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The map label for this gene is cbbA3 [H]

Identifier: 94309448

GI number: 94309448

Start: 533897

End: 534961

Strand: Direct

Name: cbbA3 [H]

Synonym: Rmet_0503

Alternate gene names: 94309448

Gene position: 533897-534961 (Clockwise)

Preceding gene: 94309447

Following gene: 94309449

Centisome position: 13.59

GC content: 63.47

Gene sequence:

>1065_bases
ATGCCACTCGTATCCATGCGCCAGTTGCTGGACCATGCCGCCGAGAACAACTACGGTCTGCCGGCTTTCAACGTGAACAA
CCTCGAGCAGGTTCAGGCCATCATGCAGGCCGCCGACGAGGTCAACGCCCCGGTGATCATGCAGGCATCGGCAGGCGCGC
GCAAATACGCTGGCGAGCACTTCCTGCGTCACCTGATCGAAGCCGCCGTGGAAGCCTATCCGCACATCCCGGTGGTGATG
CACCAGGATCACGGCCAGTCGCCGGCGATCTGCAAGGCCGCCATCGACCTGAACTTCTCGTCGGTGATGATGGATGGCTC
GCTGAAGGAAGACGGCAAGACCCCGTCGGACTACGAGTACAACGTCGACGTGACCCGCAAGGTGGTGCAGATGGCCCACG
CGCTGGGCGTGACCGTGGAAGGCGAACTGGGTTGCCTGGGCTCGCTGGAAACCGGTGAAGCCGGCGAGGAAGACGGCATT
GGCGCCGAAGGCAAGCTCGATCACTCGATGCTGCTGACCGATCCGGAGCAGGCCGCCGACTTCGTCAAGGCCACCCAGCT
CGACGCGCTGGCCATCGCCATCGGCACCTCGCACGGCGCGTACAAGTTCACGCGCAAGCCCACGGGCGACATCCTGGCCA
TCGGGCGCATCAAGGAAATCCACGCCCGCATTCCGAACACTCACCTGGTGATGCACGGTTCGTCGTCGGTGCCGCAGGAA
CTGCTGGCTGAAATCCGCCAGTTCGGTGGCGACATGAAGGAAACGTACGGCGTGCCCGTGGAGGAAATCCAGGAAGCGAT
CAAGTACGGCGTGCGCAAGATCAACATCGACACCGACATCCGTCTGGCGATGACCGGCGCGATCCGCCGCTTCTTCGTGG
AGAACCCGAGCAAGTTCGACCCGCGCGAGTACCTGAAGCCGGCCCGCGAAGCCGCCAAGCTCGTGTGCAAGGCCCGCTAC
ATCGCCTTCGGTTGTGAAGGCCAGGCCAGCAAGATCAAGGCCGTGTCGCTGACCGACGTTGCCCAGCAGTACAAGGCCGG
CAAGCTCGCCCAGGTCGTGCAGTAA

Upstream 100 bases:

>100_bases
CGCCAGACAGACATGACCGCGCCCGATGCGCGAGCCTGTTTGGCGCAGCAACGATAAGAATTCAGAAATACCCCAAGCTA
TTTACATTCAGGAGTTAGAC

Downstream 100 bases:

>100_bases
ATTGTGTCGTTGCCCCGCCTGGTGCGGGGCTTTGCTTCTTCATGGGGCTTCGCATCGCGCTCGAAGCCCCGCTTGTTTTT
CAGCCGCAGCCGTTTTCACA

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPLVSMRQLLDHAAENNYGLPAFNVNNLEQVQAIMQAADEVNAPVIMQASAGARKYAGEHFLRHLIEAAVEAYPHIPVVM
HQDHGQSPAICKAAIDLNFSSVMMDGSLKEDGKTPSDYEYNVDVTRKVVQMAHALGVTVEGELGCLGSLETGEAGEEDGI
GAEGKLDHSMLLTDPEQAADFVKATQLDALAIAIGTSHGAYKFTRKPTGDILAIGRIKEIHARIPNTHLVMHGSSSVPQE
LLAEIRQFGGDMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAIRRFFVENPSKFDPREYLKPAREAAKLVCKARY
IAFGCEGQASKIKAVSLTDVAQQYKAGKLAQVVQ

Sequences:

>Translated_354_residues
MPLVSMRQLLDHAAENNYGLPAFNVNNLEQVQAIMQAADEVNAPVIMQASAGARKYAGEHFLRHLIEAAVEAYPHIPVVM
HQDHGQSPAICKAAIDLNFSSVMMDGSLKEDGKTPSDYEYNVDVTRKVVQMAHALGVTVEGELGCLGSLETGEAGEEDGI
GAEGKLDHSMLLTDPEQAADFVKATQLDALAIAIGTSHGAYKFTRKPTGDILAIGRIKEIHARIPNTHLVMHGSSSVPQE
LLAEIRQFGGDMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAIRRFFVENPSKFDPREYLKPAREAAKLVCKARY
IAFGCEGQASKIKAVSLTDVAQQYKAGKLAQVVQ
>Mature_353_residues
PLVSMRQLLDHAAENNYGLPAFNVNNLEQVQAIMQAADEVNAPVIMQASAGARKYAGEHFLRHLIEAAVEAYPHIPVVMH
QDHGQSPAICKAAIDLNFSSVMMDGSLKEDGKTPSDYEYNVDVTRKVVQMAHALGVTVEGELGCLGSLETGEAGEEDGIG
AEGKLDHSMLLTDPEQAADFVKATQLDALAIAIGTSHGAYKFTRKPTGDILAIGRIKEIHARIPNTHLVMHGSSSVPQEL
LAEIRQFGGDMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAIRRFFVENPSKFDPREYLKPAREAAKLVCKARYI
AFGCEGQASKIKAVSLTDVAQQYKAGKLAQVVQ

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=334, Percent_Identity=32.0359281437126, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=32.5227963525836, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788072, Length=329, Percent_Identity=30.0911854103343, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789293, Length=358, Percent_Identity=25.1396648044693, Blast_Score=95, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6322790, Length=361, Percent_Identity=26.8698060941828, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38511; Mature: 38380

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMRQLLDHAAENNYGLPAFNVNNLEQVQAIMQAADEVNAPVIMQASAGARKYAGEH
CCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
FLRHLIEAAVEAYPHIPVVMHQDHGQSPAICKAAIDLNFSSVMMDGSLKEDGKTPSDYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCHHHHEECCCCCCCCCCCCCEEE
NVDVTRKVVQMAHALGVTVEGELGCLGSLETGEAGEEDGIGAEGKLDHSMLLTDPEQAAD
CHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHH
FVKATQLDALAIAIGTSHGAYKFTRKPTGDILAIGRIKEIHARIPNTHLVMHGSSSVPQE
HHHHHHHCEEEEEEECCCCCEEECCCCCCCEEEECHHHHHHHCCCCCEEEEECCCCCHHH
LLAEIRQFGGDMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAIRRFFVENPSKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCC
PREYLKPAREAAKLVCKARYIAFGCEGQASKIKAVSLTDVAQQYKAGKLAQVVQ
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure 
PLVSMRQLLDHAAENNYGLPAFNVNNLEQVQAIMQAADEVNAPVIMQASAGARKYAGEH
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
FLRHLIEAAVEAYPHIPVVMHQDHGQSPAICKAAIDLNFSSVMMDGSLKEDGKTPSDYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCHHHHEECCCCCCCCCCCCCEEE
NVDVTRKVVQMAHALGVTVEGELGCLGSLETGEAGEEDGIGAEGKLDHSMLLTDPEQAAD
CHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHH
FVKATQLDALAIAIGTSHGAYKFTRKPTGDILAIGRIKEIHARIPNTHLVMHGSSSVPQE
HHHHHHHCEEEEEEECCCCCEEECCCCCCCEEEECHHHHHHHCCCCCEEEEECCCCCHHH
LLAEIRQFGGDMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAIRRFFVENPSKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCC
PREYLKPAREAAKLVCKARYIAFGCEGQASKIKAVSLTDVAQQYKAGKLAQVVQ
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550527 [H]