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The map label for this gene is ggt [H]

Identifier: 94309915

GI number: 94309915

Start: 1054235

End: 1056196

Strand: Direct

Name: ggt [H]

Synonym: Rmet_0970

Alternate gene names: 94309915

Gene position: 1054235-1056196 (Clockwise)

Preceding gene: 94309914

Following gene: 94309920

Centisome position: 26.84

GC content: 66.87

Gene sequence:

>1962_bases
ATGGCTGACACACTCATAGCGACTTCAACAGGATCTTCCGCGCAATCTGTCGCGCAGCGTGCCGCGAACCGGCACTGGCG
CGGCGCGCTGGCCGGGGCGATGGTTTCCCTGCTGGCCGCGTCGCTATCAGGCTGCGGCACGGTGGACAAGGAGGCGGGGA
CGTCCGCCGCATCGACCGACCCGGCCACGGGGACGGTGCCGGCGTCTACCGGGGCCGTGGCGTCAGCCGGGTTGCCGCCC
GCCGCCGAAGTTGCCTCGGGCTACCGCCCGGGGATGACCACGACCTATGCGCAGAAGCATATGGCCGCGGCCGCGAATCC
ACTGGCCACGGAGGCAGGTCGCGAGATGCTGCGTGCTGGCGGGTCGGCCATCGATGCCGCCGTGGCGATGCAGGCAGTGC
TGACGCTGGTCGAGCCACAGGCTTCCGGGATCGGTGGCGGCGCCTTCATCATGTACTGGGACGGCAAGCGCGTGCAGACC
TATGACGGCCGCGAAACGGCACCCGCTGGCGCCACCGAGAACCTGTTCATGCGTGCCGATGGCAAGCCGATGGAGTTCTC
GGCGGGGCAGATCGGTGGGCGCTCGGTCGGCGTGCCGGGTGTATTGCGCGCGCTGGAGCTCGCGCATCGCCAGCACGGCC
GCTTGCCGTGGGCACGCCTGTTCGAGCCAGCCATCGCGCTGGCCGACAAGGGCTTTCCGATCTCGCAGCGCCTCTATACG
CAGGTTGCCGCAGACAAGTTTCTGACCGGCTCCCCCGAGATGAAGGCGTATTTCCTCGACGATCAGGGCAAGCCGAAGCC
GGTCGGCACGCTGGTCAGGAATCCGCAGCTCGCGCAGACATTGAGGGAGATCGCCAGACACGGGCCGAACGTGTTCTACA
ACGGCCCCATCGCGCATGACATCGTGGCCAAGGTCAACGCTCATGCGAATCCTGGCAGCCTGTCCGTGGCCGATCTGAAG
GGGTACAAGGCCAAGGAGCGCCCGCCGGTCTGCACGAACTACAAGGCCTGGAAGGTCTGCGGGATGCCGCCGCCTTCGTC
GGGTGGCATCGCTATCGCGCAGATTCTCGGCAACCTCGAAGCACTCGAAAAGCGCGATCCGCGCTACGCGCTGGCAAAGC
TCAAGCCGGCGCAGGTCAATACGCCGGCGGGGTTCGAGGCCAATCCGCTGGCGGTGCACGCCATCTCGGAGGCCGACCGT
CTGGCCTACGCGGACCGTGGGCTCTACGTGGCCGACGCCGATTTCGTGCCTGTAGACGTGGGCGCGCTCGTGAATCCGCA
ATACCTGGCCGAGCGTGCCGAACTGATTGGCGAGAAGAGTATGGGCAAGGCCGAACCGGGCACGCCGCCCGGGGTCAACG
TTGCCTTTGCGCCTGACCGCTCGCCACCGCGCATTTCCACGTCGCAGGTGGCGGCGGTGGATGACCGTGGTGGCGCGTTG
TCGATGACCACGACGGTCGAGTCGTACTTCGGCTCGCACATCATGGTGCGCGGCTTCATGCTGAACAACCAGCTGACCGA
CTTCTCGTTCAACCCGACCGAGAACGGCAAGCCTGTGGCCAATCGGGTGCAGGCTGGCAAGCGGCCGCGCTCGTCGATGG
CGCCGACGCTGGTGTTTGACCGCAAGAGTGGCAGGCTGGTGGCGGCGCTTGGCTCTCCGGGCGGTTCGCAGATCATCGAG
TATGTCTCGAAGACGCTGGTCGGCCTGCTCGACTGGAACATGGACGTGCAGCAGGCCGTGAGCATGGCGAACTTCGGTAG
CCGTAACGGCCCGACGGAAGTCGAGCGCGGGCTGGTGACGCCTCAACTGGTGCAGGCGCTCAAGGATCAGGGCCATCAGG
TGGCCGAGATCGAGATGACCAGTGGCACGCAGGCGATCATGCGCAAGGCGGGCCCGAATGGTCGGCCAGTCTGGGCTGGC
GGCGCTGATCCACGGCGTGAGGGCGTGGCGCTGGGCGATTGA

Upstream 100 bases:

>100_bases
CTGCCGAGTAACCCCGGGTTAACGTTGTCAGACAAACGCCGATTTCAACAGCGGGTGTGATCGCCAAGAATCGCCGGATC
TTCTCGACAGGAGGGACGGC

Downstream 100 bases:

>100_bases
ATGCTCGCGGATTGCACCCCTCTCCCGCGCGGGAGAGGGGCCGGCGGAGAACGCTGGCGCTTCAGGTTCCTGTCATGACT
GGCCAATGAAGAACGGGCGC

Product: Gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 653; Mature: 652

Protein sequence:

>653_residues
MADTLIATSTGSSAQSVAQRAANRHWRGALAGAMVSLLAASLSGCGTVDKEAGTSAASTDPATGTVPASTGAVASAGLPP
AAEVASGYRPGMTTTYAQKHMAAAANPLATEAGREMLRAGGSAIDAAVAMQAVLTLVEPQASGIGGGAFIMYWDGKRVQT
YDGRETAPAGATENLFMRADGKPMEFSAGQIGGRSVGVPGVLRALELAHRQHGRLPWARLFEPAIALADKGFPISQRLYT
QVAADKFLTGSPEMKAYFLDDQGKPKPVGTLVRNPQLAQTLREIARHGPNVFYNGPIAHDIVAKVNAHANPGSLSVADLK
GYKAKERPPVCTNYKAWKVCGMPPPSSGGIAIAQILGNLEALEKRDPRYALAKLKPAQVNTPAGFEANPLAVHAISEADR
LAYADRGLYVADADFVPVDVGALVNPQYLAERAELIGEKSMGKAEPGTPPGVNVAFAPDRSPPRISTSQVAAVDDRGGAL
SMTTTVESYFGSHIMVRGFMLNNQLTDFSFNPTENGKPVANRVQAGKRPRSSMAPTLVFDRKSGRLVAALGSPGGSQIIE
YVSKTLVGLLDWNMDVQQAVSMANFGSRNGPTEVERGLVTPQLVQALKDQGHQVAEIEMTSGTQAIMRKAGPNGRPVWAG
GADPRREGVALGD

Sequences:

>Translated_653_residues
MADTLIATSTGSSAQSVAQRAANRHWRGALAGAMVSLLAASLSGCGTVDKEAGTSAASTDPATGTVPASTGAVASAGLPP
AAEVASGYRPGMTTTYAQKHMAAAANPLATEAGREMLRAGGSAIDAAVAMQAVLTLVEPQASGIGGGAFIMYWDGKRVQT
YDGRETAPAGATENLFMRADGKPMEFSAGQIGGRSVGVPGVLRALELAHRQHGRLPWARLFEPAIALADKGFPISQRLYT
QVAADKFLTGSPEMKAYFLDDQGKPKPVGTLVRNPQLAQTLREIARHGPNVFYNGPIAHDIVAKVNAHANPGSLSVADLK
GYKAKERPPVCTNYKAWKVCGMPPPSSGGIAIAQILGNLEALEKRDPRYALAKLKPAQVNTPAGFEANPLAVHAISEADR
LAYADRGLYVADADFVPVDVGALVNPQYLAERAELIGEKSMGKAEPGTPPGVNVAFAPDRSPPRISTSQVAAVDDRGGAL
SMTTTVESYFGSHIMVRGFMLNNQLTDFSFNPTENGKPVANRVQAGKRPRSSMAPTLVFDRKSGRLVAALGSPGGSQIIE
YVSKTLVGLLDWNMDVQQAVSMANFGSRNGPTEVERGLVTPQLVQALKDQGHQVAEIEMTSGTQAIMRKAGPNGRPVWAG
GADPRREGVALGD
>Mature_652_residues
ADTLIATSTGSSAQSVAQRAANRHWRGALAGAMVSLLAASLSGCGTVDKEAGTSAASTDPATGTVPASTGAVASAGLPPA
AEVASGYRPGMTTTYAQKHMAAAANPLATEAGREMLRAGGSAIDAAVAMQAVLTLVEPQASGIGGGAFIMYWDGKRVQTY
DGRETAPAGATENLFMRADGKPMEFSAGQIGGRSVGVPGVLRALELAHRQHGRLPWARLFEPAIALADKGFPISQRLYTQ
VAADKFLTGSPEMKAYFLDDQGKPKPVGTLVRNPQLAQTLREIARHGPNVFYNGPIAHDIVAKVNAHANPGSLSVADLKG
YKAKERPPVCTNYKAWKVCGMPPPSSGGIAIAQILGNLEALEKRDPRYALAKLKPAQVNTPAGFEANPLAVHAISEADRL
AYADRGLYVADADFVPVDVGALVNPQYLAERAELIGEKSMGKAEPGTPPGVNVAFAPDRSPPRISTSQVAAVDDRGGALS
MTTTVESYFGSHIMVRGFMLNNQLTDFSFNPTENGKPVANRVQAGKRPRSSMAPTLVFDRKSGRLVAALGSPGGSQIIEY
VSKTLVGLLDWNMDVQQAVSMANFGSRNGPTEVERGLVTPQLVQALKDQGHQVAEIEMTSGTQAIMRKAGPNGRPVWAGG
ADPRREGVALGD

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=571, Percent_Identity=32.399299474606, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI73915090, Length=571, Percent_Identity=32.399299474606, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI73915096, Length=571, Percent_Identity=32.399299474606, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI73915094, Length=571, Percent_Identity=32.399299474606, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI113429324, Length=570, Percent_Identity=31.9298245614035, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI113429326, Length=576, Percent_Identity=31.7708333333333, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI109148539, Length=531, Percent_Identity=27.8719397363465, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI153266885, Length=541, Percent_Identity=27.1719038817006, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI153266901, Length=542, Percent_Identity=26.5682656826568, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI153266907, Length=538, Percent_Identity=26.0223048327138, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI30581157, Length=192, Percent_Identity=33.8541666666667, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI30581155, Length=192, Percent_Identity=33.8541666666667, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI171543825, Length=217, Percent_Identity=30.4147465437788, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1789856, Length=566, Percent_Identity=34.452296819788, Blast_Score=267, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17542894, Length=576, Percent_Identity=31.5972222222222, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI212646519, Length=501, Percent_Identity=30.3393213572854, Blast_Score=197, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI72000294, Length=501, Percent_Identity=30.3393213572854, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI193208247, Length=567, Percent_Identity=29.2768959435626, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI193208245, Length=579, Percent_Identity=28.8428324697755, Blast_Score=188, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17506189, Length=535, Percent_Identity=28.411214953271, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI72001495, Length=227, Percent_Identity=28.6343612334802, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI72001497, Length=227, Percent_Identity=28.6343612334802, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17564448, Length=441, Percent_Identity=24.7165532879819, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=553, Percent_Identity=24.7739602169982, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45551474, Length=567, Percent_Identity=28.5714285714286, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI161077880, Length=567, Percent_Identity=28.5714285714286, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24642670, Length=567, Percent_Identity=28.5714285714286, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24642666, Length=567, Percent_Identity=28.5714285714286, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI161077878, Length=567, Percent_Identity=28.5714285714286, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI18859893, Length=527, Percent_Identity=29.4117647058824, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI161077496, Length=535, Percent_Identity=26.3551401869159, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI18859741, Length=534, Percent_Identity=26.4044943820225, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 68348; Mature: 68217

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTLIATSTGSSAQSVAQRAANRHWRGALAGAMVSLLAASLSGCGTVDKEAGTSAASTD
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCC
PATGTVPASTGAVASAGLPPAAEVASGYRPGMTTTYAQKHMAAAANPLATEAGREMLRAG
CCCCCCCCCCCCHHCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCC
GSAIDAAVAMQAVLTLVEPQASGIGGGAFIMYWDGKRVQTYDGRETAPAGATENLFMRAD
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCEEEECC
GKPMEFSAGQIGGRSVGVPGVLRALELAHRQHGRLPWARLFEPAIALADKGFPISQRLYT
CCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHH
QVAADKFLTGSPEMKAYFLDDQGKPKPVGTLVRNPQLAQTLREIARHGPNVFYNGPIAHD
HHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCEEECCCHHHH
IVAKVNAHANPGSLSVADLKGYKAKERPPVCTNYKAWKVCGMPPPSSGGIAIAQILGNLE
HHHHHCCCCCCCCEEEHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEHHHHHCCHH
ALEKRDPRYALAKLKPAQVNTPAGFEANPLAVHAISEADRLAYADRGLYVADADFVPVDV
HHHHCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHCCCEEEECCCCEEECC
GALVNPQYLAERAELIGEKSMGKAEPGTPPGVNVAFAPDRSPPRISTSQVAAVDDRGGAL
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCEE
SMTTTVESYFGSHIMVRGFMLNNQLTDFSFNPTENGKPVANRVQAGKRPRSSMAPTLVFD
EEHHHHHHHHCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEE
RKSGRLVAALGSPGGSQIIEYVSKTLVGLLDWNMDVQQAVSMANFGSRNGPTEVERGLVT
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHCCCC
PQLVQALKDQGHQVAEIEMTSGTQAIMRKAGPNGRPVWAGGADPRREGVALGD
HHHHHHHHHCCCEEEEEEECCCHHHHHHHCCCCCCEEECCCCCHHHCCCCCCC
>Mature Secondary Structure 
ADTLIATSTGSSAQSVAQRAANRHWRGALAGAMVSLLAASLSGCGTVDKEAGTSAASTD
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCC
PATGTVPASTGAVASAGLPPAAEVASGYRPGMTTTYAQKHMAAAANPLATEAGREMLRAG
CCCCCCCCCCCCHHCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCC
GSAIDAAVAMQAVLTLVEPQASGIGGGAFIMYWDGKRVQTYDGRETAPAGATENLFMRAD
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCEEEECC
GKPMEFSAGQIGGRSVGVPGVLRALELAHRQHGRLPWARLFEPAIALADKGFPISQRLYT
CCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHH
QVAADKFLTGSPEMKAYFLDDQGKPKPVGTLVRNPQLAQTLREIARHGPNVFYNGPIAHD
HHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCEEECCCHHHH
IVAKVNAHANPGSLSVADLKGYKAKERPPVCTNYKAWKVCGMPPPSSGGIAIAQILGNLE
HHHHHCCCCCCCCEEEHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEHHHHHCCHH
ALEKRDPRYALAKLKPAQVNTPAGFEANPLAVHAISEADRLAYADRGLYVADADFVPVDV
HHHHCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHCCCEEEECCCCEEECC
GALVNPQYLAERAELIGEKSMGKAEPGTPPGVNVAFAPDRSPPRISTSQVAAVDDRGGAL
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCEE
SMTTTVESYFGSHIMVRGFMLNNQLTDFSFNPTENGKPVANRVQAGKRPRSSMAPTLVFD
EEHHHHHHHHCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEE
RKSGRLVAALGSPGGSQIIEYVSKTLVGLLDWNMDVQQAVSMANFGSRNGPTEVERGLVT
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHCCCC
PQLVQALKDQGHQVAEIEMTSGTQAIMRKAGPNGRPVWAGGADPRREGVALGD
HHHHHHHHHCCCEEEEEEECCCHHHHHHHCCCCCCEEECCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]