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The map label for this gene is hemH

Identifier: 94309946

GI number: 94309946

Start: 1093215

End: 1094330

Strand: Direct

Name: hemH

Synonym: Rmet_1001

Alternate gene names: 94309946

Gene position: 1093215-1094330 (Clockwise)

Preceding gene: 94309945

Following gene: 94309947

Centisome position: 27.83

GC content: 64.34

Gene sequence:

>1116_bases
ATGACGTTTTCGCCTGAACCGGCACACCAGCACGGCCAGCCGCCGCGCACCGCGATCCTGCTGATCAACCTCGGCACCCC
GGACGCGCCCACGCCTAAGGCGGTGGGGCGCTACCTGAAGGCGTTCCTGTCCGACCCGCGCGTGGTAGAGATCCCGCGCC
TGGCCTGGCTGCCGATCCTGCACGGCCTGATCCTGCCGTTCCGCTCGCGGGCGTCGGCCATGAAGTACGAGTCGATCTGG
CTGCGCGAGGCGCATATGACCGGGTCGCCGCTACTTGTGTATACAGAGCGCCAAGCTCATGCGCTGCAACTGTTGATGCA
GCAGCAGGGTCACGACGTAACGGTGGCCTGTGCGATGCGCTATGGCAATCCGTCGATCGAATCGGTCATGGAAGCGCTGC
GCCGGCAGGGTACCGAACAGATCCTGTTGCTGCCGCTGTATCCGCAGTTCTCCGGCACGACCACGGCCACCGCTTTCGAC
GAGGCATTTCGTGTCCTGTCGACATGGCGCAACCAGCCCGAGTTACGGCTGGTCAAGCATTTCCACGATCACCCGGCGTA
TATCTCTGCGCTGCACAAGCAGGTGGGCGGCTATTGGGCCCAGCATGGCAAGCCGGACTTCGCGCGCGGTGACAAGCTGA
TTCTGTCGTTCCACGGCCTTCCGCGCCGGTTGCTGGACCTGGGTGATCCCTATCACTGCGAGTGTCTGAAGACCGGTCGT
CTGCTCGGCGAGGCGCTGGGCTTGCAGCCCGGCCAGTTTCAGGTGACGTTTCAGTCTCGCTTTGGCAAGGCGGAGTGGTT
ACAGCCCTACACGGCGCCGACGCTGGCCGAACTGGGCAAGGTCGGGACACAGCGCGTGGACGTGTTCTGTCCCGGCTTTC
CGGCCGACTGCATCGAGACGCTCGAGGAGATCGCGATGGAGGGGCAGTCGGAATTCCGCTTGGCCGGCGGCCAGGATTTC
CATTTCATCCCGTGCCTCAACGATGCCGAGGCGTGGATCGCCGGATTGGCGGATATTGCATTGCAGCATTTGCAGGGGTG
GCCGCTCAATGTTCCACATCCCCACGAACTGGAAGCGAGACGCTCCCGCGCGCAGGCGCGTGGCGCGGGAGCCTGA

Upstream 100 bases:

>100_bases
ATTGACACGGTGGACGTGTCTGTCCTGAGTCGGCCGCCTGCAACGGCTTGCGGCCGGCCCCAGATTCGCCAGCGCCCCCG
GCAGTCCCAACGGAAACCCT

Downstream 100 bases:

>100_bases
GGCCGTAACGGCAGTCACGGGCGGCCACGGCTAGTAACGGACGGTAATCATGCAAGTCGATTTCGAACCCGATGCGCGGC
TGCGCATCGACAAATGGCTC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MTFSPEPAHQHGQPPRTAILLINLGTPDAPTPKAVGRYLKAFLSDPRVVEIPRLAWLPILHGLILPFRSRASAMKYESIW
LREAHMTGSPLLVYTERQAHALQLLMQQQGHDVTVACAMRYGNPSIESVMEALRRQGTEQILLLPLYPQFSGTTTATAFD
EAFRVLSTWRNQPELRLVKHFHDHPAYISALHKQVGGYWAQHGKPDFARGDKLILSFHGLPRRLLDLGDPYHCECLKTGR
LLGEALGLQPGQFQVTFQSRFGKAEWLQPYTAPTLAELGKVGTQRVDVFCPGFPADCIETLEEIAMEGQSEFRLAGGQDF
HFIPCLNDAEAWIAGLADIALQHLQGWPLNVPHPHELEARRSRAQARGAGA

Sequences:

>Translated_371_residues
MTFSPEPAHQHGQPPRTAILLINLGTPDAPTPKAVGRYLKAFLSDPRVVEIPRLAWLPILHGLILPFRSRASAMKYESIW
LREAHMTGSPLLVYTERQAHALQLLMQQQGHDVTVACAMRYGNPSIESVMEALRRQGTEQILLLPLYPQFSGTTTATAFD
EAFRVLSTWRNQPELRLVKHFHDHPAYISALHKQVGGYWAQHGKPDFARGDKLILSFHGLPRRLLDLGDPYHCECLKTGR
LLGEALGLQPGQFQVTFQSRFGKAEWLQPYTAPTLAELGKVGTQRVDVFCPGFPADCIETLEEIAMEGQSEFRLAGGQDF
HFIPCLNDAEAWIAGLADIALQHLQGWPLNVPHPHELEARRSRAQARGAGA
>Mature_370_residues
TFSPEPAHQHGQPPRTAILLINLGTPDAPTPKAVGRYLKAFLSDPRVVEIPRLAWLPILHGLILPFRSRASAMKYESIWL
REAHMTGSPLLVYTERQAHALQLLMQQQGHDVTVACAMRYGNPSIESVMEALRRQGTEQILLLPLYPQFSGTTTATAFDE
AFRVLSTWRNQPELRLVKHFHDHPAYISALHKQVGGYWAQHGKPDFARGDKLILSFHGLPRRLLDLGDPYHCECLKTGRL
LGEALGLQPGQFQVTFQSRFGKAEWLQPYTAPTLAELGKVGTQRVDVFCPGFPADCIETLEEIAMEGQSEFRLAGGQDFH
FIPCLNDAEAWIAGLADIALQHLQGWPLNVPHPHELEARRSRAQARGAGA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=349, Percent_Identity=24.3553008595989, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI60499025, Length=349, Percent_Identity=24.3553008595989, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1786681, Length=325, Percent_Identity=45.8461538461538, Blast_Score=278, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6324750, Length=358, Percent_Identity=24.0223463687151, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17864156, Length=346, Percent_Identity=25.4335260115607, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24651774, Length=271, Percent_Identity=26.9372693726937, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_RALME (Q1LPN9)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_583156.1
- ProteinModelPortal:   Q1LPN9
- SMR:   Q1LPN9
- STRING:   Q1LPN9
- GeneID:   4037798
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_1001
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- PhylomeDB:   Q1LPN9
- ProtClustDB:   PRK00035
- BioCyc:   RMET266264:RMET_1001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 41404; Mature: 41273

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFSPEPAHQHGQPPRTAILLINLGTPDAPTPKAVGRYLKAFLSDPRVVEIPRLAWLPIL
CCCCCCCCHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHH
HGLILPFRSRASAMKYESIWLREAHMTGSPLLVYTERQAHALQLLMQQQGHDVTVACAMR
HHHHHHHHHHHHHHHHHHHHEEHHCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEEE
YGNPSIESVMEALRRQGTEQILLLPLYPQFSGTTTATAFDEAFRVLSTWRNQPELRLVKH
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
FHDHPAYISALHKQVGGYWAQHGKPDFARGDKLILSFHGLPRRLLDLGDPYHCECLKTGR
HCCCHHHHHHHHHHHCCHHHHCCCCCCCCCCEEEEEECCCHHHHHHCCCCCCHHHHHHHH
LLGEALGLQPGQFQVTFQSRFGKAEWLQPYTAPTLAELGKVGTQRVDVFCPGFPADCIET
HHHHHHCCCCCCEEEEEHHCCCCHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHH
LEEIAMEGQSEFRLAGGQDFHFIPCLNDAEAWIAGLADIALQHLQGWPLNVPHPHELEAR
HHHHHHCCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
RSRAQARGAGA
HHHHHHCCCCC
>Mature Secondary Structure 
TFSPEPAHQHGQPPRTAILLINLGTPDAPTPKAVGRYLKAFLSDPRVVEIPRLAWLPIL
CCCCCCCHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHH
HGLILPFRSRASAMKYESIWLREAHMTGSPLLVYTERQAHALQLLMQQQGHDVTVACAMR
HHHHHHHHHHHHHHHHHHHHEEHHCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEEE
YGNPSIESVMEALRRQGTEQILLLPLYPQFSGTTTATAFDEAFRVLSTWRNQPELRLVKH
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
FHDHPAYISALHKQVGGYWAQHGKPDFARGDKLILSFHGLPRRLLDLGDPYHCECLKTGR
HCCCHHHHHHHHHHHCCHHHHCCCCCCCCCCEEEEEECCCHHHHHHCCCCCCHHHHHHHH
LLGEALGLQPGQFQVTFQSRFGKAEWLQPYTAPTLAELGKVGTQRVDVFCPGFPADCIET
HHHHHHCCCCCCEEEEEHHCCCCHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHH
LEEIAMEGQSEFRLAGGQDFHFIPCLNDAEAWIAGLADIALQHLQGWPLNVPHPHELEAR
HHHHHHCCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
RSRAQARGAGA
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA