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The map label for this gene is adhC [C]

Identifier: 94309490

GI number: 94309490

Start: 580390

End: 581487

Strand: Direct

Name: adhC [C]

Synonym: Rmet_0545

Alternate gene names: 94309490

Gene position: 580390-581487 (Clockwise)

Preceding gene: 94309489

Following gene: 94309493

Centisome position: 14.78

GC content: 64.21

Gene sequence:

>1098_bases
ATGAAAGCCGCAGTGATGGAAAAAGCAGGCGCGCCGCTCGTGATCCATGACGTTGCCATTGCCGAACCGGGTCCGCGCGA
GGTGCGGGTGCGAACGGCGGCCGTGGGGTTGTGCCATAGTGATCTTCACATGATGCAGGGCACCTATCCGCTACCACTGC
CCGCCGTGCTTGGGCACGAGGTGTCGGGCGTGGTGGAGGCCGTTGGCACGCAGGTATCCGGACTGAAGGCGGGCGATCAT
GTGGTGGGCTGCCTGTCGGTCTATTGCGGCCACTGCTCGGTATGCGCGTCGGGCCATCAGGTGCTGTGCCAGAACCCGGA
GGTGAAGCTTCCGCCCGGCAAGGCCAACCGTCTGCGCCTGGCGGGGAATCCGCTCAGCCAGGTGTTCAATCTCTCCGGTT
TCGCCGAAGAGATCCTCGTGCACGAGAACGCGCTGGTGAAGATTCGCGACGATATGCCGCTCGATCGCGCGGCGCTGCTC
GGCTGCGCGGTCATCACCGGCACTGGCGCGGTCTTCCATAGCGCGAAGGTGCCGCCGGGCAGCACCGTGGTGGTGGTCGG
CTGCGGCGGTGTCGGGCTGTCCGTGATCAACGGCGCGGTGATTGCCGGCGCGTCGCGTGTGATCGCCGTGGACATGCTGC
CTGCCAAGCTGGAACTGGCTCGCAAGTTCGGGGCGACCGACGTTGTCAATGCGGGCGATGGGGATCCGGTCGCGCAGGTG
ATGCAACTGACCGGCGGCGGTGCCGAATTCGCTTTCGAATGCATCGGCTTGAAGCAGACCGCCGAGCAGTGCTACGCGAT
GCTGGCCCCCGGTGGCACGGCGACGGTGATCGGCCTGTTCCGTCCGGATGCGAGGATCGAACTGCCCGCACTCGACTTCC
TGAAAGAGAAGCGCATCCAGGGCTCGTTCATGGGTTCGAACCGCCTGAGTCTGGATATCCCTCGACTGGTCGAGTTGTAC
ATGCAGGGCAAGCTGCTGCTCGACGATCTGATTTCGCAGCGGATCTCGCTGGAGGATATCAATGAGGGGTTCATCGCCAT
GCAGTCGGGAAGCGTGGCGCGAAGCGTGATCACATTCCCTGGGGTAGGCGGGTTGTAA

Upstream 100 bases:

>100_bases
TCGAGCCTCGCCTTGCCGCGATGCTGCAACGCTATCTGGCCGGGCCGCCGCACGTCCCGGCTCCGTGAAGCAAGTTGATT
CAACCAAGGAGACACAGAAG

Downstream 100 bases:

>100_bases
GACGCCGCCAATCTGCCGCGCGCCATGCCGGATGCGGCGTGGCGCGCGGTGTCGCGACTGCTACAGCTATTGCGCGGTCC
AGCCGCCGTCCATGGCCCAG

Product: alcohol dehydrogenase, zinc-containing

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MKAAVMEKAGAPLVIHDVAIAEPGPREVRVRTAAVGLCHSDLHMMQGTYPLPLPAVLGHEVSGVVEAVGTQVSGLKAGDH
VVGCLSVYCGHCSVCASGHQVLCQNPEVKLPPGKANRLRLAGNPLSQVFNLSGFAEEILVHENALVKIRDDMPLDRAALL
GCAVITGTGAVFHSAKVPPGSTVVVVGCGGVGLSVINGAVIAGASRVIAVDMLPAKLELARKFGATDVVNAGDGDPVAQV
MQLTGGGAEFAFECIGLKQTAEQCYAMLAPGGTATVIGLFRPDARIELPALDFLKEKRIQGSFMGSNRLSLDIPRLVELY
MQGKLLLDDLISQRISLEDINEGFIAMQSGSVARSVITFPGVGGL

Sequences:

>Translated_365_residues
MKAAVMEKAGAPLVIHDVAIAEPGPREVRVRTAAVGLCHSDLHMMQGTYPLPLPAVLGHEVSGVVEAVGTQVSGLKAGDH
VVGCLSVYCGHCSVCASGHQVLCQNPEVKLPPGKANRLRLAGNPLSQVFNLSGFAEEILVHENALVKIRDDMPLDRAALL
GCAVITGTGAVFHSAKVPPGSTVVVVGCGGVGLSVINGAVIAGASRVIAVDMLPAKLELARKFGATDVVNAGDGDPVAQV
MQLTGGGAEFAFECIGLKQTAEQCYAMLAPGGTATVIGLFRPDARIELPALDFLKEKRIQGSFMGSNRLSLDIPRLVELY
MQGKLLLDDLISQRISLEDINEGFIAMQSGSVARSVITFPGVGGL
>Mature_365_residues
MKAAVMEKAGAPLVIHDVAIAEPGPREVRVRTAAVGLCHSDLHMMQGTYPLPLPAVLGHEVSGVVEAVGTQVSGLKAGDH
VVGCLSVYCGHCSVCASGHQVLCQNPEVKLPPGKANRLRLAGNPLSQVFNLSGFAEEILVHENALVKIRDDMPLDRAALL
GCAVITGTGAVFHSAKVPPGSTVVVVGCGGVGLSVINGAVIAGASRVIAVDMLPAKLELARKFGATDVVNAGDGDPVAQV
MQLTGGGAEFAFECIGLKQTAEQCYAMLAPGGTATVIGLFRPDARIELPALDFLKEKRIQGSFMGSNRLSLDIPRLVELY
MQGKLLLDDLISQRISLEDINEGFIAMQSGSVARSVITFPGVGGL

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=365, Percent_Identity=36.986301369863, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI4501933, Length=365, Percent_Identity=36.1643835616438, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI4501929, Length=365, Percent_Identity=35.8904109589041, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=35.149863760218, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI71565152, Length=370, Percent_Identity=35.4054054054054, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI71743840, Length=365, Percent_Identity=34.2465753424658, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI262073058, Length=365, Percent_Identity=34.2465753424658, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI156523966, Length=363, Percent_Identity=34.435261707989, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI4501939, Length=356, Percent_Identity=34.8314606741573, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI156627571, Length=349, Percent_Identity=26.3610315186246, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=35.792349726776, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1788073, Length=332, Percent_Identity=29.5180722891566, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87082125, Length=356, Percent_Identity=27.5280898876405, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790045, Length=368, Percent_Identity=27.445652173913, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786518, Length=367, Percent_Identity=29.4277929155313, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788075, Length=343, Percent_Identity=27.6967930029155, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1788407, Length=367, Percent_Identity=28.0653950953678, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI87081918, Length=366, Percent_Identity=29.5081967213115, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI226510992, Length=355, Percent_Identity=25.3521126760563, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786825, Length=371, Percent_Identity=25.6064690026954, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1787863, Length=355, Percent_Identity=25.9154929577465, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082401, Length=314, Percent_Identity=25.4777070063694, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790718, Length=315, Percent_Identity=24.7619047619048, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=35.9249329758713, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=35.7333333333333, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17565904, Length=337, Percent_Identity=35.0148367952522, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17562584, Length=363, Percent_Identity=28.099173553719, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17562876, Length=358, Percent_Identity=27.6536312849162, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17562878, Length=355, Percent_Identity=27.887323943662, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17562582, Length=365, Percent_Identity=27.6712328767123, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=363, Percent_Identity=26.7217630853994, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=34.2318059299191, Blast_Score=212, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6323099, Length=362, Percent_Identity=30.1104972375691, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=382, Percent_Identity=26.1780104712042, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=365, Percent_Identity=26.3013698630137, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=367, Percent_Identity=28.6103542234332, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=352, Percent_Identity=26.1363636363636, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=386, Percent_Identity=29.2746113989637, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=386, Percent_Identity=29.2746113989637, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=359, Percent_Identity=26.7409470752089, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=283, Percent_Identity=27.208480565371, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=146, Percent_Identity=32.8767123287671, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=39.5663956639566, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI17137530, Length=341, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17737897, Length=342, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45550770, Length=349, Percent_Identity=26.647564469914, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45551930, Length=349, Percent_Identity=26.647564469914, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221457811, Length=349, Percent_Identity=26.647564469914, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 37943; Mature: 37943

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVMEKAGAPLVIHDVAIAEPGPREVRVRTAAVGLCHSDLHMMQGTYPLPLPAVLGHE
CCCCHHHHCCCCEEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHCCH
VSGVVEAVGTQVSGLKAGDHVVGCLSVYCGHCSVCASGHQVLCQNPEVKLPPGKANRLRL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHEECCCCEEEECCCCEECCCCCCCEEEE
AGNPLSQVFNLSGFAEEILVHENALVKIRDDMPLDRAALLGCAVITGTGAVFHSAKVPPG
CCCHHHHHHCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHEECCCHHEECCCCCCC
STVVVVGCGGVGLSVINGAVIAGASRVIAVDMLPAKLELARKFGATDVVNAGDGDPVAQV
CEEEEEECCCCCHHHHCCHHEECCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCHHHHH
MQLTGGGAEFAFECIGLKQTAEQCYAMLAPGGTATVIGLFRPDARIELPALDFLKEKRIQ
HHHCCCCHHEEEEECCHHHHHHHHHEEECCCCCEEEEEEECCCCEEECCHHHHHHHHHHC
GSFMGSNRLSLDIPRLVELYMQGKLLLDDLISQRISLEDINEGFIAMQSGSVARSVITFP
CEEECCCCCEECHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCCEEEEECCCHHHHEEECC
GVGGL
CCCCC
>Mature Secondary Structure
MKAAVMEKAGAPLVIHDVAIAEPGPREVRVRTAAVGLCHSDLHMMQGTYPLPLPAVLGHE
CCCCHHHHCCCCEEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHCCH
VSGVVEAVGTQVSGLKAGDHVVGCLSVYCGHCSVCASGHQVLCQNPEVKLPPGKANRLRL
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHEECCCCEEEECCCCEECCCCCCCEEEE
AGNPLSQVFNLSGFAEEILVHENALVKIRDDMPLDRAALLGCAVITGTGAVFHSAKVPPG
CCCHHHHHHCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHEECCCHHEECCCCCCC
STVVVVGCGGVGLSVINGAVIAGASRVIAVDMLPAKLELARKFGATDVVNAGDGDPVAQV
CEEEEEECCCCCHHHHCCHHEECCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCHHHHH
MQLTGGGAEFAFECIGLKQTAEQCYAMLAPGGTATVIGLFRPDARIELPALDFLKEKRIQ
HHHCCCCHHEEEEECCHHHHHHHHHEEECCCCCEEEEEEECCCCEEECCHHHHHHHHHHC
GSFMGSNRLSLDIPRLVELYMQGKLLLDDLISQRISLEDINEGFIAMQSGSVARSVITFP
CEEECCCCCEECHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCCEEEEECCCHHHHEEECC
GVGGL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]