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The map label for this gene is etfA [H]

Identifier: 94309683

GI number: 94309683

Start: 815619

End: 816554

Strand: Direct

Name: etfA [H]

Synonym: Rmet_0738

Alternate gene names: 94309683

Gene position: 815619-816554 (Clockwise)

Preceding gene: 94309682

Following gene: 94309684

Centisome position: 20.76

GC content: 64.96

Gene sequence:

>936_bases
ATGACTGCACTCGTCATTGCTGAACACGACAATCAATCGATCAAGGCCGCCACGCTGAACACCGTGACGGCAGCTGCCCA
ATGCGGCGGCGATGTCCACGTGCTGGTGGCTGGCTCGAACGCCAAGGCTGCCGCCGATGCCGCCGCGAAGATCGCCGGCG
TGTCGAAGGTCCTGCTGGCCGACGCACCGTACTTTGGTGACGGCCTGGCCGAGAACCTCGCCGAGCAGATTCTGGCCGTG
GCCAGCGACTACTCGCACATCCTGGCTCCGGCTACCGCCTCGGGCAAGAACGTCCTGCCGCGCGTTGCCGCCAAGCTGGA
TGTGGCACAACTGTCGGACATCACCAAGGTCGACTCGCCCGACACGTTCGAGCGCCCGATCTACGCTGGCAACGCCATCG
CCATCGTGAAGTCGTCGGACAAGATCAAGGTCATCACCGTGCGCGGTACCGGCTTCGACGCCGCCGCAGCCGAAGGTGGC
TCGGCTTCCGTGGACACGATCCCGGTCGTAGCCGACGCTGGCATCTCGCAATTCGTGTCGCGTGAAGTGACCAAGAGCGA
TCGTCCGGAACTGACCGCCGCCAAGATCATCGTCTCGGGTGGCCGTGGCGTGGGTTCGGGTGAGAACTACACCAAGGTGC
TGACGCCGCTGGCCGACAAGCTGGGCGCCGCGCTGGGCGCATCGCGCGCGGCAGTCGATGCCGGCTTCGTGCCGAACGAC
TACCAGGTTGGTCAGACCGGCAAGATCGTTGCCCCGCAGCTGTACATCGCCGTCGGTATCTCCGGCGCGATCCAGCATCT
GGCCGGCATGAAGGACTCCAAGGTGATCGTCGCGATCAACAAGGATGCCGAAGCCCCGATCTTCTCGGTGGCCGACTATG
GTCTGGTGGGCGACCTGAACACCGTGGTGCCGGAGCTGGTGGCCGCACTGGGCTGA

Upstream 100 bases:

>100_bases
CGCGAAGCGCAGTGCTGGCGTGATGGTCCCGGATGTGGCCACGCTGGTGCAGAAGCTGAAGACGGAAGCCAAGGTTATCT
GAGCGCGGGGGAGATAGAAC

Downstream 100 bases:

>100_bases
TAGGTAACACTGGGCTTATGGCCTGATCGGCCGGCGGAAAGCCGGTCGATCGAACAAGAAGAATGAAGCCGTTCCGGGTA
TCGCCCGCGAGCGGCTTTTT

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTALVIAEHDNQSIKAATLNTVTAAAQCGGDVHVLVAGSNAKAAADAAAKIAGVSKVLLADAPYFGDGLAENLAEQILAV
ASDYSHILAPATASGKNVLPRVAAKLDVAQLSDITKVDSPDTFERPIYAGNAIAIVKSSDKIKVITVRGTGFDAAAAEGG
SASVDTIPVVADAGISQFVSREVTKSDRPELTAAKIIVSGGRGVGSGENYTKVLTPLADKLGAALGASRAAVDAGFVPND
YQVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDAEAPIFSVADYGLVGDLNTVVPELVAALG

Sequences:

>Translated_311_residues
MTALVIAEHDNQSIKAATLNTVTAAAQCGGDVHVLVAGSNAKAAADAAAKIAGVSKVLLADAPYFGDGLAENLAEQILAV
ASDYSHILAPATASGKNVLPRVAAKLDVAQLSDITKVDSPDTFERPIYAGNAIAIVKSSDKIKVITVRGTGFDAAAAEGG
SASVDTIPVVADAGISQFVSREVTKSDRPELTAAKIIVSGGRGVGSGENYTKVLTPLADKLGAALGASRAAVDAGFVPND
YQVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDAEAPIFSVADYGLVGDLNTVVPELVAALG
>Mature_310_residues
TALVIAEHDNQSIKAATLNTVTAAAQCGGDVHVLVAGSNAKAAADAAAKIAGVSKVLLADAPYFGDGLAENLAEQILAVA
SDYSHILAPATASGKNVLPRVAAKLDVAQLSDITKVDSPDTFERPIYAGNAIAIVKSSDKIKVITVRGTGFDAAAAEGGS
ASVDTIPVVADAGISQFVSREVTKSDRPELTAAKIIVSGGRGVGSGENYTKVLTPLADKLGAALGASRAAVDAGFVPNDY
QVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDAEAPIFSVADYGLVGDLNTVVPELVAALG

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=311, Percent_Identity=61.7363344051447, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI189181759, Length=275, Percent_Identity=62.5454545454545, Blast_Score=325, Evalue=2e-89,
Organism=Escherichia coli, GI1787990, Length=247, Percent_Identity=35.2226720647773, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1786226, Length=229, Percent_Identity=35.3711790393013, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082157, Length=253, Percent_Identity=32.4110671936759, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17506929, Length=313, Percent_Identity=56.8690095846645, Blast_Score=329, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6325261, Length=288, Percent_Identity=45.8333333333333, Blast_Score=241, Evalue=8e-65,
Organism=Drosophila melanogaster, GI17136898, Length=312, Percent_Identity=62.5, Blast_Score=359, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24652801, Length=312, Percent_Identity=62.5, Blast_Score=359, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 31355; Mature: 31224

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALVIAEHDNQSIKAATLNTVTAAAQCGGDVHVLVAGSNAKAAADAAAKIAGVSKVLLA
CEEEEEEECCCCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEEE
DAPYFGDGLAENLAEQILAVASDYSHILAPATASGKNVLPRVAAKLDVAQLSDITKVDSP
CCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
DTFERPIYAGNAIAIVKSSDKIKVITVRGTGFDAAAAEGGSASVDTIPVVADAGISQFVS
CCCCCCEECCCEEEEEECCCCEEEEEEECCCCCHHCCCCCCCCCCEEEEEECCCHHHHHH
REVTKSDRPELTAAKIIVSGGRGVGSGENYTKVLTPLADKLGAALGASRAAVDAGFVPND
HHHCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
YQVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDAEAPIFSVADYGLVGDLN
CEECCCCCEECCEEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCCCCCCHH
TVVPELVAALG
HHHHHHHHHCC
>Mature Secondary Structure 
TALVIAEHDNQSIKAATLNTVTAAAQCGGDVHVLVAGSNAKAAADAAAKIAGVSKVLLA
EEEEEEECCCCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEEE
DAPYFGDGLAENLAEQILAVASDYSHILAPATASGKNVLPRVAAKLDVAQLSDITKVDSP
CCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
DTFERPIYAGNAIAIVKSSDKIKVITVRGTGFDAAAAEGGSASVDTIPVVADAGISQFVS
CCCCCCEECCCEEEEEECCCCEEEEEEECCCCCHHCCCCCCCCCCEEEEEECCCHHHHHH
REVTKSDRPELTAAKIIVSGGRGVGSGENYTKVLTPLADKLGAALGASRAAVDAGFVPND
HHHCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
YQVGQTGKIVAPQLYIAVGISGAIQHLAGMKDSKVIVAINKDAEAPIFSVADYGLVGDLN
CEECCCCCEECCEEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCCCCCCHH
TVVPELVAALG
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]