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The map label for this gene is ybiC [H]

Identifier: 94310576

GI number: 94310576

Start: 1762543

End: 1763637

Strand: Reverse

Name: ybiC [H]

Synonym: Rmet_1634

Alternate gene names: 94310576

Gene position: 1763637-1762543 (Counterclockwise)

Preceding gene: 94310577

Following gene: 94310575

Centisome position: 44.9

GC content: 68.13

Gene sequence:

>1095_bases
ATGAGTGAACACCGTATTCCGACCGCCGGCCTGCATCAGTGGGTGGTCGATCTCTGGCTGGCGGCAGGCTCCGATGCCCG
CGAGGCCCGGCTGACCGCCGATCACCTCGTGGGCGCCAACCTGTCGGGCCACGACTCTCACGGCGTGGGGATGATCCCGA
AGTATGTGATGTCGTGGCAAGGCGATCAGCTCCAGCTCAACCAGAAGGTCAGCGTGGTGCACGAATCGGGCGGCATCCTG
AGCCTGGACGGCAATCGCGGCATGGGCCAGGCGGTGACCGAACAGGCCATGGGGATGGGCATCGAACGCGCCCGCGAGCA
TGGTGTCTGCGTGCTTGGCCTGCGCCGCTCGCACCATCTGGGCCGGGTCGGCCACTGGGCCGAGCAGGCCACGGCAGCCG
GCATGATCTCGATCCATTTCGTCAACGTCCTCTCCAAGCCGATCGTCGCGCCACACGGCGGCTACGACGCGCGCTTCGGC
ACCAATCCGTTCACGATCGGCGTGCCGCTACCCGCGCAGCCGCCTCTGGTGCTCGACTTCGCCACCAGCGCCATCGCGCT
TGGCAAGGTGCGCGTGGCCCACAACAAGGGCGTGGCGGTACCGCCGGGCTCCTTGATGGACCCGAACGGTCACCCCACCG
ACGATCCCTCGGTCATGTTCCCGGGCGCTGGCGGCCCGCAGGGCGCGCTGCGCACGTTCGGCGAGCACAAGGGCTACGTG
CTGGCCGTGATGTGCGAACTGCTCGGCGCGGCGGTGACCGGTGGCCATACGATCCGTCCGGAGACGCTCACGCACGAACA
TGCGGTGTGGAACAACATGCTGGCGATCATCTTCGATCCGGCACGACTGGGCAGCAGCACCACCTTCGGCCACGAGGTCG
AGGCGTTTGTCGAATGGGTCAAGGCGTCACGGCTGCAGCCGGGCAATGACCAGATCCGCCTGCCCGGCGACACGGAACGC
GAATGGCGCCGCGCCCGCGCCGATTTCATCCCCGTGGACAGCAGCACGCTGGCCCAGCTAGACGATGCCGCCGCTCGCGT
GCTTCAGGCGCGTGGCAAGTCGCCGGGGCCGGTCTCGGCGCTGGCGACCGATTGA

Upstream 100 bases:

>100_bases
CCTCGGGCGCCGGCCCCACCGAACTGGGCAACTTCCAGAAAAGCGAAGTTGCCAAATGGGCAAACCTGATCAAGGTGGCC
AATATTCACCTGGAGTAAGC

Downstream 100 bases:

>100_bases
ACCAGGAGTAACCGCATGACCCAACATCTGCCGCAGATCACCCCCCTGCCAAACCGTTTCCGGGCCGACGTGCTCGCGCG
CAAGCGCCTGATTGGCCTGT

Product: putative dehydrogenase

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSEHRIPTAGLHQWVVDLWLAAGSDAREARLTADHLVGANLSGHDSHGVGMIPKYVMSWQGDQLQLNQKVSVVHESGGIL
SLDGNRGMGQAVTEQAMGMGIERAREHGVCVLGLRRSHHLGRVGHWAEQATAAGMISIHFVNVLSKPIVAPHGGYDARFG
TNPFTIGVPLPAQPPLVLDFATSAIALGKVRVAHNKGVAVPPGSLMDPNGHPTDDPSVMFPGAGGPQGALRTFGEHKGYV
LAVMCELLGAAVTGGHTIRPETLTHEHAVWNNMLAIIFDPARLGSSTTFGHEVEAFVEWVKASRLQPGNDQIRLPGDTER
EWRRARADFIPVDSSTLAQLDDAAARVLQARGKSPGPVSALATD

Sequences:

>Translated_364_residues
MSEHRIPTAGLHQWVVDLWLAAGSDAREARLTADHLVGANLSGHDSHGVGMIPKYVMSWQGDQLQLNQKVSVVHESGGIL
SLDGNRGMGQAVTEQAMGMGIERAREHGVCVLGLRRSHHLGRVGHWAEQATAAGMISIHFVNVLSKPIVAPHGGYDARFG
TNPFTIGVPLPAQPPLVLDFATSAIALGKVRVAHNKGVAVPPGSLMDPNGHPTDDPSVMFPGAGGPQGALRTFGEHKGYV
LAVMCELLGAAVTGGHTIRPETLTHEHAVWNNMLAIIFDPARLGSSTTFGHEVEAFVEWVKASRLQPGNDQIRLPGDTER
EWRRARADFIPVDSSTLAQLDDAAARVLQARGKSPGPVSALATD
>Mature_363_residues
SEHRIPTAGLHQWVVDLWLAAGSDAREARLTADHLVGANLSGHDSHGVGMIPKYVMSWQGDQLQLNQKVSVVHESGGILS
LDGNRGMGQAVTEQAMGMGIERAREHGVCVLGLRRSHHLGRVGHWAEQATAAGMISIHFVNVLSKPIVAPHGGYDARFGT
NPFTIGVPLPAQPPLVLDFATSAIALGKVRVAHNKGVAVPPGSLMDPNGHPTDDPSVMFPGAGGPQGALRTFGEHKGYVL
AVMCELLGAAVTGGHTIRPETLTHEHAVWNNMLAIIFDPARLGSSTTFGHEVEAFVEWVKASRLQPGNDQIRLPGDTERE
WRRARADFIPVDSSTLAQLDDAAARVLQARGKSPGPVSALATD

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=350, Percent_Identity=49.4285714285714, Blast_Score=327, Evalue=7e-91,
Organism=Escherichia coli, GI1786727, Length=360, Percent_Identity=28.0555555555556, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790000, Length=322, Percent_Identity=22.9813664596273, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17507179, Length=351, Percent_Identity=27.9202279202279, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17536633, Length=343, Percent_Identity=25.9475218658892, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45553211, Length=321, Percent_Identity=26.1682242990654, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24667912, Length=321, Percent_Identity=26.1682242990654, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24667908, Length=321, Percent_Identity=26.1682242990654, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667904, Length=321, Percent_Identity=26.1682242990654, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24658010, Length=345, Percent_Identity=23.4782608695652, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24648360, Length=343, Percent_Identity=23.3236151603499, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 38757; Mature: 38626

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHRIPTAGLHQWVVDLWLAAGSDAREARLTADHLVGANLSGHDSHGVGMIPKYVMSWQ
CCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCC
GDQLQLNQKVSVVHESGGILSLDGNRGMGQAVTEQAMGMGIERAREHGVCVLGLRRSHHL
CCEEEECCEEEEEECCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHCCEEEEEECCCCCC
GRVGHWAEQATAAGMISIHFVNVLSKPIVAPHGGYDARFGTNPFTIGVPLPAQPPLVLDF
CHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEE
ATSAIALGKVRVAHNKGVAVPPGSLMDPNGHPTDDPSVMFPGAGGPQGALRTFGEHKGYV
HHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHCCCCHH
LAVMCELLGAAVTGGHTIRPETLTHEHAVWNNMLAIIFDPARLGSSTTFGHEVEAFVEWV
HHHHHHHHHHHHCCCCEECCCCCCHHHHHHHCEEEEEECHHHCCCCCCCCHHHHHHHHHH
KASRLQPGNDQIRLPGDTEREWRRARADFIPVDSSTLAQLDDAAARVLQARGKSPGPVSA
HHHCCCCCCCEEECCCCCHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
LATD
CCCC
>Mature Secondary Structure 
SEHRIPTAGLHQWVVDLWLAAGSDAREARLTADHLVGANLSGHDSHGVGMIPKYVMSWQ
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCC
GDQLQLNQKVSVVHESGGILSLDGNRGMGQAVTEQAMGMGIERAREHGVCVLGLRRSHHL
CCEEEECCEEEEEECCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHCCEEEEEECCCCCC
GRVGHWAEQATAAGMISIHFVNVLSKPIVAPHGGYDARFGTNPFTIGVPLPAQPPLVLDF
CHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEE
ATSAIALGKVRVAHNKGVAVPPGSLMDPNGHPTDDPSVMFPGAGGPQGALRTFGEHKGYV
HHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHCCCCHH
LAVMCELLGAAVTGGHTIRPETLTHEHAVWNNMLAIIFDPARLGSSTTFGHEVEAFVEWV
HHHHHHHHHHHHCCCCEECCCCCCHHHHHHHCEEEEEECHHHCCCCCCCCHHHHHHHHHH
KASRLQPGNDQIRLPGDTEREWRRARADFIPVDSSTLAQLDDAAARVLQARGKSPGPVSA
HHHCCCCCCCEEECCCCCHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
LATD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]