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The map label for this gene is garR [H]

Identifier: 94310574

GI number: 94310574

Start: 1760807

End: 1761718

Strand: Reverse

Name: garR [H]

Synonym: Rmet_1632

Alternate gene names: 94310574

Gene position: 1761718-1760807 (Counterclockwise)

Preceding gene: 94310575

Following gene: 94310573

Centisome position: 44.85

GC content: 65.13

Gene sequence:

>912_bases
ATGAGCAAGATCGGATTTATCGGACTCGGCGTAATGGGCAAGCCCATGGCGCTGCATCTGCAAACGGGCGGCCACGCCGT
CCATGCTCATACGCGCAGCGGCGTGCCGCAGGCGTTGCTGGATGCGGGCGTCAAGTCGTGCGCCAGTGCGGCCGATGTGG
CGCGGCAGGCCGACGTCATCTTCCTGATGCTGCCGGACACCCCCGACGTCGCACGCGTGCTGTTCGGCGAACAGGGCGTG
GCCGAGGGCCTGTCCCCGGGCAAGATCGTGGTGGATATGAGCTCGATCTCGCCAATCGAGACGCGCGAATTCGCGGCACG
CATCGAGAAGCTCGGCTGCGACTACGTTGACGCGCCGGTTTCCGGCGGCGAGGTTGGCGCGAAGGCCGCCACGCTGTCGA
TCATGGCCGGTGGCAAGCAGGATGTCTTCGACAAGGTGCTGCCGCTGCTGCAACTGATGGGCAAGAACATCACGCTGGTC
GGCAATGCCGGCGACGGACAGGTGGCCAAGGTGGCGAATCAGGTCATCGTCGCGCTGACGATCGAAGCTGTCAGCGAGGC
GCTGGTGCTGGCTGCCAAGGCCGGCGCCGATCCGGCACGCGTGCGGCAGGCGCTGATGGGCGGCTTTGCGAGTTCGCGCA
TTCTGGAAGTGCACGGCGAGCGCATGATCAAGCGCACCTTCGAACCGGGATTCCGCATCGAACTGCATCAGAAGGACCTG
AACCTGGCGCTGTCCACTGCCAAGGCGCTCGGTCTGGGCCTGCCTAACACCGCGTCGTGCCAGCAACTGTTCAACGTATG
CGTGGCGCAGGGCGGCGCGGGCTGGGATCACTCGGGACTGGTCAAAGCGATCGAGCACATGTCGTCGTTCGCGATCGGTG
ACAAGCCGACCAACGCTCCGACCAAAGGCTGA

Upstream 100 bases:

>100_bases
ATTTTGTTGCGGTGGGTATCGACAACGCACTGCTGCGCGACGCGGCACGCGCGTTGCGCGAGCGCTTTACCGTGTGACTC
CCCTTCAACCGGATATCGAC

Downstream 100 bases:

>100_bases
TGTCGGCACTTAACTCCGACGATCTCGCGTGCTTTATCTGCGTGGCCAACACGCAGAGCATTTCGCGCGCGGCGCTGGAA
CTGGGCGCGGACCAGTCGAC

Product: tartronate semialdehyde reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSKIGFIGLGVMGKPMALHLQTGGHAVHAHTRSGVPQALLDAGVKSCASAADVARQADVIFLMLPDTPDVARVLFGEQGV
AEGLSPGKIVVDMSSISPIETREFAARIEKLGCDYVDAPVSGGEVGAKAATLSIMAGGKQDVFDKVLPLLQLMGKNITLV
GNAGDGQVAKVANQVIVALTIEAVSEALVLAAKAGADPARVRQALMGGFASSRILEVHGERMIKRTFEPGFRIELHQKDL
NLALSTAKALGLGLPNTASCQQLFNVCVAQGGAGWDHSGLVKAIEHMSSFAIGDKPTNAPTKG

Sequences:

>Translated_303_residues
MSKIGFIGLGVMGKPMALHLQTGGHAVHAHTRSGVPQALLDAGVKSCASAADVARQADVIFLMLPDTPDVARVLFGEQGV
AEGLSPGKIVVDMSSISPIETREFAARIEKLGCDYVDAPVSGGEVGAKAATLSIMAGGKQDVFDKVLPLLQLMGKNITLV
GNAGDGQVAKVANQVIVALTIEAVSEALVLAAKAGADPARVRQALMGGFASSRILEVHGERMIKRTFEPGFRIELHQKDL
NLALSTAKALGLGLPNTASCQQLFNVCVAQGGAGWDHSGLVKAIEHMSSFAIGDKPTNAPTKG
>Mature_302_residues
SKIGFIGLGVMGKPMALHLQTGGHAVHAHTRSGVPQALLDAGVKSCASAADVARQADVIFLMLPDTPDVARVLFGEQGVA
EGLSPGKIVVDMSSISPIETREFAARIEKLGCDYVDAPVSGGEVGAKAATLSIMAGGKQDVFDKVLPLLQLMGKNITLVG
NAGDGQVAKVANQVIVALTIEAVSEALVLAAKAGADPARVRQALMGGFASSRILEVHGERMIKRTFEPGFRIELHQKDLN
LALSTAKALGLGLPNTASCQQLFNVCVAQGGAGWDHSGLVKAIEHMSSFAIGDKPTNAPTKG

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=301, Percent_Identity=30.5647840531561, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=27.0175438596491, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1786719, Length=287, Percent_Identity=64.808362369338, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI145693186, Length=293, Percent_Identity=44.0273037542662, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1790315, Length=288, Percent_Identity=31.25, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789092, Length=282, Percent_Identity=29.4326241134752, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17557316, Length=279, Percent_Identity=32.258064516129, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24655230, Length=261, Percent_Identity=34.0996168582375, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI19922568, Length=261, Percent_Identity=34.0996168582375, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI28574115, Length=279, Percent_Identity=27.5985663082437, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31363; Mature: 31232

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIGFIGLGVMGKPMALHLQTGGHAVHAHTRSGVPQALLDAGVKSCASAADVARQADVI
CCCCCEEEECCCCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
FLMLPDTPDVARVLFGEQGVAEGLSPGKIVVDMSSISPIETREFAARIEKLGCDYVDAPV
EEECCCCCHHHHHHHCCCCHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
SGGEVGAKAATLSIMAGGKQDVFDKVLPLLQLMGKNITLVGNAGDGQVAKVANQVIVALT
CCCCCCCHHEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHEEEE
IEAVSEALVLAAKAGADPARVRQALMGGFASSRILEVHGERMIKRTFEPGFRIELHQKDL
HHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCHHHHHHHHHHHHHHCCCCCEEEEECCCH
NLALSTAKALGLGLPNTASCQQLFNVCVAQGGAGWDHSGLVKAIEHMSSFAIGDKPTNAP
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
TKG
CCC
>Mature Secondary Structure 
SKIGFIGLGVMGKPMALHLQTGGHAVHAHTRSGVPQALLDAGVKSCASAADVARQADVI
CCCCEEEECCCCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
FLMLPDTPDVARVLFGEQGVAEGLSPGKIVVDMSSISPIETREFAARIEKLGCDYVDAPV
EEECCCCCHHHHHHHCCCCHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
SGGEVGAKAATLSIMAGGKQDVFDKVLPLLQLMGKNITLVGNAGDGQVAKVANQVIVALT
CCCCCCCHHEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHEEEE
IEAVSEALVLAAKAGADPARVRQALMGGFASSRILEVHGERMIKRTFEPGFRIELHQKDL
HHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCHHHHHHHHHHHHHHCCCCCEEEEECCCH
NLALSTAKALGLGLPNTASCQQLFNVCVAQGGAGWDHSGLVKAIEHMSSFAIGDKPTNAP
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
TKG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]