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The map label for this gene is dapA [H]

Identifier: 94309611

GI number: 94309611

Start: 733257

End: 734165

Strand: Direct

Name: dapA [H]

Synonym: Rmet_0666

Alternate gene names: 94309611

Gene position: 733257-734165 (Clockwise)

Preceding gene: 94309607

Following gene: 94309613

Centisome position: 18.67

GC content: 66.01

Gene sequence:

>909_bases
ATGCAGAACACGCAGTCCCATCCTGGTTTTCGCGGCATCTGGCTGCCGCTCGTGACCCCTTTTCACCGTGGCGAAGTCGA
TTTCGATGCCTTGCAGCGTCTGGTTGGCCACTTCAGCGTCACCGGCATCGCCGGTTTCGTCGTATGTGGCAGCACCGGCG
AAGCGGCCGCGCTGGAGGAGCCCGAGCAACTGGCCGTGCTCGATACGGTGCTCGAATGCGCAAACGGGCTACCGGTGATC
ATGGGTCTGGCCGGCAACCATCTGGGTCATGTGCTGGCACGCCTGGGCCGCTGCAACGAACGGCCGCTGGCGGGCGTGCT
GGCCCCGGCGCCGTACTACATCCGTCCGTCGCAGGACGGATTGCGCGACTACTTCCGGCGCCTGGCAGATGCCTCGCGGG
CCCCGCTCGTGCTCTATGACATTCCGTACCGAACCGGCACGACGCTGATGCTGGAGACGCTGCTATCGCTGGCTGATCAC
GGCAATATCGGCGCGATCAAGGATTGCGGCGGCAATGCCCTTAACACGCAGGCGCTGATCGCCGATGGCAGGCTGGCGGT
GTTGGCGGGAGAGGATCACCAGCTTCTCGGCACGCTGGCGTTGGGCGGGCAGGGCGCGATCATCGCTTGCGCGCACTTCC
ATCCGGAGCGGTTCGTGGCGATCTGGCGTGCTGTGTCCGAGGGGCGGCTGGACGAGGCGCGCCGCTTGTTCTACGCATTG
ATGCCGCTGATCCAGACGCTGTTCGCGGAGCCGAACCCGGGGCCGATCAAGGCGCTGCTGGCGCGTCATGGCTGGTTGCG
CGACGAACTGCGCGCGCCGATGACCTGCGCATCGCCGGAACTGGCGAACCAGCTCGCGGCGATGTTCGATGCGATGGATA
TCGTGAGCGGGGCGGTCAGCCAGCCTTGA

Upstream 100 bases:

>100_bases
CAGTACCGGTCGAAGGGGCGATCTGCCCGCGTTTGCATTCCCCGTGTCCTGCCGCGTCGCGCTCTGACGGTTTCCGAATC
GGTCGATCCGGAGTCCTTTC

Downstream 100 bases:

>100_bases
AGGCCTTGGCGGCGGCAGCCACCGTCGCCTCGATGATCGCATCGTCATGCTTGGCCGACACGAAGCCGGCCTCGAAGGCC
GACGGCGCCAGGTAGACGCC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS 2 [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MQNTQSHPGFRGIWLPLVTPFHRGEVDFDALQRLVGHFSVTGIAGFVVCGSTGEAAALEEPEQLAVLDTVLECANGLPVI
MGLAGNHLGHVLARLGRCNERPLAGVLAPAPYYIRPSQDGLRDYFRRLADASRAPLVLYDIPYRTGTTLMLETLLSLADH
GNIGAIKDCGGNALNTQALIADGRLAVLAGEDHQLLGTLALGGQGAIIACAHFHPERFVAIWRAVSEGRLDEARRLFYAL
MPLIQTLFAEPNPGPIKALLARHGWLRDELRAPMTCASPELANQLAAMFDAMDIVSGAVSQP

Sequences:

>Translated_302_residues
MQNTQSHPGFRGIWLPLVTPFHRGEVDFDALQRLVGHFSVTGIAGFVVCGSTGEAAALEEPEQLAVLDTVLECANGLPVI
MGLAGNHLGHVLARLGRCNERPLAGVLAPAPYYIRPSQDGLRDYFRRLADASRAPLVLYDIPYRTGTTLMLETLLSLADH
GNIGAIKDCGGNALNTQALIADGRLAVLAGEDHQLLGTLALGGQGAIIACAHFHPERFVAIWRAVSEGRLDEARRLFYAL
MPLIQTLFAEPNPGPIKALLARHGWLRDELRAPMTCASPELANQLAAMFDAMDIVSGAVSQP
>Mature_302_residues
MQNTQSHPGFRGIWLPLVTPFHRGEVDFDALQRLVGHFSVTGIAGFVVCGSTGEAAALEEPEQLAVLDTVLECANGLPVI
MGLAGNHLGHVLARLGRCNERPLAGVLAPAPYYIRPSQDGLRDYFRRLADASRAPLVLYDIPYRTGTTLMLETLLSLADH
GNIGAIKDCGGNALNTQALIADGRLAVLAGEDHQLLGTLALGGQGAIIACAHFHPERFVAIWRAVSEGRLDEARRLFYAL
MPLIQTLFAEPNPGPIKALLARHGWLRDELRAPMTCASPELANQLAAMFDAMDIVSGAVSQP

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=284, Percent_Identity=27.8169014084507, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1788823, Length=272, Percent_Identity=35.2941176470588, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI87082415, Length=242, Percent_Identity=30.5785123966942, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786463, Length=244, Percent_Identity=29.0983606557377, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789620, Length=231, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32440; Mature: 32440

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNTQSHPGFRGIWLPLVTPFHRGEVDFDALQRLVGHFSVTGIAGFVVCGSTGEAAALEE
CCCCCCCCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCC
PEQLAVLDTVLECANGLPVIMGLAGNHLGHVLARLGRCNERPLAGVLAPAPYYIRPSQDG
CHHHHHHHHHHHHHCCCEEEEEHHCHHHHHHHHHHHCCCCCCCCCEECCCCEEECCCHHH
LRDYFRRLADASRAPLVLYDIPYRTGTTLMLETLLSLADHGNIGAIKDCGGNALNTQALI
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEE
ADGRLAVLAGEDHQLLGTLALGGQGAIIACAHFHPERFVAIWRAVSEGRLDEARRLFYAL
ECCCEEEEECCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHH
MPLIQTLFAEPNPGPIKALLARHGWLRDELRAPMTCASPELANQLAAMFDAMDIVSGAVS
HHHHHHHHCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
QP
CC
>Mature Secondary Structure
MQNTQSHPGFRGIWLPLVTPFHRGEVDFDALQRLVGHFSVTGIAGFVVCGSTGEAAALEE
CCCCCCCCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCC
PEQLAVLDTVLECANGLPVIMGLAGNHLGHVLARLGRCNERPLAGVLAPAPYYIRPSQDG
CHHHHHHHHHHHHHCCCEEEEEHHCHHHHHHHHHHHCCCCCCCCCEECCCCEEECCCHHH
LRDYFRRLADASRAPLVLYDIPYRTGTTLMLETLLSLADHGNIGAIKDCGGNALNTQALI
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEE
ADGRLAVLAGEDHQLLGTLALGGQGAIIACAHFHPERFVAIWRAVSEGRLDEARRLFYAL
ECCCEEEEECCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHH
MPLIQTLFAEPNPGPIKALLARHGWLRDELRAPMTCASPELANQLAAMFDAMDIVSGAVS
HHHHHHHHCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
QP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]