Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 94309332

GI number: 94309332

Start: 414803

End: 415999

Strand: Direct

Name: fadA [H]

Synonym: Rmet_0387

Alternate gene names: 94309332

Gene position: 414803-415999 (Clockwise)

Preceding gene: 94309331

Following gene: 94309333

Centisome position: 10.56

GC content: 64.66

Gene sequence:

>1197_bases
ATGAAACAACTGCAAGACGCATACATTGTCGCGGCTACCCGTTCGCCGATCGGCAAGGCCCCGAAGGGCGCTTTCAAGAA
CACCCGTCCCGATGACCTGCTGGCGACGATCCTGCAAGCGGCCGTGGCCCAGGTGCCGAGCCTGGACCCCGCGCTGATCG
AGGACGCCATCGTCGGCTGCGCGATTCCCGAAGCGCAGCAGGGCCTGAACGTGGCGCGTATCGGCGCGCTGCTGGCAGGC
CTGCCCAACACCGTGGGCGGCATCACCGTGAACCGCTTCTGCGCGTCGGGCCTGTCGGCCGTGGCAATGGCTGCGGACCG
TATCCGCGTGGGCGAATCGGATGTAATGATCGCCGCCGGCGTGGAGTCGATGAGCATGGTGCCGATGATGGGCAACTCGC
CGTCGATGTCGCCGTCGATCTTCGAACGCGACGAGAATATCGGCATTGCCTACGGCATGGGTCTGACGGCCGAGAAGGTG
GCCACGCAGTGGAAGGTCAGCCGCGAGGACCAGGATGCGTTCTCGCTGGCATCGCACCAGAAGGCCATCGCCGCGCAGCA
GGCTGGCGAATTCAAGGACGAAATTACCCCGATTGAGGTAGTTGAGCGGTTCCCGGATCTCGCGTCTGGTCAGATCAACG
TCAAGACGCGTACTATTTCGCTGGACGAGGGACCGCGTCCCGATACGTCGGTGGAAGGGCTTGGCAAGCTGCGCGCGGTG
TTCGCCAACAAGGGCAGCGTGACGGCCGGCAATAGCTCGCAGACGTCCGATGGCGCCGGCGCGCTGATCCTGGTTTCGGA
GAAGATCCTCAAGCAGTTCAACCTGGTGCCGCGGGCCCGTTTCGTATCGTTCGCGGTGCGTGGCGTGCCGCCGGAGATCA
TGGGGATCGGTCCGAAGGCAGCGATTCCGGCTGCGCTGAAGGCCGCTGGCCTGACGCAGGACCAGATCGACTGGATCGAG
CTGAACGAAGCGTTTGCCGCGCAATCGCTGGCGGTGATGCGTGACCTGGAACTTGATCCGGCCAAGGTCAACCGGATGGG
CGGCGCCATCGCGCTGGGCCACCCGCTCGGTGCGACCGGAGCGATCCGTTCGGCCACTGTGGTGCACGCACTGCGTCGCC
ACAACATGAAGTACGGCATGGTGACCATGTGCGTGGGCACGGGCATGGGCGCAGCCGGAATCTTCGAGCGCGTATAA

Upstream 100 bases:

>100_bases
CGACCTGCTGGGCAACGGCAAGACCCAGGAGCGGATCATGGGAATGCTGCAGACGGGCAAGCCGGTGCGCAACTAATCAG
GCCAACGAGGAACCGACATC

Downstream 100 bases:

>100_bases
ATAAAGCGCGCCAGGGACAGCCCGACGGGTGGGCTGTCCCGACCTTCGATCAGGTGAGGAAATGCATGGACACGGAGATG
CCAACACACTGAAACCGAGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKQLQDAYIVAATRSPIGKAPKGAFKNTRPDDLLATILQAAVAQVPSLDPALIEDAIVGCAIPEAQQGLNVARIGALLAG
LPNTVGGITVNRFCASGLSAVAMAADRIRVGESDVMIAAGVESMSMVPMMGNSPSMSPSIFERDENIGIAYGMGLTAEKV
ATQWKVSREDQDAFSLASHQKAIAAQQAGEFKDEITPIEVVERFPDLASGQINVKTRTISLDEGPRPDTSVEGLGKLRAV
FANKGSVTAGNSSQTSDGAGALILVSEKILKQFNLVPRARFVSFAVRGVPPEIMGIGPKAAIPAALKAAGLTQDQIDWIE
LNEAFAAQSLAVMRDLELDPAKVNRMGGAIALGHPLGATGAIRSATVVHALRRHNMKYGMVTMCVGTGMGAAGIFERV

Sequences:

>Translated_398_residues
MKQLQDAYIVAATRSPIGKAPKGAFKNTRPDDLLATILQAAVAQVPSLDPALIEDAIVGCAIPEAQQGLNVARIGALLAG
LPNTVGGITVNRFCASGLSAVAMAADRIRVGESDVMIAAGVESMSMVPMMGNSPSMSPSIFERDENIGIAYGMGLTAEKV
ATQWKVSREDQDAFSLASHQKAIAAQQAGEFKDEITPIEVVERFPDLASGQINVKTRTISLDEGPRPDTSVEGLGKLRAV
FANKGSVTAGNSSQTSDGAGALILVSEKILKQFNLVPRARFVSFAVRGVPPEIMGIGPKAAIPAALKAAGLTQDQIDWIE
LNEAFAAQSLAVMRDLELDPAKVNRMGGAIALGHPLGATGAIRSATVVHALRRHNMKYGMVTMCVGTGMGAAGIFERV
>Mature_398_residues
MKQLQDAYIVAATRSPIGKAPKGAFKNTRPDDLLATILQAAVAQVPSLDPALIEDAIVGCAIPEAQQGLNVARIGALLAG
LPNTVGGITVNRFCASGLSAVAMAADRIRVGESDVMIAAGVESMSMVPMMGNSPSMSPSIFERDENIGIAYGMGLTAEKV
ATQWKVSREDQDAFSLASHQKAIAAQQAGEFKDEITPIEVVERFPDLASGQINVKTRTISLDEGPRPDTSVEGLGKLRAV
FANKGSVTAGNSSQTSDGAGALILVSEKILKQFNLVPRARFVSFAVRGVPPEIMGIGPKAAIPAALKAAGLTQDQIDWIE
LNEAFAAQSLAVMRDLELDPAKVNRMGGAIALGHPLGATGAIRSATVVHALRRHNMKYGMVTMCVGTGMGAAGIFERV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=44.3877551020408, Blast_Score=303, Evalue=1e-82,
Organism=Homo sapiens, GI167614485, Length=406, Percent_Identity=38.9162561576355, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=37.5, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI4557237, Length=407, Percent_Identity=34.8894348894349, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI4504327, Length=440, Percent_Identity=29.7727272727273, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=29.6675191815857, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=43.7956204379562, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=42.75, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=39.6039603960396, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=40.64039408867, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788683, Length=421, Percent_Identity=30.166270783848, Blast_Score=148, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=39.6508728179551, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=31.6582914572864, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=33.0864197530864, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17551802, Length=445, Percent_Identity=28.7640449438202, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17535917, Length=400, Percent_Identity=28.5, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=43, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6325229, Length=416, Percent_Identity=36.7788461538462, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24655093, Length=408, Percent_Identity=38.9705882352941, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI17648125, Length=402, Percent_Identity=39.5522388059701, Blast_Score=255, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24640423, Length=406, Percent_Identity=32.0197044334975, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17137578, Length=441, Percent_Identity=31.2925170068027, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41627; Mature: 41627

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLQDAYIVAATRSPIGKAPKGAFKNTRPDDLLATILQAAVAQVPSLDPALIEDAIVGC
CCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
AIPEAQQGLNVARIGALLAGLPNTVGGITVNRFCASGLSAVAMAADRIRVGESDVMIAAG
CCCHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEC
VESMSMVPMMGNSPSMSPSIFERDENIGIAYGMGLTAEKVATQWKVSREDQDAFSLASHQ
CCCCEECEECCCCCCCCCHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHH
KAIAAQQAGEFKDEITPIEVVERFPDLASGQINVKTRTISLDEGPRPDTSVEGLGKLRAV
HHHHHHHHCCHHHCCCHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHH
FANKGSVTAGNSSQTSDGAGALILVSEKILKQFNLVPRARFVSFAVRGVPPEIMGIGPKA
HCCCCCEECCCCCCCCCCCCEEEEEEHHHHHHHCCCCHHHHHHHHHCCCCHHHCCCCCHH
AIPAALKAAGLTQDQIDWIELNEAFAAQSLAVMRDLELDPAKVNRMGGAIALGHPLGATG
HHHHHHHHCCCCHHCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCCC
AIRSATVVHALRRHNMKYGMVTMCVGTGMGAAGIFERV
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure
MKQLQDAYIVAATRSPIGKAPKGAFKNTRPDDLLATILQAAVAQVPSLDPALIEDAIVGC
CCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
AIPEAQQGLNVARIGALLAGLPNTVGGITVNRFCASGLSAVAMAADRIRVGESDVMIAAG
CCCHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEC
VESMSMVPMMGNSPSMSPSIFERDENIGIAYGMGLTAEKVATQWKVSREDQDAFSLASHQ
CCCCEECEECCCCCCCCCHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHH
KAIAAQQAGEFKDEITPIEVVERFPDLASGQINVKTRTISLDEGPRPDTSVEGLGKLRAV
HHHHHHHHCCHHHCCCHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHH
FANKGSVTAGNSSQTSDGAGALILVSEKILKQFNLVPRARFVSFAVRGVPPEIMGIGPKA
HCCCCCEECCCCCCCCCCCCEEEEEEHHHHHHHCCCCHHHHHHHHHCCCCHHHCCCCCHH
AIPAALKAAGLTQDQIDWIELNEAFAAQSLAVMRDLELDPAKVNRMGGAIALGHPLGATG
HHHHHHHHCCCCHHCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCCC
AIRSATVVHALRRHNMKYGMVTMCVGTGMGAAGIFERV
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]