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The map label for this gene is coxB [H]

Identifier: 94309206

GI number: 94309206

Start: 278395

End: 279663

Strand: Direct

Name: coxB [H]

Synonym: Rmet_0261

Alternate gene names: 94309206

Gene position: 278395-279663 (Clockwise)

Preceding gene: 94309205

Following gene: 94309207

Centisome position: 7.09

GC content: 63.2

Gene sequence:

>1269_bases
ATGAAAATGTGGAAGAAGGCATCCGCAGCATGTCTGGCAGGCGCGTCCCTGCTTGTCAGCCAGGCGGCCTCCGCGGTCAG
TGACATGCCAGGCGGCCCCGCCGTCCGACAGCTCAACCTGGCCGAACCCGTTACAAAAATCGCCGAACAGATTCACTGGC
TGAACTGGATGATGCTGATCATCTGCACGGTGATCTTCGTCGCCGTGTTCGGCGTGATGTTCTATTCCATCTTCAAGCAC
CGGAAGAGCAAGGGCGCCCGCCCGGCCTCTTTCCACGAAAGCATCACGGTGGAAGTGGTCTGGACGATCGTGCCGTTCCT
GATCGTGATCGCCATGGCGCTGCCGGCGACGAAGACCGTGGTGGCGATGAAGGACACCACGAACTCGGATATCACGATCA
AGGCCACCGGCTATCAGTGGAAGTGGGGCTATGACTACCTCAAGGGCCAGGGCGAGGGCATCTCGTTCGTGTCCACGCTG
ACCACGCCGCGCGAGCAGATCAACAACCAGCAGGAAAAGTCGAACACCTACCTGATGGAGGTGGACAACGAACTGGTGGT
GCCCGTCAACAAGAAGATCCGTATCGTCACCACTGCCAATGACGTGATCCACGCCTGGATGATTCCGGCGTTCGGCGTCA
AGCAGGATGCGATCCCGGGCTTCGTGCGCGACACCTGGTTCCGTGCCGAGAAGACCGGCGTCTATCGTGGCCAGTGCGCC
GAACTCTGCGGCAAGGAACACGCGTTCATGCCGATCGTGGTGCGCGTCGTGTCCGATGCCGAGTACACGAAGTGGGTTGA
CGACAAGAAGAAGGCGATGGCCGCGGCGGCGGACGATCCCAACAAGGTCTGGACCCTCGACGAAATCAAGGCGCGCGGCG
AAAAGGTCTACGCGACCAACTGCGCGGTCTGCCACCAGCCGACCGGCAAGGGCGGTGGTCCGTTCCCGGCGCTGGACGGC
TCCAAGGTCGTCAACGGTCCGAAGGCTGGCCAGATGCACGTGCTGCTGGAAGGCCGTAACGCCATGCCGTCGTGGAAGCA
GCTTTCCGACACCGAGCTGGCCGCTGTCATGACGTACACGCGGAATAGCTGGGGCAACAAGACCGGCGAAGTGATTCAGC
CGGCGGACTTCACGGGCGCCCGCACGGGCAAGTTCCCGGAAGGCGGCGGCGCACAGGCCGGCGCAGGCGATGCAGCCCCG
AAGGCTGCCGCGCCGTCCAGCACCCCCGACAAGCAGGCCAGCCTCGCGGGCAACCGCGTCGCAGGCTGA

Upstream 100 bases:

>100_bases
TTCGCGCAGGAACTCGCGGTGGCCTTGCAGCGTGTCTGAAGGGACAGGTTGCGGGGCAGGGCGGGGACAGATTTGAATCT
GTAAATTGGGTAGATAAACA

Downstream 100 bases:

>100_bases
CCCGCGGTAGCCCCGCATTCAGGAATTGATGGAGTCATTGCGATGAGTACCGCTACCCCGGAGACACTGGGCCATCCGCA
CGACCACGCGCACGATCACG

Product: cytochrome c oxidase, subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II; Oxidase aa(3) subunit 2 [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKMWKKASAACLAGASLLVSQAASAVSDMPGGPAVRQLNLAEPVTKIAEQIHWLNWMMLIICTVIFVAVFGVMFYSIFKH
RKSKGARPASFHESITVEVVWTIVPFLIVIAMALPATKTVVAMKDTTNSDITIKATGYQWKWGYDYLKGQGEGISFVSTL
TTPREQINNQQEKSNTYLMEVDNELVVPVNKKIRIVTTANDVIHAWMIPAFGVKQDAIPGFVRDTWFRAEKTGVYRGQCA
ELCGKEHAFMPIVVRVVSDAEYTKWVDDKKKAMAAAADDPNKVWTLDEIKARGEKVYATNCAVCHQPTGKGGGPFPALDG
SKVVNGPKAGQMHVLLEGRNAMPSWKQLSDTELAAVMTYTRNSWGNKTGEVIQPADFTGARTGKFPEGGGAQAGAGDAAP
KAAAPSSTPDKQASLAGNRVAG

Sequences:

>Translated_422_residues
MKMWKKASAACLAGASLLVSQAASAVSDMPGGPAVRQLNLAEPVTKIAEQIHWLNWMMLIICTVIFVAVFGVMFYSIFKH
RKSKGARPASFHESITVEVVWTIVPFLIVIAMALPATKTVVAMKDTTNSDITIKATGYQWKWGYDYLKGQGEGISFVSTL
TTPREQINNQQEKSNTYLMEVDNELVVPVNKKIRIVTTANDVIHAWMIPAFGVKQDAIPGFVRDTWFRAEKTGVYRGQCA
ELCGKEHAFMPIVVRVVSDAEYTKWVDDKKKAMAAAADDPNKVWTLDEIKARGEKVYATNCAVCHQPTGKGGGPFPALDG
SKVVNGPKAGQMHVLLEGRNAMPSWKQLSDTELAAVMTYTRNSWGNKTGEVIQPADFTGARTGKFPEGGGAQAGAGDAAP
KAAAPSSTPDKQASLAGNRVAG
>Mature_422_residues
MKMWKKASAACLAGASLLVSQAASAVSDMPGGPAVRQLNLAEPVTKIAEQIHWLNWMMLIICTVIFVAVFGVMFYSIFKH
RKSKGARPASFHESITVEVVWTIVPFLIVIAMALPATKTVVAMKDTTNSDITIKATGYQWKWGYDYLKGQGEGISFVSTL
TTPREQINNQQEKSNTYLMEVDNELVVPVNKKIRIVTTANDVIHAWMIPAFGVKQDAIPGFVRDTWFRAEKTGVYRGQCA
ELCGKEHAFMPIVVRVVSDAEYTKWVDDKKKAMAAAADDPNKVWTLDEIKARGEKVYATNCAVCHQPTGKGGGPFPALDG
SKVVNGPKAGQMHVLLEGRNAMPSWKQLSDTELAAVMTYTRNSWGNKTGEVIQPADFTGARTGKFPEGGGAQAGAGDAAP
KAAAPSSTPDKQASLAGNRVAG

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=161, Percent_Identity=39.1304347826087, Blast_Score=140, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6226540, Length=177, Percent_Identity=37.8531073446328, Blast_Score=132, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 45654; Mature: 45654

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA ; PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMWKKASAACLAGASLLVSQAASAVSDMPGGPAVRQLNLAEPVTKIAEQIHWLNWMMLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCHHHHHHHHHHHHHHHHHHHHH
ICTVIFVAVFGVMFYSIFKHRKSKGARPASFHESITVEVVWTIVPFLIVIAMALPATKTV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEE
VAMKDTTNSDITIKATGYQWKWGYDYLKGQGEGISFVSTLTTPREQINNQQEKSNTYLME
EEEECCCCCCEEEEECCEEEECCHHHHCCCCCCEEEEHHHCCCHHHHCCHHHHCCEEEEE
VDNELVVPVNKKIRIVTTANDVIHAWMIPAFGVKQDAIPGFVRDTWFRAEKTGVYRGQCA
ECCEEEEECCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
ELCGKEHAFMPIVVRVVSDAEYTKWVDDKKKAMAAAADDPNKVWTLDEIKARGEKVYATN
HHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHCCCEEEEEC
CAVCHQPTGKGGGPFPALDGSKVVNGPKAGQMHVLLEGRNAMPSWKQLSDTELAAVMTYT
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHCCCCHHHHHHHHH
RNSWGNKTGEVIQPADFTGARTGKFPEGGGAQAGAGDAAPKAAAPSSTPDKQASLAGNRV
HCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCC
AG
CC
>Mature Secondary Structure
MKMWKKASAACLAGASLLVSQAASAVSDMPGGPAVRQLNLAEPVTKIAEQIHWLNWMMLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCHHHHHHHHHHHHHHHHHHHHH
ICTVIFVAVFGVMFYSIFKHRKSKGARPASFHESITVEVVWTIVPFLIVIAMALPATKTV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEE
VAMKDTTNSDITIKATGYQWKWGYDYLKGQGEGISFVSTLTTPREQINNQQEKSNTYLME
EEEECCCCCCEEEEECCEEEECCHHHHCCCCCCEEEEHHHCCCHHHHCCHHHHCCEEEEE
VDNELVVPVNKKIRIVTTANDVIHAWMIPAFGVKQDAIPGFVRDTWFRAEKTGVYRGQCA
ECCEEEEECCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
ELCGKEHAFMPIVVRVVSDAEYTKWVDDKKKAMAAAADDPNKVWTLDEIKARGEKVYATN
HHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHCCCEEEEEC
CAVCHQPTGKGGGPFPALDGSKVVNGPKAGQMHVLLEGRNAMPSWKQLSDTELAAVMTYT
CEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHCCCCHHHHHHHHH
RNSWGNKTGEVIQPADFTGARTGKFPEGGGAQAGAGDAAPKAAAPSSTPDKQASLAGNRV
HCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCC
AG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1648008 [H]