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The map label for this gene is lrp [H]

Identifier: 94309686

GI number: 94309686

Start: 819951

End: 820460

Strand: Direct

Name: lrp [H]

Synonym: Rmet_0741

Alternate gene names: 94309686

Gene position: 819951-820460 (Clockwise)

Preceding gene: 94309684

Following gene: 94309690

Centisome position: 20.87

GC content: 63.53

Gene sequence:

>510_bases
ATGAGAACGAGTCGTCAGCCGGTACGTGCGCTGGATCGGCTGGACCGGAAGATTCTGGGGGTCCTGCAGGCCGATGGCCG
GATTTCGATGAAGGAGCTGGCGGAGGCCGTCGGGCTGACCATCACGCCGTGCATCGAGCGCGTGAAGCGGCTCGAACGCG
ACGGGGTCATCATGGGGTACTACGCGCGGCTGAACCCGACGCTGCTCGGCAGCGCGCTGCTGGTCTTCGTAGAGATCTCT
CTTGGGAATAAGTCGGGCAACATGTTCGAGCAGTTCCGGCGCGAGGTGCTGCGGATCCCCGAGGTGCTCGAGTGCCACCT
GGTATCGGGCGATTTCGATTACCTGATCAAGGCGCGCATCCGCGAGATCGGCGAGTATCGCCGGCTGCTCGGCGACATCC
TGCTGCAACTGCCGGGCGCGGCGCAGTCGAAAAGCTACGTGGTAATGGAAGAGATCAAGGAGACGCTGGCGATCGCGGTG
GACGAGAAGGAGCGCAGCCAACCAGGCTGA

Upstream 100 bases:

>100_bases
CTCTCTACTGCGGAATGGATGTGTGGGAGAATTCGCTTCTATACTATTGACTTCAAGGCAGTCATAGTTACCGAATTTCT
CTGCAAAACAGGAAAAAATC

Downstream 100 bases:

>100_bases
CGGCTCCTGGCCTGCTGGCTCAGAAAAGGCTGCCCTGCGGCGAATCCTCGGGCGGCACGCGGAACAGATCGGTGCGCAGC
GGGTGGCGCTCTTGATTGAG

Product: DNA-binding protein transcriptional dual regulator, leucine-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MRTSRQPVRALDRLDRKILGVLQADGRISMKELAEAVGLTITPCIERVKRLERDGVIMGYYARLNPTLLGSALLVFVEIS
LGNKSGNMFEQFRREVLRIPEVLECHLVSGDFDYLIKARIREIGEYRRLLGDILLQLPGAAQSKSYVVMEEIKETLAIAV
DEKERSQPG

Sequences:

>Translated_169_residues
MRTSRQPVRALDRLDRKILGVLQADGRISMKELAEAVGLTITPCIERVKRLERDGVIMGYYARLNPTLLGSALLVFVEIS
LGNKSGNMFEQFRREVLRIPEVLECHLVSGDFDYLIKARIREIGEYRRLLGDILLQLPGAAQSKSYVVMEEIKETLAIAV
DEKERSQPG
>Mature_169_residues
MRTSRQPVRALDRLDRKILGVLQADGRISMKELAEAVGLTITPCIERVKRLERDGVIMGYYARLNPTLLGSALLVFVEIS
LGNKSGNMFEQFRREVLRIPEVLECHLVSGDFDYLIKARIREIGEYRRLLGDILLQLPGAAQSKSYVVMEEIKETLAIAV
DEKERSQPG

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=153, Percent_Identity=54.9019607843137, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=37.0860927152318, Blast_Score=113, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19115; Mature: 19115

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTSRQPVRALDRLDRKILGVLQADGRISMKELAEAVGLTITPCIERVKRLERDGVIMGY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEE
YARLNPTLLGSALLVFVEISLGNKSGNMFEQFRREVLRIPEVLECHLVSGDFDYLIKARI
HHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHH
REIGEYRRLLGDILLQLPGAAQSKSYVVMEEIKETLAIAVDEKERSQPG
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCC
>Mature Secondary Structure
MRTSRQPVRALDRLDRKILGVLQADGRISMKELAEAVGLTITPCIERVKRLERDGVIMGY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEE
YARLNPTLLGSALLVFVEISLGNKSGNMFEQFRREVLRIPEVLECHLVSGDFDYLIKARI
HHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHH
REIGEYRRLLGDILLQLPGAAQSKSYVVMEEIKETLAIAVDEKERSQPG
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]