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The map label for this gene is edd [H]

Identifier: 94309990

GI number: 94309990

Start: 1137061

End: 1138950

Strand: Direct

Name: edd [H]

Synonym: Rmet_1045

Alternate gene names: 94309990

Gene position: 1137061-1138950 (Clockwise)

Preceding gene: 94309988

Following gene: 94309991

Centisome position: 28.95

GC content: 68.36

Gene sequence:

>1890_bases
ATGTCCCAAGCCGTTCTTGCCGAGGTACTGGCCGTCACGCAACGTATCGTCGACCGCAGTCGCGCCAGCCGGGCGGCCTA
TCTAGCCAGATGCGAGCGCGCCCAGCAGGAACTCGGGCCCTTGCGCGGCATGTCCTGCGCGAACCTTGCCCACGGCTACG
CCGCACTGCCTTCGGACGATAAGCTCAAGCTGCGGGTCGAACATGCCCCGAATCTCGGCATCGTGACCGCCTACAACGAC
ATGCTGTCCGCCCACCAGCCCTATGAGCGTTACCCGGCCGTGATTCGCGAGGCCGCGCGCGCCGTGGGTGGCGTGGCGCA
GGTGGCGGGTGGCGTGCCGGCCATGTGTGACGGGATTACCCAGGGCAACGCCGGCATGGAGTTGTCGTTGTTCTCGCGCG
ATGCGATCGCGATGGGCACGGCCGTTGCGCTGTCGCACAACACGTTCGATGCAGCGCTGATGCTGGGCGTGTGCGACAAG
ATCGTGCCGGGTTTGCTGATGGGGGCGCTGCAGTTTGGCCATCTGCCGATCGTGTTCGCCCCGGCCGGGCCGATGGCAAC
GGGCCTGTCGAACAAGGAAAAGGCGCGTGTGCGCCAGCTCTATGCCACCGGGCAGGTCGGGCGCGATGCGTTGCTGGAGG
CCGAATGCGCCGCCTATCACGGCGCGGGTACCTGCACCTTCTATGGCACCGCCAATAGCAACCAGTTCCTGATGGAGATC
ATGGGCCTGCACATGCCCGGCTCGGCGTTCGTGCATCCGGACAGCGGCCTGCGTGACCCGCTCACCGCCGCGGCAGCCCA
GCGGGCGCTGGCCCTGATCGCTCGCGGTGACGCCTATACCCCGCTGGCGAAGATTGTCGACGAACGGGCGATCGTCAACG
CGATGGTTGGCCTGCTGGCCACTGGCGGCTCGACCAACCACACGATTCACCTGGTGGCGATGGCGCGCGCCGCCGGCATC
CTGATCGACTGGAACGATTTCGACTGCCTGTCAGCGATCACGCCATTGCTGGCGCGTGTGTATCCGAATGGCTCGGCCGA
TGTGAACCATTTCCACGCAGCGGGCGGCGTGGCCTATGTGATTGCCCAACTGCTCGACGCCGGTCTGCTGCACGAGGACG
TGCAGACCGTGGCGGGCCCCGGCCTGAAGCGCTACACCGAGGAGCCGGTCATGAACGATGGCGTGCTGCGCTGGCGGGCT
GGCCCGGCCACGAGCGGGGATGAGTCGGTGCTGGCGCCAGCGTCGGCGCCGTTCTCACCCGAGGGGGGGCTGCGGCTGAT
GGCGGGCAACGTGGGGCGCGGGGTGATCAAGGTCTCGGCCGTGGCCGACGAGCACCGAGTGGTCGAGGCGCCGGCGCGAG
TCTTCGATTCGCAGGAAGCGCTGCAGGCCGCCTTCGAGGCAGGCGAACTTGATCGTGACGTAGTGGCCGTGGTGCGCTTC
CAGGGCCCGAATGCCAATGGCATGCCCGAGTTGCACCGGCTTACCCCCGCGCTTGGCGCGCTGCAGGATGCCGGACGCAA
GGTCGCGCTGGTAACCGATGGCCGCATGTCGGGCGCGTCGGGCAAGGTGCCCGCCGTGATCCATGTCGGGCCGGAGGCGC
TGGCAGGCGGGCCGCTGGCTCGGGTGCGCGACGGCGACGTCATTCGCGTGGACGCATTGGCGGGCACGCTCGATCTGGTG
GGTGATGCTGCCACCCAGGCTGACTTTGCCGGGCGAGTGCCGGCAGCGGCGCCAGTCGACGAATTCACCCGTTTCAGCAT
GGGCCGGGGCCTGTTCGGCCTGTTCCGCCGCCATGCGCGGGCCGCCGAGGAGGGGGGCAGCGCGCTGGACCTGTCCGAAG
CCGATGCTCTGGCACCCGCTGTCCAAACGGCGTCCGCCGTCGCACAATAG

Upstream 100 bases:

>100_bases
CTGTCTTCCGGTAGCGTGAATCTCATGGATATAATGTAGAAATTCTACATGCCGAGCGTCCAATGGATGCCTCGGTTTCC
CCACCAGGAAGAACTCCAAC

Downstream 100 bases:

>100_bases
GCGGGCCGTCAGGCGGCGCTCGCGCCAATCATTCCGTTTCTCTTGCGTACTCTTCCGGGGTGCCCGGCAGCACGCGCTGC
ACCCCGGAAGCACCTTCGCG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 629; Mature: 628

Protein sequence:

>629_residues
MSQAVLAEVLAVTQRIVDRSRASRAAYLARCERAQQELGPLRGMSCANLAHGYAALPSDDKLKLRVEHAPNLGIVTAYND
MLSAHQPYERYPAVIREAARAVGGVAQVAGGVPAMCDGITQGNAGMELSLFSRDAIAMGTAVALSHNTFDAALMLGVCDK
IVPGLLMGALQFGHLPIVFAPAGPMATGLSNKEKARVRQLYATGQVGRDALLEAECAAYHGAGTCTFYGTANSNQFLMEI
MGLHMPGSAFVHPDSGLRDPLTAAAAQRALALIARGDAYTPLAKIVDERAIVNAMVGLLATGGSTNHTIHLVAMARAAGI
LIDWNDFDCLSAITPLLARVYPNGSADVNHFHAAGGVAYVIAQLLDAGLLHEDVQTVAGPGLKRYTEEPVMNDGVLRWRA
GPATSGDESVLAPASAPFSPEGGLRLMAGNVGRGVIKVSAVADEHRVVEAPARVFDSQEALQAAFEAGELDRDVVAVVRF
QGPNANGMPELHRLTPALGALQDAGRKVALVTDGRMSGASGKVPAVIHVGPEALAGGPLARVRDGDVIRVDALAGTLDLV
GDAATQADFAGRVPAAAPVDEFTRFSMGRGLFGLFRRHARAAEEGGSALDLSEADALAPAVQTASAVAQ

Sequences:

>Translated_629_residues
MSQAVLAEVLAVTQRIVDRSRASRAAYLARCERAQQELGPLRGMSCANLAHGYAALPSDDKLKLRVEHAPNLGIVTAYND
MLSAHQPYERYPAVIREAARAVGGVAQVAGGVPAMCDGITQGNAGMELSLFSRDAIAMGTAVALSHNTFDAALMLGVCDK
IVPGLLMGALQFGHLPIVFAPAGPMATGLSNKEKARVRQLYATGQVGRDALLEAECAAYHGAGTCTFYGTANSNQFLMEI
MGLHMPGSAFVHPDSGLRDPLTAAAAQRALALIARGDAYTPLAKIVDERAIVNAMVGLLATGGSTNHTIHLVAMARAAGI
LIDWNDFDCLSAITPLLARVYPNGSADVNHFHAAGGVAYVIAQLLDAGLLHEDVQTVAGPGLKRYTEEPVMNDGVLRWRA
GPATSGDESVLAPASAPFSPEGGLRLMAGNVGRGVIKVSAVADEHRVVEAPARVFDSQEALQAAFEAGELDRDVVAVVRF
QGPNANGMPELHRLTPALGALQDAGRKVALVTDGRMSGASGKVPAVIHVGPEALAGGPLARVRDGDVIRVDALAGTLDLV
GDAATQADFAGRVPAAAPVDEFTRFSMGRGLFGLFRRHARAAEEGGSALDLSEADALAPAVQTASAVAQ
>Mature_628_residues
SQAVLAEVLAVTQRIVDRSRASRAAYLARCERAQQELGPLRGMSCANLAHGYAALPSDDKLKLRVEHAPNLGIVTAYNDM
LSAHQPYERYPAVIREAARAVGGVAQVAGGVPAMCDGITQGNAGMELSLFSRDAIAMGTAVALSHNTFDAALMLGVCDKI
VPGLLMGALQFGHLPIVFAPAGPMATGLSNKEKARVRQLYATGQVGRDALLEAECAAYHGAGTCTFYGTANSNQFLMEIM
GLHMPGSAFVHPDSGLRDPLTAAAAQRALALIARGDAYTPLAKIVDERAIVNAMVGLLATGGSTNHTIHLVAMARAAGIL
IDWNDFDCLSAITPLLARVYPNGSADVNHFHAAGGVAYVIAQLLDAGLLHEDVQTVAGPGLKRYTEEPVMNDGVLRWRAG
PATSGDESVLAPASAPFSPEGGLRLMAGNVGRGVIKVSAVADEHRVVEAPARVFDSQEALQAAFEAGELDRDVVAVVRFQ
GPNANGMPELHRLTPALGALQDAGRKVALVTDGRMSGASGKVPAVIHVGPEALAGGPLARVRDGDVIRVDALAGTLDLVG
DAATQADFAGRVPAAAPVDEFTRFSMGRGLFGLFRRHARAAEEGGSALDLSEADALAPAVQTASAVAQ

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=604, Percent_Identity=59.1059602649007, Blast_Score=723, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=521, Percent_Identity=30.9021113243762, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI2367371, Length=473, Percent_Identity=31.9238900634249, Blast_Score=162, Evalue=7e-41,
Organism=Escherichia coli, GI1786464, Length=478, Percent_Identity=31.3807531380753, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322476, Length=500, Percent_Identity=29.2, Blast_Score=175, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65362; Mature: 65231

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00136 SUBTILASE_ASP ; PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAVLAEVLAVTQRIVDRSRASRAAYLARCERAQQELGPLRGMSCANLAHGYAALPSDD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEECCCCC
KLKLRVEHAPNLGIVTAYNDMLSAHQPYERYPAVIREAARAVGGVAQVAGGVPAMCDGIT
CEEEEEECCCCCCEEEECHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCHHHCCCC
QGNAGMELSLFSRDAIAMGTAVALSHNTFDAALMLGVCDKIVPGLLMGALQFGHLPIVFA
CCCCCCEEEEECCCHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
PAGPMATGLSNKEKARVRQLYATGQVGRDALLEAECAAYHGAGTCTFYGTANSNQFLMEI
CCCCHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
MGLHMPGSAFVHPDSGLRDPLTAAAAQRALALIARGDAYTPLAKIVDERAIVNAMVGLLA
HCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
TGGSTNHTIHLVAMARAAGILIDWNDFDCLSAITPLLARVYPNGSADVNHFHAAGGVAYV
CCCCCCCEEEEEEEHHHCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHH
IAQLLDAGLLHEDVQTVAGPGLKRYTEEPVMNDGVLRWRAGPATSGDESVLAPASAPFSP
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEECCCCCCCCCCEECCCCCCCCC
EGGLRLMAGNVGRGVIKVSAVADEHRVVEAPARVFDSQEALQAAFEAGELDRDVVAVVRF
CCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEEEEE
QGPNANGMPELHRLTPALGALQDAGRKVALVTDGRMSGASGKVPAVIHVGPEALAGGPLA
ECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECHHHHCCCCCC
RVRDGDVIRVDALAGTLDLVGDAATQADFAGRVPAAAPVDEFTRFSMGRGLFGLFRRHAR
EECCCCEEEEEEHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
AAEEGGSALDLSEADALAPAVQTASAVAQ
HHHCCCCEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQAVLAEVLAVTQRIVDRSRASRAAYLARCERAQQELGPLRGMSCANLAHGYAALPSDD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEECCCCC
KLKLRVEHAPNLGIVTAYNDMLSAHQPYERYPAVIREAARAVGGVAQVAGGVPAMCDGIT
CEEEEEECCCCCCEEEECHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCHHHCCCC
QGNAGMELSLFSRDAIAMGTAVALSHNTFDAALMLGVCDKIVPGLLMGALQFGHLPIVFA
CCCCCCEEEEECCCHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
PAGPMATGLSNKEKARVRQLYATGQVGRDALLEAECAAYHGAGTCTFYGTANSNQFLMEI
CCCCHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
MGLHMPGSAFVHPDSGLRDPLTAAAAQRALALIARGDAYTPLAKIVDERAIVNAMVGLLA
HCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
TGGSTNHTIHLVAMARAAGILIDWNDFDCLSAITPLLARVYPNGSADVNHFHAAGGVAYV
CCCCCCCEEEEEEEHHHCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHH
IAQLLDAGLLHEDVQTVAGPGLKRYTEEPVMNDGVLRWRAGPATSGDESVLAPASAPFSP
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEECCCCCCCCCCEECCCCCCCCC
EGGLRLMAGNVGRGVIKVSAVADEHRVVEAPARVFDSQEALQAAFEAGELDRDVVAVVRF
CCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEEEEE
QGPNANGMPELHRLTPALGALQDAGRKVALVTDGRMSGASGKVPAVIHVGPEALAGGPLA
ECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECHHHHCCCCCC
RVRDGDVIRVDALAGTLDLVGDAATQADFAGRVPAAAPVDEFTRFSMGRGLFGLFRRHAR
EECCCCEEEEEEHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
AAEEGGSALDLSEADALAPAVQTASAVAQ
HHHCCCCEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]