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The map label for this gene is mmlH [H]

Identifier: 94309441

GI number: 94309441

Start: 525747

End: 527072

Strand: Direct

Name: mmlH [H]

Synonym: Rmet_0496

Alternate gene names: 94309441

Gene position: 525747-527072 (Clockwise)

Preceding gene: 94309440

Following gene: 94309442

Centisome position: 13.38

GC content: 65.69

Gene sequence:

>1326_bases
ATGCTGGACTGGTTCAGAGAGTTGTCGCGCGCCGAGCGCAAGGGGTTCTACGGCGCCTTCCTGGGTCATGCGGTCGACGT
GTTCGACTTCATGATCTATTCGTTCCTGATTTCCACGTTGCTGGCCCAGTGGGGCATGAGCAAGTCGATGGCGGGCGCCA
TCGTCACGTGGACGCTGGTGTCATCACTGGTCGGCGCGATCGGCGCGGGACTGCTGGCGGACCGCTTTGGCCGCGTGCGC
GTGCTTCGCTGGACGATTCTGGTGTTCGCGGTGTCGTGCTTCCTGTGTGGTATCTCCACCTCGCCCGAACAGCTCATGAT
GTTCCGCATGCTGCAGGGGCTGGGTTTCGGCGGCGAGTCGTCGCTATGCATGGTGCTGGTGACCGAGCTGATCCGGAATC
CCGCGCACCGCGGCAAGTACTCGGGCTTCACAGCCAGCAGCTATTCGTTCGGCTGGGGTGGCGCGGCCATTGCCTACGCG
ATCACGTTCAACCTGTTCGAGCCGGAAGTGGCGTGGCGCGTCTGTTTCTTCCTGGGCATCCTGCCGGCGCTGGTGGTGGT
CTATCTGCGCCGTAACCTGCAGGAACCCGAGGTCTTTCTCAAGAGCCGCGCGGAACGCGGCAACGTATCTGCGGCGGCCG
ATCTCGCGCGCGTGTTCCGGGGCCCGCTGCTGCGCAAGACGGTGCTGTGCAGCCTGCTTTCGGGCGGGATGCTGGGCGCG
TACTACGCCATCGCCACATGGCTGCCGACGTTCCTGAAGACCGAGCGCGGCCTGTCGGTGTTCGGCACGAGTTCCTATCT
GGCGGTGACGATCCTTGGCTCGCTGGTGGGCTACGTGGCCGGCGCGTACGCAACGGACCGCTGGGGCCGACGCCTGACCT
ACATGGCATTCGCGGCGGGCGCGTTCGTGATGGCGATGATCTACATGGTCATCCCGGTATCGAACACGTCGATGCTGTTC
CTCGGCTTCCCGCTCGGCGTGCTGATGCAGGGCGTGTTCTCGGGCATCGGCGCGACGATCTCCGAGTCGTATCCGAGCAG
CATCCGCGCCACGGGCTATGGTGTGTCGTACAACCTCGGCCGCGTGATCGGCTCGTTCTTCCCGCTGGCTGTAGGCTGGC
TCAACAGTGGCCGCACGACGCTGGCGCTGGCGATCGCGATGGTGGCGGGCGTTGGCTATGCGCTGGTGATGGTGTCCGCC
GCGATGTTGCCGGAAACGTCCGGTATCGATCTGGGCCAGGCTGGTGGCGGCGATGACGGCGAGGCGAAACAGCAGGCTGC
GGCCGAGCCCGTGACGGTGGCGCCGACCGCCGGACGCCCCGCCTGA

Upstream 100 bases:

>100_bases
ATCGCTGCGGTTCGCGCAGCAGCTTGAGGCAGCCGGCCACGTGTTCCGCCAGCCGCGCGCCTGACACGCAAGTTCACAAC
GGTAAAAGGGGAGAAAGACC

Downstream 100 bases:

>100_bases
AACCGGGATGCCGACGCCCGCGGATTGACCCCGAAACAACACTTTTAAGCCGCCACTTACCAGCGGCTGTCACACGCCTA
TAATGGCTCTTTCGCTGTCG

Product: major facilitator superfamily transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MLDWFRELSRAERKGFYGAFLGHAVDVFDFMIYSFLISTLLAQWGMSKSMAGAIVTWTLVSSLVGAIGAGLLADRFGRVR
VLRWTILVFAVSCFLCGISTSPEQLMMFRMLQGLGFGGESSLCMVLVTELIRNPAHRGKYSGFTASSYSFGWGGAAIAYA
ITFNLFEPEVAWRVCFFLGILPALVVVYLRRNLQEPEVFLKSRAERGNVSAAADLARVFRGPLLRKTVLCSLLSGGMLGA
YYAIATWLPTFLKTERGLSVFGTSSYLAVTILGSLVGYVAGAYATDRWGRRLTYMAFAAGAFVMAMIYMVIPVSNTSMLF
LGFPLGVLMQGVFSGIGATISESYPSSIRATGYGVSYNLGRVIGSFFPLAVGWLNSGRTTLALAIAMVAGVGYALVMVSA
AMLPETSGIDLGQAGGGDDGEAKQQAAAEPVTVAPTAGRPA

Sequences:

>Translated_441_residues
MLDWFRELSRAERKGFYGAFLGHAVDVFDFMIYSFLISTLLAQWGMSKSMAGAIVTWTLVSSLVGAIGAGLLADRFGRVR
VLRWTILVFAVSCFLCGISTSPEQLMMFRMLQGLGFGGESSLCMVLVTELIRNPAHRGKYSGFTASSYSFGWGGAAIAYA
ITFNLFEPEVAWRVCFFLGILPALVVVYLRRNLQEPEVFLKSRAERGNVSAAADLARVFRGPLLRKTVLCSLLSGGMLGA
YYAIATWLPTFLKTERGLSVFGTSSYLAVTILGSLVGYVAGAYATDRWGRRLTYMAFAAGAFVMAMIYMVIPVSNTSMLF
LGFPLGVLMQGVFSGIGATISESYPSSIRATGYGVSYNLGRVIGSFFPLAVGWLNSGRTTLALAIAMVAGVGYALVMVSA
AMLPETSGIDLGQAGGGDDGEAKQQAAAEPVTVAPTAGRPA
>Mature_441_residues
MLDWFRELSRAERKGFYGAFLGHAVDVFDFMIYSFLISTLLAQWGMSKSMAGAIVTWTLVSSLVGAIGAGLLADRFGRVR
VLRWTILVFAVSCFLCGISTSPEQLMMFRMLQGLGFGGESSLCMVLVTELIRNPAHRGKYSGFTASSYSFGWGGAAIAYA
ITFNLFEPEVAWRVCFFLGILPALVVVYLRRNLQEPEVFLKSRAERGNVSAAADLARVFRGPLLRKTVLCSLLSGGMLGA
YYAIATWLPTFLKTERGLSVFGTSSYLAVTILGSLVGYVAGAYATDRWGRRLTYMAFAAGAFVMAMIYMVIPVSNTSMLF
LGFPLGVLMQGVFSGIGATISESYPSSIRATGYGVSYNLGRVIGSFFPLAVGWLNSGRTTLALAIAMVAGVGYALVMVSA
AMLPETSGIDLGQAGGGDDGEAKQQAAAEPVTVAPTAGRPA

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082404, Length=400, Percent_Identity=26.5, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI87082231, Length=441, Percent_Identity=26.3038548752834, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1790550, Length=448, Percent_Identity=25.4464285714286, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082159, Length=374, Percent_Identity=25.9358288770053, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081723, Length=330, Percent_Identity=26.3636363636364, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47162; Mature: 47162

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCEEECCCCCCCC
>Mature Secondary Structure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HHHHHHCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]