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The map label for this gene is mrdA [H]

Identifier: 94308999

GI number: 94308999

Start: 61236

End: 63617

Strand: Direct

Name: mrdA [H]

Synonym: Rmet_0054

Alternate gene names: 94308999

Gene position: 61236-63617 (Clockwise)

Preceding gene: 94308998

Following gene: 94309000

Centisome position: 1.56

GC content: 66.54

Gene sequence:

>2382_bases
ATGACCGAAATTCGCAACGTCGAACTGGAAATCGGCCGCTTCCGCATCCGCGTGGCGGCCGCCGCCCTGTTCACGGTCGT
CTGCTTTGGCCTGCTGTTCTCCCGCTTTCTGTGGCTGCAGTGGTACAAGCACGACCAGTACTCGGCCAAGGCCGAGGACA
ACCGCATCTCCGTGGCGCCGATCGAGCCTAACCGCGGCATCATCATGGACCGCAACGGCGTGGTGCTGGCGCGCAACTAC
TCCGCGTACACGCTTGAAATCACGCCGTCCAAGCTGACCGACACGCTCGACAACACGATCGAGGAGCTGGCCACGCTCGT
CGATATCCAACCGCGCGACCGTCGCCGCTTCAAGCGGCTGCTGGAGGAATCGCGCAGCTTCGAAAGCCTGCCGATACGCA
GCCAGCTCACCGACGAGGAGGTAGCCCGGTTTTCGGCGCAGCGCTTCCGCTTTCCGGGCGTCGACGTGCGCGCGCGGTTG
TTCCGCCAGTATCCGCTGGGCGAAGCGGCCAGCCACGTGGTCGGCTACCTGGGTCGCATCTCGCAGCGTGACCAGGAGCG
GATCGAGGCCATGGACGAGGCCAACGACGCCGCCGATGGCGACAAGTACGATCCGCGCAAGGACGCCGACAACTACAAGG
GCTCCAACTACATCGGCAAGATCGGGCTGGAACAGAGCTACGAGACCGAGCTGCACGGCCTGACGGGCTTCGAGGAGGTG
GAGGTCAGCGCAGGTGGGCGGCCGATTCGCACCCTGTCCACGTCGCCGGCCACGCCGGGCAACAACCTGATCCTGTCGCT
CGACATCCGCCTGCAGCAACTGGCCGAGCAGCTGTTCGGCGATCGCCGTGGAGCGCTGGTGGCGATCGAGCCCGAAACGG
GCGACATCCTGGCCTTCGTGTCCAAGCCGACCTTCGATCCGAACCTGTTCGTCGAAGGCATCGACTCCAAGACCTGGGAC
GAACTGAACAACTCACCCGACAAGCCGCTGCTGAACCGACCGTTGCGCGGCACCTATCCGCCTGGCTCGACGTACAAGCC
GTTCATGGCGCTGGCTGCGCTGACCACGGGCAAGCGCACTGCCGCCTGGGGGATGCACGATCCAGGGTTCTTCACGCTTG
GCAACCACACGTTCCGCGACGACAAGCCCGGCGGCCACGGCTGGGTGGACATGCAGGCGTCGATCGTGCAGTCGTGCGAC
ACCTATTACTACATGCTGGCGCGTGACATGGGCGTCAACGCGATCCACGATTTCATGAAGCCGCTCGGCTTCGGCCAGAT
CACCGGCATCGATATCGAGGGCGAAAACCGCGGCATCCTGCCATCCACGGACTGGAAGCGAAAGGCGTACCGCCGCCCCG
AGCAGCAGAAGTGGTATGACGGCGAAACCATTTCGCTGGGCATCGGGCAGGGCTACAACAGCTTCACGATCCTGCAGTTG
GCCAACGCGGTGTCGATCCTGGTCAACAACGGCGTGGCGATGAAGCCCCACCTGGTCAAGGCCGTGGAGGATTCGGTCTC
GCGCAAGCGCACGCTGACCGTGCCCAAGGAAAGCTATCGCATCCCGCTCAAGCAGGGCGATATCGACGTGATCAAGCGTT
CGATGGTTGCCGTGACGCACTCCGGTACCGCTGCACGGGTGTTCGCCGGCGCTGCCTACGAGTCGGCCGGCAAGACCGGT
ACGGCGCAGACCTACACGCTGGGCAAGAACGAGAAGTACAACCACCATGCGCTGGACGAGCGCAAGCGCGACCACTCGCT
CTACACCGCGTTCGCCCCGGCCGATCATCCGAAGATCGCGCTGGCGCTGATCGTCGAGAACGCGGGTTTTGGCGCCGCCG
TGGCCGCGCCGATCGCGCGCAAGGTGATGGACTACTACCTGCTGGGCAAGTGGCCGGAGGAACTGGCCGCGACGGCCCCG
CCGCCCGCGGAGCGCGAGCGCGCTGGCGGCAAGCCGCCTGTCGACACGCCGAGCGTGTTCACGACTGGCCAGACCGCCAA
TGCCGCCAGTGCCACGGTGATGCAGACAGCACCGGCCGCCGCGTCGGATGCCACGACGGGCGCTGCAAATGCCGCAGGCG
CGAGCGCGGCGGGGGCTTCCGCATCGGTGCCGGCGGCACGGTCGGCATCCGACACGATTGCCGGCCAGCTCGACCCGGAT
GCCATCGCCCCGGCCTCGGCCGAAGTGACGCTCGATGCGCGGATGCTGCAGGCGCTTGGCCACAGCAAGCCAGCGCCGAC
GCCACCCGCCACGCCGTCGCGCGCAACGCCCGCCTCGGCCCCGGCACCCGCCAAGCCGAAGACGCAGCCCGCCCGGCCAA
AGCCCGCCAATGTCGCGGGCCCGGCCTCGGGCTCGTCGGCCCGCAACAACGTTTCAGAGTAA

Upstream 100 bases:

>100_bases
CTGCTGCTGGCGCCGCAACGCAGATCGAACGAAGTCGATGAGACGCGTCCGATCTAGTCCCAATCCCTGACGCGCTCACC
ACGCCGCCCGCAGTACCGCC

Downstream 100 bases:

>100_bases
TAAGGAGACGCGCATGGACCGACGCCGCGTCGTATCGATCATCAAGTCTGCCCTGACCGGCTTCGACAAGCCGCTGGCCT
TGATCGTCTTTCTGCTGTTC

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 793; Mature: 792

Protein sequence:

>793_residues
MTEIRNVELEIGRFRIRVAAAALFTVVCFGLLFSRFLWLQWYKHDQYSAKAEDNRISVAPIEPNRGIIMDRNGVVLARNY
SAYTLEITPSKLTDTLDNTIEELATLVDIQPRDRRRFKRLLEESRSFESLPIRSQLTDEEVARFSAQRFRFPGVDVRARL
FRQYPLGEAASHVVGYLGRISQRDQERIEAMDEANDAADGDKYDPRKDADNYKGSNYIGKIGLEQSYETELHGLTGFEEV
EVSAGGRPIRTLSTSPATPGNNLILSLDIRLQQLAEQLFGDRRGALVAIEPETGDILAFVSKPTFDPNLFVEGIDSKTWD
ELNNSPDKPLLNRPLRGTYPPGSTYKPFMALAALTTGKRTAAWGMHDPGFFTLGNHTFRDDKPGGHGWVDMQASIVQSCD
TYYYMLARDMGVNAIHDFMKPLGFGQITGIDIEGENRGILPSTDWKRKAYRRPEQQKWYDGETISLGIGQGYNSFTILQL
ANAVSILVNNGVAMKPHLVKAVEDSVSRKRTLTVPKESYRIPLKQGDIDVIKRSMVAVTHSGTAARVFAGAAYESAGKTG
TAQTYTLGKNEKYNHHALDERKRDHSLYTAFAPADHPKIALALIVENAGFGAAVAAPIARKVMDYYLLGKWPEELAATAP
PPAERERAGGKPPVDTPSVFTTGQTANAASATVMQTAPAAASDATTGAANAAGASAAGASASVPAARSASDTIAGQLDPD
AIAPASAEVTLDARMLQALGHSKPAPTPPATPSRATPASAPAPAKPKTQPARPKPANVAGPASGSSARNNVSE

Sequences:

>Translated_793_residues
MTEIRNVELEIGRFRIRVAAAALFTVVCFGLLFSRFLWLQWYKHDQYSAKAEDNRISVAPIEPNRGIIMDRNGVVLARNY
SAYTLEITPSKLTDTLDNTIEELATLVDIQPRDRRRFKRLLEESRSFESLPIRSQLTDEEVARFSAQRFRFPGVDVRARL
FRQYPLGEAASHVVGYLGRISQRDQERIEAMDEANDAADGDKYDPRKDADNYKGSNYIGKIGLEQSYETELHGLTGFEEV
EVSAGGRPIRTLSTSPATPGNNLILSLDIRLQQLAEQLFGDRRGALVAIEPETGDILAFVSKPTFDPNLFVEGIDSKTWD
ELNNSPDKPLLNRPLRGTYPPGSTYKPFMALAALTTGKRTAAWGMHDPGFFTLGNHTFRDDKPGGHGWVDMQASIVQSCD
TYYYMLARDMGVNAIHDFMKPLGFGQITGIDIEGENRGILPSTDWKRKAYRRPEQQKWYDGETISLGIGQGYNSFTILQL
ANAVSILVNNGVAMKPHLVKAVEDSVSRKRTLTVPKESYRIPLKQGDIDVIKRSMVAVTHSGTAARVFAGAAYESAGKTG
TAQTYTLGKNEKYNHHALDERKRDHSLYTAFAPADHPKIALALIVENAGFGAAVAAPIARKVMDYYLLGKWPEELAATAP
PPAERERAGGKPPVDTPSVFTTGQTANAASATVMQTAPAAASDATTGAANAAGASAAGASASVPAARSASDTIAGQLDPD
AIAPASAEVTLDARMLQALGHSKPAPTPPATPSRATPASAPAPAKPKTQPARPKPANVAGPASGSSARNNVSE
>Mature_792_residues
TEIRNVELEIGRFRIRVAAAALFTVVCFGLLFSRFLWLQWYKHDQYSAKAEDNRISVAPIEPNRGIIMDRNGVVLARNYS
AYTLEITPSKLTDTLDNTIEELATLVDIQPRDRRRFKRLLEESRSFESLPIRSQLTDEEVARFSAQRFRFPGVDVRARLF
RQYPLGEAASHVVGYLGRISQRDQERIEAMDEANDAADGDKYDPRKDADNYKGSNYIGKIGLEQSYETELHGLTGFEEVE
VSAGGRPIRTLSTSPATPGNNLILSLDIRLQQLAEQLFGDRRGALVAIEPETGDILAFVSKPTFDPNLFVEGIDSKTWDE
LNNSPDKPLLNRPLRGTYPPGSTYKPFMALAALTTGKRTAAWGMHDPGFFTLGNHTFRDDKPGGHGWVDMQASIVQSCDT
YYYMLARDMGVNAIHDFMKPLGFGQITGIDIEGENRGILPSTDWKRKAYRRPEQQKWYDGETISLGIGQGYNSFTILQLA
NAVSILVNNGVAMKPHLVKAVEDSVSRKRTLTVPKESYRIPLKQGDIDVIKRSMVAVTHSGTAARVFAGAAYESAGKTGT
AQTYTLGKNEKYNHHALDERKRDHSLYTAFAPADHPKIALALIVENAGFGAAVAAPIARKVMDYYLLGKWPEELAATAPP
PAERERAGGKPPVDTPSVFTTGQTANAASATVMQTAPAAASDATTGAANAAGASAAGASASVPAARSASDTIAGQLDPDA
IAPASAEVTLDARMLQALGHSKPAPTPPATPSRATPASAPAPAKPKTQPARPKPANVAGPASGSSARNNVSE

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=647, Percent_Identity=39.258114374034, Blast_Score=477, Evalue=1e-135,
Organism=Escherichia coli, GI1786272, Length=624, Percent_Identity=23.5576923076923, Blast_Score=126, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 86010; Mature: 85878

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEIRNVELEIGRFRIRVAAAALFTVVCFGLLFSRFLWLQWYKHDQYSAKAEDNRISVAP
CCCCCEEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEE
IEPNRGIIMDRNGVVLARNYSAYTLEITPSKLTDTLDNTIEELATLVDIQPRDRRRFKRL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LEESRSFESLPIRSQLTDEEVARFSAQRFRFPGVDVRARLFRQYPLGEAASHVVGYLGRI
HHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SQRDQERIEAMDEANDAADGDKYDPRKDADNYKGSNYIGKIGLEQSYETELHGLTGFEEV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHCCCCCCCEE
EVSAGGRPIRTLSTSPATPGNNLILSLDIRLQQLAEQLFGDRRGALVAIEPETGDILAFV
EECCCCCEEEEECCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEE
SKPTFDPNLFVEGIDSKTWDELNNSPDKPLLNRPLRGTYPPGSTYKPFMALAALTTGKRT
ECCCCCCCCEEECCCCCHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCE
AAWGMHDPGFFTLGNHTFRDDKPGGHGWVDMQASIVQSCDTYYYMLARDMGVNAIHDFMK
EECCCCCCCEEEECCCCCCCCCCCCCCEECHHHHHHHHHHHHHEEHHHHCCHHHHHHHHH
PLGFGQITGIDIEGENRGILPSTDWKRKAYRRPEQQKWYDGETISLGIGQGYNSFTILQL
HCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHCCCCCCEEEEECCCCCCCEEHHHH
ANAVSILVNNGVAMKPHLVKAVEDSVSRKRTLTVPKESYRIPLKQGDIDVIKRSMVAVTH
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEECCHHHCCCCCCCCCHHHHHHHHEEEEC
SGTAARVFAGAAYESAGKTGTAQTYTLGKNEKYNHHALDERKRDHSLYTAFAPADHPKIA
CCCEEEEEECHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCEE
LALIVENAGFGAAVAAPIARKVMDYYLLGKWPEELAATAPPPAERERAGGKPPVDTPSVF
EEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHCCCCCCCCCCCEE
TTGQTANAASATVMQTAPAAASDATTGAANAAGASAAGASASVPAARSASDTIAGQLDPD
ECCCCCCCCHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
AIAPASAEVTLDARMLQALGHSKPAPTPPATPSRATPASAPAPAKPKTQPARPKPANVAG
HCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PASGSSARNNVSE
CCCCCCCCCCCCC
>Mature Secondary Structure 
TEIRNVELEIGRFRIRVAAAALFTVVCFGLLFSRFLWLQWYKHDQYSAKAEDNRISVAP
CCCCEEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEE
IEPNRGIIMDRNGVVLARNYSAYTLEITPSKLTDTLDNTIEELATLVDIQPRDRRRFKRL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LEESRSFESLPIRSQLTDEEVARFSAQRFRFPGVDVRARLFRQYPLGEAASHVVGYLGRI
HHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SQRDQERIEAMDEANDAADGDKYDPRKDADNYKGSNYIGKIGLEQSYETELHGLTGFEEV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHCCCCCCCEE
EVSAGGRPIRTLSTSPATPGNNLILSLDIRLQQLAEQLFGDRRGALVAIEPETGDILAFV
EECCCCCEEEEECCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEE
SKPTFDPNLFVEGIDSKTWDELNNSPDKPLLNRPLRGTYPPGSTYKPFMALAALTTGKRT
ECCCCCCCCEEECCCCCHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCE
AAWGMHDPGFFTLGNHTFRDDKPGGHGWVDMQASIVQSCDTYYYMLARDMGVNAIHDFMK
EECCCCCCCEEEECCCCCCCCCCCCCCEECHHHHHHHHHHHHHEEHHHHCCHHHHHHHHH
PLGFGQITGIDIEGENRGILPSTDWKRKAYRRPEQQKWYDGETISLGIGQGYNSFTILQL
HCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHCCCCCCEEEEECCCCCCCEEHHHH
ANAVSILVNNGVAMKPHLVKAVEDSVSRKRTLTVPKESYRIPLKQGDIDVIKRSMVAVTH
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEECCHHHCCCCCCCCCHHHHHHHHEEEEC
SGTAARVFAGAAYESAGKTGTAQTYTLGKNEKYNHHALDERKRDHSLYTAFAPADHPKIA
CCCEEEEEECHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCEE
LALIVENAGFGAAVAAPIARKVMDYYLLGKWPEELAATAPPPAERERAGGKPPVDTPSVF
EEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHCCCCCCCCCCCEE
TTGQTANAASATVMQTAPAAASDATTGAANAAGASAAGASASVPAARSASDTIAGQLDPD
ECCCCCCCCHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
AIAPASAEVTLDARMLQALGHSKPAPTPPATPSRATPASAPAPAKPKTQPARPKPANVAG
HCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PASGSSARNNVSE
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]