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLSKVGVRNP CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCC LFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCC PPLLDRMEVIRLSGYTEDEKVNIATRYLLPKQIRNNGLKQGEIEVTEAAIRDIIRYYTRE CHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH AGVRSLEREVSKIARKVVKMLLLKKESTAVKVDSENLDKFLGVRKYDFGLAGKENQVGQV HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCHHCCCCCCCCCCCCCCE TGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESVEAARSVVRSRARRLGIADEM ECEEHHHCCCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH FEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG HCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIMPVRWIDRVLELALERKPEPL HHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCC PEEDAKPAEVADKAASQVERIHH CCCCCCHHHHHHHHHHHHHHHCC >Mature Secondary Structure SGTQLLPAEPIRLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETAMESGKSIMLVAQKT CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECC AAKDEPTADDLYEVGCIANILQMLKLPDGTVKVLVEGTQRANITEVSEDDSHFMCEAVPV CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCC PPAPVESAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPIKL CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCH EQKQKILEMVKVTERLESLLSQLEGEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH QKELGEGEEGADLEELDKRIKAARMPKEAKKKADAEFKKLKLMSPMSAEATVVRNYIDTL HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH VSLPWRKKSKVNNDLANAERVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP HCCCCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC GVGKTSLGQSVARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLSKVGVRNP CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCC LFLLDEIDKMGMDFRGDPSSALLEVLDPEQNHTFQDHYIEVDFDLSDVMFVATSNSLNIP HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCC PPLLDRMEVIRLSGYTEDEKVNIATRYLLPKQIRNNGLKQGEIEVTEAAIRDIIRYYTRE CHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH AGVRSLEREVSKIARKVVKMLLLKKESTAVKVDSENLDKFLGVRKYDFGLAGKENQVGQV HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCHHCCCCCCCCCCCCCCE TGLAWTEVGGDLLTIEAAIMPGKGNITRTGSLGDVMKESVEAARSVVRSRARRLGIADEM ECEEHHHCCCCEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH FEKRDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG HCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC LKEKLLAAHRGGIKLVLIPEENVKDLADIPDNVKNAIEIMPVRWIDRVLELALERKPEPL HHHHHHHHHCCCEEEEEECCCCHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCC PEEDAKPAEVADKAASQVERIHH CCCCCCHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8981986; 12620739 [H]