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The map label for this gene is cobW [H]

Identifier: 94310043

GI number: 94310043

Start: 1194940

End: 1196133

Strand: Direct

Name: cobW [H]

Synonym: Rmet_1098

Alternate gene names: 94310043

Gene position: 1194940-1196133 (Clockwise)

Preceding gene: 94310041

Following gene: 94310044

Centisome position: 30.42

GC content: 62.73

Gene sequence:

>1194_bases
ATGCTTCCAGCCAAGCTTCCTGTCACCGTGCTCTCGGGCTTCCTCGGCGCGGGCAAGACCACCTTGCTTAATCACATCCT
CCATAACCGTGAGGGTCGTCGCGTCGCGGTGATCGTCAACGACATGTCCGACGTCAACATTGATGCGGGGCTTGTCCGGG
ATGGCGGCGCCAATCTTTCGCGGACGGAAGAGACATTGGTGGAGATGAGCAACGGGTGCATCTGCTGCACGCTGCGCGAA
GATCTGCTGCTGGAAGTCGAACGGCTGGCCAGGGAAGGGCGATTCGACCAACTGGTTATCGAATCAACCGGGATCTCGGA
GCCCCTGCCGGTGGCGGAGACCTTTACGTTCGAAGGCGAAGATGGCCGCAGTCTCAATGAGGTGGCCCATCTGGACACCA
TGGTCACAGTGGTCGACGCCTTCAATTTCCTCCGGGACTACGGCTCGCGCGACAGTCTGCAATCGCGCGGCGAGTCACTG
GGCGAGGAGGACGCGCGTACCGTCGTGGACCTCCTGATCGATCAGGTCGAATTCTGCGATGTGCTGGTCTTGAACAAGGT
CGATCTGATCGCCGACGCGGACCGCGAGCGCCTCCTGGCCATTCTGCGCGCCCTCAACCCCAGGGCACGCATCGAGATCG
CCGAGTTTGGCCGGGTGCCACTCGAGCGGGTGCTCGGCACGGGCTTGTTCGATTTCGAGGAAGCATCGAAAGCGCCCGGC
TGGTTACAGGAAATGCGCGGCCAGCACGTGCCTGAGACCGAGGAATACGGCATTCGCAGCTTCGTCTACGGCGCCCGTCG
ACCATTTCATCCTCAACGCTTCCACGCGTTTGTCGCGGCCGAATGGCCGGGTGTGGTGCGATCAAAGGGGTTCTTCTGGC
TGGCAAGCCATCCGACGCTCGCTGGAACCTGGTCACAGGCTGGCGCCGTTGCCAGGCACGGCCCGGCCGGTTACTGGTGG
GCCGCGGTGCCGCCCGAGCGCTGGCCGGACGACCCGGAGTCCGTTGCCTTGATTCGCGCCAAATGGGACGACAGCGTCGG
CGATGCGCGTCAGGAAATCGTGCTGATTGGTGTCGACATGGACGAATTCGAGCTTCGCAGATGTCTGGACGCCTGCCTGT
TGACGGACGACGAGATGGCGCAGGGTCCCGATGTGTGGACCACCTGGCACAACCCCTTTCCTGACTGGCCCTGA

Upstream 100 bases:

>100_bases
TGAAATGCAACAAGGTTGCATTTAAGATCTGTTTGCAACAATGTTGCATTAACCGATCGCCCGCACTTGGCAGGATGCCT
TGCGGGCAAACCAAATCCCC

Downstream 100 bases:

>100_bases
CACTTTGGGCTCCCCATGCGCCCAGGACATTGGGGATGCCTTCCCAATCCGAACGAAAGCATGAGCGCAGCCCTTCCCGA
CGTTTCCCTGACCGAAGCCT

Product: cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MLPAKLPVTVLSGFLGAGKTTLLNHILHNREGRRVAVIVNDMSDVNIDAGLVRDGGANLSRTEETLVEMSNGCICCTLRE
DLLLEVERLAREGRFDQLVIESTGISEPLPVAETFTFEGEDGRSLNEVAHLDTMVTVVDAFNFLRDYGSRDSLQSRGESL
GEEDARTVVDLLIDQVEFCDVLVLNKVDLIADADRERLLAILRALNPRARIEIAEFGRVPLERVLGTGLFDFEEASKAPG
WLQEMRGQHVPETEEYGIRSFVYGARRPFHPQRFHAFVAAEWPGVVRSKGFFWLASHPTLAGTWSQAGAVARHGPAGYWW
AAVPPERWPDDPESVALIRAKWDDSVGDARQEIVLIGVDMDEFELRRCLDACLLTDDEMAQGPDVWTTWHNPFPDWP

Sequences:

>Translated_397_residues
MLPAKLPVTVLSGFLGAGKTTLLNHILHNREGRRVAVIVNDMSDVNIDAGLVRDGGANLSRTEETLVEMSNGCICCTLRE
DLLLEVERLAREGRFDQLVIESTGISEPLPVAETFTFEGEDGRSLNEVAHLDTMVTVVDAFNFLRDYGSRDSLQSRGESL
GEEDARTVVDLLIDQVEFCDVLVLNKVDLIADADRERLLAILRALNPRARIEIAEFGRVPLERVLGTGLFDFEEASKAPG
WLQEMRGQHVPETEEYGIRSFVYGARRPFHPQRFHAFVAAEWPGVVRSKGFFWLASHPTLAGTWSQAGAVARHGPAGYWW
AAVPPERWPDDPESVALIRAKWDDSVGDARQEIVLIGVDMDEFELRRCLDACLLTDDEMAQGPDVWTTWHNPFPDWP
>Mature_397_residues
MLPAKLPVTVLSGFLGAGKTTLLNHILHNREGRRVAVIVNDMSDVNIDAGLVRDGGANLSRTEETLVEMSNGCICCTLRE
DLLLEVERLAREGRFDQLVIESTGISEPLPVAETFTFEGEDGRSLNEVAHLDTMVTVVDAFNFLRDYGSRDSLQSRGESL
GEEDARTVVDLLIDQVEFCDVLVLNKVDLIADADRERLLAILRALNPRARIEIAEFGRVPLERVLGTGLFDFEEASKAPG
WLQEMRGQHVPETEEYGIRSFVYGARRPFHPQRFHAFVAAEWPGVVRSKGFFWLASHPTLAGTWSQAGAVARHGPAGYWW
AAVPPERWPDDPESVALIRAKWDDSVGDARQEIVLIGVDMDEFELRRCLDACLLTDDEMAQGPDVWTTWHNPFPDWP

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI148727351, Length=397, Percent_Identity=28.2115869017632, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI33469141, Length=342, Percent_Identity=30.1169590643275, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI146231952, Length=397, Percent_Identity=28.463476070529, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI126722884, Length=342, Percent_Identity=29.8245614035088, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI223941779, Length=342, Percent_Identity=28.6549707602339, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI223941776, Length=328, Percent_Identity=28.6585365853659, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI119120938, Length=169, Percent_Identity=34.9112426035503, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI87082430, Length=305, Percent_Identity=28.5245901639344, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788499, Length=110, Percent_Identity=35.4545454545455, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324356, Length=235, Percent_Identity=27.2340425531915, Blast_Score=96, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 44376; Mature: 44376

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPAKLPVTVLSGFLGAGKTTLLNHILHNREGRRVAVIVNDMSDVNIDAGLVRDGGANLS
CCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEECCCCCCH
RTEETLVEMSNGCICCTLREDLLLEVERLAREGRFDQLVIESTGISEPLPVAETFTFEGE
HHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEECCC
DGRSLNEVAHLDTMVTVVDAFNFLRDYGSRDSLQSRGESLGEEDARTVVDLLIDQVEFCD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VLVLNKVDLIADADRERLLAILRALNPRARIEIAEFGRVPLERVLGTGLFDFEEASKAPG
HHHHCCCHHHHCCCHHHHHHHHHHCCCCCEEEHHHHCCCCHHHHHCCCCCCHHHHCCCCH
WLQEMRGQHVPETEEYGIRSFVYGARRPFHPQRFHAFVAAEWPGVVRSKGFFWLASHPTL
HHHHHCCCCCCCHHHHCHHHHHHHCCCCCCHHHHEEEEEECCCCCHHCCCEEEEECCCCC
AGTWSQAGAVARHGPAGYWWAAVPPERWPDDPESVALIRAKWDDSVGDARQEIVLIGVDM
CCCHHHCCCHHCCCCCCEEEECCCCCCCCCCCHHEEEEEECCCCCCCCCCCEEEEEECCC
DEFELRRCLDACLLTDDEMAQGPDVWTTWHNPFPDWP
CHHHHHHHHHHHHCCCCHHHCCCCEEECCCCCCCCCC
>Mature Secondary Structure
MLPAKLPVTVLSGFLGAGKTTLLNHILHNREGRRVAVIVNDMSDVNIDAGLVRDGGANLS
CCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEECCCCCCH
RTEETLVEMSNGCICCTLREDLLLEVERLAREGRFDQLVIESTGISEPLPVAETFTFEGE
HHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEECCC
DGRSLNEVAHLDTMVTVVDAFNFLRDYGSRDSLQSRGESLGEEDARTVVDLLIDQVEFCD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VLVLNKVDLIADADRERLLAILRALNPRARIEIAEFGRVPLERVLGTGLFDFEEASKAPG
HHHHCCCHHHHCCCHHHHHHHHHHCCCCCEEEHHHHCCCCHHHHHCCCCCCHHHHCCCCH
WLQEMRGQHVPETEEYGIRSFVYGARRPFHPQRFHAFVAAEWPGVVRSKGFFWLASHPTL
HHHHHCCCCCCCHHHHCHHHHHHHCCCCCCHHHHEEEEEECCCCCHHCCCEEEEECCCCC
AGTWSQAGAVARHGPAGYWWAAVPPERWPDDPESVALIRAKWDDSVGDARQEIVLIGVDM
CCCHHHCCCHHCCCCCCEEEECCCCCCCCCCCHHEEEEEECCCCCCCCCCCEEEEEECCC
DEFELRRCLDACLLTDDEMAQGPDVWTTWHNPFPDWP
CHHHHHHHHHHHHCCCCHHHCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]