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The map label for this gene is aceE [H]

Identifier: 94310141

GI number: 94310141

Start: 1312479

End: 1315166

Strand: Direct

Name: aceE [H]

Synonym: Rmet_1196

Alternate gene names: 94310141

Gene position: 1312479-1315166 (Clockwise)

Preceding gene: 94310138

Following gene: 94310142

Centisome position: 33.41

GC content: 64.03

Gene sequence:

>2688_bases
ATGTCCGCTGTACCAGAGCAGATCCTCGGCGCCAGCAGCGCCAACGACGCAGATCCCCAGGAAACGCACGAATGGCTGGA
CGCCCTGCAGGGCGTCCTCAACGCGGAAGGCACCGAGCGCGCCGCGTTCCTGATCGACAAGCAAATCGAATACGCGCGCG
TGAACGGCGTTACCCAGCCGTTCCATGCCGAAACGCCGTACATCAACACCATCCCGGTGGAGCAGCAGGCCCGCATTCCC
GGCGACCAGGACATCGAGCACCGCATCCGCTCGTACACGCGCTGGAACGCGATGGCCATGGTGCTGCGTGCCAACAAGCA
CACCAACGTCGGCGGCCACATCTCGTCGTTCGCCTCGGCGGCCACGCTCTATGACGTGGGCTACAACCACTTCTGGCGCG
CCCCGTCGGAGCAGAGCGGCGGCGACCTCGTTTTCGTGCAGGGCCATTCGGCACCGGGCGTCTACTCGCGCGCCTTCCTG
CTAGGCCGCCTGACGCCCGAACAGCTCGACAGCTTCCGTCAGGAAGTGGACGGCAAGGGCATCTCGTCGTACCCGCACCC
GTGGCTGATGCCGGACTTCTGGCAGTTCCCGACCGTGTCGATGGGCCTGGGCCCGATCATGGCGATCTACCAGGCCCGCT
TCATGAAGTACCTGGCCAGCCGTGGCCTGGTGAACGCCGGCGACCGCAAGGTATGGGCGTTCCTGGGTGATGGCGAGACC
GACGAGCCGGAATCGCTGGGCGCGATCGGCATGGCCGGCCGCGAGAAGCTGGACAACCTGGTTTTCGTGATCAACTGCAA
CCTGCAGCGCCTGGATGGCCCGGTGCGCGGCAATGGCAAGATCATCCAGGAACTGGAATCGGAATTCCGTGGCTCGGGCT
GGAACGTGATCAAGCTGATCTGGGGCAGCCGCTGGGATCCGCTGCTGCAGCGCGACACCAAGGGCCTGCTGATGAAGCGC
ATGATGGAATGCGTGGACGGCGAGTACCAGACCTTCAAGGCCAAGGATGGCGCCTACGTGCGCGAGCACTTCTTCAATAC
GCCGGAACTGAAGGCCATGGTGGCCGACTGGTCCGACGACGACATCTGGCGCCTGAACCGCGGCGGCCATGATCCGCACA
AGGTCTACGCGGCCTACAAGGCGGCTAGCGAGCACAAGGGCCAGCCGACGCTGATCCTGGCCAAGACCATCAAGGGCTAT
GGCATGGGCGATGCCGGGCAGGCCATGAACGTGGCCCACCAGCAGAAGAAGATGCCGGTGGACGCGATCCGCGCGTTCCG
CGACCAGTTCAACATCCCGGTGGCGGACGACAAGCTGGAAGAAGTCCCGTACCTGACCTTCCCGGAAGGCTCGAAGGAAC
TGGAGTACATGCGCAAGGCGCGCATGGACCTGGGCGGCTACCTGCCGGCCCGCCGTATGAAGGCCGAGGCGCTGAAGGTG
CCCGAGCTGTCGGCGTTCGAAGCGCTGATCAAGGCCACTGGCGAAGGCCGCGAAGTGTCCACCACGATGGCCTTCGTGCG
TATCCTGAACACGCTGCTCAAGGACAAGCAGGTCGGCAAGCACGTGGTGCCCATCGTGCCGGACGAGTCGCGCACCTTCG
GCATGGAAGGCCTGTTCCGCCAGGTTGGTATCTGGAACCAGGAAGGCCAGAAGTACGTGCCGGAAGACCATGACCAGTTG
ATGTTCTACAAGGAATCGCAGACGGGTCAGGTGCTGCAGGAAGGCATCAACGAAGCCGGCGCCATGTGCGACTGGATCGC
CGCCGCCACGTCGTACTCGACGCACGGCGTGCAGATGATCCCGTTCTACATCTACTATTCGATGTTCGGCATCCAGCGTA
TCGGCGACTTGTGCTGGGCCGCCGCCGACATGCGCTCGCGCGGCTTCCTGCTGGGCGGCACCGCTGGCCGCACCACGCTG
AACGGTGAAGGCTTGCAGCACGAGGATGGTCACTCGCACGTGTTCCACGCTGTGATCCCGAACTGTATCTCGTACGATCC
GACGTTCCAGTACGAACTCGCCGTGATCATGCAGGACGGCCTGCGCCGCATGTATGCCGAACAGGAAGACGTGTACTACT
ACCTGACGGTGATGAACGAGAACTACGAGCATCCGGAAATGCCGGCTGGCGTGGAACGCGACATCGTCCAGGGCATGTAC
CAGTTCCGCAAGGGCGTGGAGAACAGCAACGCGCCGCGCGTGCAACTGCTGGGCTCGGGCACGATCTTCCGCGAGGTGAT
CGCCGCCGCCGACCTGCTCAAGAAGGACTGGGGCGTGGAATCGGATCTGTGGAGCTGCCCGAGCTTCACCGAACTGGCCC
GCGAAGGCCAGGAAGTTGAGCGTCACAACCTGCTGAACCCGACCGGCACGCAGCGCGAATCGTTTGTCGCCCAGAAGCTC
AAGGGCGTGCGCGGTCCGGTCATCGCGTCCACCGACTACATCCGTGCGTTCGCCGAGCAGATCCGTCCGTTCGTGCCGCG
TCGCTACGTGGTGCTGGGCACCGATGGCTTCGGCCGCTCGGATACCCGCGAGAAGCTGCGCCACTTCTTCGAAGTGGACC
GCTACTGGGTCACGGTGGCCGCGCTGAAGGCGCTGGCTGACGAAGGCGCGATCGGTCGCGAGAAGGTGGCCGAGGCCATC
AAGAAGTACAACCTCGACCCGAACAAGCCGAACCCGATGTCGGTCTGA

Upstream 100 bases:

>100_bases
CTTGGCGCTCCGCCGCGACGTCACAAACCGTCAAGACCGGCCGCTGGAGTCCCGCGCTTCGCTGTGTGGGCACCGGGCAG
GAATTCACCAGGAGACAGTC

Downstream 100 bases:

>100_bases
CCCCGGACTTGCACGACTGAACCCCCGCAGCGCGGCACCCGCCGCGCCGCAGTGTGCCACCGGCTGACCCGGCGGCGCAC
CACGGCGAATGGTGATGCGC

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 895; Mature: 894

Protein sequence:

>895_residues
MSAVPEQILGASSANDADPQETHEWLDALQGVLNAEGTERAAFLIDKQIEYARVNGVTQPFHAETPYINTIPVEQQARIP
GDQDIEHRIRSYTRWNAMAMVLRANKHTNVGGHISSFASAATLYDVGYNHFWRAPSEQSGGDLVFVQGHSAPGVYSRAFL
LGRLTPEQLDSFRQEVDGKGISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFMKYLASRGLVNAGDRKVWAFLGDGET
DEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGSGWNVIKLIWGSRWDPLLQRDTKGLLMKR
MMECVDGEYQTFKAKDGAYVREHFFNTPELKAMVADWSDDDIWRLNRGGHDPHKVYAAYKAASEHKGQPTLILAKTIKGY
GMGDAGQAMNVAHQQKKMPVDAIRAFRDQFNIPVADDKLEEVPYLTFPEGSKELEYMRKARMDLGGYLPARRMKAEALKV
PELSAFEALIKATGEGREVSTTMAFVRILNTLLKDKQVGKHVVPIVPDESRTFGMEGLFRQVGIWNQEGQKYVPEDHDQL
MFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVQMIPFYIYYSMFGIQRIGDLCWAAADMRSRGFLLGGTAGRTTL
NGEGLQHEDGHSHVFHAVIPNCISYDPTFQYELAVIMQDGLRRMYAEQEDVYYYLTVMNENYEHPEMPAGVERDIVQGMY
QFRKGVENSNAPRVQLLGSGTIFREVIAAADLLKKDWGVESDLWSCPSFTELAREGQEVERHNLLNPTGTQRESFVAQKL
KGVRGPVIASTDYIRAFAEQIRPFVPRRYVVLGTDGFGRSDTREKLRHFFEVDRYWVTVAALKALADEGAIGREKVAEAI
KKYNLDPNKPNPMSV

Sequences:

>Translated_895_residues
MSAVPEQILGASSANDADPQETHEWLDALQGVLNAEGTERAAFLIDKQIEYARVNGVTQPFHAETPYINTIPVEQQARIP
GDQDIEHRIRSYTRWNAMAMVLRANKHTNVGGHISSFASAATLYDVGYNHFWRAPSEQSGGDLVFVQGHSAPGVYSRAFL
LGRLTPEQLDSFRQEVDGKGISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFMKYLASRGLVNAGDRKVWAFLGDGET
DEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGSGWNVIKLIWGSRWDPLLQRDTKGLLMKR
MMECVDGEYQTFKAKDGAYVREHFFNTPELKAMVADWSDDDIWRLNRGGHDPHKVYAAYKAASEHKGQPTLILAKTIKGY
GMGDAGQAMNVAHQQKKMPVDAIRAFRDQFNIPVADDKLEEVPYLTFPEGSKELEYMRKARMDLGGYLPARRMKAEALKV
PELSAFEALIKATGEGREVSTTMAFVRILNTLLKDKQVGKHVVPIVPDESRTFGMEGLFRQVGIWNQEGQKYVPEDHDQL
MFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVQMIPFYIYYSMFGIQRIGDLCWAAADMRSRGFLLGGTAGRTTL
NGEGLQHEDGHSHVFHAVIPNCISYDPTFQYELAVIMQDGLRRMYAEQEDVYYYLTVMNENYEHPEMPAGVERDIVQGMY
QFRKGVENSNAPRVQLLGSGTIFREVIAAADLLKKDWGVESDLWSCPSFTELAREGQEVERHNLLNPTGTQRESFVAQKL
KGVRGPVIASTDYIRAFAEQIRPFVPRRYVVLGTDGFGRSDTREKLRHFFEVDRYWVTVAALKALADEGAIGREKVAEAI
KKYNLDPNKPNPMSV
>Mature_894_residues
SAVPEQILGASSANDADPQETHEWLDALQGVLNAEGTERAAFLIDKQIEYARVNGVTQPFHAETPYINTIPVEQQARIPG
DQDIEHRIRSYTRWNAMAMVLRANKHTNVGGHISSFASAATLYDVGYNHFWRAPSEQSGGDLVFVQGHSAPGVYSRAFLL
GRLTPEQLDSFRQEVDGKGISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFMKYLASRGLVNAGDRKVWAFLGDGETD
EPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGSGWNVIKLIWGSRWDPLLQRDTKGLLMKRM
MECVDGEYQTFKAKDGAYVREHFFNTPELKAMVADWSDDDIWRLNRGGHDPHKVYAAYKAASEHKGQPTLILAKTIKGYG
MGDAGQAMNVAHQQKKMPVDAIRAFRDQFNIPVADDKLEEVPYLTFPEGSKELEYMRKARMDLGGYLPARRMKAEALKVP
ELSAFEALIKATGEGREVSTTMAFVRILNTLLKDKQVGKHVVPIVPDESRTFGMEGLFRQVGIWNQEGQKYVPEDHDQLM
FYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVQMIPFYIYYSMFGIQRIGDLCWAAADMRSRGFLLGGTAGRTTLN
GEGLQHEDGHSHVFHAVIPNCISYDPTFQYELAVIMQDGLRRMYAEQEDVYYYLTVMNENYEHPEMPAGVERDIVQGMYQ
FRKGVENSNAPRVQLLGSGTIFREVIAAADLLKKDWGVESDLWSCPSFTELAREGQEVERHNLLNPTGTQRESFVAQKLK
GVRGPVIASTDYIRAFAEQIRPFVPRRYVVLGTDGFGRSDTREKLRHFFEVDRYWVTVAALKALADEGAIGREKVAEAIK
KYNLDPNKPNPMSV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=884, Percent_Identity=61.6515837104072, Blast_Score=1124, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 100670; Mature: 100539

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVPEQILGASSANDADPQETHEWLDALQGVLNAEGTERAAFLIDKQIEYARVNGVTQP
CCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHCCCCCC
FHAETPYINTIPVEQQARIPGDQDIEHRIRSYTRWNAMAMVLRANKHTNVGGHISSFASA
CCCCCCEEECCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHH
ATLYDVGYNHFWRAPSEQSGGDLVFVQGHSAPGVYSRAFLLGRLTPEQLDSFRQEVDGKG
HHHHHCCHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCC
ISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFMKYLASRGLVNAGDRKVWAFLGDGET
CCCCCCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
DEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGSGWNVIKLI
CCCHHCCCCCCCCHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEE
WGSRWDPLLQRDTKGLLMKRMMECVDGEYQTFKAKDGAYVREHFFNTPELKAMVADWSDD
ECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCCCHHHEEEECCCCC
DIWRLNRGGHDPHKVYAAYKAASEHKGQPTLILAKTIKGYGMGDAGQAMNVAHQQKKMPV
CEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCH
DAIRAFRDQFNIPVADDKLEEVPYLTFPEGSKELEYMRKARMDLGGYLPARRMKAEALKV
HHHHHHHHHCCCCCCCCHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
PELSAFEALIKATGEGREVSTTMAFVRILNTLLKDKQVGKHVVPIVPDESRTFGMEGLFR
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHH
QVGIWNQEGQKYVPEDHDQLMFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVQMI
HHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
PFYIYYSMFGIQRIGDLCWAAADMRSRGFLLGGTAGRTTLNGEGLQHEDGHSHVFHAVIP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEECCCCCCCCCCCCHHHHHHHH
NCISYDPTFQYELAVIMQDGLRRMYAEQEDVYYYLTVMNENYEHPEMPAGVERDIVQGMY
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHH
QFRKGVENSNAPRVQLLGSGTIFREVIAAADLLKKDWGVESDLWSCPSFTELAREGQEVE
HHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHH
RHNLLNPTGTQRESFVAQKLKGVRGPVIASTDYIRAFAEQIRPFVPRRYVVLGTDGFGRS
HHCCCCCCCCHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
DTREKLRHFFEVDRYWVTVAALKALADEGAIGREKVAEAIKKYNLDPNKPNPMSV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SAVPEQILGASSANDADPQETHEWLDALQGVLNAEGTERAAFLIDKQIEYARVNGVTQP
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHCCCCCC
FHAETPYINTIPVEQQARIPGDQDIEHRIRSYTRWNAMAMVLRANKHTNVGGHISSFASA
CCCCCCEEECCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHH
ATLYDVGYNHFWRAPSEQSGGDLVFVQGHSAPGVYSRAFLLGRLTPEQLDSFRQEVDGKG
HHHHHCCHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCC
ISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFMKYLASRGLVNAGDRKVWAFLGDGET
CCCCCCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
DEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGSGWNVIKLI
CCCHHCCCCCCCCHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEE
WGSRWDPLLQRDTKGLLMKRMMECVDGEYQTFKAKDGAYVREHFFNTPELKAMVADWSDD
ECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCCCHHHEEEECCCCC
DIWRLNRGGHDPHKVYAAYKAASEHKGQPTLILAKTIKGYGMGDAGQAMNVAHQQKKMPV
CEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCH
DAIRAFRDQFNIPVADDKLEEVPYLTFPEGSKELEYMRKARMDLGGYLPARRMKAEALKV
HHHHHHHHHCCCCCCCCHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
PELSAFEALIKATGEGREVSTTMAFVRILNTLLKDKQVGKHVVPIVPDESRTFGMEGLFR
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHH
QVGIWNQEGQKYVPEDHDQLMFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVQMI
HHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
PFYIYYSMFGIQRIGDLCWAAADMRSRGFLLGGTAGRTTLNGEGLQHEDGHSHVFHAVIP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEECCCCCCCCCCCCHHHHHHHH
NCISYDPTFQYELAVIMQDGLRRMYAEQEDVYYYLTVMNENYEHPEMPAGVERDIVQGMY
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHH
QFRKGVENSNAPRVQLLGSGTIFREVIAAADLLKKDWGVESDLWSCPSFTELAREGQEVE
HHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHH
RHNLLNPTGTQRESFVAQKLKGVRGPVIASTDYIRAFAEQIRPFVPRRYVVLGTDGFGRS
HHCCCCCCCCHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
DTREKLRHFFEVDRYWVTVAALKALADEGAIGREKVAEAIKKYNLDPNKPNPMSV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8021225 [H]