Click here to switch to the map view.

The map label for this gene is xdhA [H]

Identifier: 94309838

GI number: 94309838

Start: 979504

End: 981000

Strand: Reverse

Name: xdhA [H]

Synonym: Rmet_0893

Alternate gene names: 94309838

Gene position: 981000-979504 (Counterclockwise)

Preceding gene: 94309840

Following gene: 94309837

Centisome position: 24.97

GC content: 67.2

Gene sequence:

>1497_bases
ATGGAGACGCAAACCATCCGCTTCTACCACCGCGGCCAGGTCCAGGAAGTATCTGACGCCCCCGTGACGCGCACCCTGCT
GCAGTACCTGCGCGAAGATGTCCGCTGCACCGGTACCAAGGAAGGCTGCGCCGAAGGCGACTGCGGCGCCTGCACCGTCG
TGATCGGCGAGTTGCAGGACAGCGGCGACGTCGAGTTCAAGGCCGTCAACGCCTGCATCCAGTTCCTGCCCACGCTCGAC
GGCAAGGCCCTGATCACGGTCGAAGACCTGCGTCAGGCAGATGGTGCGCTGCACCCCGTGCAGGAAGCCATGGTCGAGTG
CCACGGTTCGCAATGCGGTTTCTGCACCCCCGGCTTCGTGATGTCGCTGTGGGCGCTGTACCAGCAGCACACCCCGGGTG
GCGAGCCGCCCCCGCGCCAGACCATCTGCGACGCCCTGACCGGCAACCTTTGCCGCTGCACCGGCTATCGCCCGATCATC
GACGCCGGCCAGCGCATGATGGCCCTGCCCGCGCCGCAGGCCGACCGCATCGACCCCCGCCAGATCGCCGACACGCTGCG
CAACCTGAAGCGCGGCGAGACGTTCCACTACAACGCGCGCGGCCAGCATTTCTACGCCCCGCGCACGGCCGCCGAATTCG
GCGCGATCAAGGCCGCCGAGCCGAACATCCGCATCCTGGCCGGCAGCACGGACGTCGGCCTGTGGGTAACCAAGCAGTTC
CGCGAACTGGGCAACCTGCTCTACGTCGGTCAGGTGGAAGATCTGAACCAGATCGCCGAGCACGACGGCTTCATCGAAAT
CGGCGCCGCCGTGACGCTGGAAAAAGCCTATGCCGCGCTGAACACCGCCCATCCGGAGCTCGAGGAACTGTGGAAGCGCT
TTGCTTCCCTGCCGATCCGCAATGCCGGCACGCTGGGCGGCAACATTGCCAACGGCTCGCCGATCGGTGACTCGATGCCG
GCGCTGATTGCCCTGGGCACGCAAGTCGTGCTGCAACGTGGCGACGTCCGCCGCGTGATGCCGCTCGAGGACCTGTACCT
GGCCTACCAGAAGACGGCCATGGTCGAAGGCGAATTCGTCGCCGGACTGCGCGTGCCGGTGCAAGGGCCGCAGCATTTCC
GCACGTACAAGCTGTCCAAGCGCTTTGACGAGGATATCTCCGCCGTGTGCGCCGCGTTTGGCATCACGGTCGAGAACGGC
ATAGTCACGGCGGCATGCATCGCCTTCGGCGGCATGGCCGCCACCCCGAAGCGGGCCGTGCTGGCAGAGGATGCGCTGAC
CGGCAAACCCTGGAACGAGGCCACCGCGCGCGCCGGCATGGCGGCGCTGGGCCAGGACTACACGCCACTGACCGATATGC
GCGCCACTGCCGACTATCGCAGCCGGGGCGCCGCCAACCTGCTCTATCGCTTCTGGCTGGAGACACGCGACAGCGCGTTG
CCCGCCGCCATGGTCAACGTCCGCGCCATCGGCGCCGGTGAAACCGTGAGCGCCTGA

Upstream 100 bases:

>100_bases
CGCCGCCGGATGCGCGCGTTGATGGGGCATATCACATGGGCCGAATATTGCGTCAAAGGGCCAGTGCTATGTTTCCGCCA
TCCCCGAAAGAGAGAAGATC

Downstream 100 bases:

>100_bases
GGAGAGCCTGCATGAACAAGCAAACCGAACCTTTCCTGCTCGACGCCAGCGTCGCCGCCGAATCGGCGCCGCAAGTGGGC
ATCTCGCGCCCGCATGAATC

Product: xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Products: NA

Alternate protein names: CO dehydrogenase subunit S; CO-DH S [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
METQTIRFYHRGQVQEVSDAPVTRTLLQYLREDVRCTGTKEGCAEGDCGACTVVIGELQDSGDVEFKAVNACIQFLPTLD
GKALITVEDLRQADGALHPVQEAMVECHGSQCGFCTPGFVMSLWALYQQHTPGGEPPPRQTICDALTGNLCRCTGYRPII
DAGQRMMALPAPQADRIDPRQIADTLRNLKRGETFHYNARGQHFYAPRTAAEFGAIKAAEPNIRILAGSTDVGLWVTKQF
RELGNLLYVGQVEDLNQIAEHDGFIEIGAAVTLEKAYAALNTAHPELEELWKRFASLPIRNAGTLGGNIANGSPIGDSMP
ALIALGTQVVLQRGDVRRVMPLEDLYLAYQKTAMVEGEFVAGLRVPVQGPQHFRTYKLSKRFDEDISAVCAAFGITVENG
IVTAACIAFGGMAATPKRAVLAEDALTGKPWNEATARAGMAALGQDYTPLTDMRATADYRSRGAANLLYRFWLETRDSAL
PAAMVNVRAIGAGETVSA

Sequences:

>Translated_498_residues
METQTIRFYHRGQVQEVSDAPVTRTLLQYLREDVRCTGTKEGCAEGDCGACTVVIGELQDSGDVEFKAVNACIQFLPTLD
GKALITVEDLRQADGALHPVQEAMVECHGSQCGFCTPGFVMSLWALYQQHTPGGEPPPRQTICDALTGNLCRCTGYRPII
DAGQRMMALPAPQADRIDPRQIADTLRNLKRGETFHYNARGQHFYAPRTAAEFGAIKAAEPNIRILAGSTDVGLWVTKQF
RELGNLLYVGQVEDLNQIAEHDGFIEIGAAVTLEKAYAALNTAHPELEELWKRFASLPIRNAGTLGGNIANGSPIGDSMP
ALIALGTQVVLQRGDVRRVMPLEDLYLAYQKTAMVEGEFVAGLRVPVQGPQHFRTYKLSKRFDEDISAVCAAFGITVENG
IVTAACIAFGGMAATPKRAVLAEDALTGKPWNEATARAGMAALGQDYTPLTDMRATADYRSRGAANLLYRFWLETRDSAL
PAAMVNVRAIGAGETVSA
>Mature_498_residues
METQTIRFYHRGQVQEVSDAPVTRTLLQYLREDVRCTGTKEGCAEGDCGACTVVIGELQDSGDVEFKAVNACIQFLPTLD
GKALITVEDLRQADGALHPVQEAMVECHGSQCGFCTPGFVMSLWALYQQHTPGGEPPPRQTICDALTGNLCRCTGYRPII
DAGQRMMALPAPQADRIDPRQIADTLRNLKRGETFHYNARGQHFYAPRTAAEFGAIKAAEPNIRILAGSTDVGLWVTKQF
RELGNLLYVGQVEDLNQIAEHDGFIEIGAAVTLEKAYAALNTAHPELEELWKRFASLPIRNAGTLGGNIANGSPIGDSMP
ALIALGTQVVLQRGDVRRVMPLEDLYLAYQKTAMVEGEFVAGLRVPVQGPQHFRTYKLSKRFDEDISAVCAAFGITVENG
IVTAACIAFGGMAATPKRAVLAEDALTGKPWNEATARAGMAALGQDYTPLTDMRATADYRSRGAANLLYRFWLETRDSAL
PAAMVNVRAIGAGETVSA

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=529, Percent_Identity=28.5444234404537, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI71773480, Length=529, Percent_Identity=27.0321361058601, Blast_Score=142, Evalue=7e-34,
Organism=Escherichia coli, GI1786480, Length=150, Percent_Identity=36, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1789231, Length=262, Percent_Identity=25.9541984732824, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789232, Length=160, Percent_Identity=36.25, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17540638, Length=159, Percent_Identity=46.5408805031447, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32566215, Length=344, Percent_Identity=29.6511627906977, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17539860, Length=139, Percent_Identity=48.2014388489209, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI17737937, Length=487, Percent_Identity=33.264887063655, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24647197, Length=506, Percent_Identity=31.6205533596838, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24647201, Length=490, Percent_Identity=28.7755102040816, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24647199, Length=493, Percent_Identity=29.0060851926978, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24647195, Length=330, Percent_Identity=34.2424242424242, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24647193, Length=511, Percent_Identity=27.9843444227006, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 53982; Mature: 53982

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METQTIRFYHRGQVQEVSDAPVTRTLLQYLREDVRCTGTKEGCAEGDCGACTVVIGELQD
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCEEEEEEEECCC
SGDVEFKAVNACIQFLPTLDGKALITVEDLRQADGALHPVQEAMVECHGSQCGFCTPGFV
CCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHH
MSLWALYQQHTPGGEPPPRQTICDALTGNLCRCTGYRPIIDAGQRMMALPAPQADRIDPR
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEECCCCHHHHCCCCEEECCCCCCCCCCHH
QIADTLRNLKRGETFHYNARGQHFYAPRTAAEFGAIKAAEPNIRILAGSTDVGLWVTKQF
HHHHHHHHHHCCCEEEECCCCCEEECCCCHHHHCCEEECCCCEEEEECCCCCCHHHHHHH
RELGNLLYVGQVEDLNQIAEHDGFIEIGAAVTLEKAYAALNTAHPELEELWKRFASLPIR
HHHCCEEEECCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
NAGTLGGNIANGSPIGDSMPALIALGTQVVLQRGDVRRVMPLEDLYLAYQKTAMVEGEFV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEECCCEE
AGLRVPVQGPQHFRTYKLSKRFDEDISAVCAAFGITVENGIVTAACIAFGGMAATPKRAV
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHCCCCCCCCHHH
LAEDALTGKPWNEATARAGMAALGQDYTPLTDMRATADYRSRGAANLLYRFWLETRDSAL
HHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
PAAMVNVRAIGAGETVSA
CCHHHEEEEECCCCCCCC
>Mature Secondary Structure
METQTIRFYHRGQVQEVSDAPVTRTLLQYLREDVRCTGTKEGCAEGDCGACTVVIGELQD
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCEEEEEEEECCC
SGDVEFKAVNACIQFLPTLDGKALITVEDLRQADGALHPVQEAMVECHGSQCGFCTPGFV
CCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHH
MSLWALYQQHTPGGEPPPRQTICDALTGNLCRCTGYRPIIDAGQRMMALPAPQADRIDPR
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEECCCCHHHHCCCCEEECCCCCCCCCCHH
QIADTLRNLKRGETFHYNARGQHFYAPRTAAEFGAIKAAEPNIRILAGSTDVGLWVTKQF
HHHHHHHHHHCCCEEEECCCCCEEECCCCHHHHCCEEECCCCEEEEECCCCCCHHHHHHH
RELGNLLYVGQVEDLNQIAEHDGFIEIGAAVTLEKAYAALNTAHPELEELWKRFASLPIR
HHHCCEEEECCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
NAGTLGGNIANGSPIGDSMPALIALGTQVVLQRGDVRRVMPLEDLYLAYQKTAMVEGEFV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEECCCEE
AGLRVPVQGPQHFRTYKLSKRFDEDISAVCAAFGITVENGIVTAACIAFGGMAATPKRAV
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHCCCCCCCCHHH
LAEDALTGKPWNEATARAGMAALGQDYTPLTDMRATADYRSRGAANLLYRFWLETRDSAL
HHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
PAAMVNVRAIGAGETVSA
CCHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10482497; 2818128; 10966817; 11076018 [H]