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The map label for this gene is lpxH [H]

Identifier: 94310026

GI number: 94310026

Start: 1173646

End: 1174437

Strand: Reverse

Name: lpxH [H]

Synonym: Rmet_1081

Alternate gene names: 94310026

Gene position: 1174437-1173646 (Counterclockwise)

Preceding gene: 94310027

Following gene: 94310023

Centisome position: 29.9

GC content: 70.45

Gene sequence:

>792_bases
ATGACCGCTCCCACCCGCACGCCGGTGGCCGCCCCGATCGAGGTGCAGGCGCCGGCGTGGTTCATTTCCGATCTCCACCT
GACGGCCGACATGCCGCGCACGCTGGCGGCCTTCCACCGTGTGCTCGAGCGTGCGGCACGGGATGCGCGCACGCTGTTCA
TCCTGGGGGACTTTTTCGAGTTCTGGGTAGGGGATGAGGAAACCGACTCGCCGTTCGCGGCCGAGGTTGCCGCCGCGCTG
CGCCGGCTTGCCGATGCCGGCGTGCCGGTCTATCTGATGCACGGCAATCGTGATTTCCTGCTTGGCCGTCGATTCGCGGC
CAGGGCGGGCGCGTCGCTGCTGCCGGACCCGTCGGTTATCGTCTGTGCTGGCCGCCGCGTGGCGCTCAGCCACGGCGACA
TGCTGTGCACGGACGACGAGCGCTACATGCGCTTTCGCCGCTGGACACGCAAGGGCTGGGTACAACGGCTGTTCCTGCTG
CTGCCACTCGGCACGCGACTGTCGATCGCCCGACGCCTTCGGGCGGACAGCGAGGCCGGGCGCACGCGCCAAGACATCGA
CGCGGCGCCGGTCACCTATGGCGATGCGGCACCGGACGCCGTCAACGCACTGCTCGCCTCGAGCGGGGCCGGCACGCTGG
TGCACGGCCACACGCACCATCCCGCGCGCCACACGCACGAAGCGGGCGAGCGCTGGGTGCTGACGGACTGGGACCTCGAT
GGCCGCCATCCGAGGGCCGCCGTGCTCGAACTCGACGGCACCGGCTTCCGCGTGCTGCCGCAGGTCGACTGA

Upstream 100 bases:

>100_bases
TCGTGATCGAGAAAGCCACGATTGTCGAGTAATCGCGCTTAACGTCGATTCGAACGACAGGCGGCATGCCGCTCGTGGTG
AATACAGACATCCGGACCGC

Downstream 100 bases:

>100_bases
CGATGCCTGGCTCGCGCCAATCGCCACGCAGACCGGCGTGCGCCTCCACTACTTCATCAGCTTGCGCAGCTCGCTCGCGT
CGAAGCGGTCGTTCGGCGTG

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MTAPTRTPVAAPIEVQAPAWFISDLHLTADMPRTLAAFHRVLERAARDARTLFILGDFFEFWVGDEETDSPFAAEVAAAL
RRLADAGVPVYLMHGNRDFLLGRRFAARAGASLLPDPSVIVCAGRRVALSHGDMLCTDDERYMRFRRWTRKGWVQRLFLL
LPLGTRLSIARRLRADSEAGRTRQDIDAAPVTYGDAAPDAVNALLASSGAGTLVHGHTHHPARHTHEAGERWVLTDWDLD
GRHPRAAVLELDGTGFRVLPQVD

Sequences:

>Translated_263_residues
MTAPTRTPVAAPIEVQAPAWFISDLHLTADMPRTLAAFHRVLERAARDARTLFILGDFFEFWVGDEETDSPFAAEVAAAL
RRLADAGVPVYLMHGNRDFLLGRRFAARAGASLLPDPSVIVCAGRRVALSHGDMLCTDDERYMRFRRWTRKGWVQRLFLL
LPLGTRLSIARRLRADSEAGRTRQDIDAAPVTYGDAAPDAVNALLASSGAGTLVHGHTHHPARHTHEAGERWVLTDWDLD
GRHPRAAVLELDGTGFRVLPQVD
>Mature_262_residues
TAPTRTPVAAPIEVQAPAWFISDLHLTADMPRTLAAFHRVLERAARDARTLFILGDFFEFWVGDEETDSPFAAEVAAALR
RLADAGVPVYLMHGNRDFLLGRRFAARAGASLLPDPSVIVCAGRRVALSHGDMLCTDDERYMRFRRWTRKGWVQRLFLLL
PLGTRLSIARRLRADSEAGRTRQDIDAAPVTYGDAAPDAVNALLASSGAGTLVHGHTHHPARHTHEAGERWVLTDWDLDG
RHPRAAVLELDGTGFRVLPQVD

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=225, Percent_Identity=44, Blast_Score=182, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: 3.6.1.-

Molecular weight: Translated: 29098; Mature: 28967

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPTRTPVAAPIEVQAPAWFISDLHLTADMPRTLAAFHRVLERAARDARTLFILGDFFE
CCCCCCCCCCCCEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEEEEHHHH
FWVGDEETDSPFAAEVAAALRRLADAGVPVYLMHGNRDFLLGRRFAARAGASLLPDPSVI
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHCCCCCCCCCCEE
VCAGRRVALSHGDMLCTDDERYMRFRRWTRKGWVQRLFLLLPLGTRLSIARRLRADSEAG
EECCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
RTRQDIDAAPVTYGDAAPDAVNALLASSGAGTLVHGHTHHPARHTHEAGERWVLTDWDLD
CCHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCHHHHHCCCEEEEEECCCC
GRHPRAAVLELDGTGFRVLPQVD
CCCCCEEEEEECCCCEEEECCCC
>Mature Secondary Structure 
TAPTRTPVAAPIEVQAPAWFISDLHLTADMPRTLAAFHRVLERAARDARTLFILGDFFE
CCCCCCCCCCCEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEEEEHHHH
FWVGDEETDSPFAAEVAAALRRLADAGVPVYLMHGNRDFLLGRRFAARAGASLLPDPSVI
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHCCCCCCCCCCEE
VCAGRRVALSHGDMLCTDDERYMRFRRWTRKGWVQRLFLLLPLGTRLSIARRLRADSEAG
EECCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
RTRQDIDAAPVTYGDAAPDAVNALLASSGAGTLVHGHTHHPARHTHEAGERWVLTDWDLD
CCHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCHHHHHCCCEEEEEECCCC
GRHPRAAVLELDGTGFRVLPQVD
CCCCCEEEEEECCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]