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The map label for this gene is macA [H]

Identifier: 94310729

GI number: 94310729

Start: 1943011

End: 1944219

Strand: Direct

Name: macA [H]

Synonym: Rmet_1791

Alternate gene names: 94310729

Gene position: 1943011-1944219 (Clockwise)

Preceding gene: 94310728

Following gene: 94310730

Centisome position: 49.46

GC content: 65.18

Gene sequence:

>1209_bases
TTGGCTGATCCAGACCTGAGCAAGCTGAAAATCGATCGTAGCGCCATGGCGCCCGCCCAGCGCCGCCGCCGTCCCTGGCT
GCGCTACGCGATCATCGCGGTGGTGATCCTCGTGCTGGCCGGCATCGGCCTGAAGCTGGCCGGGCCCCAGACCGTGGAAA
CGGCGACGGTCACTTCGGCATACCCGTCGCAAAACTTCACGCTGCTCAACGCTACGGGTTACGTGGTGCCACAGCGCAAG
GCGGCGGTAGCATCTAAGGCGCAGGGCCGGCTGGAGTGGCTTGGTGTGCTGGAAGGCTCCCGCGTCAAGAAGGATGAGAT
CATCGCGCGGATCGAAAGCCGCGACGTCGAGGCGTCCGCCGCGCAGGCGCGAGCCCAGGTCCAGGTAGCCGAAGCCAATC
TGGCATTGCAACAGGCCGAACTGCGTGACGCCGATGTCAATCTGCGCCGGTCGAAGGAACTGCTTGCGCCGGCAGCGATT
TCCCAACAGCAATACGATTCCGATCTGGCGCGCTACAACAAGGCGCGCGCGTCGATCAGCAATTCGGAGGCGTCGATCAC
CTCGGCCAAGGCCAATGCCCGCGCCGCTGAAGTGGCGGTGGAGCAGACCGTGGTTCGCGCGCCGTTCGACGGTGTGGTGC
TGATCAAGCATGCCAACGTCGGCGACAACATTACCCCGTTCTCGGCGGCCGCCGACACCAAGGGTGCGATCGTGACCATC
GCCGACATGTCCACGCTCGAAGTGGAAGCGGACGTAGCGGAATCCAATATCGCGAAGATCACGGTCGAGCAGCCCTGCGA
GGTTCTGCTCGATGCCCTGCCGAACCTGCGCCAGGAGGGCCGCGTGTCACGCATTGTCCCGACCGTCGACCGGTCAAAGG
CGACCGTGCTGGTCAAGATCCGCTTCGTCGATCGCGACCCGCGCGTGCTGCCGGACATGAGCGCCAAGATCGCCTTCCTT
TCCAAGCCGGTGGCACCTGCCGAAAACAAGCCTCTGACGGCCATCCAGCCATCGGCCGTGGTCGAGCGCGACGGCAAGCC
CGTGGTGTTCCTGGTGCAGGACGGCAGGGCAAAACAGGCGCCCGTGACGCGCGGCGCGAAGATCGGCGAACTGCTGGCCG
TTCAGGGCGTGAAGCCGGGCGATGTGGTGGTGCTAGCGCCGTCCGAGAAGCTGGGCGACGGCAGCAAGGTCTCCGTCGCA
AAGAAGTGA

Upstream 100 bases:

>100_bases
CCATTTTGCGACCCTTGTAACGGGCCGCCTGCCGGCCACCGCCACTCGCTATACTGGGGGCCTTTCTCGGCATTCGTCCG
TTTTCGCGACGCATCTTAAA

Downstream 100 bases:

>100_bases
CCGGAAGGAAGTGACCGCCATCATGTCCGCCGCTCCCCTCGTTTCGATCCGCCATTTGGCCAAGTCGTATCAGCGCGGCG
CCCAGACCGTACCGGTGCTG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MADPDLSKLKIDRSAMAPAQRRRRPWLRYAIIAVVILVLAGIGLKLAGPQTVETATVTSAYPSQNFTLLNATGYVVPQRK
AAVASKAQGRLEWLGVLEGSRVKKDEIIARIESRDVEASAAQARAQVQVAEANLALQQAELRDADVNLRRSKELLAPAAI
SQQQYDSDLARYNKARASISNSEASITSAKANARAAEVAVEQTVVRAPFDGVVLIKHANVGDNITPFSAAADTKGAIVTI
ADMSTLEVEADVAESNIAKITVEQPCEVLLDALPNLRQEGRVSRIVPTVDRSKATVLVKIRFVDRDPRVLPDMSAKIAFL
SKPVAPAENKPLTAIQPSAVVERDGKPVVFLVQDGRAKQAPVTRGAKIGELLAVQGVKPGDVVVLAPSEKLGDGSKVSVA
KK

Sequences:

>Translated_402_residues
MADPDLSKLKIDRSAMAPAQRRRRPWLRYAIIAVVILVLAGIGLKLAGPQTVETATVTSAYPSQNFTLLNATGYVVPQRK
AAVASKAQGRLEWLGVLEGSRVKKDEIIARIESRDVEASAAQARAQVQVAEANLALQQAELRDADVNLRRSKELLAPAAI
SQQQYDSDLARYNKARASISNSEASITSAKANARAAEVAVEQTVVRAPFDGVVLIKHANVGDNITPFSAAADTKGAIVTI
ADMSTLEVEADVAESNIAKITVEQPCEVLLDALPNLRQEGRVSRIVPTVDRSKATVLVKIRFVDRDPRVLPDMSAKIAFL
SKPVAPAENKPLTAIQPSAVVERDGKPVVFLVQDGRAKQAPVTRGAKIGELLAVQGVKPGDVVVLAPSEKLGDGSKVSVA
KK
>Mature_401_residues
ADPDLSKLKIDRSAMAPAQRRRRPWLRYAIIAVVILVLAGIGLKLAGPQTVETATVTSAYPSQNFTLLNATGYVVPQRKA
AVASKAQGRLEWLGVLEGSRVKKDEIIARIESRDVEASAAQARAQVQVAEANLALQQAELRDADVNLRRSKELLAPAAIS
QQQYDSDLARYNKARASISNSEASITSAKANARAAEVAVEQTVVRAPFDGVVLIKHANVGDNITPFSAAADTKGAIVTIA
DMSTLEVEADVAESNIAKITVEQPCEVLLDALPNLRQEGRVSRIVPTVDRSKATVLVKIRFVDRDPRVLPDMSAKIAFLS
KPVAPAENKPLTAIQPSAVVERDGKPVVFLVQDGRAKQAPVTRGAKIGELLAVQGVKPGDVVVLAPSEKLGDGSKVSVAK
K

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=380, Percent_Identity=27.3684210526316, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082036, Length=339, Percent_Identity=25.9587020648968, Blast_Score=82, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42901; Mature: 42770

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPDLSKLKIDRSAMAPAQRRRRPWLRYAIIAVVILVLAGIGLKLAGPQTVETATVTSA
CCCCCCHHEEECHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEEEC
YPSQNFTLLNATGYVVPQRKAAVASKAQGRLEWLGVLEGSRVKKDEIIARIESRDVEASA
CCCCCEEEEEECCEEECCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCHHHH
AQARAQVQVAEANLALQQAELRDADVNLRRSKELLAPAAISQQQYDSDLARYNKARASIS
HHHHHEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NSEASITSAKANARAAEVAVEQTVVRAPFDGVVLIKHANVGDNITPFSAAADTKGAIVTI
CCCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEE
ADMSTLEVEADVAESNIAKITVEQPCEVLLDALPNLRQEGRVSRIVPTVDRSKATVLVKI
ECCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHCHHHCCCCCCCCCCCCCCCEEEEEEE
RFVDRDPRVLPDMSAKIAFLSKPVAPAENKPLTAIQPSAVVERDGKPVVFLVQDGRAKQA
EEECCCCCCCCCCCCEEEEEECCCCCCCCCCCEEECCCHHHCCCCCCEEEEEECCCCCCC
PVTRGAKIGELLAVQGVKPGDVVVLAPSEKLGDGSKVSVAKK
CCCCCCCHHHEEEECCCCCCCEEEECCCHHCCCCCEEEEECC
>Mature Secondary Structure 
ADPDLSKLKIDRSAMAPAQRRRRPWLRYAIIAVVILVLAGIGLKLAGPQTVETATVTSA
CCCCCHHEEECHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEEEC
YPSQNFTLLNATGYVVPQRKAAVASKAQGRLEWLGVLEGSRVKKDEIIARIESRDVEASA
CCCCCEEEEEECCEEECCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCHHHH
AQARAQVQVAEANLALQQAELRDADVNLRRSKELLAPAAISQQQYDSDLARYNKARASIS
HHHHHEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NSEASITSAKANARAAEVAVEQTVVRAPFDGVVLIKHANVGDNITPFSAAADTKGAIVTI
CCCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEE
ADMSTLEVEADVAESNIAKITVEQPCEVLLDALPNLRQEGRVSRIVPTVDRSKATVLVKI
ECCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHCHHHCCCCCCCCCCCCCCCEEEEEEE
RFVDRDPRVLPDMSAKIAFLSKPVAPAENKPLTAIQPSAVVERDGKPVVFLVQDGRAKQA
EEECCCCCCCCCCCCEEEEEECCCCCCCCCCCEEECCCHHHCCCCCCEEEEEECCCCCCC
PVTRGAKIGELLAVQGVKPGDVVVLAPSEKLGDGSKVSVAKK
CCCCCCCHHHEEEECCCCCCCEEEECCCHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]