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The map label for this gene is coxA [H]

Identifier: 94309207

GI number: 94309207

Start: 279706

End: 281316

Strand: Direct

Name: coxA [H]

Synonym: Rmet_0262

Alternate gene names: 94309207

Gene position: 279706-281316 (Clockwise)

Preceding gene: 94309206

Following gene: 335055484

Centisome position: 7.12

GC content: 63.63

Gene sequence:

>1611_bases
ATGAGTACCGCTACCCCGGAGACACTGGGCCATCCGCACGACCACGCGCACGATCACGATCATGCGCACGATCACCCGCA
TGGCTGGCGCCGCTGGCTGTTCGCCACCAACCACAAGGATATCGGCACGCTGTACCTGCTGTTCTCGTTCACCATGCTGC
TGTCCGGCGGCGTGCTGGCGCTGCTGATCCGCCTGGAGCTGTTCGAGCCGGGCCTGCAGTTCTTCCGCCCCGAACTGTTC
AACCAGTTCACCACGATGCACGGGCTGATCATGGTGTTCGGCGCGATCATGCCGGCGTTCGTCGGCTTCGCGAACTGGAT
GATCCCGCTGCAGATCGGCGCCTCTGACATGGCGTTCGCGCGCATGAACAACTTCAGCTTCTGGCTGATGCCGCCGGCCG
CGCTGCTGCTGGTTGGCTCGTTCTTCGCGCCGGGCGGCGCCACCGCCGCGGGCTGGACGCTCTACGCGCCGCTGTCGGTG
CAGATGGGCCCGGGCATGGACATGGCGATTTTCGCCATGCACATCATGGGCGCGTCGTCGATCATGGGCTCGATCAACAT
CATCGTCACCATCCTCAACATGCGCGCGCCTGGCATGACGCTGATGAAGATGCCGATGTTCTGCTGGACGTGGCTGATCA
CCGCCTACCTGCTGATCGCCGTGATGCCGGTGCTGGCTGGCGCGATCACGATGGTGCTGACCGACCGCCATTTCGGCACG
AGCTTCTTCTCGGCCGCCGGCGGCGGTGACCCGGTGATGTACCAGCATATCTTCTGGTTCTTCGGTCACCCCGAGGTCTA
CATCATGATCTTGCCGGCGTTCGGCATCATCTCGCACGTCGTGCCGGCCTTCGCGCGCAAGCGCCTGTTCGGCTACAGCT
CGATGGTGTACGCCACGGCCTCGATCGCGATCCTGTCGTTCATCGTGTGGGCGCACCACATGTTCACCACCGGCATGCCG
GTGACGGGCCAGCTGTTCTTCATGTACGCGACGATGCTGATCGCGGTGCCGACGGCCGTGAAGATCTTCAACTGGATCGC
CACGATGTGGCGCGGCTCGATGACGTTCGAGACCCCGATGCTGTTCGCGATCGGCTTCATCTTCGTGTTCACGATCGGCG
GCTTCACGGGCCTGATGCCGGCTGTCGCTCCGATCGACATCCAGCTGCAGGACACCTACTTCATCGTGGCGCACTTCCAC
TACGTGCTGGTGGCGGGCTCGCTGTTCGCGCTGTTCGCGGGCTTCTACTACTGGGGTCCGAAGTGGAGCGGGTTCATGTA
TGACGAGATGCGCGGCAAGATCCATTTCTGGGGCTCGCTGATCTTCTTCAACGTGACCTTCTTCCCGATGCACTTCCTGG
GCCTGGCCGGCATGCCGCGCCGCTATGCGGACTACCCGACCCAGTTCACGGACTTCAACGCGATCGCCTCGATCGGCGCG
CTGGGCTTCGGCCTGATGCAGGTGTACTTCTTCTTCTGCGTGGTCCTGCCGTCGTACCGCGGTGGCCAGGCCGCTGGCGA
CAAGCCGTGGGATGGCGCGGAAGGCCTCGAGTGGACCGTGCCGTCGCCGGCACCGTTCCACACGTTCGAAGAGCCGCCGG
TCGTCAAGTAA

Upstream 100 bases:

>100_bases
GCCGTCCAGCACCCCCGACAAGCAGGCCAGCCTCGCGGGCAACCGCGTCGCAGGCTGACCCGCGGTAGCCCCGCATTCAG
GAATTGATGGAGTCATTGCG

Downstream 100 bases:

>100_bases
TCCAGTAATCCAGTAACACCGGCCGGATGCCAGCCCTCGGGGCAGGTATCCGGCCCGCTAACCAGATGCTCATGCAGCCC
TCGGAAACAAGCCCATCGCC

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSTATPETLGHPHDHAHDHDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFTMLLSGGVLALLIRLELFEPGLQFFRPELF
NQFTTMHGLIMVFGAIMPAFVGFANWMIPLQIGASDMAFARMNNFSFWLMPPAALLLVGSFFAPGGATAAGWTLYAPLSV
QMGPGMDMAIFAMHIMGASSIMGSINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGT
SFFSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIISHVVPAFARKRLFGYSSMVYATASIAILSFIVWAHHMFTTGMP
VTGQLFFMYATMLIAVPTAVKIFNWIATMWRGSMTFETPMLFAIGFIFVFTIGGFTGLMPAVAPIDIQLQDTYFIVAHFH
YVLVAGSLFALFAGFYYWGPKWSGFMYDEMRGKIHFWGSLIFFNVTFFPMHFLGLAGMPRRYADYPTQFTDFNAIASIGA
LGFGLMQVYFFFCVVLPSYRGGQAAGDKPWDGAEGLEWTVPSPAPFHTFEEPPVVK

Sequences:

>Translated_536_residues
MSTATPETLGHPHDHAHDHDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFTMLLSGGVLALLIRLELFEPGLQFFRPELF
NQFTTMHGLIMVFGAIMPAFVGFANWMIPLQIGASDMAFARMNNFSFWLMPPAALLLVGSFFAPGGATAAGWTLYAPLSV
QMGPGMDMAIFAMHIMGASSIMGSINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGT
SFFSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIISHVVPAFARKRLFGYSSMVYATASIAILSFIVWAHHMFTTGMP
VTGQLFFMYATMLIAVPTAVKIFNWIATMWRGSMTFETPMLFAIGFIFVFTIGGFTGLMPAVAPIDIQLQDTYFIVAHFH
YVLVAGSLFALFAGFYYWGPKWSGFMYDEMRGKIHFWGSLIFFNVTFFPMHFLGLAGMPRRYADYPTQFTDFNAIASIGA
LGFGLMQVYFFFCVVLPSYRGGQAAGDKPWDGAEGLEWTVPSPAPFHTFEEPPVVK
>Mature_535_residues
STATPETLGHPHDHAHDHDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFTMLLSGGVLALLIRLELFEPGLQFFRPELFN
QFTTMHGLIMVFGAIMPAFVGFANWMIPLQIGASDMAFARMNNFSFWLMPPAALLLVGSFFAPGGATAAGWTLYAPLSVQ
MGPGMDMAIFAMHIMGASSIMGSINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTS
FFSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIISHVVPAFARKRLFGYSSMVYATASIAILSFIVWAHHMFTTGMPV
TGQLFFMYATMLIAVPTAVKIFNWIATMWRGSMTFETPMLFAIGFIFVFTIGGFTGLMPAVAPIDIQLQDTYFIVAHFHY
VLVAGSLFALFAGFYYWGPKWSGFMYDEMRGKIHFWGSLIFFNVTFFPMHFLGLAGMPRRYADYPTQFTDFNAIASIGAL
GFGLMQVYFFFCVVLPSYRGGQAAGDKPWDGAEGLEWTVPSPAPFHTFEEPPVVK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=514, Percent_Identity=50.3891050583658, Blast_Score=466, Evalue=1e-131,
Organism=Escherichia coli, GI1786634, Length=514, Percent_Identity=41.6342412451362, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6226519, Length=532, Percent_Identity=46.4285714285714, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=50.4643962848297, Blast_Score=328, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6226523, Length=247, Percent_Identity=46.5587044534413, Blast_Score=216, Evalue=6e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59846; Mature: 59715

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
7.1 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
6.9 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTATPETLGHPHDHAHDHDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFTMLLSGGVLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHCCHHH
LLIRLELFEPGLQFFRPELFNQFTTMHGLIMVFGAIMPAFVGFANWMIPLQIGASDMAFA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHH
RMNNFSFWLMPPAALLLVGSFFAPGGATAAGWTLYAPLSVQMGPGMDMAIFAMHIMGASS
HHCCCEEEECCHHHHHHHHHHCCCCCCCCCCEEEEECEEEECCCCCCHHHHHHHHHHHHH
IMGSINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGT
HHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SFFSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIISHVVPAFARKRLFGYSSMVYATA
HHHHCCCCCCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SIAILSFIVWAHHMFTTGMPVTGQLFFMYATMLIAVPTAVKIFNWIATMWRGSMTFETPM
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LFAIGFIFVFTIGGFTGLMPAVAPIDIQLQDTYFIVAHFHYVLVAGSLFALFAGFYYWGP
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHCCC
KWSGFMYDEMRGKIHFWGSLIFFNVTFFPMHFLGLAGMPRRYADYPTQFTDFNAIASIGA
CCCCEEHHHHCCCEEEEEHEEHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCHHHHHHHHH
LGFGLMQVYFFFCVVLPSYRGGQAAGDKPWDGAEGLEWTVPSPAPFHTFEEPPVVK
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STATPETLGHPHDHAHDHDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFTMLLSGGVLA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHCCHHH
LLIRLELFEPGLQFFRPELFNQFTTMHGLIMVFGAIMPAFVGFANWMIPLQIGASDMAFA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHH
RMNNFSFWLMPPAALLLVGSFFAPGGATAAGWTLYAPLSVQMGPGMDMAIFAMHIMGASS
HHCCCEEEECCHHHHHHHHHHCCCCCCCCCCEEEEECEEEECCCCCCHHHHHHHHHHHHH
IMGSINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGT
HHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SFFSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIISHVVPAFARKRLFGYSSMVYATA
HHHHCCCCCCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SIAILSFIVWAHHMFTTGMPVTGQLFFMYATMLIAVPTAVKIFNWIATMWRGSMTFETPM
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LFAIGFIFVFTIGGFTGLMPAVAPIDIQLQDTYFIVAHFHYVLVAGSLFALFAGFYYWGP
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHCCC
KWSGFMYDEMRGKIHFWGSLIFFNVTFFPMHFLGLAGMPRRYADYPTQFTDFNAIASIGA
CCCCEEHHHHCCCEEEEEHEEHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCHHHHHHHHH
LGFGLMQVYFFFCVVLPSYRGGQAAGDKPWDGAEGLEWTVPSPAPFHTFEEPPVVK
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]