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The map label for this gene is lpxD

Identifier: 94310387

GI number: 94310387

Start: 1567183

End: 1568292

Strand: Direct

Name: lpxD

Synonym: Rmet_1445

Alternate gene names: 94310387

Gene position: 1567183-1568292 (Clockwise)

Preceding gene: 94310386

Following gene: 94310388

Centisome position: 39.9

GC content: 61.17

Gene sequence:

>1110_bases
ATGAAGACACCCACACTGGGTCAGCTCGCCACCGAGAACGGCGCGCAGGTTGTGGGTGATCCCGACCTGGCCGTAGTCGG
CCTGGCGCCGCTAGACCAGGCTGGTCCCGGCGACCTGTCTTTCCTCTCCAATCCGCTGTATTTGCCACAGGCGCTCGCCT
CGGCCGCAGGCGCCGTCATCGTGTCGCCGGCAGACCTTGAACGCATTCGTGCGGATGGGCAAGCCGAAGGGCGCAATTGG
CTGGTGGCACGGAATCCCTACGTCTGCTTTGCCCGTGTTGCGCAGCGCTTCGACCGCGCCGCTAATGCCGACTCACGTAC
GGGGATCGATCCCCGTGCCAGCGTGGCGCCCGATGCGGTGGTCCCGGCATCCTGTTTTATCGGCCCGAACGTGGTGATCG
AGTCCGGCGCCCGGCTCGGCGAGCGTGTTCGGATCCTCGCAAATGCCTTTATCGGCGCAAGCGCGGAGATAGGCGAAGAT
ACGCTCATCTACGCCAATGTTTCTGTATATCATCGTTGCGTGATTGGCGCGCGCAACATCCTGCATAGCGGGGCGGTGAT
TGGCGCAGATGGCTTTGGTTTTGCGCCGGACATCGGACCGACGGGTGTCGAGTACGTCAAGATTCCCCAGGTGGGACGCG
CGGTGCTCGGCAATGACGTGGAAATTGGCGCCAATACGGCCGTGGATCGTGGCGCGATGGCTGACACGGTGATCGAGGAC
GGCTGCAAGATCGACAACCAGGTGCAGATCGCGCATAACGTGCATGTGGGTGCCCATACCGTTATCGCGGGAACGGCTGC
GGTTTCGGGTAGCACAAAGATTGGCCGGTTCTGCGTGATCGGCGGCGCGGCCAACTTTTCTGGCCATTTGAATATCGCTG
ACCGGACCACAGTGTCCGGCGGTACGTCGATTACCAAATCGATTACTAAACCCGGTGGGCATTACACGAGCGTGTTCCCG
TTCACGTCGCATGGCGAGTGGGAGCGAAACGCGGCAATCGTACGTGGCTTGTCAAAGCTGCGCGAACGTGTCGTGCAACT
GGAACGCAGGCAGCGCGGTGAAAACAACGCCCCCGCACAGAACAAACAAGACGAAGAGAAATCATCATGA

Upstream 100 bases:

>100_bases
ACCGACGACGTGATGAAGGCGCTGAACGCCGGCAGCACGGGCAAGTAAGCGACGGCGCCAAAGCGTCGTCTGCCGTTTCG
ATTCTCAAGGAAGTACTGCC

Downstream 100 bases:

>100_bases
CCGCATCCGAAATCGATATCCGCAAGATCCTGAAGCTGCTGCCGCATCGGTATCCGATCCTGCTGGTCGACCGTGTGCTC
GAGTTCGAACCGCAGAAGCG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKTPTLGQLATENGAQVVGDPDLAVVGLAPLDQAGPGDLSFLSNPLYLPQALASAAGAVIVSPADLERIRADGQAEGRNW
LVARNPYVCFARVAQRFDRAANADSRTGIDPRASVAPDAVVPASCFIGPNVVIESGARLGERVRILANAFIGASAEIGED
TLIYANVSVYHRCVIGARNILHSGAVIGADGFGFAPDIGPTGVEYVKIPQVGRAVLGNDVEIGANTAVDRGAMADTVIED
GCKIDNQVQIAHNVHVGAHTVIAGTAAVSGSTKIGRFCVIGGAANFSGHLNIADRTTVSGGTSITKSITKPGGHYTSVFP
FTSHGEWERNAAIVRGLSKLRERVVQLERRQRGENNAPAQNKQDEEKSS

Sequences:

>Translated_369_residues
MKTPTLGQLATENGAQVVGDPDLAVVGLAPLDQAGPGDLSFLSNPLYLPQALASAAGAVIVSPADLERIRADGQAEGRNW
LVARNPYVCFARVAQRFDRAANADSRTGIDPRASVAPDAVVPASCFIGPNVVIESGARLGERVRILANAFIGASAEIGED
TLIYANVSVYHRCVIGARNILHSGAVIGADGFGFAPDIGPTGVEYVKIPQVGRAVLGNDVEIGANTAVDRGAMADTVIED
GCKIDNQVQIAHNVHVGAHTVIAGTAAVSGSTKIGRFCVIGGAANFSGHLNIADRTTVSGGTSITKSITKPGGHYTSVFP
FTSHGEWERNAAIVRGLSKLRERVVQLERRQRGENNAPAQNKQDEEKSS
>Mature_369_residues
MKTPTLGQLATENGAQVVGDPDLAVVGLAPLDQAGPGDLSFLSNPLYLPQALASAAGAVIVSPADLERIRADGQAEGRNW
LVARNPYVCFARVAQRFDRAANADSRTGIDPRASVAPDAVVPASCFIGPNVVIESGARLGERVRILANAFIGASAEIGED
TLIYANVSVYHRCVIGARNILHSGAVIGADGFGFAPDIGPTGVEYVKIPQVGRAVLGNDVEIGANTAVDRGAMADTVIED
GCKIDNQVQIAHNVHVGAHTVIAGTAAVSGSTKIGRFCVIGGAANFSGHLNIADRTTVSGGTSITKSITKPGGHYTSVFP
FTSHGEWERNAAIVRGLSKLRERVVQLERRQRGENNAPAQNKQDEEKSS

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=356, Percent_Identity=40.1685393258427, Blast_Score=259, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_RALME (Q1LNE8)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_583597.1
- ProteinModelPortal:   Q1LNE8
- STRING:   Q1LNE8
- GeneID:   4038248
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_1445
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   AKIMKSA
- PhylomeDB:   Q1LNE8
- ProtClustDB:   PRK00892
- BioCyc:   RMET266264:RMET_1445-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 38503; Mature: 38503

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPTLGQLATENGAQVVGDPDLAVVGLAPLDQAGPGDLSFLSNPLYLPQALASAAGAVI
CCCCCCCHHHCCCCCEEECCCCEEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHCCEEE
VSPADLERIRADGQAEGRNWLVARNPYVCFARVAQRFDRAANADSRTGIDPRASVAPDAV
ECCHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
VPASCFIGPNVVIESGARLGERVRILANAFIGASAEIGEDTLIYANVSVYHRCVIGARNI
CCHHHCCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHH
LHSGAVIGADGFGFAPDIGPTGVEYVKIPQVGRAVLGNDVEIGANTAVDRGAMADTVIED
HHCCCEEECCCCCCCCCCCCCCCEEEECCCHHHHHHCCCEEECCCCCCCCCCHHHHHHHC
GCKIDNQVQIAHNVHVGAHTVIAGTAAVSGSTKIGRFCVIGGAANFSGHLNIADRTTVSG
CCCCCCEEEEEEEEECCCEEEEEEEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCCC
GTSITKSITKPGGHYTSVFPFTSHGEWERNAAIVRGLSKLRERVVQLERRQRGENNAPAQ
CCHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NKQDEEKSS
CCCCHHCCC
>Mature Secondary Structure
MKTPTLGQLATENGAQVVGDPDLAVVGLAPLDQAGPGDLSFLSNPLYLPQALASAAGAVI
CCCCCCCHHHCCCCCEEECCCCEEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHCCEEE
VSPADLERIRADGQAEGRNWLVARNPYVCFARVAQRFDRAANADSRTGIDPRASVAPDAV
ECCHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
VPASCFIGPNVVIESGARLGERVRILANAFIGASAEIGEDTLIYANVSVYHRCVIGARNI
CCHHHCCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHH
LHSGAVIGADGFGFAPDIGPTGVEYVKIPQVGRAVLGNDVEIGANTAVDRGAMADTVIED
HHCCCEEECCCCCCCCCCCCCCCEEEECCCHHHHHHCCCEEECCCCCCCCCCHHHHHHHC
GCKIDNQVQIAHNVHVGAHTVIAGTAAVSGSTKIGRFCVIGGAANFSGHLNIADRTTVSG
CCCCCCEEEEEEEEECCCEEEEEEEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCCC
GTSITKSITKPGGHYTSVFPFTSHGEWERNAAIVRGLSKLRERVVQLERRQRGENNAPAQ
CCHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NKQDEEKSS
CCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA