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The map label for this gene is fdsB [H]

Identifier: 94309499

GI number: 94309499

Start: 591399

End: 592955

Strand: Direct

Name: fdsB [H]

Synonym: Rmet_0554

Alternate gene names: 94309499

Gene position: 591399-592955 (Clockwise)

Preceding gene: 94309498

Following gene: 94309500

Centisome position: 15.06

GC content: 66.99

Gene sequence:

>1557_bases
ATGAGCACGACGATCTTTGTACCCCGCGACTCCACCGCATTGGCGCTGGGCGCCGATGAAGTGGCGCAGGCCATCGCGCG
CGAGGCGGAAAAGCGCGGCGCGGATGTGCGCATCGTGCGCAACGGCTCGCGTGGGATGTTCTGGCTGGAACCGCTCGTCG
AGGTGCAGACCGATGCGGGCCGGGTGGCGTATGGCCCGGTCACCGAGGACGATGTGTCCGCGCTGTTCGACGCGGGATTC
CTGCACGGCGGCAGCCATGCGCTAAGCCACGGCGCGACTGCCGAGATTCCGTTCCTGAAGAAGCAGGAGCGGCTGACGTT
CATGCGCGTTGGCATTACCGACCCCTTGTCGCTTGACGACTACATCGCGCACGAGGGCTTCGTCGGGCTGACCCGCGCGC
TGTCGATGGCGCCCGCGGAGATCGTGCAGGAGGTCGTCGATTCGGGCCTGCGCGGCCGTGGCGGCGCGGCGTTCCCTACC
GGCATCAAATGGAAGACCGTGCTCGGCGCCCGGTCCGACGTCAAGTACGTGGTGTGCAATGCCGACGAGGGCGACTCGGG
CACATTCTCCGACCGCATGGTGATGGAGGACGACCCGTTCATGCTGATCGAGGGCATGGTGATCGCGGGTCTGGCCGTCG
GGGCGGAGCAGGGCTACATCTACACGCGATCCGAGTATCCGCACGCGATTGCCGCGACCGAGGCAGCGATCGAGATCGCC
ACGCGTGCCGGCTGGCTTGGCGACGACATTCGCGGCAGCGGCCGCTGCTTCCAGCTGGAAGTGCGCAAGGGCGCCGGCGC
CTACGTCTGCGGCGAGGAAACCGCGCTGCTCGAAAGCCTGGAAGGCAAGCGCGGCGTGGTGCGCGCCAAGCCTCCACTGC
CTGCGCTGGAGGGGCTGTTCGGCAAGCCTACTGTTATCAACAATGTGATCTCCCTGGCCACCGTGCCAGTGATTCTCGCG
CGCGGCGCGAAGTTCTATCAGGACTTCGGCATGGGCCGGTCGCGCGGCACGCTGCCGTTCCAGTTGGCCGGCAACATCCG
CCAGGGTGGTCTGGTCGAAAAGGCGTTCGGCGTGACGCTGCGCGAGCTGATGCTCGACTATGGCGGCGGCACGCGCAGCG
GACGTGCAATCCGCGCGGTGCAGGTGGGCGGGCCGCTCGGCGCGTACCTGCCCGAGTCACGATTCGACACACCGATCGAC
TACGAGGCGTACGCGGCGTTCGGCGCGGTAGTGGGGCACGGCGGTATCGTGGTGTTCGACGAGACCGTGGACATGGCGAA
GATGGCGCGCTACGCAATGGAGTTCTGCGCGATCGAGTCGTGCGGCAAGTGCACACCATGCCGGATCGGGTCCACGCGCG
GCGTCGAGGTGATGGACCGCATCATCGCCGGCGACCAGCCCGTGAAGCACGTGGCGCTGGTGCGCGATCTTTGCGACACG
ATGGTCAACGGCTCGCTTTGCGCGATGGGCAGCATGACGCCGTACCCGGTGCTGTCTGCACTGGACGAGTTTCCGGAAGA
CTTCGGCCTGTCGGGCAAGGCTGCGAAGGCAGCCTGA

Upstream 100 bases:

>100_bases
GCCCGGCAATGACGATCGGCGATCGTTTGCATGGGCGCGTCGACATGCAGCGATTCGACAAGCTGATCGACGCAGTCCGC
GAGCGCGAGGAGGCCCAGGC

Downstream 100 bases:

>100_bases
ACGCGGCCTGAGCGCGGCAATCAAAAAAAGCACGACGCGCTCCTCAGGAGCGCGCGACCTCACAGCAGTGAAAGACGGGA
GACATCCCTTGAACGCTCGA

Product: NAD-dependent formate dehydrogenase subunit beta

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MSTTIFVPRDSTALALGADEVAQAIAREAEKRGADVRIVRNGSRGMFWLEPLVEVQTDAGRVAYGPVTEDDVSALFDAGF
LHGGSHALSHGATAEIPFLKKQERLTFMRVGITDPLSLDDYIAHEGFVGLTRALSMAPAEIVQEVVDSGLRGRGGAAFPT
GIKWKTVLGARSDVKYVVCNADEGDSGTFSDRMVMEDDPFMLIEGMVIAGLAVGAEQGYIYTRSEYPHAIAATEAAIEIA
TRAGWLGDDIRGSGRCFQLEVRKGAGAYVCGEETALLESLEGKRGVVRAKPPLPALEGLFGKPTVINNVISLATVPVILA
RGAKFYQDFGMGRSRGTLPFQLAGNIRQGGLVEKAFGVTLRELMLDYGGGTRSGRAIRAVQVGGPLGAYLPESRFDTPID
YEAYAAFGAVVGHGGIVVFDETVDMAKMARYAMEFCAIESCGKCTPCRIGSTRGVEVMDRIIAGDQPVKHVALVRDLCDT
MVNGSLCAMGSMTPYPVLSALDEFPEDFGLSGKAAKAA

Sequences:

>Translated_518_residues
MSTTIFVPRDSTALALGADEVAQAIAREAEKRGADVRIVRNGSRGMFWLEPLVEVQTDAGRVAYGPVTEDDVSALFDAGF
LHGGSHALSHGATAEIPFLKKQERLTFMRVGITDPLSLDDYIAHEGFVGLTRALSMAPAEIVQEVVDSGLRGRGGAAFPT
GIKWKTVLGARSDVKYVVCNADEGDSGTFSDRMVMEDDPFMLIEGMVIAGLAVGAEQGYIYTRSEYPHAIAATEAAIEIA
TRAGWLGDDIRGSGRCFQLEVRKGAGAYVCGEETALLESLEGKRGVVRAKPPLPALEGLFGKPTVINNVISLATVPVILA
RGAKFYQDFGMGRSRGTLPFQLAGNIRQGGLVEKAFGVTLRELMLDYGGGTRSGRAIRAVQVGGPLGAYLPESRFDTPID
YEAYAAFGAVVGHGGIVVFDETVDMAKMARYAMEFCAIESCGKCTPCRIGSTRGVEVMDRIIAGDQPVKHVALVRDLCDT
MVNGSLCAMGSMTPYPVLSALDEFPEDFGLSGKAAKAA
>Mature_517_residues
STTIFVPRDSTALALGADEVAQAIAREAEKRGADVRIVRNGSRGMFWLEPLVEVQTDAGRVAYGPVTEDDVSALFDAGFL
HGGSHALSHGATAEIPFLKKQERLTFMRVGITDPLSLDDYIAHEGFVGLTRALSMAPAEIVQEVVDSGLRGRGGAAFPTG
IKWKTVLGARSDVKYVVCNADEGDSGTFSDRMVMEDDPFMLIEGMVIAGLAVGAEQGYIYTRSEYPHAIAATEAAIEIAT
RAGWLGDDIRGSGRCFQLEVRKGAGAYVCGEETALLESLEGKRGVVRAKPPLPALEGLFGKPTVINNVISLATVPVILAR
GAKFYQDFGMGRSRGTLPFQLAGNIRQGGLVEKAFGVTLRELMLDYGGGTRSGRAIRAVQVGGPLGAYLPESRFDTPIDY
EAYAAFGAVVGHGGIVVFDETVDMAKMARYAMEFCAIESCGKCTPCRIGSTRGVEVMDRIIAGDQPVKHVALVRDLCDTM
VNGSLCAMGSMTPYPVLSALDEFPEDFGLSGKAAKAA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=413, Percent_Identity=37.5302663438257, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI260656005, Length=413, Percent_Identity=37.5302663438257, Blast_Score=258, Evalue=8e-69,
Organism=Escherichia coli, GI1788620, Length=407, Percent_Identity=40.7862407862408, Blast_Score=313, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI17531727, Length=423, Percent_Identity=37.5886524822695, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI19920794, Length=371, Percent_Identity=39.0835579514825, Blast_Score=258, Evalue=9e-69,
Organism=Drosophila melanogaster, GI45550452, Length=368, Percent_Identity=38.0434782608696, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24653819, Length=361, Percent_Identity=30.4709141274238, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24653817, Length=332, Percent_Identity=28.3132530120482, Blast_Score=155, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55100; Mature: 54969

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTIFVPRDSTALALGADEVAQAIAREAEKRGADVRIVRNGSRGMFWLEPLVEVQTDAG
CCCEEEEECCCCEEEECHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECHHHHHCCCCC
RVAYGPVTEDDVSALFDAGFLHGGSHALSHGATAEIPFLKKQERLTFMRVGITDPLSLDD
EEEECCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHCCEEEEEECCCCCCCCHH
YIAHEGFVGLTRALSMAPAEIVQEVVDSGLRGRGGAAFPTGIKWKTVLGARSDVKYVVCN
HHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEE
ADEGDSGTFSDRMVMEDDPFMLIEGMVIAGLAVGAEQGYIYTRSEYPHAIAATEAAIEIA
CCCCCCCCCCCCEEECCCCEEEEHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHH
TRAGWLGDDIRGSGRCFQLEVRKGAGAYVCGEETALLESLEGKRGVVRAKPPLPALEGLF
HHCCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHHHCCCCCCEEECCCCCHHHHCCC
GKPTVINNVISLATVPVILARGAKFYQDFGMGRSRGTLPFQLAGNIRQGGLVEKAFGVTL
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEECCCCCCCCCHHHHHHHHH
RELMLDYGGGTRSGRAIRAVQVGGPLGAYLPESRFDTPIDYEAYAAFGAVVGHGGIVVFD
HHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
ETVDMAKMARYAMEFCAIESCGKCTPCRIGSTRGVEVMDRIIAGDQPVKHVALVRDLCDT
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
MVNGSLCAMGSMTPYPVLSALDEFPEDFGLSGKAAKAA
HHCCCEEECCCCCCHHHHHHHHHCHHHHCCCCCCCCCC
>Mature Secondary Structure 
STTIFVPRDSTALALGADEVAQAIAREAEKRGADVRIVRNGSRGMFWLEPLVEVQTDAG
CCEEEEECCCCEEEECHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECHHHHHCCCCC
RVAYGPVTEDDVSALFDAGFLHGGSHALSHGATAEIPFLKKQERLTFMRVGITDPLSLDD
EEEECCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHCCEEEEEECCCCCCCCHH
YIAHEGFVGLTRALSMAPAEIVQEVVDSGLRGRGGAAFPTGIKWKTVLGARSDVKYVVCN
HHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEE
ADEGDSGTFSDRMVMEDDPFMLIEGMVIAGLAVGAEQGYIYTRSEYPHAIAATEAAIEIA
CCCCCCCCCCCCEEECCCCEEEEHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHH
TRAGWLGDDIRGSGRCFQLEVRKGAGAYVCGEETALLESLEGKRGVVRAKPPLPALEGLF
HHCCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHHHCCCCCCEEECCCCCHHHHCCC
GKPTVINNVISLATVPVILARGAKFYQDFGMGRSRGTLPFQLAGNIRQGGLVEKAFGVTL
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEECCCCCCCCCHHHHHHHHH
RELMLDYGGGTRSGRAIRAVQVGGPLGAYLPESRFDTPIDYEAYAAFGAVVGHGGIVVFD
HHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
ETVDMAKMARYAMEFCAIESCGKCTPCRIGSTRGVEVMDRIIAGDQPVKHVALVRDLCDT
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
MVNGSLCAMGSMTPYPVLSALDEFPEDFGLSGKAAKAA
HHCCCEEECCCCCCHHHHHHHHHCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]