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The map label for this gene is 94310210

Identifier: 94310210

GI number: 94310210

Start: 1387484

End: 1388893

Strand: Reverse

Name: 94310210

Synonym: Rmet_1266

Alternate gene names: NA

Gene position: 1388893-1387484 (Counterclockwise)

Preceding gene: 335055522

Following gene: 94310209

Centisome position: 35.36

GC content: 62.84

Gene sequence:

>1410_bases
ATGAAACTCAGTTTTTTGGGCGCAGCCCGAGAAGTCACCGGATCGTGCTTCCTGGTCGAAGCGGCTAATGTCCGCTTCCT
GGTCGATTGCGGCATGGTTCAAGGTGGGCGTGTAGCAGCAGCACGCAACTACGAGCCGTTTGCGTTCGACCCGGCGTCCA
TTGACTTCGTCCTGCTGACCCACGCCCACATCGACCATAGCGGGCTATTGCCCAAACTGACGCGCGCCGGGTTCAAGGGG
CCCATCTACGCCACGCCAGCGACGGTTGATCTGCTCGGGGTGATGCTGCCCGATAGCGCTCACATCCAGGAAAGCGATGC
CAAGCGGGTTGCCAAGCGGTTCAAAGAGAAGACCGTGCCGCCACCCCTGTATACCCTGCAGGATACACACGAATGCCTGC
AGCAGGTACGCGGCATCGAATACGACCGGGAGTTCGCACCCCGCGTCGGGGTGCGCGCCCGCTTTCGTGATGCCGGCCAC
ATCCTCGGCTCGGCCATCGTGGAAGTGTGGATTACCGAGTACGGTTACCCCACGAAGATCGTGTTCAGCGGCGATTTGGG
CCAGCCGGGACGCCCCATCCTGCGCGACCCGACACCCATCGAGGACGCGGACATCCTCGTCATCGAGTCCACCTACGGCG
ACCGCCGGCACAAGGATTTTTCGGCGACCGAAGCGGACATGATCGGCATCGTCGAGAAAACCCTGTTCGAGCGCGGCGGC
AATGTCATCGTTCCGGCCTTTGCGGTCGGCCGAACCCAGGAGGTGCTCTACCACCTACATCGTCTCACCTGCGAAGGGCG
TCTGCAGCGTCCAATGGTGTTTGTCGATTCGCCGATGGCCACCGAGGCCACACGCATCACGCGTGAGCATCTCGAATTGT
TCGACGAACAGGCGAAGCGGTTGGCCGGATGGCATGCGCGCGGCGAGAACCTCCCGTATCTGGATTTCACCGCGAGCGCT
GAGGAGTCCATGGCGCTGAACCGGATTCGCTCCGGGGCCATCATTATTTCTGCCAGCGGCATGTGCGATGCGGGGCGTAT
CCGGCACCACCTGCGCCACAACTTGCCACGCCGCGAATGCAGCATCTTGTTTCCCGGTTTCCAGGCGCAGGGGACGCTTG
GCCGGCGCCTGATCGAGGGGGCCGAACGTGTACGCATCTTCGGTGAGGACATCCCGGTACGTGCGGCGATCCACAGCGTG
GACGGCCTCTCGGCGCATGCCGACCAAAAGGCGCTGCTGGATTGGGCCCGTGCTTTCATTCAAGCACCGGCGCAAACCTT
CGTGGTGCATGGGGAATCGTCGGCCGCGCAAGCCTTCGCTGAACTCTTGCAGCAGCAACTCGGCTGGCAGGTCACGGTGC
CCGAGTATGGCCATGCGCTGCGCTGGCCGGACTTTCTGGCGCACGAGTGA

Upstream 100 bases:

>100_bases
GGAATCATGCCGCTCCTCACCGGCCTGGCAGGCCGCTGTCCTGGCTATCGCCTGCTCGGCCTCAGCACTTGCCCGATGCG
AAAACCCGAGTGAACGCCCT

Downstream 100 bases:

>100_bases
TGAAACCTGCAGAAGATCTCGCTGAACGCCTGCGCGCCATCCGCGAGTCACCAACATACCGTCTTGCGTACGAAGACATC
GAGCTGCTTGGCCAGGACGA

Product: putative RNA Modifying Enzyme

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MKLSFLGAAREVTGSCFLVEAANVRFLVDCGMVQGGRVAAARNYEPFAFDPASIDFVLLTHAHIDHSGLLPKLTRAGFKG
PIYATPATVDLLGVMLPDSAHIQESDAKRVAKRFKEKTVPPPLYTLQDTHECLQQVRGIEYDREFAPRVGVRARFRDAGH
ILGSAIVEVWITEYGYPTKIVFSGDLGQPGRPILRDPTPIEDADILVIESTYGDRRHKDFSATEADMIGIVEKTLFERGG
NVIVPAFAVGRTQEVLYHLHRLTCEGRLQRPMVFVDSPMATEATRITREHLELFDEQAKRLAGWHARGENLPYLDFTASA
EESMALNRIRSGAIIISASGMCDAGRIRHHLRHNLPRRECSILFPGFQAQGTLGRRLIEGAERVRIFGEDIPVRAAIHSV
DGLSAHADQKALLDWARAFIQAPAQTFVVHGESSAAQAFAELLQQQLGWQVTVPEYGHALRWPDFLAHE

Sequences:

>Translated_469_residues
MKLSFLGAAREVTGSCFLVEAANVRFLVDCGMVQGGRVAAARNYEPFAFDPASIDFVLLTHAHIDHSGLLPKLTRAGFKG
PIYATPATVDLLGVMLPDSAHIQESDAKRVAKRFKEKTVPPPLYTLQDTHECLQQVRGIEYDREFAPRVGVRARFRDAGH
ILGSAIVEVWITEYGYPTKIVFSGDLGQPGRPILRDPTPIEDADILVIESTYGDRRHKDFSATEADMIGIVEKTLFERGG
NVIVPAFAVGRTQEVLYHLHRLTCEGRLQRPMVFVDSPMATEATRITREHLELFDEQAKRLAGWHARGENLPYLDFTASA
EESMALNRIRSGAIIISASGMCDAGRIRHHLRHNLPRRECSILFPGFQAQGTLGRRLIEGAERVRIFGEDIPVRAAIHSV
DGLSAHADQKALLDWARAFIQAPAQTFVVHGESSAAQAFAELLQQQLGWQVTVPEYGHALRWPDFLAHE
>Mature_469_residues
MKLSFLGAAREVTGSCFLVEAANVRFLVDCGMVQGGRVAAARNYEPFAFDPASIDFVLLTHAHIDHSGLLPKLTRAGFKG
PIYATPATVDLLGVMLPDSAHIQESDAKRVAKRFKEKTVPPPLYTLQDTHECLQQVRGIEYDREFAPRVGVRARFRDAGH
ILGSAIVEVWITEYGYPTKIVFSGDLGQPGRPILRDPTPIEDADILVIESTYGDRRHKDFSATEADMIGIVEKTLFERGG
NVIVPAFAVGRTQEVLYHLHRLTCEGRLQRPMVFVDSPMATEATRITREHLELFDEQAKRLAGWHARGENLPYLDFTASA
EESMALNRIRSGAIIISASGMCDAGRIRHHLRHNLPRRECSILFPGFQAQGTLGRRLIEGAERVRIFGEDIPVRAAIHSV
DGLSAHADQKALLDWARAFIQAPAQTFVVHGESSAAQAFAELLQQQLGWQVTVPEYGHALRWPDFLAHE

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=433, Percent_Identity=26.0969976905312, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI33300633, Length=473, Percent_Identity=24.9471458773784, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32564696, Length=482, Percent_Identity=25.9336099585062, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32566029, Length=431, Percent_Identity=25.2900232018561, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323307, Length=445, Percent_Identity=22.0224719101124, Blast_Score=106, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24648013, Length=450, Percent_Identity=24.4444444444444, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI21358523, Length=480, Percent_Identity=24.5833333333333, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 52083; Mature: 52083

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSFLGAAREVTGSCFLVEAANVRFLVDCGMVQGGRVAAARNYEPFAFDPASIDFVLLT
CCCCCCCCHHHCCCCEEEEEECCEEEEEECCCCCCCEEEEECCCCCCEECCCCCEEEEEE
HAHIDHSGLLPKLTRAGFKGPIYATPATVDLLGVMLPDSAHIQESDAKRVAKRFKEKTVP
EEECCCCCCCHHHHHCCCCCCEEECCCHHHHHHEECCCCCCCCHHHHHHHHHHHHHCCCC
PPLYTLQDTHECLQQVRGIEYDREFAPRVGVRARFRDAGHILGSAIVEVWITEYGYPTKI
CCCEEHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VFSGDLGQPGRPILRDPTPIEDADILVIESTYGDRRHKDFSATEADMIGIVEKTLFERGG
EEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
NVIVPAFAVGRTQEVLYHLHRLTCEGRLQRPMVFVDSPMATEATRITREHLELFDEQAKR
CEEEEEHCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LAGWHARGENLPYLDFTASAEESMALNRIRSGAIIISASGMCDAGRIRHHLRHNLPRREC
HHCCCCCCCCCCEEEEECCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCC
SILFPGFQAQGTLGRRLIEGAERVRIFGEDIPVRAAIHSVDGLSAHADQKALLDWARAFI
EEEECCCCCCCHHHHHHHHHHHHEEEECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHH
QAPAQTFVVHGESSAAQAFAELLQQQLGWQVTVPEYGHALRWPDFLAHE
HCCCEEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MKLSFLGAAREVTGSCFLVEAANVRFLVDCGMVQGGRVAAARNYEPFAFDPASIDFVLLT
CCCCCCCCHHHCCCCEEEEEECCEEEEEECCCCCCCEEEEECCCCCCEECCCCCEEEEEE
HAHIDHSGLLPKLTRAGFKGPIYATPATVDLLGVMLPDSAHIQESDAKRVAKRFKEKTVP
EEECCCCCCCHHHHHCCCCCCEEECCCHHHHHHEECCCCCCCCHHHHHHHHHHHHHCCCC
PPLYTLQDTHECLQQVRGIEYDREFAPRVGVRARFRDAGHILGSAIVEVWITEYGYPTKI
CCCEEHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VFSGDLGQPGRPILRDPTPIEDADILVIESTYGDRRHKDFSATEADMIGIVEKTLFERGG
EEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
NVIVPAFAVGRTQEVLYHLHRLTCEGRLQRPMVFVDSPMATEATRITREHLELFDEQAKR
CEEEEEHCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LAGWHARGENLPYLDFTASAEESMALNRIRSGAIIISASGMCDAGRIRHHLRHNLPRREC
HHCCCCCCCCCCEEEEECCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCC
SILFPGFQAQGTLGRRLIEGAERVRIFGEDIPVRAAIHSVDGLSAHADQKALLDWARAFI
EEEECCCCCCCHHHHHHHHHHHHEEEECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHH
QAPAQTFVVHGESSAAQAFAELLQQQLGWQVTVPEYGHALRWPDFLAHE
HCCCEEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA