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The map label for this gene is ntpA [H]

Identifier: 94309325

GI number: 94309325

Start: 406145

End: 406666

Strand: Direct

Name: ntpA [H]

Synonym: Rmet_0380

Alternate gene names: 94309325

Gene position: 406145-406666 (Clockwise)

Preceding gene: 94309324

Following gene: 94309326

Centisome position: 10.34

GC content: 66.28

Gene sequence:

>522_bases
ATGCTTTGGTTTGTCCCTGCCGCCCTTCCCATGCGCTACAAGATTCCCGAATCGGTACTGGTCGTGATCCACACACCAGA
CCTGCAAGTCCTCCTGATCGAGCGCGCCGACCGGCCCGGCTATTGGCAGTCGGTGACCGGCAGCCTCGATGCCGAGGACG
AGCCGCTACCCATGACCGCCGCGCGCGAGGTGGCCGAGGAAACCGGACTTATCGCCAGCCGCTATTCGCTGACCGACTGG
CAACACACCATCGACTACGAGATCTATCCGCAATGGCGCCACCGCTATGCGCCGGGCATCACTCGCAATACCGAGCACTG
GTTCGGGTTGTGCGTACCCGCGCCGATGCCGGTGACGCTGGCGCCGCGTGAGCACCTGCGCTTCGAATGGCTGCCCTGGC
AGGCGGCCGCGGCGCGTTGCTTCTCCAGCAGCAATGCCGAAGCAGTGCGCCAGCTTGCCTGGCGCGTGGCAGGCGGTCAG
GGCGCCGGGCTCGACGTCACGAACGGAGCCGCCGCACCATGA

Upstream 100 bases:

>100_bases
CAGCCGGGTGACCGTCAGGCGACGATCCGCCCCGGCGAACATACATTGGCCTGAGTAGGAGGGCAGCGGCCGGAGCGCGC
CATTGGCGTCCGGCTGCGCT

Downstream 100 bases:

>100_bases
AGTTGCGCGTTGTCACCTACAACATTCACAAGGGTGTAAAGGGATTCACCGGCAAGCCACGAATCCAGAGCGTGCGAACC
GGCCTGCAGTCGATGGACGC

Product: dihydroneopterin triphosphate pyrophosphatase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MLWFVPAALPMRYKIPESVLVVIHTPDLQVLLIERADRPGYWQSVTGSLDAEDEPLPMTAAREVAEETGLIASRYSLTDW
QHTIDYEIYPQWRHRYAPGITRNTEHWFGLCVPAPMPVTLAPREHLRFEWLPWQAAAARCFSSSNAEAVRQLAWRVAGGQ
GAGLDVTNGAAAP

Sequences:

>Translated_173_residues
MLWFVPAALPMRYKIPESVLVVIHTPDLQVLLIERADRPGYWQSVTGSLDAEDEPLPMTAAREVAEETGLIASRYSLTDW
QHTIDYEIYPQWRHRYAPGITRNTEHWFGLCVPAPMPVTLAPREHLRFEWLPWQAAAARCFSSSNAEAVRQLAWRVAGGQ
GAGLDVTNGAAAP
>Mature_173_residues
MLWFVPAALPMRYKIPESVLVVIHTPDLQVLLIERADRPGYWQSVTGSLDAEDEPLPMTAAREVAEETGLIASRYSLTDW
QHTIDYEIYPQWRHRYAPGITRNTEHWFGLCVPAPMPVTLAPREHLRFEWLPWQAAAARCFSSSNAEAVRQLAWRVAGGQ
GAGLDVTNGAAAP

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=148, Percent_Identity=45.945945945946, Blast_Score=122, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19407; Mature: 19407

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLWFVPAALPMRYKIPESVLVVIHTPDLQVLLIERADRPGYWQSVTGSLDAEDEPLPMTA
CEEEECCCCCEEEECCCEEEEEEECCCEEEEEEEECCCCCCCEECCCCCCCCCCCCCHHH
AREVAEETGLIASRYSLTDWQHTIDYEIYPQWRHRYAPGITRNTEHWFGLCVPAPMPVTL
HHHHHHHCCCEEEECCCCCCCEEECEEECCCHHHHCCCCCCCCCCCEEEEEECCCCCEEE
APREHLRFEWLPWQAAAARCFSSSNAEAVRQLAWRVAGGQGAGLDVTNGAAAP
CCHHHCEEEECCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCC
>Mature Secondary Structure
MLWFVPAALPMRYKIPESVLVVIHTPDLQVLLIERADRPGYWQSVTGSLDAEDEPLPMTA
CEEEECCCCCEEEECCCEEEEEEECCCEEEEEEEECCCCCCCEECCCCCCCCCCCCCHHH
AREVAEETGLIASRYSLTDWQHTIDYEIYPQWRHRYAPGITRNTEHWFGLCVPAPMPVTL
HHHHHHHCCCEEEECCCCCCCEEECEEECCCHHHHCCCCCCCCCCCEEEEEECCCCCEEE
APREHLRFEWLPWQAAAARCFSSSNAEAVRQLAWRVAGGQGAGLDVTNGAAAP
CCHHHCEEEECCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]