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The map label for this gene is xdhB [H]

Identifier: 94309837

GI number: 94309837

Start: 977141

End: 979492

Strand: Reverse

Name: xdhB [H]

Synonym: Rmet_0892

Alternate gene names: 94309837

Gene position: 979492-977141 (Counterclockwise)

Preceding gene: 94309838

Following gene: 94309836

Centisome position: 24.94

GC content: 65.82

Gene sequence:

>2352_bases
ATGAACAAGCAAACCGAACCTTTCCTGCTCGACGCCAGCGTCGCCGCCGAATCGGCGCCGCAAGTGGGCATCTCGCGCCC
GCATGAATCGGCCCACCTGCACGTGGCAGGCACCGCCACCTATACCGACGACATTCCCGAGCTGGCCGGCACGCTGCACG
CCGCGCTCGGCATGAGCGCGCGCGCCCATGCGCGCCTGAAGTCGGTCGGTCTCGAACGCGTGCGCAAGGCGCCCGGCGTA
GTGTCGGTGCTGACCGTCGACGACATTCCTGGCGCCAACGAATGCGGCCCGATCATCCATGACGACCCGATCCTGGTGAA
AGACGTCGTTCAGTTCATCGGTCAGCCGATCTTCATCGTGGTAGCGACGTCGCATGACGCGGCACGCCGCGCCGCCCGTC
TGGCCGACATCGAGTACGAAGACCTGCCCCCCGTGCTGTCGCCCGAGGCCGCGCACGCCGCAGGCAGCTATGTGCTGCCG
CCGATGCACCTGAAGCGCGGCGAACCTGCCCGCCACATCGACGCGGCCATCCACCGCGACGCCGGCAAGATCCACCTGGG
CGGTCAGGAGCAGTTCTATCTGGAAGGCCAGATCGCCTACGCTGTGCCGCGCGAGAATGACGGCATGCACGTCTGGTGTT
CGACGCAACACCCGACCGAAATGCAGCATCACGTGGCCCACATGCTCGGCTGGCACGCGCATCAGGTGCTGGTGGAGTGC
CGCCGCATGGGCGGTGGCTTCGGCGGCAAGGAATCGCAATCAGCCATGTTCGCCTGCTGCGCGTCGCTGGCCGCGTGGAA
GCTGCTGTGTCCGGTCAAGCTGCGCCCGGACCGCGACGACGACATGATGATCACCGGCAAGCGTCACGACTTCGTGTTCG
ACTTCGATGTCGGCCACGATGACGCCGGCCGCATCGAAGGCGTGCGCGTGGAGATGGTGTCTCGCGCGGGCTTCTCGGCC
GACCTGTCGGGTCCGGTCATGACGCGCGCGATCTGTCACTTCGACAATGCCTACTGGCTGCCGAACGTGCAGATCGACGG
CTACTGCGGCAAGACCAACACGCAGAGCAACACCGCGTTCCGCGGCTTCGGTGGCCCGCAAGGCGCGTTCGCCGTGGAGT
ACATCCTCGACAACATCGCGCGCAACGTGGGCAAGGATTCGCTCGACGTGCGCCGCGCCAACTTCTACGGCAAGACGGAC
AACAACGTCACGCCGTATGGCCAGACCGTCGAAGACAACGTCATCCACGAGCTGATCGACGAACTCGTGGCGTCGAGCGA
ATACAAGGCCCGCCGCGCCGCCACGCGCGCGTTCAACGAGACCAGCCCGATCCTCAAGAAAGGGATCGCCATCACGCCGG
TCAAGTTCGGCATCTCGTTCAACGTGGCCCACTACAACCAGGCCGGCGCGCTCGTGCACGTCTACAACGACGGTTCGGTG
CTCGTGAACCACGGTGGCACGGAAATGGGCCAGGGCCTGAACACCAAGGTGGCGATGGTCGTGGCGCACGAACTCGGCAT
CCGCATGGAACGTGTGCGCGTGACCGCTACGGACACCAGCAAGGTAGCCAACACGTCCGCAACCGCCGCATCGACCGGCG
CCGACCTGAACGGCAAGGCCGCGCAGGACGCCGCCCGCCAGATCCGCGAGCGGCTGGCCGCGTTCGCCGCCCGCAAGGCC
GGCGTGCCCGTCGAAGACGTGCGCTTCGGCGACGACCTCGTGGTGGCTGGCGAGCTGCGCCAGTCGTTCGGTGATCTTGC
CCGCGAAGCCTACGTGGCCCGCGTGCAACTGTGGTCCGATGGTTTCTACACCACGCCCAAGCTGCACTGGGACCAGAAGG
CGCTGCAGGGCCGCCCGTTCTATTACTACGCCTACGGCGCAGCGTGCTCGGAAGTGCTGGTCGATACGCTCACCGGCGAA
TGGAAGCTGCTGCGTGCCGATGCATTGCACGACGCCGGCAAGTCGCTGAACCCGGCCATCGATATCGGCCAGGTGGAAGG
CGCGTTCATCCAGGGCATGGGCTGGCTGACCACAGAGGAACTGTGGTGGAACCAGAACGGCAAGCTGATGACGCACGCGC
CCTCGACCTACAAGATTCCGACGATCAACGACTGCCCTGAAGAGTTCAACGTGCGGCTGTTCCAGAACCGAAACGTCGAG
GACAGCATCCATCGCTCGAAGGCCGTTGGCGAGCCACCGCTACTGCTGCCGTTCTCGGTGTTCTTCGCGATCCGCGATGC
GATTGCTGCGGTGGGCGACTACAAGGTCAACCCGCCGCTGCGCGCGCCCGCCACCAGCGAAGCGATCCTCGACGCCGTGG
AGGCCGTGCAGGCCGCCGTGGTTTCCGCCTGA

Upstream 100 bases:

>100_bases
GCTTCTGGCTGGAGACACGCGACAGCGCGTTGCCCGCCGCCATGGTCAACGTCCGCGCCATCGGCGCCGGTGAAACCGTG
AGCGCCTGAGGAGAGCCTGC

Downstream 100 bases:

>100_bases
CGCAATACCAGGACCGATCATGCAGGACGCCCCCCTCAAACCGTTCCGCTTCGCCGACGCCACCCGCTGGGTGCGCGCCG
GCGTGCCCGTGGCGATGGTC

Product: xanthine dehydrogenase, subunit B

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 783; Mature: 783

Protein sequence:

>783_residues
MNKQTEPFLLDASVAAESAPQVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSARAHARLKSVGLERVRKAPGV
VSVLTVDDIPGANECGPIIHDDPILVKDVVQFIGQPIFIVVATSHDAARRAARLADIEYEDLPPVLSPEAAHAAGSYVLP
PMHLKRGEPARHIDAAIHRDAGKIHLGGQEQFYLEGQIAYAVPRENDGMHVWCSTQHPTEMQHHVAHMLGWHAHQVLVEC
RRMGGGFGGKESQSAMFACCASLAAWKLLCPVKLRPDRDDDMMITGKRHDFVFDFDVGHDDAGRIEGVRVEMVSRAGFSA
DLSGPVMTRAICHFDNAYWLPNVQIDGYCGKTNTQSNTAFRGFGGPQGAFAVEYILDNIARNVGKDSLDVRRANFYGKTD
NNVTPYGQTVEDNVIHELIDELVASSEYKARRAATRAFNETSPILKKGIAITPVKFGISFNVAHYNQAGALVHVYNDGSV
LVNHGGTEMGQGLNTKVAMVVAHELGIRMERVRVTATDTSKVANTSATAASTGADLNGKAAQDAARQIRERLAAFAARKA
GVPVEDVRFGDDLVVAGELRQSFGDLAREAYVARVQLWSDGFYTTPKLHWDQKALQGRPFYYYAYGAACSEVLVDTLTGE
WKLLRADALHDAGKSLNPAIDIGQVEGAFIQGMGWLTTEELWWNQNGKLMTHAPSTYKIPTINDCPEEFNVRLFQNRNVE
DSIHRSKAVGEPPLLLPFSVFFAIRDAIAAVGDYKVNPPLRAPATSEAILDAVEAVQAAVVSA

Sequences:

>Translated_783_residues
MNKQTEPFLLDASVAAESAPQVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSARAHARLKSVGLERVRKAPGV
VSVLTVDDIPGANECGPIIHDDPILVKDVVQFIGQPIFIVVATSHDAARRAARLADIEYEDLPPVLSPEAAHAAGSYVLP
PMHLKRGEPARHIDAAIHRDAGKIHLGGQEQFYLEGQIAYAVPRENDGMHVWCSTQHPTEMQHHVAHMLGWHAHQVLVEC
RRMGGGFGGKESQSAMFACCASLAAWKLLCPVKLRPDRDDDMMITGKRHDFVFDFDVGHDDAGRIEGVRVEMVSRAGFSA
DLSGPVMTRAICHFDNAYWLPNVQIDGYCGKTNTQSNTAFRGFGGPQGAFAVEYILDNIARNVGKDSLDVRRANFYGKTD
NNVTPYGQTVEDNVIHELIDELVASSEYKARRAATRAFNETSPILKKGIAITPVKFGISFNVAHYNQAGALVHVYNDGSV
LVNHGGTEMGQGLNTKVAMVVAHELGIRMERVRVTATDTSKVANTSATAASTGADLNGKAAQDAARQIRERLAAFAARKA
GVPVEDVRFGDDLVVAGELRQSFGDLAREAYVARVQLWSDGFYTTPKLHWDQKALQGRPFYYYAYGAACSEVLVDTLTGE
WKLLRADALHDAGKSLNPAIDIGQVEGAFIQGMGWLTTEELWWNQNGKLMTHAPSTYKIPTINDCPEEFNVRLFQNRNVE
DSIHRSKAVGEPPLLLPFSVFFAIRDAIAAVGDYKVNPPLRAPATSEAILDAVEAVQAAVVSA
>Mature_783_residues
MNKQTEPFLLDASVAAESAPQVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSARAHARLKSVGLERVRKAPGV
VSVLTVDDIPGANECGPIIHDDPILVKDVVQFIGQPIFIVVATSHDAARRAARLADIEYEDLPPVLSPEAAHAAGSYVLP
PMHLKRGEPARHIDAAIHRDAGKIHLGGQEQFYLEGQIAYAVPRENDGMHVWCSTQHPTEMQHHVAHMLGWHAHQVLVEC
RRMGGGFGGKESQSAMFACCASLAAWKLLCPVKLRPDRDDDMMITGKRHDFVFDFDVGHDDAGRIEGVRVEMVSRAGFSA
DLSGPVMTRAICHFDNAYWLPNVQIDGYCGKTNTQSNTAFRGFGGPQGAFAVEYILDNIARNVGKDSLDVRRANFYGKTD
NNVTPYGQTVEDNVIHELIDELVASSEYKARRAATRAFNETSPILKKGIAITPVKFGISFNVAHYNQAGALVHVYNDGSV
LVNHGGTEMGQGLNTKVAMVVAHELGIRMERVRVTATDTSKVANTSATAASTGADLNGKAAQDAARQIRERLAAFAARKA
GVPVEDVRFGDDLVVAGELRQSFGDLAREAYVARVQLWSDGFYTTPKLHWDQKALQGRPFYYYAYGAACSEVLVDTLTGE
WKLLRADALHDAGKSLNPAIDIGQVEGAFIQGMGWLTTEELWWNQNGKLMTHAPSTYKIPTINDCPEEFNVRLFQNRNVE
DSIHRSKAVGEPPLLLPFSVFFAIRDAIAAVGDYKVNPPLRAPATSEAILDAVEAVQAAVVSA

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=759, Percent_Identity=42.5559947299078, Blast_Score=589, Evalue=1e-168,
Organism=Homo sapiens, GI71773480, Length=771, Percent_Identity=36.8352788586252, Blast_Score=464, Evalue=1e-130,
Organism=Escherichia coli, GI1789246, Length=744, Percent_Identity=27.4193548387097, Blast_Score=201, Evalue=2e-52,
Organism=Escherichia coli, GI1789230, Length=751, Percent_Identity=27.5632490013316, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1786478, Length=741, Percent_Identity=24.6963562753036, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17540638, Length=771, Percent_Identity=40.8560311284047, Blast_Score=523, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI32566215, Length=705, Percent_Identity=31.9148936170213, Blast_Score=329, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI17539860, Length=719, Percent_Identity=32.5452016689847, Blast_Score=321, Evalue=8e-88,
Organism=Drosophila melanogaster, GI17737937, Length=765, Percent_Identity=41.3071895424837, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24647193, Length=782, Percent_Identity=31.4578005115089, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24647199, Length=730, Percent_Identity=31.2328767123288, Blast_Score=315, Evalue=8e-86,
Organism=Drosophila melanogaster, GI24647201, Length=757, Percent_Identity=29.4583883751651, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24647197, Length=766, Percent_Identity=28.5900783289817, Blast_Score=273, Evalue=5e-73,
Organism=Drosophila melanogaster, GI24647195, Length=766, Percent_Identity=28.5900783289817, Blast_Score=272, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 85142; Mature: 85142

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQTEPFLLDASVAAESAPQVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSA
CCCCCCCEEEECHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCH
RAHARLKSVGLERVRKAPGVVSVLTVDDIPGANECGPIIHDDPILVKDVVQFIGQPIFIV
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEE
VATSHDAARRAARLADIEYEDLPPVLSPEAAHAAGSYVLPPMHLKRGEPARHIDAAIHRD
EECCCHHHHHHHHHHCCCHHCCCCCCCCCHHHCCCCCCCCCHHCCCCCCHHHHHHHHHCC
AGKIHLGGQEQFYLEGQIAYAVPRENDGMHVWCSTQHPTEMQHHVAHMLGWHAHQVLVEC
CCEEEECCCCEEEEECEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
RRMGGGFGGKESQSAMFACCASLAAWKLLCPVKLRPDRDDDMMITGKRHDFVFDFDVGHD
HHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCEEEEECCCCC
DAGRIEGVRVEMVSRAGFSADLSGPVMTRAICHFDNAYWLPNVQIDGYCGKTNTQSNTAF
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEECCCEEECCCCCCCCCCCCCEE
RGFGGPQGAFAVEYILDNIARNVGKDSLDVRRANFYGKTDNNVTPYGQTVEDNVIHELID
ECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCCCCCCCCCCCCHHHHHHHHHHH
ELVASSEYKARRAATRAFNETSPILKKGIAITPVKFGISFNVAHYNQAGALVHVYNDGSV
HHHCCCHHHHHHHHHHHHCCCCHHHHCCCEEEEEEECEEEEEEEECCCCCEEEEEECCEE
LVNHGGTEMGQGLNTKVAMVVAHELGIRMERVRVTATDTSKVANTSATAASTGADLNGKA
EEECCCHHHCCCCCCEEEEEEHHHHCCEEEEEEEEECCCHHHCCCCCCCCCCCCCCCCHH
AQDAARQIRERLAAFAARKAGVPVEDVRFGDDLVVAGELRQSFGDLAREAYVARVQLWSD
HHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCEEEHHHHHHHHHHHHHHHHHEEEEEECC
GFYTTPKLHWDQKALQGRPFYYYAYGAACSEVLVDTLTGEWKLLRADALHDAGKSLNPAI
CCEECCCCCCCHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEEEHHHHHHCCCCCCCCE
DIGQVEGAFIQGMGWLTTEELWWNQNGKLMTHAPSTYKIPTINDCPEEFNVRLFQNRNVE
ECCCCCCHHCCCCCCCEEHHHEECCCCCEEEECCCCEECCCCCCCCHHCCEEEEECCCCH
DSIHRSKAVGEPPLLLPFSVFFAIRDAIAAVGDYKVNPPLRAPATSEAILDAVEAVQAAV
HHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VSA
HCC
>Mature Secondary Structure
MNKQTEPFLLDASVAAESAPQVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSA
CCCCCCCEEEECHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCH
RAHARLKSVGLERVRKAPGVVSVLTVDDIPGANECGPIIHDDPILVKDVVQFIGQPIFIV
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEE
VATSHDAARRAARLADIEYEDLPPVLSPEAAHAAGSYVLPPMHLKRGEPARHIDAAIHRD
EECCCHHHHHHHHHHCCCHHCCCCCCCCCHHHCCCCCCCCCHHCCCCCCHHHHHHHHHCC
AGKIHLGGQEQFYLEGQIAYAVPRENDGMHVWCSTQHPTEMQHHVAHMLGWHAHQVLVEC
CCEEEECCCCEEEEECEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
RRMGGGFGGKESQSAMFACCASLAAWKLLCPVKLRPDRDDDMMITGKRHDFVFDFDVGHD
HHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCEEEEECCCCC
DAGRIEGVRVEMVSRAGFSADLSGPVMTRAICHFDNAYWLPNVQIDGYCGKTNTQSNTAF
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEECCCEEECCCCCCCCCCCCCEE
RGFGGPQGAFAVEYILDNIARNVGKDSLDVRRANFYGKTDNNVTPYGQTVEDNVIHELID
ECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCCCCCCCCCCCCHHHHHHHHHHH
ELVASSEYKARRAATRAFNETSPILKKGIAITPVKFGISFNVAHYNQAGALVHVYNDGSV
HHHCCCHHHHHHHHHHHHCCCCHHHHCCCEEEEEEECEEEEEEEECCCCCEEEEEECCEE
LVNHGGTEMGQGLNTKVAMVVAHELGIRMERVRVTATDTSKVANTSATAASTGADLNGKA
EEECCCHHHCCCCCCEEEEEEHHHHCCEEEEEEEEECCCHHHCCCCCCCCCCCCCCCCHH
AQDAARQIRERLAAFAARKAGVPVEDVRFGDDLVVAGELRQSFGDLAREAYVARVQLWSD
HHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCEEEHHHHHHHHHHHHHHHHHEEEEEECC
GFYTTPKLHWDQKALQGRPFYYYAYGAACSEVLVDTLTGEWKLLRADALHDAGKSLNPAI
CCEECCCCCCCHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEEEHHHHHHCCCCCCCCE
DIGQVEGAFIQGMGWLTTEELWWNQNGKLMTHAPSTYKIPTINDCPEEFNVRLFQNRNVE
ECCCCCCHHCCCCCCCEEHHHEECCCCCEEEECCCCEECCCCCCCCHHCCEEEEECCCCH
DSIHRSKAVGEPPLLLPFSVFFAIRDAIAAVGDYKVNPPLRAPATSEAILDAVEAVQAAV
HHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VSA
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]