Click here to switch to the map view.

The map label for this gene is agrS [H]

Identifier: 94310690

GI number: 94310690

Start: 1901477

End: 1902886

Strand: Direct

Name: agrS [H]

Synonym: Rmet_1752

Alternate gene names: 94310690

Gene position: 1901477-1902886 (Clockwise)

Preceding gene: 94310689

Following gene: 94310691

Centisome position: 48.41

GC content: 56.81

Gene sequence:

>1410_bases
ATGCGTAAAAGGTCGCTTACCGCTCGGCTCGCACTTGCATTTGCCCTGATCGCCGGACTAACTTTTTCCGGCGTGGGAAT
CTATCTGTATGGTTCCCTCGCAAGCCAGATCATCGATCGCGACGACGCTGAACTTCTCCGCAAAGCCGCGCGAGCCCAAC
AGGAACTAGCTGAGCTTCGAAGCTCCCCCACCGAAAACCGATGGGAGGAGGTACTTGGCGTGGTGAAAGGAAACGAGGAG
TTCGGCATCCGCATATTGGATGCGCGCGGCGTGCAGTTGGCGGCGGCCGGTGCAAACTATGGGATAAAGCCGATTGGTGG
CGGCGCTTACGCCAAAGTGCCGGACGCGGCCGGGTCAATTCAGGCCTGGAGCACACCGAGCGACATGCCGGTACGCATGA
CCACTATCAAGGCTAGCGTCAGCGGTGAGGCATCACCTGTAGTGGTGGAACTGTATCAGGTCGCTAGCAGTCGTGTTTCC
CTCCTGCGAGACTATCGCTGGAAACTATTTATCGCAGTCCTTTTAGGCACAGTCGGTGCAGGCGGGCTGGGATACGCGGC
GCTTCGGGCTGGCATGGCGCCATTGCGAAGTATCGCAGCCGGCACGGCCTCCGTGACCTTTACAAGTGGAGCGCTACCCG
TTGATCCATCCAGGCTGCCTGCGGAACTAGATGATTTGGCGCGCGCCCTGCAGAGAATGATCGACCGTCTCCGCGAACGG
TACGATAGGCTTTCGCAGTTTTCAGCGGACCTTGCCCACGACTTCCGTACGCCAATTACCAATCTGCTCGGACAGACCCA
AGTCGCACTGAGCAGCGACCGATCTATTGAAGAGTACCAATCGCTGCTGGTCTCGAATGTTGAAGAGTATGAGCGCCTTT
CTCGGATGATTGAGAACATGCTCTTCCTGGCAAGAGCCGACAATGCACGGGTAGCCATTCGCGCTACGGAGCTCGACCTT
CGCGAGGAACTGCATCGACAGGCAGACTACTTTGAATCATTGGCGGAAGCACGGCAAATAACCATCCAGGTGAATGCGCA
AGGGAAGGTTTTCGCAGACCCAACGCTCTTCCGACGCGCGTTAAGTAACTTGCTGTCAAACGCAATCCGCTATGCCAATG
AGGGCACCAGCGTAACCGTTCACGGTCGACACACTGGAGGTGTCGCTCAAGTTAAGGTGGAAAACGTCGGACCAGGCATT
GCCCCGGAGCATCTATCCCTCCTCTTCGACCGCTTTTTTCGCGCAGACCCCGCGCGCGCCAACTCTGGTGAATCATCGGG
AATTGGGCTTGCAATCGTCAAGACCATCATGGATCTTCACCACGGAGCGGTTTCTGTCCGCTCAGTACTGAATGCCACTA
CGTCCTTCCAGCTGGAGTTTCCTGACAATAGGACAATTCCGCATACCTGA

Upstream 100 bases:

>100_bases
CGATTCGACGCCTTCGAGCGAAGATGGATGACACTTACGCTCCCAAACTTATCCATAGCGTCCGCGGCATCGGCTACGTC
CTTGAGAACCGACAGTCTTG

Downstream 100 bases:

>100_bases
CGGGCAACATCGTCGCTATCCGTGTAGAAAGCGGCTCCGCTTTCGAATCTTCATTACTACTTTCCTCCTCACAATGTCGG
CACGATAAGCGAATCCGCAA

Product: signal transduction histidine kinase, heavy metal sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MRKRSLTARLALAFALIAGLTFSGVGIYLYGSLASQIIDRDDAELLRKAARAQQELAELRSSPTENRWEEVLGVVKGNEE
FGIRILDARGVQLAAAGANYGIKPIGGGAYAKVPDAAGSIQAWSTPSDMPVRMTTIKASVSGEASPVVVELYQVASSRVS
LLRDYRWKLFIAVLLGTVGAGGLGYAALRAGMAPLRSIAAGTASVTFTSGALPVDPSRLPAELDDLARALQRMIDRLRER
YDRLSQFSADLAHDFRTPITNLLGQTQVALSSDRSIEEYQSLLVSNVEEYERLSRMIENMLFLARADNARVAIRATELDL
REELHRQADYFESLAEARQITIQVNAQGKVFADPTLFRRALSNLLSNAIRYANEGTSVTVHGRHTGGVAQVKVENVGPGI
APEHLSLLFDRFFRADPARANSGESSGIGLAIVKTIMDLHHGAVSVRSVLNATTSFQLEFPDNRTIPHT

Sequences:

>Translated_469_residues
MRKRSLTARLALAFALIAGLTFSGVGIYLYGSLASQIIDRDDAELLRKAARAQQELAELRSSPTENRWEEVLGVVKGNEE
FGIRILDARGVQLAAAGANYGIKPIGGGAYAKVPDAAGSIQAWSTPSDMPVRMTTIKASVSGEASPVVVELYQVASSRVS
LLRDYRWKLFIAVLLGTVGAGGLGYAALRAGMAPLRSIAAGTASVTFTSGALPVDPSRLPAELDDLARALQRMIDRLRER
YDRLSQFSADLAHDFRTPITNLLGQTQVALSSDRSIEEYQSLLVSNVEEYERLSRMIENMLFLARADNARVAIRATELDL
REELHRQADYFESLAEARQITIQVNAQGKVFADPTLFRRALSNLLSNAIRYANEGTSVTVHGRHTGGVAQVKVENVGPGI
APEHLSLLFDRFFRADPARANSGESSGIGLAIVKTIMDLHHGAVSVRSVLNATTSFQLEFPDNRTIPHT
>Mature_469_residues
MRKRSLTARLALAFALIAGLTFSGVGIYLYGSLASQIIDRDDAELLRKAARAQQELAELRSSPTENRWEEVLGVVKGNEE
FGIRILDARGVQLAAAGANYGIKPIGGGAYAKVPDAAGSIQAWSTPSDMPVRMTTIKASVSGEASPVVVELYQVASSRVS
LLRDYRWKLFIAVLLGTVGAGGLGYAALRAGMAPLRSIAAGTASVTFTSGALPVDPSRLPAELDDLARALQRMIDRLRER
YDRLSQFSADLAHDFRTPITNLLGQTQVALSSDRSIEEYQSLLVSNVEEYERLSRMIENMLFLARADNARVAIRATELDL
REELHRQADYFESLAEARQITIQVNAQGKVFADPTLFRRALSNLLSNAIRYANEGTSVTVHGRHTGGVAQVKVENVGPGI
APEHLSLLFDRFFRADPARANSGESSGIGLAIVKTIMDLHHGAVSVRSVLNATTSFQLEFPDNRTIPHT

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=46.0076045627376, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI1788279, Length=466, Percent_Identity=31.9742489270386, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1786600, Length=217, Percent_Identity=29.9539170506912, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1787894, Length=249, Percent_Identity=30.5220883534137, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=23.943661971831, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1790861, Length=283, Percent_Identity=29.3286219081272, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789403, Length=231, Percent_Identity=30.3030303030303, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790346, Length=231, Percent_Identity=30.3030303030303, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=24.1666666666667, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1790436, Length=243, Percent_Identity=25.5144032921811, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789808, Length=229, Percent_Identity=29.2576419213974, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=24.8995983935743, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1787374, Length=288, Percent_Identity=25.6944444444444, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=264, Percent_Identity=26.8939393939394, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=252, Percent_Identity=25, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789149, Length=221, Percent_Identity=22.6244343891403, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=24.5535714285714, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081816, Length=223, Percent_Identity=25.5605381165919, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50961; Mature: 50961

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKRSLTARLALAFALIAGLTFSGVGIYLYGSLASQIIDRDDAELLRKAARAQQELAELR
CCCHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SSPTENRWEEVLGVVKGNEEFGIRILDARGVQLAAAGANYGIKPIGGGAYAKVPDAAGSI
CCCCHHHHHHHHHHHCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
QAWSTPSDMPVRMTTIKASVSGEASPVVVELYQVASSRVSLLRDYRWKLFIAVLLGTVGA
EECCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGLGYAALRAGMAPLRSIAAGTASVTFTSGALPVDPSRLPAELDDLARALQRMIDRLRER
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YDRLSQFSADLAHDFRTPITNLLGQTQVALSSDRSIEEYQSLLVSNVEEYERLSRMIENM
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHH
LFLARADNARVAIRATELDLREELHRQADYFESLAEARQITIQVNAQGKVFADPTLFRRA
HHHEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEECCHHHHHHH
LSNLLSNAIRYANEGTSVTVHGRHTGGVAQVKVENVGPGIAPEHLSLLFDRFFRADPARA
HHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
NSGESSGIGLAIVKTIMDLHHGAVSVRSVLNATTSFQLEFPDNRTIPHT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MRKRSLTARLALAFALIAGLTFSGVGIYLYGSLASQIIDRDDAELLRKAARAQQELAELR
CCCHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SSPTENRWEEVLGVVKGNEEFGIRILDARGVQLAAAGANYGIKPIGGGAYAKVPDAAGSI
CCCCHHHHHHHHHHHCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
QAWSTPSDMPVRMTTIKASVSGEASPVVVELYQVASSRVSLLRDYRWKLFIAVLLGTVGA
EECCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGLGYAALRAGMAPLRSIAAGTASVTFTSGALPVDPSRLPAELDDLARALQRMIDRLRER
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YDRLSQFSADLAHDFRTPITNLLGQTQVALSSDRSIEEYQSLLVSNVEEYERLSRMIENM
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHH
LFLARADNARVAIRATELDLREELHRQADYFESLAEARQITIQVNAQGKVFADPTLFRRA
HHHEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEECCHHHHHHH
LSNLLSNAIRYANEGTSVTVHGRHTGGVAQVKVENVGPGIAPEHLSLLFDRFFRADPARA
HHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
NSGESSGIGLAIVKTIMDLHHGAVSVRSVLNATTSFQLEFPDNRTIPHT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]