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The map label for this gene is norG [H]

Identifier: 94309149

GI number: 94309149

Start: 212650

End: 214095

Strand: Reverse

Name: norG [H]

Synonym: Rmet_0204

Alternate gene names: 94309149

Gene position: 214095-212650 (Counterclockwise)

Preceding gene: 94309153

Following gene: 94309144

Centisome position: 5.45

GC content: 69.09

Gene sequence:

>1446_bases
ATGCTCAACCTAAACCTTGTTCGCAGCCGCCGTGGCGGCGAGACGCTGACCGAACAGATCGTCGCCGGCATCGCCGCGCT
CGTGGACAGCCGGGCCCTGCGGGCCGGCGCGTTGCTCCCGTCGGTGCGTCGCTTCGCCCAGCAACACGATGTCAGCACCT
TCACCGTAGCCGAGGCCTATGGCCGGCTGACAGCGCTCGGGTATCTCGCGGCCCGCCCCGGCTCCGGCTACACGGTGGCA
CACCGGCACGCCCCAGCCGGCCATGCGCGCGTGCCGCACTGGGAAGCCCCGGGACTCAACGCGGCCTGGCTGCTTTCCGA
CGTATTCGCCGACCACTCCGTGCCGATCAAGGCAGGGGCCGGCTGGCTGCCCGGCGACTGGCTCAACGAGGAAGGATTGC
ATCAGGCCATGCGCAGCGCGGCGCGCGTGCCGGCCGCGCAGGTGTCTGGATACGGCCATCCCTATGGCTTCGGCGCGCTG
CGCGAGCATATCGCCGCGCACCTGAGCCAGTACGGCATTCCGGCGCAATCGCAACAGGTGGTGCTGACCCAGGGCGCCAC
GCAGGCGCTGGATCTGGTCGTGCGCACACTGTTGCGCCCCGGCGACACGGTACTGGTGGAGTCGCCGTGCTACTGCAATC
TGCTGCAGATCCTTCGGCTGGCGGGCCTGCGCGCGATCGGCGTGCCGCGCACGGCTGCGGGCCTCGACACGGACGCGCTC
GAAGACGCCATTCGCCAGCACTCGCCGCGTGCGTTGTTCATCAACACGGTGCTGCAGAACCCCACCGGCGCGAGCCTGAC
CAGCATGAACGCGTTCCGCGTGTTGCAGATCGCGGAGCAGCACCGGCTACTGGTGGTGGAAGACGACATCTATCGCGAAC
TGGCGCCGGCCGGGTCGCCGATGCTCGCGGCAATGGACGGGCTCTCGCAGGTGGTCTATGTGAACGGTTTCTCGAAGACG
ATCGCGCCGTCGCTGCGCGTCGGCTATCTGGCCGCAAGCCCGGATCTGGCCAAGGCCTTCGCACGCACGAAGATGGCCGT
GGGACTGACGTCCTCGGAAGTGACCGAGCGGCTCGTGTATTCGGTCCTGACCAGCGGGCACTATGGCCGGCACGTGGCGG
CGCTCGCCGAGCGGCTACGCGCCCAGCAGGATCTGGTGACCGAGAAGATGGACGCGCACGGCCTGGAGGTCCTGCTGCGC
CCCGAAGGCGGGATGTTTGCGTGGGCACGCATGCGGGAAACCGACGGGCCCGCGCCGTCGGGCAACCGGCTGGCCACGCT
TGCGCTGGAACACGGCATCTGGCTGGCGCCGGGCGCCTACTTCGAGCCCGGCGAAGCCGATTCGCCCTGGATTCGCTTCA
ATGTGGCGACCAGCGACGCACCGCAGCTGTGGGACTTCTTCGATGCGGTACGCACCGATCAGGGCGCGTTGGCGCGCGCC
GCCTGA

Upstream 100 bases:

>100_bases
AAAGACCCCGTGCTGGCACTGGAATAAGGACTCACGCTGCAACGCATCAATCTGCCGTACCCGCTACACTGTACAGGTTT
CGTTCTCTTGCGGGCGTCGA

Downstream 100 bases:

>100_bases
TCAGCCGGCCGTCAGAATCAGAAGCGATAGCGCACGTACCCGGTGTACAGGTTGGTGCCCGGGTTCGGTTCCTTGATGCC
GGCGTTCGAGATGTGCTGGA

Product: GntR family transcriptional regulator, HTH:Aminotransferase, class I and II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MLNLNLVRSRRGGETLTEQIVAGIAALVDSRALRAGALLPSVRRFAQQHDVSTFTVAEAYGRLTALGYLAARPGSGYTVA
HRHAPAGHARVPHWEAPGLNAAWLLSDVFADHSVPIKAGAGWLPGDWLNEEGLHQAMRSAARVPAAQVSGYGHPYGFGAL
REHIAAHLSQYGIPAQSQQVVLTQGATQALDLVVRTLLRPGDTVLVESPCYCNLLQILRLAGLRAIGVPRTAAGLDTDAL
EDAIRQHSPRALFINTVLQNPTGASLTSMNAFRVLQIAEQHRLLVVEDDIYRELAPAGSPMLAAMDGLSQVVYVNGFSKT
IAPSLRVGYLAASPDLAKAFARTKMAVGLTSSEVTERLVYSVLTSGHYGRHVAALAERLRAQQDLVTEKMDAHGLEVLLR
PEGGMFAWARMRETDGPAPSGNRLATLALEHGIWLAPGAYFEPGEADSPWIRFNVATSDAPQLWDFFDAVRTDQGALARA
A

Sequences:

>Translated_481_residues
MLNLNLVRSRRGGETLTEQIVAGIAALVDSRALRAGALLPSVRRFAQQHDVSTFTVAEAYGRLTALGYLAARPGSGYTVA
HRHAPAGHARVPHWEAPGLNAAWLLSDVFADHSVPIKAGAGWLPGDWLNEEGLHQAMRSAARVPAAQVSGYGHPYGFGAL
REHIAAHLSQYGIPAQSQQVVLTQGATQALDLVVRTLLRPGDTVLVESPCYCNLLQILRLAGLRAIGVPRTAAGLDTDAL
EDAIRQHSPRALFINTVLQNPTGASLTSMNAFRVLQIAEQHRLLVVEDDIYRELAPAGSPMLAAMDGLSQVVYVNGFSKT
IAPSLRVGYLAASPDLAKAFARTKMAVGLTSSEVTERLVYSVLTSGHYGRHVAALAERLRAQQDLVTEKMDAHGLEVLLR
PEGGMFAWARMRETDGPAPSGNRLATLALEHGIWLAPGAYFEPGEADSPWIRFNVATSDAPQLWDFFDAVRTDQGALARA
A
>Mature_481_residues
MLNLNLVRSRRGGETLTEQIVAGIAALVDSRALRAGALLPSVRRFAQQHDVSTFTVAEAYGRLTALGYLAARPGSGYTVA
HRHAPAGHARVPHWEAPGLNAAWLLSDVFADHSVPIKAGAGWLPGDWLNEEGLHQAMRSAARVPAAQVSGYGHPYGFGAL
REHIAAHLSQYGIPAQSQQVVLTQGATQALDLVVRTLLRPGDTVLVESPCYCNLLQILRLAGLRAIGVPRTAAGLDTDAL
EDAIRQHSPRALFINTVLQNPTGASLTSMNAFRVLQIAEQHRLLVVEDDIYRELAPAGSPMLAAMDGLSQVVYVNGFSKT
IAPSLRVGYLAASPDLAKAFARTKMAVGLTSSEVTERLVYSVLTSGHYGRHVAALAERLRAQQDLVTEKMDAHGLEVLLR
PEGGMFAWARMRETDGPAPSGNRLATLALEHGIWLAPGAYFEPGEADSPWIRFNVATSDAPQLWDFFDAVRTDQGALARA
A

Specific function: Positively regulates the expression of the NorB efflux pump and negatively regulates the expression of the AbcA efflux pump. Binds specifically to the promoters of norA, norB and norC and abcA genes. Could also have an aminotransferase activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=310, Percent_Identity=26.4516129032258, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI33469970, Length=310, Percent_Identity=26.4516129032258, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI1787710, Length=461, Percent_Identity=30.3687635574837, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1790797, Length=444, Percent_Identity=27.2522522522523, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788722, Length=313, Percent_Identity=24.2811501597444, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321929, Length=380, Percent_Identity=20.7894736842105, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000524
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 51694; Mature: 51694

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLNLVRSRRGGETLTEQIVAGIAALVDSRALRAGALLPSVRRFAQQHDVSTFTVAEAY
CCCCEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
GRLTALGYLAARPGSGYTVAHRHAPAGHARVPHWEAPGLNAAWLLSDVFADHSVPIKAGA
HHHHHHHHHEECCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCC
GWLPGDWLNEEGLHQAMRSAARVPAAQVSGYGHPYGFGALREHIAAHLSQYGIPAQSQQV
CCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEE
VLTQGATQALDLVVRTLLRPGDTVLVESPCYCNLLQILRLAGLRAIGVPRTAAGLDTDAL
EEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
EDAIRQHSPRALFINTVLQNPTGASLTSMNAFRVLQIAEQHRLLVVEDDIYRELAPAGSP
HHHHHHCCCCEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEECHHHHHHCCCCCC
MLAAMDGLSQVVYVNGFSKTIAPSLRVGYLAASPDLAKAFARTKMAVGLTSSEVTERLVY
HHHHHHCCCEEEEEECCHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHH
SVLTSGHYGRHVAALAERLRAQQDLVTEKMDAHGLEVLLRPEGGMFAWARMRETDGPAPS
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCCCC
GNRLATLALEHGIWLAPGAYFEPGEADSPWIRFNVATSDAPQLWDFFDAVRTDQGALARA
CCCEEEEEEECCEEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCC
A
C
>Mature Secondary Structure
MLNLNLVRSRRGGETLTEQIVAGIAALVDSRALRAGALLPSVRRFAQQHDVSTFTVAEAY
CCCCEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
GRLTALGYLAARPGSGYTVAHRHAPAGHARVPHWEAPGLNAAWLLSDVFADHSVPIKAGA
HHHHHHHHHEECCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCC
GWLPGDWLNEEGLHQAMRSAARVPAAQVSGYGHPYGFGALREHIAAHLSQYGIPAQSQQV
CCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEE
VLTQGATQALDLVVRTLLRPGDTVLVESPCYCNLLQILRLAGLRAIGVPRTAAGLDTDAL
EEECCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
EDAIRQHSPRALFINTVLQNPTGASLTSMNAFRVLQIAEQHRLLVVEDDIYRELAPAGSP
HHHHHHCCCCEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEECHHHHHHCCCCCC
MLAAMDGLSQVVYVNGFSKTIAPSLRVGYLAASPDLAKAFARTKMAVGLTSSEVTERLVY
HHHHHHCCCEEEEEECCHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHH
SVLTSGHYGRHVAALAERLRAQQDLVTEKMDAHGLEVLLRPEGGMFAWARMRETDGPAPS
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCCCC
GNRLATLALEHGIWLAPGAYFEPGEADSPWIRFNVATSDAPQLWDFFDAVRTDQGALARA
CCCEEEEEEECCEEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA