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The map label for this gene is lysA [H]

Identifier: 94310055

GI number: 94310055

Start: 1208965

End: 1210158

Strand: Reverse

Name: lysA [H]

Synonym: Rmet_1110

Alternate gene names: 94310055

Gene position: 1210158-1208965 (Counterclockwise)

Preceding gene: 94310056

Following gene: 94310054

Centisome position: 30.81

GC content: 65.24

Gene sequence:

>1194_bases
ATGGATCTGACACACGTTACCCGCTACATCGCCGGGCGGGATACTCGCGAGCCGGTCTGCGCCTATCTCTACGATCTCGA
CGATCTGCGCCTGCGCACGACACGCTTGCGGGCGGCGCTGCCGGAGCAATGCGCACTGTATTACGCCGTGAAGGCCAACA
GCGACGCGCCCGTCCTTCGGGCCTTGCTCGGTGTGGCCGATGGTTTCGAAGTGGCCTCGTTCGGCGAGATCGAGCGCGTC
CGCGGCGTCGATGCCGAAGTACCCATCGCATTCGGCGGCCCGGGCAAGACCGATGCCGAGCTCGAAGGCGCGCTGCGTCT
TGGCGTCGGCCTGATTCACGTGGAAAGCACGCTGCAGCTAAGTCGGCTGGATGCCGTAGCACGACGGCAAGGCCGCTGCG
CCGATGTGCTGCTTCGCGCGAACCCCGCCTACGGTCTGCCCGGCGCCACGCTCCAGATGGGCGGCGGCGCCACGCAGTTC
GGCATCGACGAGGCCCTGCTACCCGATGTGCTGGCGCAGTCCCGCACGATGCCCAATGTGCGCGTGGTTGGCCTGCATGT
GCACGCCGGGTCCAACAGTCTCGATGCCGACACCCATCTGGCCCTGATCGACCGCCATATCGCGCTGGCCAAGCGCCTGC
GCGACCTGCACGGCCTGACACTCGAATGGCTGAACGTCGGTGGTGGCATCGGCATCGACTATCAGAATCCGGAGCGCCAC
TTCGACTGGGACCGTTTTTGCCATGGACTGGCTGCCCTGCTGCGGGAGACAGCGCCGAGTACGCGCATCGTCTTCGAGTG
CGGCCGCTTTATCAGCGCGGGCTGTGGCTGCTATGTTGCCGAGGTCATCGACCTGAAGCGGAATCACGACAAATGGTTCG
CGGTGCTGCGCGGTGGCACGCACCACTTCCGGCTGCCCGTGTCATGGCAGCACAACCATCCGTTCCAGGTGCTGCCGAAT
GACCACTGGGACTATCCGTTTCCGAGGCCCGTGGTAGAGCGGCAGCCAGTGACGCTGTGTGGCGAACTCTGTACGCCGAA
GGATGTGCTGGCGCGCGAGGTGCCAGTGGATCGGCTGCGTGTCGGAGATCGCATCGCTTTCACCATGGCTGGCGCGTACG
GCTGGCATATCTCGCACCACGACTTCCTGAGCCATCCGCACCCCGAGCGCGTCTTCATCGGCGGTCAACCTTGA

Upstream 100 bases:

>100_bases
GCGACGATCGCGGCATCGCCCGCCGTGCGATGGCCGCCCACCGGCAGGCGTGCATTGCCTAGCAGCAGCAGGACATAAGC
TGCCTCGAACAGGAACAACC

Downstream 100 bases:

>100_bases
TCCTACCGGGACGATTCGCAAGGAATGCTTGCCCCGGGGGCTAGCCCGATATACGGTGAAACCGGACGGTCCGGTGGTGT
GTCGTGCTCACCGGCCGGTC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MDLTHVTRYIAGRDTREPVCAYLYDLDDLRLRTTRLRAALPEQCALYYAVKANSDAPVLRALLGVADGFEVASFGEIERV
RGVDAEVPIAFGGPGKTDAELEGALRLGVGLIHVESTLQLSRLDAVARRQGRCADVLLRANPAYGLPGATLQMGGGATQF
GIDEALLPDVLAQSRTMPNVRVVGLHVHAGSNSLDADTHLALIDRHIALAKRLRDLHGLTLEWLNVGGGIGIDYQNPERH
FDWDRFCHGLAALLRETAPSTRIVFECGRFISAGCGCYVAEVIDLKRNHDKWFAVLRGGTHHFRLPVSWQHNHPFQVLPN
DHWDYPFPRPVVERQPVTLCGELCTPKDVLAREVPVDRLRVGDRIAFTMAGAYGWHISHHDFLSHPHPERVFIGGQP

Sequences:

>Translated_397_residues
MDLTHVTRYIAGRDTREPVCAYLYDLDDLRLRTTRLRAALPEQCALYYAVKANSDAPVLRALLGVADGFEVASFGEIERV
RGVDAEVPIAFGGPGKTDAELEGALRLGVGLIHVESTLQLSRLDAVARRQGRCADVLLRANPAYGLPGATLQMGGGATQF
GIDEALLPDVLAQSRTMPNVRVVGLHVHAGSNSLDADTHLALIDRHIALAKRLRDLHGLTLEWLNVGGGIGIDYQNPERH
FDWDRFCHGLAALLRETAPSTRIVFECGRFISAGCGCYVAEVIDLKRNHDKWFAVLRGGTHHFRLPVSWQHNHPFQVLPN
DHWDYPFPRPVVERQPVTLCGELCTPKDVLAREVPVDRLRVGDRIAFTMAGAYGWHISHHDFLSHPHPERVFIGGQP
>Mature_397_residues
MDLTHVTRYIAGRDTREPVCAYLYDLDDLRLRTTRLRAALPEQCALYYAVKANSDAPVLRALLGVADGFEVASFGEIERV
RGVDAEVPIAFGGPGKTDAELEGALRLGVGLIHVESTLQLSRLDAVARRQGRCADVLLRANPAYGLPGATLQMGGGATQF
GIDEALLPDVLAQSRTMPNVRVVGLHVHAGSNSLDADTHLALIDRHIALAKRLRDLHGLTLEWLNVGGGIGIDYQNPERH
FDWDRFCHGLAALLRETAPSTRIVFECGRFISAGCGCYVAEVIDLKRNHDKWFAVLRGGTHHFRLPVSWQHNHPFQVLPN
DHWDYPFPRPVVERQPVTLCGELCTPKDVLAREVPVDRLRVGDRIAFTMAGAYGWHISHHDFLSHPHPERVFIGGQP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=399, Percent_Identity=26.0651629072682, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562780, Length=382, Percent_Identity=25.130890052356, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 43944; Mature: 43944

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTHVTRYIAGRDTREPVCAYLYDLDDLRLRTTRLRAALPEQCALYYAVKANSDAPVLR
CCHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHEEEEEEECCCCCHHHH
ALLGVADGFEVASFGEIERVRGVDAEVPIAFGGPGKTDAELEGALRLGVGLIHVESTLQL
HHHHHCCCCCCCCCCCHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCEEEEEEHHHHHH
SRLDAVARRQGRCADVLLRANPAYGLPGATLQMGGGATQFGIDEALLPDVLAQSRTMPNV
HHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCE
RVVGLHVHAGSNSLDADTHLALIDRHIALAKRLRDLHGLTLEWLNVGGGIGIDYQNPERH
EEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCC
FDWDRFCHGLAALLRETAPSTRIVFECGRFISAGCGCYVAEVIDLKRNHDKWFAVLRGGT
CCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCC
HHFRLPVSWQHNHPFQVLPNDHWDYPFPRPVVERQPVTLCGELCTPKDVLAREVPVDRLR
EEEEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHCCCHHHHH
VGDRIAFTMAGAYGWHISHHDFLSHPHPERVFIGGQP
CCCEEEEEEECCEEEECCCCHHHCCCCCCEEEECCCC
>Mature Secondary Structure
MDLTHVTRYIAGRDTREPVCAYLYDLDDLRLRTTRLRAALPEQCALYYAVKANSDAPVLR
CCHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHEEEEEEECCCCCHHHH
ALLGVADGFEVASFGEIERVRGVDAEVPIAFGGPGKTDAELEGALRLGVGLIHVESTLQL
HHHHHCCCCCCCCCCCHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCEEEEEEHHHHHH
SRLDAVARRQGRCADVLLRANPAYGLPGATLQMGGGATQFGIDEALLPDVLAQSRTMPNV
HHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCE
RVVGLHVHAGSNSLDADTHLALIDRHIALAKRLRDLHGLTLEWLNVGGGIGIDYQNPERH
EEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCC
FDWDRFCHGLAALLRETAPSTRIVFECGRFISAGCGCYVAEVIDLKRNHDKWFAVLRGGT
CCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCC
HHFRLPVSWQHNHPFQVLPNDHWDYPFPRPVVERQPVTLCGELCTPKDVLAREVPVDRLR
EEEEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHCCCHHHHH
VGDRIAFTMAGAYGWHISHHDFLSHPHPERVFIGGQP
CCCEEEEEEECCEEEECCCCHHHCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]