Click here to switch to the map view.

The map label for this gene is fmt [H]

Identifier: 93007291

GI number: 93007291

Start: 3048724

End: 3049815

Strand: Reverse

Name: fmt [H]

Synonym: Pcryo_2467

Alternate gene names: 93007291

Gene position: 3049815-3048724 (Counterclockwise)

Preceding gene: 93007293

Following gene: 93007290

Centisome position: 99.67

GC content: 44.23

Gene sequence:

>1092_bases
ATGACCACACTTGCTTGTACCCCTGATGTATCTCTTAATAATGATAACTTTAAACCGACGCGTACAGAGCCGTTAAAAGT
GGTATTTGCTGGCACGCCTGAGTTTGCCGCCGTGAGTCTTGAGGCATTAATCAAGCAGCAACAGGCATTGAATATCAGTA
TTGTAGCGGTCTATAGTCAGCCTGATCGTAAAGCTGGCCGCGGACAAAAGCTGGCGGCATCTGCGGTCAAGCAAGTAGCA
TTGGCACATGATATCGCTGTTGAACAGCCAGAGACCTTTAAAAAATCAAGTATAGAAGGGGTAATAGCAAGGCAAACTTT
GCAAGATTATCAACCCGATGTAATGATTGTTGCTGCTTATGGGTTGATTCTTCCTGTTGGTGTCTTGAATACGCCGACTT
ATGGTTGCTTAAACATCCACGCCTCATTATTACCACGCTGGCGTGGTGCAGCGCCTATTCACCGCGCATTATTGGCTGGT
GATAGTGAGACTGGCGTTACTATTATGCAGATGAATAAAGGGCTTGATACTGGAGACATGCTTTATAAAGTCAGTGCTAG
TATTGAGTCTGATGATACGGCTGCCAGCCTACATGATAAAATGGCTGAGCTTGGTGCGACCGCCATTATTACTGTGCTAC
AAGATTTACCACACTATCAAGCTCAGGCTATAGTACAAGATGACAGTCAAGCCAATTATGCTGAAAAGTTAGTCAAAAAT
GAGGGTGAAATTGATTGGACGCAGTCTGCCACTGTGATTGAACGACAAATTCGTGGCTTAACTCCTTGGCCTGGTGCTTA
TACCTTTTTGGCAGGTCAGCGTGTCAAAATTTTAGCCAGCTTGCCTGTGAATGCATCGCAACCAACCGATAAACAAGCAG
GTACAGTTATTAGTGTGGGGCGCAAGGCAATTTTAGTCGCTTGTGGTAAAGATAATAATATTGATACTGATGTAAATAGC
GAAAAACCTCAAGCCAGTACTTTAGCTGTTACTCAGCTACAGTTTGCAGGCAGCAAACCTGTGAGCGCCGAACAAATCTG
CCATGGCAATCAGCTTAATGATGGCGACCAGTTTAGTAAAGAAACGAAATAA

Upstream 100 bases:

>100_bases
CAGACGCATTAGTAGCGCTTGATTGTGGCTATTACAATCATGGCACAACGCCACAAACTCACCTATAATAGCTTTATTAC
TTATTAATATTGCCTAAACT

Downstream 100 bases:

>100_bases
CTCCATTTAGATATACCTAATCCAAATCGCACAAGACGCTAACTATTAGACGTCAAGGAAATTCAATTTAATGAGACAAA
CCAGCACTGCACCAAGAAAT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTTLACTPDVSLNNDNFKPTRTEPLKVVFAGTPEFAAVSLEALIKQQQALNISIVAVYSQPDRKAGRGQKLAASAVKQVA
LAHDIAVEQPETFKKSSIEGVIARQTLQDYQPDVMIVAAYGLILPVGVLNTPTYGCLNIHASLLPRWRGAAPIHRALLAG
DSETGVTIMQMNKGLDTGDMLYKVSASIESDDTAASLHDKMAELGATAIITVLQDLPHYQAQAIVQDDSQANYAEKLVKN
EGEIDWTQSATVIERQIRGLTPWPGAYTFLAGQRVKILASLPVNASQPTDKQAGTVISVGRKAILVACGKDNNIDTDVNS
EKPQASTLAVTQLQFAGSKPVSAEQICHGNQLNDGDQFSKETK

Sequences:

>Translated_363_residues
MTTLACTPDVSLNNDNFKPTRTEPLKVVFAGTPEFAAVSLEALIKQQQALNISIVAVYSQPDRKAGRGQKLAASAVKQVA
LAHDIAVEQPETFKKSSIEGVIARQTLQDYQPDVMIVAAYGLILPVGVLNTPTYGCLNIHASLLPRWRGAAPIHRALLAG
DSETGVTIMQMNKGLDTGDMLYKVSASIESDDTAASLHDKMAELGATAIITVLQDLPHYQAQAIVQDDSQANYAEKLVKN
EGEIDWTQSATVIERQIRGLTPWPGAYTFLAGQRVKILASLPVNASQPTDKQAGTVISVGRKAILVACGKDNNIDTDVNS
EKPQASTLAVTQLQFAGSKPVSAEQICHGNQLNDGDQFSKETK
>Mature_362_residues
TTLACTPDVSLNNDNFKPTRTEPLKVVFAGTPEFAAVSLEALIKQQQALNISIVAVYSQPDRKAGRGQKLAASAVKQVAL
AHDIAVEQPETFKKSSIEGVIARQTLQDYQPDVMIVAAYGLILPVGVLNTPTYGCLNIHASLLPRWRGAAPIHRALLAGD
SETGVTIMQMNKGLDTGDMLYKVSASIESDDTAASLHDKMAELGATAIITVLQDLPHYQAQAIVQDDSQANYAEKLVKNE
GEIDWTQSATVIERQIRGLTPWPGAYTFLAGQRVKILASLPVNASQPTDKQAGTVISVGRKAILVACGKDNNIDTDVNSE
KPQASTLAVTQLQFAGSKPVSAEQICHGNQLNDGDQFSKETK

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI238814322, Length=306, Percent_Identity=28.7581699346405, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI164663775, Length=306, Percent_Identity=30.3921568627451, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI21614513, Length=228, Percent_Identity=27.1929824561404, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1789683, Length=330, Percent_Identity=43.9393939393939, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1788589, Length=287, Percent_Identity=27.1777003484321, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI133930964, Length=265, Percent_Identity=26.0377358490566, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319458, Length=279, Percent_Identity=26.5232974910394, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550868, Length=329, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28571984, Length=241, Percent_Identity=31.5352697095436, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585660, Length=247, Percent_Identity=29.1497975708502, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 38933; Mature: 38801

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLACTPDVSLNNDNFKPTRTEPLKVVFAGTPEFAAVSLEALIKQQQALNISIVAVYSQ
CCEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEEECC
PDRKAGRGQKLAASAVKQVALAHDIAVEQPETFKKSSIEGVIARQTLQDYQPDVMIVAAY
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
GLILPVGVLNTPTYGCLNIHASLLPRWRGAAPIHRALLAGDSETGVTIMQMNKGLDTGDM
HHHHHHHHCCCCCCCCEEHHHHHCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCE
LYKVSASIESDDTAASLHDKMAELGATAIITVLQDLPHYQAQAIVQDDSQANYAEKLVKN
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEECCCCCHHHHHHHHCC
EGEIDWTQSATVIERQIRGLTPWPGAYTFLAGQRVKILASLPVNASQPTDKQAGTVISVG
CCCEEECCCHHHHHHHHCCCCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCEEECC
RKAILVACGKDNNIDTDVNSEKPQASTLAVTQLQFAGSKPVSAEQICHGNQLNDGDQFSK
CEEEEEEECCCCCCCCCCCCCCCCCHHEEEEEEEECCCCCCCHHHHHCCCCCCCCHHHHC
ETK
CCC
>Mature Secondary Structure 
TTLACTPDVSLNNDNFKPTRTEPLKVVFAGTPEFAAVSLEALIKQQQALNISIVAVYSQ
CEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEEECC
PDRKAGRGQKLAASAVKQVALAHDIAVEQPETFKKSSIEGVIARQTLQDYQPDVMIVAAY
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
GLILPVGVLNTPTYGCLNIHASLLPRWRGAAPIHRALLAGDSETGVTIMQMNKGLDTGDM
HHHHHHHHCCCCCCCCEEHHHHHCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCE
LYKVSASIESDDTAASLHDKMAELGATAIITVLQDLPHYQAQAIVQDDSQANYAEKLVKN
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEECCCCCHHHHHHHHCC
EGEIDWTQSATVIERQIRGLTPWPGAYTFLAGQRVKILASLPVNASQPTDKQAGTVISVG
CCCEEECCCHHHHHHHHCCCCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCEEECC
RKAILVACGKDNNIDTDVNSEKPQASTLAVTQLQFAGSKPVSAEQICHGNQLNDGDQFSK
CEEEEEEECCCCCCCCCCCCCCCCCHHEEEEEEEECCCCCCCHHHHHCCCCCCCCHHHHC
ETK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA