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The map label for this gene is guaA [H]

Identifier: 94310405

GI number: 94310405

Start: 1583673

End: 1585292

Strand: Direct

Name: guaA [H]

Synonym: Rmet_1463

Alternate gene names: 94310405

Gene position: 1583673-1585292 (Clockwise)

Preceding gene: 94310404

Following gene: 94310407

Centisome position: 40.32

GC content: 63.95

Gene sequence:

>1620_bases
ATGCACGACAAAATCCTCATTCTTGACTTCGGCTCGCAAGTCACACAGCTCATTGCCCGCCGCGTTCGCGAAGCGCACGT
CTACTGCGAAATCCATCCGAACGACGTCACCGACGAGTTTGTGCGCGAGTTCGCGCCGAAGGGCGTCATCCTGTCCGGCA
GCCACGCCAGCACCTACGAGGACCACCAACTGCGCGCGCCGCAGGCCGTGTGGGACCTGGGCGTGCCGGTGCTCGGCATC
TGCTACGGCATGCAGACGATGGCCGTGCAACTGGGCGGCAAGGTGGAGTGGAGCGATTCGCGCGAGTTTGGTTACGCGGA
AGTGCGCGCCCATGGCCACACGAACCTGCTCAAGGGCATCGAGGACTTCGCCACGGACGAAGGCCACGGCATGCTGAAGG
TCTGGATGAGCCACGGCGACAAGGTCACGGCACTGCCGGCCGGCTTCAAGCTGATGGCCTCCACGCCGAGCTGTCCGATC
GCCGGCATGGCCGACGAGGCGCGCGGTTACTATGGCGTGCAATTCCACCCGGAAGTCACGCATACGTCGAAGGGCCGCGA
GATGATCGAGCGCTTCGTGCTGGAGATCTGCGCCACGAAGGCCGACTGGGTCATGCGTGACCACATCGCCGAAGCCGTCG
AGAAGATCCGCGAACAGGTGGGCGATGAAGAGGTGATCCTCGGCCTGTCCGGTGGTGTCGATTCGTCGGTGGCCGCCGCG
CTGATCCATCGCGCCATTGGCGACCAGCTCACCTGCGTGTTCGTCGATCACGGCCTGCTGCGCCTGGACGAAGGCAAGAT
GGTGATGGACATGTTCGCAGGCCGCCTGCACGCCAAGGTTGTCCATATTGATGCCTCCGAGCAATTCCTGGGTCATCTGA
CCGGCGTGACCGACCCCGAGCAGAAGCGCAAGATCATTGGCCGCGAGTTCGTCGAGGTCTTCCAGGCCGAAGCAAAGAAG
CTGAGCAACGCCAAGTGGCTGGCGCAGGGCACGATCTACCCGGACGTGGTGGAGTCGGGCGGTACCAAGACCAAGAAGGC
TACGACGATCAAGAGCCACCACAATGTGGGTGGCCTGCCGGAAACGCTGGGCCTGAAGTTGCTGGAGCCGCTGCGCGACC
TGTTCAAGGACGAAGTGCGCGAACTGGGCGTGGCATTGGGCCTGCCGCCCGAGATGGTCTACCGTCATCCGTTCCCGGGC
CCGGGTCTGGGTGTGCGGATTCTCGGCGAGGTCAAGCGCGACTATGCTGACCTGCTGCGTCGCGCCGATGCAATCTTCAT
CGAGGAACTCCGCAAGACGATCGCCACGGAGCAGGACGCCGCTGCCGGTCTGTGCGAAGCGAATCAGGTGGGCAAGAGCT
GGTACGACCTGACCAGCCAGGCATTTGCCGTGTTCCTGCCGGTGAAGTCCGTAGGCGTGATGGGCGATGGCCGTACGTAC
GACTATGTCGTCGCGCTGCGCGCGGTGCAGACCACCGACTTCATGACCGCCCACTGGGCGCACCTGCCGTACTCGCTGCT
GGGCCGCTGCTCGAACCGCATCATCAACGAGGTTCGCGGGCTGAACCGCGTGGTGTACGACGTCTCGGGCAAGCCGCCTG
CGACGATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GAATACCGGCGCGAGCCGGGTATCACGCCACCGCCTGGCTATGGTCCGGGCACCGAGGTGATGCCCGAACCCGATCCGGA
AGCACTGCCAACTGCCAATC

Downstream 100 bases:

>100_bases
ATTTACGTCCTTCAGGGACTATCGCCAGCCATCCGAAAACCCGTCGTAACGTGTTGATTTAGAAGGAAATACGTCGCGGC
AGCTATCGGTGGCTATCGCC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVTDEFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDSREFGYAEVRAHGHTNLLKGIEDFATDEGHGMLKVWMSHGDKVTALPAGFKLMASTPSCPI
AGMADEARGYYGVQFHPEVTHTSKGREMIERFVLEICATKADWVMRDHIAEAVEKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHIDASEQFLGHLTGVTDPEQKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKRDYADLLRRADAIFIEELRKTIATEQDAAAGLCEANQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVVALRAVQTTDFMTAHWAHLPYSLLGRCSNRIINEVRGLNRVVYDVSGKPPATIEWE

Sequences:

>Translated_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVTDEFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDSREFGYAEVRAHGHTNLLKGIEDFATDEGHGMLKVWMSHGDKVTALPAGFKLMASTPSCPI
AGMADEARGYYGVQFHPEVTHTSKGREMIERFVLEICATKADWVMRDHIAEAVEKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHIDASEQFLGHLTGVTDPEQKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKRDYADLLRRADAIFIEELRKTIATEQDAAAGLCEANQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVVALRAVQTTDFMTAHWAHLPYSLLGRCSNRIINEVRGLNRVVYDVSGKPPATIEWE
>Mature_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVTDEFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDSREFGYAEVRAHGHTNLLKGIEDFATDEGHGMLKVWMSHGDKVTALPAGFKLMASTPSCPI
AGMADEARGYYGVQFHPEVTHTSKGREMIERFVLEICATKADWVMRDHIAEAVEKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHIDASEQFLGHLTGVTDPEQKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKRDYADLLRRADAIFIEELRKTIATEQDAAAGLCEANQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVVALRAVQTTDFMTAHWAHLPYSLLGRCSNRIINEVRGLNRVVYDVSGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=563, Percent_Identity=34.2806394316163, Blast_Score=281, Evalue=2e-75,
Organism=Escherichia coli, GI1788854, Length=536, Percent_Identity=63.9925373134328, Blast_Score=700, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=35, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=35, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI133901714, Length=580, Percent_Identity=35, Blast_Score=285, Evalue=5e-77,
Organism=Saccharomyces cerevisiae, GI6323873, Length=548, Percent_Identity=47.992700729927, Blast_Score=508, Evalue=1e-145,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=35.3571428571429, Blast_Score=290, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59574; Mature: 59574

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVTDEFVREFAPKGVILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHCCCCEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDSREFGYAEVRAHGHTNLLKGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEECCCHHHHHHH
EDFATDEGHGMLKVWMSHGDKVTALPAGFKLMASTPSCPIAGMADEARGYYGVQFHPEVT
HHHCCCCCCCEEEEEECCCCEEEECCCCCEEEECCCCCCCCCCCHHCCCEECEEECCCCC
HTSKGREMIERFVLEICATKADWVMRDHIAEAVEKIREQVGDEEVILGLSGGVDSSVAAA
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHIDASEQFLGHLTGVTDPE
HHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCHH
QKRKIIGREFVEVFQAEAKKLSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCCEEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVKRDYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRKTIATEQDAAAGLCEANQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHEEEEEEHHHHCCCCCCCCE
DYVVALRAVQTTDFMTAHWAHLPYSLLGRCSNRIINEVRGLNRVVYDVSGKPPATIEWE
EHHEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCEECC
>Mature Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVTDEFVREFAPKGVILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHCCCCEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDSREFGYAEVRAHGHTNLLKGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEECCCHHHHHHH
EDFATDEGHGMLKVWMSHGDKVTALPAGFKLMASTPSCPIAGMADEARGYYGVQFHPEVT
HHHCCCCCCCEEEEEECCCCEEEECCCCCEEEECCCCCCCCCCCHHCCCEECEEECCCCC
HTSKGREMIERFVLEICATKADWVMRDHIAEAVEKIREQVGDEEVILGLSGGVDSSVAAA
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHIDASEQFLGHLTGVTDPE
HHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCHH
QKRKIIGREFVEVFQAEAKKLSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCCEEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVKRDYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRKTIATEQDAAAGLCEANQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHEEEEEEHHHHCCCCCCCCE
DYVVALRAVQTTDFMTAHWAHLPYSLLGRCSNRIINEVRGLNRVVYDVSGKPPATIEWE
EHHEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA