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The map label for this gene is bioF [C]

Identifier: 93007278

GI number: 93007278

Start: 3031390

End: 3032622

Strand: Direct

Name: bioF [C]

Synonym: Pcryo_2454

Alternate gene names: 93007278

Gene position: 3031390-3032622 (Clockwise)

Preceding gene: 93007273

Following gene: 93007279

Centisome position: 99.07

GC content: 44.36

Gene sequence:

>1233_bases
ATGACTGCTCTTATTATCAATCGTCTGCAAGAGTCGCTCAACGCGCTAAAAGCAGCGAATCAATACCGTCAGATACCTAA
CTTACAACACCATGAGCAATATGTGATTAGCGAAGGCAAGCGATTACTCAATATCGCTAGCAACGATTATCTTGGCTTGG
GCAGTAATAAGCAACTCCAGAGCGATTTCCTTAATCAACTCAATCAATTTCCAGTCGATAGCATACCTAGGATGAGTGCC
ACCTCCTCTAGGCTCTTGACAGGTAACGATGAACATCTGCAAGCATTGGAGTCTGAACTACAAGAATGGTATCAAAACGC
TGTAGACAAGAAAAACTTATCTTCATCAAAATCGGTACTGGTATTCAACAGCGGCTACCATGCCAATATAGGTATTTTGC
CTGCACTGACGACATTGCCAATCAAAACGCTCATTTTGGCAGATAAACTGGTGCACGCTAGTATTATCGACGGCATACGC
CTCAGCCAAAGTAAGCTGGTTAGCTATCGTCGTTACCGTCACAACGACTATGAGCATTTAGCCAAATTTATTGAGCAAGC
AGATTCAAGTGTTAAGCGCATTATTATTGTCACCGAAAGCATCTTTAGTATGGATGGTGACCGCGCTGACTTGGCGCAAT
TGGTGCAATTAAAAGCAAAAGATGCTCGTATTGAGCTGTATATCGATGAAGCCCATGCTATCGGTATCTTAGGTGATTCA
GGTTTAGGAGTGGCAGAAGAAACCCAAACACTGGCTGATATTGATTATCTGGTGGGGACTTTTGGTAAAGCGTTTGCGTC
CATTGGCGCTTATATCATGTGTAATGATGTCGTCAAACACTGGCTAATTAATCAGATGCGCCCCCTCATTTTTAGCACCG
CATTACCACCCATTAATCACGCATGGACACGTTTTATTTTAGCAAAAATGCCAAGCTTAACGGAGCAGCGCCTTCATTTG
GCACGGTTATCCGTCACGCTTAGTGACGCTATTCCCGAACGATATCGCGTGTCGTTAATTCATCAAGATGCAGGCTATGC
CTCCCCTATTGTGCCTTATATACTAGGCGATAATGCGCTCACTGTCGAAAAAGCAAAGCAGCTACAAGCAGCAGGATTTT
ATGCCTTACCTGTCAGACCGCCTACTGTTCCTGCCAATACTGCTCGTATTCGCTTAGTGATGAATGCAGCGCTTAGCCAT
GAGGACTGTCAGCGGCTGATAGCGCATTTATAA

Upstream 100 bases:

>100_bases
GCAATAATCCCTACTTATTCTTGAGACGATTTACTCAGAACCTCATTTTAATAAGTAAAAACGATTAAATAAAAGCGATT
AAATAAAAAAAGGGACCTCA

Downstream 100 bases:

>100_bases
TGCGATTATTTTTTAGTAACTACTTTCTTTTAGCGTTAAGCGAATTATTTGGATGCAACAAACAACATGAAACCTCCTGC
TACACCTGACATTCTCAGCA

Product: class I and II aminotransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTALIINRLQESLNALKAANQYRQIPNLQHHEQYVISEGKRLLNIASNDYLGLGSNKQLQSDFLNQLNQFPVDSIPRMSA
TSSRLLTGNDEHLQALESELQEWYQNAVDKKNLSSSKSVLVFNSGYHANIGILPALTTLPIKTLILADKLVHASIIDGIR
LSQSKLVSYRRYRHNDYEHLAKFIEQADSSVKRIIIVTESIFSMDGDRADLAQLVQLKAKDARIELYIDEAHAIGILGDS
GLGVAEETQTLADIDYLVGTFGKAFASIGAYIMCNDVVKHWLINQMRPLIFSTALPPINHAWTRFILAKMPSLTEQRLHL
ARLSVTLSDAIPERYRVSLIHQDAGYASPIVPYILGDNALTVEKAKQLQAAGFYALPVRPPTVPANTARIRLVMNAALSH
EDCQRLIAHL

Sequences:

>Translated_410_residues
MTALIINRLQESLNALKAANQYRQIPNLQHHEQYVISEGKRLLNIASNDYLGLGSNKQLQSDFLNQLNQFPVDSIPRMSA
TSSRLLTGNDEHLQALESELQEWYQNAVDKKNLSSSKSVLVFNSGYHANIGILPALTTLPIKTLILADKLVHASIIDGIR
LSQSKLVSYRRYRHNDYEHLAKFIEQADSSVKRIIIVTESIFSMDGDRADLAQLVQLKAKDARIELYIDEAHAIGILGDS
GLGVAEETQTLADIDYLVGTFGKAFASIGAYIMCNDVVKHWLINQMRPLIFSTALPPINHAWTRFILAKMPSLTEQRLHL
ARLSVTLSDAIPERYRVSLIHQDAGYASPIVPYILGDNALTVEKAKQLQAAGFYALPVRPPTVPANTARIRLVMNAALSH
EDCQRLIAHL
>Mature_409_residues
TALIINRLQESLNALKAANQYRQIPNLQHHEQYVISEGKRLLNIASNDYLGLGSNKQLQSDFLNQLNQFPVDSIPRMSAT
SSRLLTGNDEHLQALESELQEWYQNAVDKKNLSSSKSVLVFNSGYHANIGILPALTTLPIKTLILADKLVHASIIDGIRL
SQSKLVSYRRYRHNDYEHLAKFIEQADSSVKRIIIVTESIFSMDGDRADLAQLVQLKAKDARIELYIDEAHAIGILGDSG
LGVAEETQTLADIDYLVGTFGKAFASIGAYIMCNDVVKHWLINQMRPLIFSTALPPINHAWTRFILAKMPSLTEQRLHLA
RLSVTLSDAIPERYRVSLIHQDAGYASPIVPYILGDNALTVEKAKQLQAAGFYALPVRPPTVPANTARIRLVMNAALSHE
DCQRLIAHL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=411, Percent_Identity=28.2238442822384, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI284448556, Length=383, Percent_Identity=28.7206266318538, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI83977442, Length=301, Percent_Identity=29.5681063122924, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI83977440, Length=301, Percent_Identity=29.5681063122924, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI83977444, Length=301, Percent_Identity=29.5681063122924, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4502025, Length=253, Percent_Identity=30.0395256916996, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI40316939, Length=253, Percent_Identity=30.0395256916996, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4758668, Length=381, Percent_Identity=27.2965879265092, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI119220554, Length=304, Percent_Identity=29.6052631578947, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI5454084, Length=275, Percent_Identity=25.8181818181818, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786993, Length=387, Percent_Identity=33.5917312661499, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1790046, Length=377, Percent_Identity=29.7082228116711, Blast_Score=148, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=412, Percent_Identity=28.8834951456311, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17560914, Length=297, Percent_Identity=29.2929292929293, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17560912, Length=297, Percent_Identity=29.2929292929293, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI32566772, Length=386, Percent_Identity=26.1658031088083, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982617, Length=274, Percent_Identity=27.007299270073, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71982625, Length=274, Percent_Identity=26.6423357664234, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320267, Length=395, Percent_Identity=28.3544303797468, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6320438, Length=413, Percent_Identity=25.4237288135593, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323954, Length=298, Percent_Identity=25.1677852348993, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24662918, Length=406, Percent_Identity=29.064039408867, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI17137420, Length=256, Percent_Identity=34.765625, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17136286, Length=381, Percent_Identity=25.9842519685039, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24653280, Length=276, Percent_Identity=26.4492753623188, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24653276, Length=276, Percent_Identity=26.4492753623188, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24653278, Length=276, Percent_Identity=26.4492753623188, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 45708; Mature: 45577

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALIINRLQESLNALKAANQYRQIPNLQHHEQYVISEGKRLLNIASNDYLGLGSNKQLQ
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHH
SDFLNQLNQFPVDSIPRMSATSSRLLTGNDEHLQALESELQEWYQNAVDKKNLSSSKSVL
HHHHHHHHCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
VFNSGYHANIGILPALTTLPIKTLILADKLVHASIIDGIRLSQSKLVSYRRYRHNDYEHL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHCCCCHHHH
AKFIEQADSSVKRIIIVTESIFSMDGDRADLAQLVQLKAKDARIELYIDEAHAIGILGDS
HHHHHHHCCCCEEEEEEEHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCEEEEEECCC
GLGVAEETQTLADIDYLVGTFGKAFASIGAYIMCNDVVKHWLINQMRPLIFSTALPPINH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AWTRFILAKMPSLTEQRLHLARLSVTLSDAIPERYRVSLIHQDAGYASPIVPYILGDNAL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCCCCCCCCCEEECCCCE
TVEKAKQLQAAGFYALPVRPPTVPANTARIRLVMNAALSHEDCQRLIAHL
EHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
TALIINRLQESLNALKAANQYRQIPNLQHHEQYVISEGKRLLNIASNDYLGLGSNKQLQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHH
SDFLNQLNQFPVDSIPRMSATSSRLLTGNDEHLQALESELQEWYQNAVDKKNLSSSKSVL
HHHHHHHHCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
VFNSGYHANIGILPALTTLPIKTLILADKLVHASIIDGIRLSQSKLVSYRRYRHNDYEHL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHCCCCHHHH
AKFIEQADSSVKRIIIVTESIFSMDGDRADLAQLVQLKAKDARIELYIDEAHAIGILGDS
HHHHHHHCCCCEEEEEEEHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCEEEEEECCC
GLGVAEETQTLADIDYLVGTFGKAFASIGAYIMCNDVVKHWLINQMRPLIFSTALPPINH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AWTRFILAKMPSLTEQRLHLARLSVTLSDAIPERYRVSLIHQDAGYASPIVPYILGDNAL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCCCCCCCCCEEECCCCE
TVEKAKQLQAAGFYALPVRPPTVPANTARIRLVMNAALSHEDCQRLIAHL
EHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA