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The map label for this gene is comA [H]

Identifier: 94309988

GI number: 94309988

Start: 1133224

End: 1135779

Strand: Direct

Name: comA [H]

Synonym: Rmet_1043

Alternate gene names: 94309988

Gene position: 1133224-1135779 (Clockwise)

Preceding gene: 94309987

Following gene: 94309990

Centisome position: 28.85

GC content: 67.64

Gene sequence:

>2556_bases
ATGCGTGCAGTGCTGCTCGCGTTCGTGGTGGGCTGCTGGTGGTTGCAGCAGCAGGCGGCACTGCCGGGGCCATGGGATTG
GGTCGTTTGGGGGTGTTTTGCGCTGGTTGGACTGTTTGGGGTTTGGGGGGTGCGCGGGCGTGGGGCGCGGTGGGTAGTCT
GGGCTCGATGGTTGGTGAGCCTGTCAATCGCGGCAATCGTGGGGTTGGGTTGGTCGGCGTGGCGGGCGGACATGCGGCTC
GGTGCCTGGCTGGACCCGTCACTGGCAGGGCGTGATCAAATCATCGACGGTGTTGTCAGCGGATTGCCGGACGCGGCCCC
GCACGGCACGCGGTTCCTGTTCACGGTGGAGAGCGGGGCGTCGGGTGGCGTGGCGATGGGAGATCGCCACGCAGGGGTGG
CGCCACTGTCAACAGCGCCATTGCCGCCCAGGGTATTGCTGACGTGGCGAGATCCGCCGGAGGTGCTGCAGCCCGGCCAG
CGCCATCGGTTGACGGTCCGTCTGCGCAGACCGCGCGGTCTCGCGAATCCGCATGGTTTCGACTATGGCTACTGGCTGCT
TGCCGAAGGCATCGGGGCGACGGGCTATGTACGCCACGGTCAGTTGCTGAATCGTGATGCCGCGATGCCGTTGTCGATCC
GGATCACGCAGTGGCGGGCCGGATTGCGTGACCGCTTGTGGGCGGCGTTGCCATCCGATGCGCAATACCGGGCAGTGCTC
GTCGCGCTGGTGATCGGTGATCAGCGGGGCATTGGGCAGGCGGACTGGGATGTGTTCCGGCGCACCGGCATCTCCCATCT
GGTCAGCATCTCCGGGCTGCACATCACGATGATATCGGGGGCAGTTGCGGCGCTCGCGGGCATGCTTTGGCGCCATTCGT
TCGGCATCGGACGCAAGCTCCGGCGGCCGCTGCCGCTGATCTGGCCCGCGCAGAAGGTGGCGATGGTGGTAGCGGTGCAG
ACGGCGCTCGGCTACGGGCTGATTGCGGGCATGCAGATCCCGGCGCTGCGCACGGTATCGATGCTGATGGTCGCTGCCGT
GGCGCTGTGGAGCGGGCGGATGCCACCGCCGACGGTAGTGCTCGCCTGGGCGGCGGGGATCGCGGTAGCCATCGACCCAT
GGGCGGTGATGTCACCGGGCTTCTGGCTGTCATTTGGCGCGGTGGCGGTGATCTTCCTGGGCGCGCGGGGCGACGGCAGT
GGGGATGGAGGGGCGGTGGAGGAGCGGCAGGCGGATCCGAAAAGCTGTGTGAGCCGCTGTGTGAGCCGCTGGGTGAGTCG
GATTGGCGGCGTGGCTGCCGAGGCGGCGCGCACGCAATGGTCGGTGACTATCGGGCTCGTACCGTTGACGCTTCTGCTGT
TCGGGCAGGTCTCGGTGGTATCCGTGTTCGCCAATGCCGTGGCGATCCCGGTGGTTAGTCTGCTTGTTACGCCGCTGGCG
CTTGCTGGCGCGGTGTTGCCGCCTGGCTGGGCTGCGCCGCTGCTGTGGATCGCCCACAAAGCGCTGGAGTGGTTGGTTGG
GGGACTCGCGTGGCTGGCCGCGCCCGCGTGGGCAGTATGGGAGGCCGCGCACCCGGGTCCGGTGGCGACCGGGCTGGCAT
TGGCTGGTGTCTACGTCCTGCTCATCCCCCGTCCGTCGGATGCGAAAGGTGCCAGGCGAGTGCAGATCGTGCCGCGCTGG
TTGGGCGTGCTGCTGATGGTGCCGATGCTCTCGGCCGGGCCCGAGCCGGTGGAGGAAGGGGAAATGCGTGTGACAGCGCT
CGACGTCGGGCAGGGTGCAGCCGTGCTTGTGGAAACGCGCCGTCACGTGCTGCTCTACGACACTGGGCCTTCGTATGTGT
CGGGTGCCAGCGCAGGTGGTCAGGTGATCGTGCCTTATCTCCGCGCGACCGGGGTGCGGCATCTGGACATGCTGATGGTC
AGCCATGAGCATGACGACCACGCGGGCGGCGTTGAAGCCGTGCTGCAGGCCGTGCCGGTAGCGCGGGGGCTGACGGCGGA
AGGACCTGGGAACAAGCCACTGCCAGGCTTGCTGCAGGGGCGCGCGTGGCAGCCGTGTCTGGATGGCGTTGCGTGGCGTT
GGGATGGCGTGGACTTTGAGGTCCTGCACCCGACGGAAGAGGGTCTGGCGCGCCAGCGCTTGTCGGCCAACGCCCGGAGT
TGTGTGCTCCGCGTGGCAACGGCGCAGCGCAGCCTGCTGCTGACCGGCGACATTGGTGTATCGGAGGAGCGGCGGCTGAT
CGATAGCGAACTAGGTGAGCGATTGCGTGCGGATTTCCTGCTGGTGCCGCATCACGGCAGTGGCACGTCTTCACATGCGG
CATTCCTGCGGGCTGTACAACCCGAAGTGGCGGTGTTTCAGCTTGGCTTCGCGAACCGGCACAGGCATCCGCGTGAAGAT
GTCTGGCGGCGGTACGCGCGTGCGGGCGCGGCGCGGTATCGCACCGATGAAACCGGCGCGGTGTCGATCGTCACGGGCGG
CGGCGACTACGTGGTGACGTCGTTCCGTCAGCAACAGCGCCGTTATTGGCGAGACGCGCCGCCCGCGCCACGGTGA

Upstream 100 bases:

>100_bases
ACCTTCTGACACACCAACGTATCGCTCGGTCACGTTTCCCAGCTGTCAATCGCAGTACAAATAAGCCCTTCAGCAATCAG
ATGCGGGGGCGTGCCTTGCT

Downstream 100 bases:

>100_bases
GCGGCGGGCTTGGTCGTCTTGTTGGCAGGGCTGTCGGACTTAGTCGGGCGACGCGCCGCCCGGCTCGGTTTGATTGACTG
TGATGTCGCCTCGGATGCAG

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 851; Mature: 851

Protein sequence:

>851_residues
MRAVLLAFVVGCWWLQQQAALPGPWDWVVWGCFALVGLFGVWGVRGRGARWVVWARWLVSLSIAAIVGLGWSAWRADMRL
GAWLDPSLAGRDQIIDGVVSGLPDAAPHGTRFLFTVESGASGGVAMGDRHAGVAPLSTAPLPPRVLLTWRDPPEVLQPGQ
RHRLTVRLRRPRGLANPHGFDYGYWLLAEGIGATGYVRHGQLLNRDAAMPLSIRITQWRAGLRDRLWAALPSDAQYRAVL
VALVIGDQRGIGQADWDVFRRTGISHLVSISGLHITMISGAVAALAGMLWRHSFGIGRKLRRPLPLIWPAQKVAMVVAVQ
TALGYGLIAGMQIPALRTVSMLMVAAVALWSGRMPPPTVVLAWAAGIAVAIDPWAVMSPGFWLSFGAVAVIFLGARGDGS
GDGGAVEERQADPKSCVSRCVSRWVSRIGGVAAEAARTQWSVTIGLVPLTLLLFGQVSVVSVFANAVAIPVVSLLVTPLA
LAGAVLPPGWAAPLLWIAHKALEWLVGGLAWLAAPAWAVWEAAHPGPVATGLALAGVYVLLIPRPSDAKGARRVQIVPRW
LGVLLMVPMLSAGPEPVEEGEMRVTALDVGQGAAVLVETRRHVLLYDTGPSYVSGASAGGQVIVPYLRATGVRHLDMLMV
SHEHDDHAGGVEAVLQAVPVARGLTAEGPGNKPLPGLLQGRAWQPCLDGVAWRWDGVDFEVLHPTEEGLARQRLSANARS
CVLRVATAQRSLLLTGDIGVSEERRLIDSELGERLRADFLLVPHHGSGTSSHAAFLRAVQPEVAVFQLGFANRHRHPRED
VWRRYARAGAARYRTDETGAVSIVTGGGDYVVTSFRQQQRRYWRDAPPAPR

Sequences:

>Translated_851_residues
MRAVLLAFVVGCWWLQQQAALPGPWDWVVWGCFALVGLFGVWGVRGRGARWVVWARWLVSLSIAAIVGLGWSAWRADMRL
GAWLDPSLAGRDQIIDGVVSGLPDAAPHGTRFLFTVESGASGGVAMGDRHAGVAPLSTAPLPPRVLLTWRDPPEVLQPGQ
RHRLTVRLRRPRGLANPHGFDYGYWLLAEGIGATGYVRHGQLLNRDAAMPLSIRITQWRAGLRDRLWAALPSDAQYRAVL
VALVIGDQRGIGQADWDVFRRTGISHLVSISGLHITMISGAVAALAGMLWRHSFGIGRKLRRPLPLIWPAQKVAMVVAVQ
TALGYGLIAGMQIPALRTVSMLMVAAVALWSGRMPPPTVVLAWAAGIAVAIDPWAVMSPGFWLSFGAVAVIFLGARGDGS
GDGGAVEERQADPKSCVSRCVSRWVSRIGGVAAEAARTQWSVTIGLVPLTLLLFGQVSVVSVFANAVAIPVVSLLVTPLA
LAGAVLPPGWAAPLLWIAHKALEWLVGGLAWLAAPAWAVWEAAHPGPVATGLALAGVYVLLIPRPSDAKGARRVQIVPRW
LGVLLMVPMLSAGPEPVEEGEMRVTALDVGQGAAVLVETRRHVLLYDTGPSYVSGASAGGQVIVPYLRATGVRHLDMLMV
SHEHDDHAGGVEAVLQAVPVARGLTAEGPGNKPLPGLLQGRAWQPCLDGVAWRWDGVDFEVLHPTEEGLARQRLSANARS
CVLRVATAQRSLLLTGDIGVSEERRLIDSELGERLRADFLLVPHHGSGTSSHAAFLRAVQPEVAVFQLGFANRHRHPRED
VWRRYARAGAARYRTDETGAVSIVTGGGDYVVTSFRQQQRRYWRDAPPAPR
>Mature_851_residues
MRAVLLAFVVGCWWLQQQAALPGPWDWVVWGCFALVGLFGVWGVRGRGARWVVWARWLVSLSIAAIVGLGWSAWRADMRL
GAWLDPSLAGRDQIIDGVVSGLPDAAPHGTRFLFTVESGASGGVAMGDRHAGVAPLSTAPLPPRVLLTWRDPPEVLQPGQ
RHRLTVRLRRPRGLANPHGFDYGYWLLAEGIGATGYVRHGQLLNRDAAMPLSIRITQWRAGLRDRLWAALPSDAQYRAVL
VALVIGDQRGIGQADWDVFRRTGISHLVSISGLHITMISGAVAALAGMLWRHSFGIGRKLRRPLPLIWPAQKVAMVVAVQ
TALGYGLIAGMQIPALRTVSMLMVAAVALWSGRMPPPTVVLAWAAGIAVAIDPWAVMSPGFWLSFGAVAVIFLGARGDGS
GDGGAVEERQADPKSCVSRCVSRWVSRIGGVAAEAARTQWSVTIGLVPLTLLLFGQVSVVSVFANAVAIPVVSLLVTPLA
LAGAVLPPGWAAPLLWIAHKALEWLVGGLAWLAAPAWAVWEAAHPGPVATGLALAGVYVLLIPRPSDAKGARRVQIVPRW
LGVLLMVPMLSAGPEPVEEGEMRVTALDVGQGAAVLVETRRHVLLYDTGPSYVSGASAGGQVIVPYLRATGVRHLDMLMV
SHEHDDHAGGVEAVLQAVPVARGLTAEGPGNKPLPGLLQGRAWQPCLDGVAWRWDGVDFEVLHPTEEGLARQRLSANARS
CVLRVATAQRSLLLTGDIGVSEERRLIDSELGERLRADFLLVPHHGSGTSSHAAFLRAVQPEVAVFQLGFANRHRHPRED
VWRRYARAGAARYRTDETGAVSIVTGGGDYVVTSFRQQQRRYWRDAPPAPR

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=693, Percent_Identity=27.7056277056277, Blast_Score=191, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 91526; Mature: 91526

Theoretical pI: Translated: 10.59; Mature: 10.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVLLAFVVGCWWLQQQAALPGPWDWVVWGCFALVGLFGVWGVRGRGARWVVWARWLVS
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LSIAAIVGLGWSAWRADMRLGAWLDPSLAGRDQIIDGVVSGLPDAAPHGTRFLFTVESGA
HHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
SGGVAMGDRHAGVAPLSTAPLPPRVLLTWRDPPEVLQPGQRHRLTVRLRRPRGLANPHGF
CCCCEECCCCCCCCCCCCCCCCCEEEEEECCCHHHHCCCCCCEEEEEEECCCCCCCCCCC
DYGYWLLAEGIGATGYVRHGQLLNRDAAMPLSIRITQWRAGLRDRLWAALPSDAQYRAVL
CCHHEEEECCCCCCCEEECCHHHCCCCCCCEEEEEHHHHCCHHHHHHHCCCCCCHHHEEE
VALVIGDQRGIGQADWDVFRRTGISHLVSISGLHITMISGAVAALAGMLWRHSFGIGRKL
EEEEECCCCCCCCHHHHHHHHHCHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHCCCHHH
RRPLPLIWPAQKVAMVVAVQTALGYGLIAGMQIPALRTVSMLMVAAVALWSGRMPPPTVV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
LAWAAGIAVAIDPWAVMSPGFWLSFGAVAVIFLGARGDGSGDGGAVEERQADPKSCVSRC
EEECCCEEEEECCHHHCCCCHHHHHHHEEEEEEECCCCCCCCCCCCCHHCCCHHHHHHHH
VSRWVSRIGGVAAEAARTQWSVTIGLVPLTLLLFGQVSVVSVFANAVAIPVVSLLVTPLA
HHHHHHHHCCHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAGAVLPPGWAAPLLWIAHKALEWLVGGLAWLAAPAWAVWEAAHPGPVATGLALAGVYVL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHCEEEE
LIPRPSDAKGARRVQIVPRWLGVLLMVPMLSAGPEPVEEGEMRVTALDVGQGAAVLVETR
EEECCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEECC
RHVLLYDTGPSYVSGASAGGQVIVPYLRATGVRHLDMLMVSHEHDDHAGGVEAVLQAVPV
CEEEEEECCCCCCCCCCCCCCEEEEHHHHCCCHHHHHHHEECCCCCCCCHHHHHHHHHHH
ARGLTAEGPGNKPLPGLLQGRAWQPCLDGVAWRWDGVDFEVLHPTEEGLARQRLSANARS
HCCCCCCCCCCCCCCHHHCCCCCCHHHCCCEEEECCCCEEEECCCHHHHHHHHHHCCHHH
CVLRVATAQRSLLLTGDIGVSEERRLIDSELGERLRADFLLVPHHGSGTSSHAAFLRAVQ
HHEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCC
PEVAVFQLGFANRHRHPREDVWRRYARAGAARYRTDETGAVSIVTGGGDYVVTSFRQQQR
CCEEEEEECCHHCCCCCHHHHHHHHHHHCHHHCCCCCCCEEEEEECCCCEEEHHHHHHHH
RYWRDAPPAPR
HHHCCCCCCCC
>Mature Secondary Structure
MRAVLLAFVVGCWWLQQQAALPGPWDWVVWGCFALVGLFGVWGVRGRGARWVVWARWLVS
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LSIAAIVGLGWSAWRADMRLGAWLDPSLAGRDQIIDGVVSGLPDAAPHGTRFLFTVESGA
HHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
SGGVAMGDRHAGVAPLSTAPLPPRVLLTWRDPPEVLQPGQRHRLTVRLRRPRGLANPHGF
CCCCEECCCCCCCCCCCCCCCCCEEEEEECCCHHHHCCCCCCEEEEEEECCCCCCCCCCC
DYGYWLLAEGIGATGYVRHGQLLNRDAAMPLSIRITQWRAGLRDRLWAALPSDAQYRAVL
CCHHEEEECCCCCCCEEECCHHHCCCCCCCEEEEEHHHHCCHHHHHHHCCCCCCHHHEEE
VALVIGDQRGIGQADWDVFRRTGISHLVSISGLHITMISGAVAALAGMLWRHSFGIGRKL
EEEEECCCCCCCCHHHHHHHHHCHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHCCCHHH
RRPLPLIWPAQKVAMVVAVQTALGYGLIAGMQIPALRTVSMLMVAAVALWSGRMPPPTVV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
LAWAAGIAVAIDPWAVMSPGFWLSFGAVAVIFLGARGDGSGDGGAVEERQADPKSCVSRC
EEECCCEEEEECCHHHCCCCHHHHHHHEEEEEEECCCCCCCCCCCCCHHCCCHHHHHHHH
VSRWVSRIGGVAAEAARTQWSVTIGLVPLTLLLFGQVSVVSVFANAVAIPVVSLLVTPLA
HHHHHHHHCCHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAGAVLPPGWAAPLLWIAHKALEWLVGGLAWLAAPAWAVWEAAHPGPVATGLALAGVYVL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHCEEEE
LIPRPSDAKGARRVQIVPRWLGVLLMVPMLSAGPEPVEEGEMRVTALDVGQGAAVLVETR
EEECCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEECC
RHVLLYDTGPSYVSGASAGGQVIVPYLRATGVRHLDMLMVSHEHDDHAGGVEAVLQAVPV
CEEEEEECCCCCCCCCCCCCCEEEEHHHHCCCHHHHHHHEECCCCCCCCHHHHHHHHHHH
ARGLTAEGPGNKPLPGLLQGRAWQPCLDGVAWRWDGVDFEVLHPTEEGLARQRLSANARS
HCCCCCCCCCCCCCCHHHCCCCCCHHHCCCEEEECCCCEEEECCCHHHHHHHHHHCCHHH
CVLRVATAQRSLLLTGDIGVSEERRLIDSELGERLRADFLLVPHHGSGTSSHAAFLRAVQ
HHEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCC
PEVAVFQLGFANRHRHPREDVWRRYARAGAARYRTDETGAVSIVTGGGDYVVTSFRQQQR
CCEEEEEECCHHCCCCCHHHHHHHHHHHCHHHCCCCCCCEEEEEECCCCEEEHHHHHHHH
RYWRDAPPAPR
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]